WC-2 mediates WC-1-FRQ interaction within the PAS protein-linked circadian feedback loop of Neurospora

EMBO Journal

Volumn 20, Issue 1-2, 2001, Pages 109-117

  Denault, D L ^a   Loros, J J ^a   Dunlap, J C ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Circadian; Complexes; Frequency; White collar

Indexed keywords

CELL PROTEIN; PROTEIN FRQ; UNCLASSIFIED DRUG; WHITE COLLAR PROTEIN 1; WHITE COLLAR PROTEIN 2;

ARTICLE; CIRCADIAN RHYTHM; GENE EXPRESSION REGULATION; MOLECULAR INTERACTION; NEUROSPORA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; DNA-BINDING PROTEINS; FEEDBACK; FUNGAL PROTEINS; NEUROSPORA; PROTEIN BIOSYNTHESIS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0035863191     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.1.109     Document Type: Article

References (36)

1. Molecular analysis of the Neurospora clock
2. The circadian clock locus frequency: A single ORF defines period length and temperature compensation
3. Negative feedback defining a circadian clock: Autoregulation of the clock gene frequency
4. dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex
5. White collar-1, a central regulator of blue-light responses in Neurospora crassa, is a zinc-finger protein
6. Roles in dimerization and blue light photoresponses of PAS and LOV domains of Neurospora crassa white collar proteins
7. Coiled-coil domain mediated FRQ-FRQ interaction is essential for its circadian clock function in Neurospora
8. Altered circadian period length and temperature compensation in a partial loss of function mutant of white collar-2
9. Neurospora wc-1 and wc-2: Transcription, photoresponses and the origins of circadian rhythmicity
10. Closing the circadian loop: CLOCK induced transcription of its own inhibitors, per and tim
11. Genetic and microbial research techniques for Neurospora crassa
12. Isolation of new white collar mutants of Neurospora crassa and studies on their behavior in the blue light-induced formation of protoperithecia
13. Molecular bases for circadian clocks
14. Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY
15. Role of the CLOCK protein in the mammalian circadian mechanism
16. Gene organization and regulation in the qa (quinic acid) gene cluster of Neurospora crassa
17. The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors
18. Circadian oscillation of BMAL1, a partner of a mammalian clock gene Clock, in rat suprachiasmatic nucleus
19. PAS is a dimerization domain common to Drosophila Period and several transcription factors
20. PER protein interactions and temperature compensation of a circadian clock in Drosophila
21. Microbial circadian oscillatory systems in Neurospora and Synechococcus: Models for cellular clocks
22. The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation and interactions with the PER-TIM complex
23. PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL heterodimer without disrupting formation of the heterodimer: A basis for circadian transcription
24. Interconnected feedback loops in the Neurospora circadian system
25. White collar-2, a partner in blue-light signal transduction, controlling expression of light-regulated genes in Neurospora crassa
26. Blue light regulation in Neurospora crassa
27. Mutants of Neurospora crassa defective in regulation of blue light perception
28. Time at the end of the millennium: The Neurospora clock
29. Nuclear localization is required for function of the essential clock protein FREQUENCY
30. Genetic regulation of nitrogen metabolism in the fungi
31. GATA-binding transcription factors in hematopoeitic cells
32. CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless
33. Localization and light-dependent phosphorylation of white collar 1 and 2, the two central components of blue light signaling in Neurospora crassa
34. Targeted disruption of the mPER3 gene: Subtle effects on circadian clock function
35. Role of a white collar-1-white collar-2 complex in blue-light signal transduction
36. Pas domains: Internal sensors of oxygen, redox potential and light