Characterization of a novel ghrelin cell reporter mouse

Regulatory Peptides

Volumn 155, Issue 1-3, 2009, Pages 91-98

  Sakata, Ichiro ^a   Nakano, Yoshihide ^b   Osborne Lawrence, Sherri ^a   Rovinsky, Sherry A ^a   Lee, Charlotte E ^a   Perello, Mario ^a   Anderson, Jason G ^a   Coppari, Roberto ^a   Xiao, Guanghua ^c   Lowell, Bradford B ^b   Elmquist, Joel K ^a,c   Zigman, Jeffrey M ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

FACS; Ghrelin; Green fluorescence protein; Transgenic

Indexed keywords

GHRELIN; GREEN FLUORESCENT PROTEIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DUODENUM; FLUORESCENCE ACTIVATED CELL SORTER; IMMUNOREACTIVITY; MOUSE; MUCOSA CELL; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH MUCOSA; TESTIS;

ANIMALS; BRAIN; DUODENUM; FLOW CYTOMETRY; GASTRIC MUCOSA; GHRELIN; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; ISLETS OF LANGERHANS; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH; TESTIS;

MUS MUSCULUS; RENILLA RENIFORMIS;

EID: 67349157517     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2009.04.001     Document Type: Article

References (50)

1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
2. Gutierrez J.A., Solenberg P.J., Perkins D.R., Willency J.A., Knierman M.D., Jin Z., Witcher D.R., Luo S., Onyia J.E., and Hale J.E. Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A 105 (2008) 6320-6325
3. Yang J., Brown M.S., Liang G., Grishin N.V., and Goldstein J.L. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132 (2008) 387-396
4. Zigman J.M., Nakano Y., Coppari R., Balthasar N., Marcus J.N., Lee C.E., Jones J.E., Deysher A.E., Waxman A.R., White R.D., Williams T.D., Lachey J.L., Seeley R.J., Lowell B.B., and Elmquist J.K. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 115 (2005) 3564-3572
5. Sun Y., Asnicar M., Saha P.K., Chan L., and Smith R.G. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 3 (2006) 379-386
6. Lutter M., Sakata I., Osborne-Lawrence S., Rovinsky S.A., Anderson J.G., Jung S., Birnbaum S., Yanagisawa M., Elmquist J.K., Nestler E.J., and Zigman J.M. The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci 11 (2008) 752-753
7. Zigman J.M., and Elmquist J.K. In search of an effective obesity treatment: a shot in the dark or a shot in the arm?. Proc Natl Acad Sci U S A 103 (2006) 12961-12962
8. Diano S., Farr S.A., Benoit S.C., McNay E.C., da Silva I., Horvath B., Gaskin F.S., Nonaka N., Jaeger L.B., Banks W.A., Morley J.E., Pinto S., Sherwin R.S., Xu L., Yamada K.A., Sleeman M.W., Tschop M.H., and Horvath T.L. Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci 9 (2006) 381-388
9. Asakawa A., Inui A., Kaga T., Yuzuriha H., Nagata T., Ueno N., Makino S., Fujimiya M., Niijima A., Fujino M.A., and Kasuga M. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120 (2001) 337-345
10. Masuda Y., Tanaka T., Inomata N., Ohnuma N., Tanaka S., Itoh Z., Hosoda H., Kojima M., and Kangawa K. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 276 (2000) 905-908
11. Dornonville de la Cour C., Bjorkqvist M., Sandvik A.K., Bakke I., Zhao C.M., Chen D., and Hakanson R. A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control. Regul Pept 99 (2001) 141-150
12. Rindi G., Necchi V., Savio A., Torsello A., Zoli M., Locatelli V., Raimondo F., Cocchi D., and Solcia E. Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Histochem Cell Biol 117 (2002) 511-519
13. Yabuki A., Ojima T., Kojima M., Nishi Y., Mifune H., Matsumoto M., Kamimura R., Masuyama T., and Suzuki S. Characterization and species differences in gastric ghrelin cells from mice, rats and hamsters. J Anat 205 (2004) 239-246
14. Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M.S., Suganuma T., Matsukura S., Kangawa K., and Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141 (2000) 4255-4261
15. Sakata I., Nakamura K., Yamazaki M., Matsubara M., Hayashi Y., Kangawa K., and Sakai T. Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract. Peptides 23 (2002) 531-536
16. Prado C.L., Pugh-Bernard A.E., Elghazi L., Sosa-Pineda B., and Sussel L. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A 101 (2004) 2924-2929
17. Wierup N., and Sundler F. Ultrastructure of islet ghrelin cells in the human fetus. Cell Tissue Res 319 (2005) 423-428
18. Wierup N., Svensson H., Mulder H., and Sundler F. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 107 (2002) 63-69
19. Date Y., Nakazato M., Hashiguchi S., Dezaki K., Mondal M.S., Hosoda H., Kojima M., Kangawa K., Arima T., Matsuo H., Yada T., and Matsukura S. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 51 (2002) 124-129
20. Volante M., Allia E., Gugliotta P., Funaro A., Broglio F., Deghenghi R., Muccioli G., Ghigo E., and Papotti M. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 87 (2002) 1300-1308
21. Turek F.W., Joshu C., Kohsaka A., Lin E., Ivanova G., McDearmon E., Laposky A., Losee-Olson S., Easton A., Jensen D.R., Eckel R.H., Takahashi J.S., and Bass J. Obesity and metabolic syndrome in circadian clock mutant mice. Science 308 (2005) 1043-1045
22. Lu S., Guan J.L., Wang Q.P., Uehara K., Yamada S., Goto N., Date Y., Nakazato M., Kojima M., Kangawa K., and Shioda S. Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus. Neurosci Lett 321 (2002) 157-160
23. Mondal M.S., Date Y., Yamaguchi H., Toshinai K., Tsuruta T., Kangawa K., and Nakazato M. Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus. Regul Pept 126 (2005) 55-59
24. Cowley M.A., Smith R.G., Diano S., Tschop M., Pronchuk N., Grove K.L., Strasburger C.J., Bidlingmaier M., Esterman M., Heiman M.L., Garcia-Segura L.M., Nillni E.A., Mendez P., Low M.J., Sotonyi P., Friedman J.M., Liu H., Pinto S., Colmers W.F., Cone R.D., and Horvath T.L. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37 (2003) 649-661
25. Wortley K.E., Anderson K.D., Garcia K., Murray J.D., Malinova L., Liu R., Moncrieffe M., Thabet K., Cox H.J., Yancopoulos G.D., Wiegand S.J., and Sleeman M.W. Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci U S A 101 (2004) 8227-8232
26. Tena-Sempere M., Barreiro M.L., Gonzalez L.C., Gaytan F., Zhang F.P., Caminos J.E., Pinilla L., Casanueva F.F., Dieguez C., and Aguilar E. Novel expression and functional role of ghrelin in rat testis. Endocrinology 143 (2002) 717-725
27. Gnanapavan S., Kola B., Bustin S.A., Morris D.G., McGee P., Fairclough P., Bhattacharya S., Carpenter R., Grossman A.B., and Korbonits M. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87 (2002) 2988
28. Cummings D.E., Purnell J.Q., Frayo R.S., Schmidova K., Wisse B.E., and Weigle D.S. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 (2001) 1714-1719
29. Asakawa A., Inui A., Kaga T., Yuzuriha H., Nagata T., Fujimiya M., Katsuura G., Makino S., Fujino M.A., and Kasuga M. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology 74 (2001) 143-147
30. Kristenssson E., Sundqvist M., Astin M., Kjerling M., Mattsson H., Dornonville de la Cour C., Hakanson R., and Lindstrom E. Acute psychological stress raises plasma ghrelin in the rat. Regul Pept 134 (2006) 114-117
31. de la Cour C.D., Norlen P., and Hakanson R. Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: a microdialysis study. Regul Pept 143 (2007) 118-126
