Rapid effects of aldosterone and spironolactone in the isolated working rat heart

Hypertension

Volumn 40, Issue 2, 2002, Pages 130-135

  Barbato, John C ^a   Mulrow, Patrick J ^a   Shapiro, Joseph I ^a   Franco Saenz, Roberto ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Aldosterone; Cardiac function; Congestive heart failure; Fibrosis; Mineralocorticoids; Renin angiotensin system

Indexed keywords

ALDOSTERONE; ALDOSTERONE ANTAGONIST; SPIRONOLACTONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DOSE RESPONSE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART STROKE VOLUME; HEMODYNAMICS; INOTROPISM; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ALDOSTERONE; ALDOSTERONE ANTAGONISTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; MALE; MYOCARDIAL CONTRACTION; PERFUSION; RATS; RATS, INBRED WKY; SPIRONOLACTONE;

EID: 0036330326     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000025879.29822.24     Document Type: Article

References (46)

1. Relation of the renin-angiotensin-aldosterone system to clinical state in congestive heart failure
2. Effect of the renin-angiotensinaldosterone system on the cardiac interstitium in heart failure
3. Cardiac structure: Function relationship and the renin-angiotensin-aldosterone system in hypertensive heart disease
4. Myocardial collagen matrix remodeling and congestive heart failure
5. The cardiac structure-function relationship and the renin-angiotensin-aldosterone system in hypertension and heart failure
6. The renin-angiotensin-aldosterone system and myocardial collagen matrix remodeling in congestive heart failure
7. Anti-aldosterone: The evidence of the RALES study
8. Diuretic therapy in congestive heart failure: New views on spironolactone therapy
9. From myocardial hypertrophy to heart failure: Role of the interstitium
10. Role of extracellular matrix proteins in heart function
11. Structural basis for pathologic left ventricular hypertrophy
12. Signals for the remodeling of the cardiac interstitium in systemic hypertension
13. Pathological hypertrophy and cardiac interstitium: Fibrosis and renin-angiotensin-aldosterone system
14. Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic arterial hypertension
15. Aldosterone and the heart: Towards a physiological function?
16. Inotropic effects of certain steroids upon the heart muscle
17. Studies on the inotropic actions of aldosterone on isolated cardiac tissue preparations, including the effects of pH, ouabain and SC-8109
18. Aldosterone modulates both the Na/H antiport and C1/HCO3 exchanger in cultured neonatal rat cardiac cells
19. Role of 11β-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries
20. Aldosterone-specific membrane receptors and rapid non-genomic actions of mineralocorticoids
21. Nongenomic aldosterone effects: The cell membrane as a specific target of mineralocorticoid action
22. Non-genomic aldosterone action: A new concept for the mechanism of action of steroids is developed
23. Aldosterone activates Na+/H+ exchange in vascular smooth muscle cells by nongenomic and genomic mechanisms
24. Non-genomic action of the mineralocorticoid aldosterone on cytosolic sodium in cultured kidney cells
25. Rapid aldosterone effects on tyrosine phosphorylation in vascular smooth muscle cells
26. Calcium influx inhibition by steroids and analogs in C2C12 skeletal muscle cells
27. Rapid non-genomic activation of cytosolic cyclic AMP-dependent protein kinase activity and [Ca(2+)](i) by 17β-estradiol in female rat distal colon
28. Rapid effects of aldosterone on sodium-hydrogen exchange in isolated colonic crypts
29. Aldosterone specific membrane receptors, rapid activation of the sodium-hydrogen exchanger, and cardiovascular implications
30. Nongenomic effects of aldosterone on intracellular Ca2+ in vascular smooth muscle cells
31. The inositol-1,4,5-triphosphate system is involved in rapid effects of aldosterone in human mononuclear leukocytes
32. Aldosterone rapidly represses protein kinase C activity in neonatal rat cardiomyocytes in vitro
33. Effects of aldosterone and spironolactone on the isolated perfused rat heart
34. Negative inotropic effects of aldosterone antagonists in isolated human and guinea-pig ventricular heart muscle
35. Canrenone as a partial agonist at the digitalis receptor site of sodium-potassium-activated adenosine triphosphatase
36. Effect of pressure development on oxygen consumption by the isolated rat heart
37. Spectrum of aerobic endurance running performance in eleven inbred strains of rats
38. Myocardial function in rat genetic models of low and high aerobic running capacity
39. Aldosterone upregulates Ca(2+) current in adult rat cardiomyocytes
40. Positive inotropic effect of angiotensin II: Increases in intracellular Ca2+ or changes in myofilament Ca2+ responsiveness?
41. Effects of spironolactone on heart rate variability and left ventricular systolic function in severe ischemic heart failure
42. Antifibrillatory effects of electrolytes regulating steroids on isolated rabbit atria
43. The effects of digoxin, desoxycorticosterone and spironolactone on the myocardium of the mammal
44. The spironolactone renaissance
45. Bell-shaped concentration-response curve for myocardial stimulation by glucocorticoids: An experimental study in the rat
46. Myocardial production of aldosterone and corticosterone in the rat: Physiological regulation