Development of validation an RP-HPLC-UV mehod for the determination of BOL-303225-A, a new coumarin-based anti-inflammatory drug, in rat plasma

Biomedical Chromatography

Volumn 21, Issue 4, 2007, Pages 351-355

  Maltese, Adriana ^a,b   Maugeri, Francesco ^a,b   Ward, Keith W ^a   Bucolo, Claudio ^a,b  

^a BAUSCH AND LOMB   (United States)

^b UNIVERSITY OF CATANIA   (Italy)

Author keywords

Coumarin; Plasma; Rat; RP HPLC; UV detection

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ORTHOPHOSPHORIC ACID;

ANTI-INFLAMMATORY DRUGS; COUMARIN; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS; LIQUID-LIQUID EXTRACTION; RAT PLASMA; RP-HPLC; RP-HPLC/UV; SAMPLE PREPARATION; SIMPLE++; UV DETECTION;

RATS;

3 (2 DIETHYLAMINOETHYL) 7 (2 HYDROXYHEXYLOXY) 4 METHYLCHROMEN 2 ONE; 8 CHLORO 3 (2 DIETHYLAMINOETHYL) 7 (2 HYDROXYHEXYLOXY) 4 METHYLCHROMEN 2 ONE; ACETONITRILE; ANTIINFLAMMATORY AGENT; BOL 303225A; BOL 303226A; CLORICROMEN; COUMARIN DERIVATIVE; PHOSPHORIC ACID; TRIETHYLAMINE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STABILITY; DRUG STRUCTURE; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; PH; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SAMPLING; SEPARATION TECHNIQUE; STRUCTURE ANALYSIS; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

RATTUS;

EID: 34147141984     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.757     Document Type: Article

References (5)

1. Bucolo C, Cuzzocrea S, Mazzon E and Caputi AP. Effects of cloricromene, a coumarin derivative, on endotoxin-induced uveitis in Lewis rats. Investigative Ophthalmology and Visual Science 2003; 44: 1178-1184.
2. Burke A, Smyth E and FitzGerald GA. Analgesic-antipyretic agents; pharmacotherapy of gout. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, Brunton LL, Lazo JS and Parker KL (eds). McGraw Hill: New York, 2006; 671-715.
3. Cuzzocrea S, Mazzon E, Bevilaqua C, Costantino G, Britti D, Mazzullo G, De Sarro A and Caputi AP. Cloricromene, a coumarine derivative, protects against collagen-induced arthritis in Lewis rats. British Journal of Pharmacology 2000; 131: 1399-1407.
4. Murray RD. Coumarins. Natural Product Reports 1989; 8: 591-624.
5. Schimmer BP and Parker KL. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, Brunton LL, Lazo JS and Parker KL (eds). McGraw Hill: New York, 2006; 1587-1612.