Anthelmintic β-hydroxyketoamides (BKAS)

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 23, 1998, Pages 3317-3320

  Lee, Byung H ^a   Clothier, Michael F ^a   Dutton, Fred E ^a   Conder, George A ^a   Johnson, Sandra S ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; ANTHELMINTIC AGENT; COUMARIN DERIVATIVE; KETOL;

ARTICLE; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 0032402448     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00588-5     Document Type: Article

References (23)

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18. 9. This compound showed 100% clearance in our in-house sheep trial against Haemonchus contortus at a dose of 4 mg/kg.
19. 3) δ 3.38 (s, 3H), 3.41 (s, 3H), 7.42 (d, J = 9.0 Hz, 2H), 7.50 (d, J = 9.0 Hz, 2H), 11.91 (s, 1H, NH), 13.89 (s, 1H, enolic OH). MS (ES+): m/z 354, 356 (M + H).
20. 11. McCombie, S. W.; Lin, S.-I.; Tagat, J. R. Heterocycles 1993, 35, 93.
21. 3) δ 7.4-7.7 (m, 9H), 10.97 (s, 1H, NH). MS (ES+); m/z 344, 346(M + H).
22. 3) δ 7.33 (d, J = 9.0 Hz, 2H), 7.50 (d, J = 9.0 Hz, 2H), 12.59 (s, 1H, NH). MS (ES+); m/z 435, 437 (M + H).
23. 14. Conder, G. A.; Jen, L.-W.; Marbury, K. S.; Johnson, S. S.; Guimond, P. M.; Thomas, E. M.; Lee, B. L. J. Parasitology 1990, 76, 168.