Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin

Archives of Biochemistry and Biophysics

Volumn 486, Issue 2, 2009, Pages 103-110

  Castelli, Silvia ^a   Campagna, Alessia ^a   Vassallo, Oscar ^a   Tesauro, Cinzia ^a   Fiorani, Paola ^a   Tagliatesta, Pietro ^a   Oteri, Francesco ^a   Falconi, Mattia ^a   Majumder, Hemanta K ^b   Desideri, Alessandro ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

Anticancer drug; Autodock; Camptothecin (CPT); Clustering; Conjugated eicosapentaenoic acid (cEPA); Human DNA topoisomerase IB (hTop IB); Inhibition; Molecular docking

Indexed keywords

CAMPTOTHECIN; DNA TOPOISOMERASE; ICOSAPENTAENOIC ACID; TOPOISOMERASE I SUBUNIT B; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DRUG BINDING SITE; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME INHIBITION; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN DNA BINDING;

CAMPTOTHECIN; DNA; DNA TOPOISOMERASES; EICOSAPENTAENOIC ACID; ENZYME INHIBITORS; HUMANS; KINETICS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; SUBSTRATE SPECIFICITY;

EID: 67349191255     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2009.04.007     Document Type: Article

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