Clinical rejection and persistent immune regulation in kidney transplant patients

Transplant Immunology

Volumn 21, Issue 3, 2009, Pages 129-135

  Hendrikx, T K ^a   Klepper, M ^a   IJzermans, Jan ^a   Weimar, W ^a   Baan, C C ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Anti CD25 Ab induction therapy; CD4+CD25high+ regulatory T cell; Kidney transplantation; Patients; Rejectors; Steroids

Indexed keywords

DACLIZUMAB; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3;

ACUTE GRAFT REJECTION; ARTICLE; CD4+ CD25+ FOXP3+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE REDUCTION; GRAFT RECIPIENT; HUMAN; IMMUNOREACTIVITY; IMMUNOREGULATION; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MULTICENTER STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL; REGULATORY T LYMPHOCYTE; SCANNING ELECTRON MICROSCOPY; T LYMPHOCYTE SUBPOPULATION; TREATMENT RESPONSE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; FORKHEAD TRANSCRIPTION FACTORS; GLUCOCORTICOIDS; GRAFT REJECTION; HUMANS; IMMUNOGLOBULIN G; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KIDNEY TRANSPLANTATION; MYCOPHENOLIC ACID; PREDNISOLONE; STEROIDS; T-LYMPHOCYTES, REGULATORY; TACROLIMUS;

EID: 67349152690     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2009.04.003     Document Type: Article

References (29)

1. Sakaguchi S., Sakaguchi N., Asano M., et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 (1995) 1151-1164
2. + regulatory T cells. Nat Immunol 4 (2003) 330-336
3. Kingsley C.I., Nadig S.N., and Wood K.L. Transplantation tolerance: lessons from experimental rodent models. Transpl Int 20 (2007) 828-841
4. Furtado G.C., De Lafaille M.A.C., Kutchukhidze N., and Lafaille J.J. Interleukin 2 signaling is required for CD4(+) regulatory T cell function. J Exp Med 196 (2002) 85157
5. + T cell suppressor function. J Immunol 172 (2004) 6519-6523
6. Fontenot J.D., Rasmussen J.P., Gavin M.A., and Rudensky A.Y. A function of interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6 (2006) 1142-1151
7. + regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 6 (2005) 1152-1159
8. + regulatory T cells in transplantation: progress, challenges and prospects. Am J Transplant 7 (2007) 1457-1463
9. Mantel P.Y., Ouaked N., Ruckert B., et al. Molecular mechanisms underlying FOXP3 induction in human T-cells. J Immunol 176 (2006) 3593-3602
10. Vincenti F., Kirkman R., Light S., et al. Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. Daclizumab Triple Therapy Study Group. N Engl J Med 338 (1998) 161-165
11. Meulen ter C.G., Riemsdijk van I., Hené R.J., et al. Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor α therapy: a prospective, randomized, multicenter study. Am J Transplant 4 (2004) 803-810
12. Karagiannidis C., Akdis M., Holopainen P., et al. Glucocorticoids upregulate FOXP3 expression and regulatory T-cells in asthma. J Allergy Clin Immunol 114 (2004) 1425-1433
13. Baan C.C., van der Mast B.J., Klepper M., et al. Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 80 (2005) 110-117
14. + T regulatory cells in vivo and enhances their capacity to suppress EAE. Eur J Immunol 36 (2006) 2139-2149
15. +T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance. Transplantation 81 (2006) 398-407
16. Kim J.M., Rasmussen J.P., and Rudenski A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8 (2007) 191-197
17. Gambineri E., Torgerson T.R., and Ochs H.D. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome systemic autoimmunity caused by mutations in FOXP3, a critical regulator of T-cell homeostasis. Curr Opin Rheumatol 15 (2003) 430-435
18. bright+ regulatory T cells can mediate donor non-reactivity in long-term immunosuppressed kidney allograft patients. Am J Transplant 6 (2006) 2955-2964
19. Muthukumar T., Dadhania D., Ding R., et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 353 (2005) 2342-2351
20. Veronese F., Rotman S., Smith R.N., Kawai T., et al. Pathological and clinical correlates of FOXP3(+) cells in renal allografts during acute rejection. Am J Transplant 7 (2007) 914-922
21. Vlad G., Ho E.K., Vasilescu E.R., et al. Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation. Transpl Immunol 18 (2007) 13-21
22. Akl A., Jones N.D., Rogers N., et al. An investigation to assess the potential of CD25(high)CD4(+) T cells to regulate responses to donor alloantigens in clinically stable renal transplant recipients. Transpl Int 21 (2008) 65-73
23. + regulatory T cell development. J Immunol 181 (2008) 3285-3290
24. Baan C.C., Boelaars-van Haperen M.J.A.M., Van Riemsdijk I.C., van der Plas A.J., and Weimar W. IL-7 and IL-15 bypass the immunosuppressive action of anti-CD25 monoclonal antibodies. Transplant Proc 33 (2001) 2244-2246
25. Soper D.M., Kasprowicz D.J., and Ziegler S.F. IL-2Rβ links IL-2R signaling with Foxp3 expression. Eur J Immunol 37 (2007) 1817-1826
26. + cells in vitro. Am J Transplant 5 (2005) 454-464
27. + Treg pool is present in renal transplant recipients. Am J Transplant 1 (2007) 249-255
28. Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?. Cell 93 (1998) 487-490
29. Lam S., Partovi N., Ting L.S.L., and Ensom M.H.H. Corticosteroid interactions with cyclosporine, tacrolimus, mycophenolate, and sirolimus: fact or fiction?. Ann Pharmacother 42 (2008) 1037-1047