Activity of the circadian transcription factor White Collar Complex is modulated by phosphorylation of SP-motifs

FEBS Letters

Volumn 583, Issue 12, 2009, Pages 1833-1840

  Sancar, Gencer ^a   Sancar, Cigdem ^a   Brunner, Michael ^a   Schafmeier, Tobias ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Circadian clock; Neurospora; Phosphorylation; White Collar Complex

Indexed keywords

ALANINE; ASPARTIC ACID; BIOLOGICAL FACTOR; PROLINE; SERINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WHITE COLLAR 1 PROTEIN; WHITE COLLAR 2 PROTEIN; WHITE COLLAR COMPLEX;

AMINO ACID SUBSTITUTION; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; CIRCADIAN RHYTHM; DNA PRIMERS; DNA, FUNGAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUROSPORA CRASSA; PHOSPHORYLATION; SERINE; TRANSCRIPTION FACTORS;

NEUROSPORA; NEUROSPORA CRASSA;

EID: 67349174721     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.04.042     Document Type: Article

References (36)

1. Brunner M., and Kaldi K. Interlocked feedback loops of the circadian clock of Neurospora crassa. Mol. Microbiol. 68 (2008) 255-262
2. Ko C.H., and Takahashi J.S. Molecular components of the mammalian circadian clock. Hum. Mol. Genet. 15 (Spec. No. 2) (2006) R271-R277
3. Hardin P.E. The circadian timekeeping system of Drosophila. Curr. Biol. 15 (2005) R714-R722
4. Brunner M., and Schafmeier T. Transcriptional and post-transcriptional regulation of the circadian clock of cyanobacteria and Neurospora. Genes Dev. 20 (2006) 1061-1074
5. Gallego M., and Virshup D.M. Post-translational modifications regulate the ticking of the circadian clock. Nat. Rev. Mol. Cell Biol. 8 (2007) 139-148
6. Cha J., Huang G., Guo J., and Liu Y. Posttranslational control of the Neurospora circadian clock. Cold Spring Harb. Symp. Quant. Biol. 72 (2007) 185-191
7. Dunlap J.C., and Loros J.J. The neurospora circadian system. J. Biol. Rhythms 19 (2004) 414-424
8. Heintzen C., and Liu Y. The Neurospora crassa circadian clock. Adv. Genet. 58 (2007) 25-66
9. Froehlich A.C., Liu Y., Loros J.J., and Dunlap J.C. White Collar-1, a circadian blue light photoreceptor, binding to the frequency promoter. Science 297 (2002) 815-819
10. Belden W.J., Loros J.J., and Dunlap J.C. Execution of the circadian negative feedback loop in Neurospora requires the ATP-dependent chromatin-remodeling enzyme CLOCKSWITCH. Mol. Cell 25 (2007) 587-600
11. He Q., Cha J., He Q., Lee H.C., Yang Y., and Liu Y. CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop. Genes Dev. 20 (2006) 2552-2565
12. Schafmeier T., Haase A., Kaldi K., Scholz J., Fuchs M., and Brunner M. Transcriptional feedback of Neurospora circadian clock gene by phosphorylation-dependent inactivation of its transcription factor. Cell 122 (2005) 235-246
13. Schafmeier T., Kaldi K., Diernfellner A., Mohr C., and Brunner M. Phosphorylation-dependent maturation of Neurospora circadian clock protein from a nuclear repressor toward a cytoplasmic activator. Genes Dev. 20 (2006) 297-306
14. Cheng P., Yang Y., and Liu Y. Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock. Proc. Natl. Acad. Sci. USA 98 (2001) 7408-7413
15. Lee K., Loros J.J., and Dunlap J.C. Interconnected feedback loops in the Neurospora circadian system. Science 289 (2000) 107-110
16. Schafmeier T., Diernfellner A., Schafer A., Dintsis O., Neiss A., and Brunner M. Circadian activity and abundance rhythms of the Neurospora clock transcription factor WCC associated with rapid nucleo-cytoplasmic shuttling. Genes Dev. 22 (2008) 3397-3402
