Altered collagen homeostasis in human aortic smooth muscle cells (HAoSMCs) induced by aldosterone

Pflugers Archiv European Journal of Physiology

Volumn 454, Issue 3, 2007, Pages 403-413

  Gekle, Michael ^a   Mildenberger, Sigrid ^a   Freudinger, Ruth ^a   Grossmann, Claudia ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Aldosterone; Collagen; EGFR; Vascular smooth muscle cell

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ALDOSTERONE; COLLAGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; HYDROGEN PEROXIDE; ILOMASTAT; LIGAND; MINERALOCORTICOID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; REACTIVE OXYGEN METABOLITE; TYRPHOSTIN;

ANIMAL CELL; AORTA MEDIA; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL MEMBRANE; CHO CELL; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUOROMETRY; GENETIC TRANSFECTION; HOMEOSTASIS; HORMONE ACTION; HORMONE DETERMINATION; HUMAN; HUMAN CELL; LUMINANCE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR BLOCKING; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

ALDOSTERONE; BASE SEQUENCE; CELLS, CULTURED; COLLAGEN; COLLAGENASES; GELATINASES; HOMEOSTASIS; HUMANS; HYDROGEN PEROXIDE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, MINERALOCORTICOID; RNA, MESSENGER;

EID: 34248341680     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-007-0211-9     Document Type: Article

References (52)

1. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM (1987) Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237:268-275
2. Benetos A, Lacolley P, Safar ME (1997) Prevention of aortic fibrosis by spironolactone in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol 17:1152-1156
3. Brandes RP, Janiszewski M (2005) Direct detection of reactive oxygen species ex vivo. Kidney Int 67:1662-1664
4. Brilla CG, Zhou G, Matsubara L, Weber KT (1994) Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J Mol Cell Cardiol 26:809-820
5. Callera GE, Montezano ACI, Yogi A, Tostes RC, He Y, Schiffrin EL, Touyz RM (2005) c-Src-Dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension 46:1032-1038
6. Callera GE, Touyz RM, Tostes RC, Yogi A, He Y, Malkinson S, Schiffrin EL (2005) Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src. Hypertension 45:1-7
7. Dreux AC, Lamb DJ, Modjtahedi H, Ferns GAA (2006) The epidermal growth factor receptors and their family of ligands: their putative role in atherogenesis. Atherosclerosis 186:38-53
8. Ferrario CM, Strawn WB (2006) Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease. Am J Cardiol 98:121-128
9. Flamant M, Tharaux PL, Placier S, Henrion D, Coffman T, Chatziantoniou C, Dussaule JC (2003) Epidermal growth factor receptor transactivation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. FASEB J 17:327-329
10. Florian JA, Dorrance A, Webb RC, Watts SW (2001) Mineralocorticoids upregulate arterial contraction to epidermal growth factor. Am J Physiol Regul Integr Comp Physiol 281:R878-R886
11. Garnier A, Bendall JK, Fuchs S, Escoubet B, Rochais F, Hoerter J, Nehme J, Ambroisine ML, De Angelis N, Morineau G, d'Estienne P, Fischmeister R, Heymes C, Pinet F, Delcayre C (2004) Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice. Circulation 110:1819-1825
12. Griendling KK, Sorescu D, Lassegue B, Ushio-Fukai M (2000) Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol 20:2175-2183
13. Grossmann C, Benesic A, Krug AW, Freudinger R, Mildenberger S, Gassner B, Gekle M (2005) Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions. Mol Endocrinol 19:1697-1710
14. Heitzer T, Wenzel U, Hink U, Krollner D, Skatchkov M, Stahl RAK, MacHarzina R, Brasen JH, Meinertz T, Munzel T (1999) Increased NAD(P)H oxidase-mediated superoxide production in renovascular hypertension: evidence for an involvement of protein kinase C. Kidney Int 55:252-260
15. Jaffe IZ, Mendelsohn ME (2005) Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circ Res 96:643-650
16. Kagiyama S, Qian K, Kagiyama T, Phillips MI (2003) Antisense to epidermal growth factor receptor prevents the development of left ventricular hypertrophy. Hypertension 41:824-829
17. Kessler-Icekson G, Schlesinger H, Freimann S, Kessler E (2005) Expression of procollagen C-proteinase enhancer-1 in the remodeling rat heart is stimulated by aldosterone. Int J Biochem Cell Biol 38:358-365
18. Krug AW, Grossmann C, Schuster C, Freudinger R, Mildenberger S, Govindan MV, Gekle M (2003) Aldosterone stimulates epidermal growth factor receptor (EGFR) expression. J Biol Chem 278:43060-43066
19. Kuster GM, Kotlyar E, Rude MK, Siwik DA, Liao R, Colucci WS, Sam F (2005) Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload. Circulation 111:420-427
20. Lacolley P, Safar ME, Lucet B, Ledudal K, Labat C, Benetos A (2001) Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats. J Am Coll Cardiol 37:662-667
21. Lacolley P, Labat C, Pujol A, Delcayre C, Benetos A, Safar M (2002) Increased carotid wall elasticmodulus and fibronectin in aldosterone-salt- treated rats: effects of eplerenone. Circulation 106:2848-2853
22. Lemarie CA, Tharaux PL, Esposito B, Tedgui A, Lehoux S (2006) Transforming growth factor-{alpha} mediates nuclear factor {kappa}B activation in strained arteries. Circ Res 99:434-441
23. Ma J, Weisberg A, Griffin JP, Vaughan DE, Fogo AB, Brown NJ (2006) Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury. Kidney Int 69:1064-1072
24. MacFadyen RJ, Barr CS, Struthers AD (1997) Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients. Cardiovasc Res 35:30-34
25. Mazak I, Fiebeler A, Muller DN, Park JK, Shagdarsuren E, Lindschau C, Dechend R, Viedt C, Pilz B, Haller H, Luft FC (2004) Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells. Circulation 109:2792-2800
26. Min LJ, Mogi M, Li JM, Iwanami J, Iwai M, Horiuchi M (2005) Aldosterone and angiotensin II synergistically induce mitogenic response in vascular smooth muscle cells. Circ Res 97:434-442
27. Miternique-Grosse A, Griffon C, Siegel L, Neuville A, Weltin D, Stephan D (2006) Antiangiogenic effects of spironolactone and other potassium-sparing diuretics in human umbilical vein endothelial cells and in fibrin gel chambers implanted in rats. J Hypertens 24:2207-2213
28. Nagai Y, Miyata K, Sun GP, Rahman M, Kimura S, Miyatake A, Kiyomoto H, Kohno M, Abe Y, Yoshizumi M, Nishiyama A (2005) Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts. Hypertension 46:1039-1045
29. Nakano S, Kobayashi N, Yoshida K, Ohno T, Matsuoka H (2005) Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/ extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rhokinase pathways in aldosterone/salt-induced hypertensive rats. Hypertens Res 28:925-936
30. Northcott C, Florian JA, Dorrance A, Watts SW (2001) Arterial epidermal growth factor receptor expression in deoxycorticosterone acetate-salt hypertension. Hypertension 38:1337-1341
31. Ouvrard-Pascaud A, Puttini S, Sainte-Marie Y, Athman R, Fontaine V, Cluzeaud F, Farman N, Rafestin-Oblin ME, Blot-Chabaud M, Jaisser F (2004) Conditional gene expression in renal collecting duct epithelial cells: use of the inducible Cre-lox system. Am J Physiol Renal Physiol 286:F180-F187
32. Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators. N Engl J Med 341:709-717
33. Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, Bittman R, Hurley S, Kleiman J, Gatlin M (2003) Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348:1309-1321
34. Pu Q, Neves MF, Virdis A, Touyz RM, Schiffrin EL (2003) Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension 42:49-55
35. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS (1996) Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 98:2572-2579
36. Robert V, Van Thiem N, Cheav SL, Mouas C, Swynghedauw B, Delcayre C (1994) Increased cardiac types I and III collagen mRNAs in aldosterone-salt hypertension. Hypertension 24:30-36
37. Robert V, Heymes C, Silvestre JS, Sabri A, Swynghedauw B, Delcayre C (1999) Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: role in aldosterone-salt-induced fibrosis. Hypertension 33:981-986
38. Rocha R, Martin-Berger CL, Yang P, Scherrer R, Delyani J, McMahon E (2002) Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology 143:4828-4836
39. Rude MK, Duhaney TA, Kuster GM, Judge S, Heo J, Colucci WS, Siwik DA, Sam F (2005) Aldosterone stimulates matrix metalloproteinases and reactive oxygen species in adult rat ventricular cardiomyocytes. Hypertension 46:555-561
40. Schiffrin EL (2006) Effects of aldosterone on the vasculature. Hypertension 47:312-318
41. Sonder SU, Woetmann A, Odum N, Bendtzen K (2006) Spironolactone induces apoptosis and inhibits NF-kappaB independent of the mineralocorticoid receptor. Apoptosis 11:2159-2965
42. Spinale FG (2002) Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ Res 90:520-530
43. Sun Y, Zhang J, Lu L, Chen SS, Quinn MT, Weber KT (2002) Aldosterone-induced inflammation in the rat heart-role of oxidative stress. Am J Pathol 161:1773-1781
44. Tsybouleva N, Zhang L, Chen S, Patel R, Lutucuta S, Nemoto S, DeFreitas G, Entman M, Carabello BA, Roberts R, Marian AJ (2004) Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. Circulation 109:1284-1291
45. Versteeg HH, Nijhuis E, Van den Brink GR, Evertzen M, Pynaert GN, van Deventer SJ, Coffer PJ, Peppelenbosch MP (2000) A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element-binding protein. Biochem J 3(Pt 350):717-722
46. Vesey DA, Cheung CWY, Cuttle L, Endre ZA, Gobe G, Johnson DW (2002) Interleukin-1beta induces human proximal tubule cell injury, alpha-smooth muscle actin expression and fibronectin production. Kidney Int 62:31-40
47. Wang Q, Clement S, Gabbiani G, Horisberger JD, Burnier M, Rossier BC, Hummler E (2004) Chronic hyperaldosteronism in a transgenic mouse model fails to induce cardiac remodeling and fibrosis under a normal-salt diet. Am J Physiol Renal Physiol 286: F1178-F1184
48. Ward MR, Kanellakis P, Ramsey D, Funder J, Bobik A (2001) Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries. Circulation 104:467-472
49. Young M, Funder JW (2004) Eplerenone, but not steroid withdrawal, reverses cardiac fibrosis in deoxycorticosterone/salt-treated rats. Endocrinology 145:3153-3157
50. Zannad F, Alla F, Dousset B, Perez A, Pitt B (2000) Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Circulation 102:2700-2706
51. Zhang H, Chalothorn D, Jackson LF, Lee DC, Faber JE (2004) Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Circ Res 95:989-997
52. Zhou G, Kandala JC, Tyagi SC, Katwa LC, Weber KT (1996) Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts. Mol Cell Biochem 154:171-178