32. Seoane L.M., Al-Massadi O., Barreiro F., Dieguez C., and Casanueva F.F. Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system. J Endocrinol Invest 30 (2007) RC22-RC25
33. Seoane L.M., Al-Massadi O., Caminos J.E., Tovar S.A., Dieguez C., and Casanueva F.F. Sensory stimuli directly acting at the central nervous system regulate gastric ghrelin secretion. an ex vivo organ culture study. Endocrinology 148 (2007) 3998-4006
34. Muyrers J.P., Zhang Y., and Stewart A.F. Techniques: recombinogenic engineering-new options for cloning and manipulating DNA. Trends Biochem Sci 26 (2001) 325-331
35. Lee E.C., Yu D., Martinez de Velasco J., Tessarollo L., Swing D.A., Court D.L., Jenkins N.A., and Copeland N.G. A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73 (2001) 56-65
36. Zigman J.M., Jones J.E., Lee C.E., Saper C.B., and Elmquist J.K. Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 494 (2006) 528-548
37. Sakata I., Tanaka T., Yamazaki M., Tanizaki T., Zheng Z., and Sakai T. Gastric estrogen directly induces ghrelin expression and production in the rat stomach. J Endoxcrinol 190 (2006) 749-757
38. Hata S., Koyama S., Kawahara H., Doi N., Maeda T., Toyama-Sorimachi N., Abe K., Suzuki K., and Sorimachi H. Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. J Biol Chem 281 (2006) 11214-11224
39. Mills J.C., Andersson N., Stappenbeck T.S., Chen C.C., and Gordon J.I. Molecular characterization of mouse gastric zymogenic cells. J Biol Chem 278 (2003) 46138-46145
40. Shao J.S., Schepp W., and Alpers D.H. Expression of intrinsic factor and pepsinogen in the rat stomach identifies a subset of parietal cells. Am J Physiol 274 (1998) G62-70
41. Kageyama H., Kitamura Y., Hosono T., Kintaka Y., Seki M., Takenoya F., Hori Y., Nonaka N., Arata S., and Shioda S. Visualization of ghrelin-producing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice. Regul Pept 145 (2008) 116-121
42. Tomasetto C., Karam S.M., Ribieras S., Masson R., Lefebvre O., Staub A., Alexander G., Chenard M.P., and Rio M.C. Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 119 (2000) 395-405
43. Zhu X., Cao Y., Voogd K., and Steiner D.F. On the processing of proghrelin to ghrelin. J Biol Chem 281 (2006) 38867-38870
44. Ozawa A., Cai Y., and Lindberg I. Production of bioactive peptides in an in vitro system. Anal Biochem 366 (2007) 182-189
45. Walia P., Asadi A., Kieffer T.J., Johnson J.D., and Chanoine J.P. Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. Pediatr Res 65 (2009) 39-44
46. Macro J.A., Dimaline R., and Dockray G.J. Identification and expression of prohormone-converting enzymes in the rat stomach. Am J Physiol 270 (1996) G87-93
47. Shimada M., Date Y., Mondal M.S., Toshinai K., Shimbara T., Fukunaga K., Murakami N., Miyazato M., Kangawa K., Yoshimatsu H., Matsuo H., and Nakazato M. Somatostatin suppresses ghrelin secretion from the rat stomach. Biochem Biophys Res Commun 302 (2003) 520-525
48. Torbergsen K., Wiksen H., Johansen K., Rahimipoor S., Falkmer U.G., and Zhao C.M. Immunoreactivity of gastric ECL and A-like cells in fasted and fed rats and mice. Biotech Histochem 80 (2005) 21-30
49. Erickson J.D., Schafer M.K., Bonner T.I., Eiden L.E., and Weihe E. Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proc Natl Acad Sci U S A 93 (1996) 5166-5171
50. Rindi G., Paolotti D., Fiocca R., Wiedenmann B., Henry J.P., and Solcia E. Vesicular monoamine transporter 2 as a marker of gastric enterochromaffin-like cell tumors. Virchows Arch 436 (2000) 217-223