17. Huang G., Chen S., Li S., Cha J., Long C., Li L., He Q., and Liu Y. Protein kinase A and casein kinases mediate sequential phosphorylation events in the circadian negative feedback loop. Genes Dev. 21 (2007) 3283-3295
18. He Q., Shu H., Cheng P., Chen S., Wang L., and Liu Y. Light-independent phosphorylation of WHITE COLLAR-1 regulates its function in the Neurospora circadian negative feedback loop. J. Biol. Chem. 280 (2005) 17526-17532
19. Belden W.J., Larrondo L.F., Froehlich A.C., Shi M., Chen C.H., Loros J.J., and Dunlap J.C. The band mutation in Neurospora crassa is a dominant allele of ras-1 implicating RAS signaling in circadian output. Genes Dev. 21 (2007) 1494-1505
20. Neiss A., Schafmeier T., and Brunner M. Transcriptional regulation and function of the Neurospora clock gene white collar 2 and its isoforms. EMBO Rep. 9 (2008) 788-794
21. Puig O., Caspary F., Rigaut G., Rutz B., Bouveret E., Bragado-Nilsson E., Wilm M., and Seraphin B. The tandem affinity purification (TAP) method: a general procedure of protein complex purification. Methods 24 (2001) 218-229
22. Major T., von Janowsky B., Ruppert T., Mogk A., and Voos W. Proteomic analysis of mitochondrial protein turnover: identification of novel substrate proteins of the matrix protease pim1. Mol. Cell Biol. 26 (2006) 762-776
23. Schafer T., Maco B., Petfalski E., Tollervey D., Bottcher B., Aebi U., and Hurt E. Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit. Nature 441 (2006) 651-655
24. Garceau N.Y., Liu Y., Loros J.J., and Dunlap J.C. Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell 89 (1997) 469-476
25. Gorl M., Merrow M., Huttner B., Johnson J., Roenneberg T., and Brunner M. A PEST-like element in FREQUENCY determines the length of the circadian period in Neurospora crassa. EMBO J. 20 (2001) 7074-7084
26. Roenneberg T., and Taylor W. Automated recordings of bioluminescence with special reference to the analysis of circadian rhythms. Meth. Enzymol. 305 (2000) 104-119
27. Denault D.L., Loros J.J., and Dunlap J.C. WC-2 mediates WC-1-FRQ interaction within the PAS protein-linked circadian feedback loop of Neurospora. EMBO J. 20 (2001) 109-117
28. Heintzen C., Loros J.J., and Dunlap J.C. The PAS protein VIVID defines a clock-associated feedback loop that represses light input, modulates gating, and regulates clock resetting. Cell 104 (2001) 453-464
29. Cheng P., Yang Y., Wang L., He Q., and Liu Y. WHITE COLLAR-1, a multifunctional neurospora protein involved in the circadian feedback loops, light sensing, and transcription repression of wc-2. J. Biol. Chem. 278 (2003) 3801-3808
30. Roux P.P., and Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68 (2004) 320-344
31. Lu K.P. Pinning down cell signaling, cancer and Alzheimer's disease. Trends Biochem. Sci. 29 (2004) 200-209
32. Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., and Gygi S.P. A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. USA 105 (2008) 10762-10767
33. Pearson R.B., and Kemp B.E. Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations. Meth. Enzymol. 200 (1991) 62-81
34. Komeili A., and O'Shea E.K. Roles of phosphorylation sites in regulating activity of the transcription factor Pho4. Science 284 (1999) 977-980
35. O'Neill E.M., Kaffman A., Jolly E.R., and O'Shea E.K. Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex. Science 271 (1996) 209-212
36. Jeffery D.A., Springer M., King D.S., and O'Shea E.K. Multi-site phosphorylation of Pho4 by the cyclin-CDK Pho80-Pho85 is semi-processive with site preference. J. Mol. Biol. 306 (2001) 997-1010