Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase

European Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2009, Pages 3009-3019

  Frecer, Vladimir ^a,b   Megnassan, Eugene ^a,c   Miertus, Stanislav ^a  

^a UNIDO   (Italy)

^b CANCER RESEARCH INSTITUTE   (Slovakia)

^c UNIVERSITÉ NANGUI ABROGOUA   (Côte d’Ivoire)

Author keywords

Analogs of triclosan; Enoyl acyl carrier protein reductase; In silico screening; Malaria; Plasmodium falciparum; Virtual library design

Indexed keywords

ANTIMALARIAL AGENT; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); TRICLOSAN; TRICLOSAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMBINATORIAL LIBRARY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; PLASMODIUM FALCIPARUM; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADSORPTION; ANIMALS; ANTIMALARIALS; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTATIONAL BIOLOGY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PLASMODIUM FALCIPARUM; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRICLOSAN;

EID: 67349188389     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.12.028     Document Type: Article

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