Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice

Atherosclerosis

Volumn 204, Issue 2, 2009, Pages 388-394

  Sugimoto, Masayuki ^a,d   Arai, Hidenori ^a   Tamura, Yukinori ^a   Murayama, Toshinori ^a,b   Khaengkhan, Parinda ^d   Nishio, Takuya ^d   Ono, Koh ^a   Ariyasu, Hiroyuki ^b   Akamizu, Takashi ^b   Ueda, Yukihiko ^c   Kita, Toru ^a   Harada, Shigeharu ^d   Kamei, Kaeko ^d   Yokode, Masayuki ^a,b  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

^c Keihanna Hospital   (Japan)

^d KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Adipocytokine; Insulin resistance; Macrophage; Obesity; Oxidative stress

Indexed keywords

ADIPOCYTOKINE; GLUCOSE; MONOCYTE CHEMOTACTIC PROTEIN 1; MORUS ALBA EXTRACT; NATURAL PRODUCT; PIOGLITAZONE; PLANT EXTRACT; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; MACROPHAGE; METABOLIC DISORDER; MOUSE; MULBERRY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHITE ADIPOSE TISSUE;

ADIPOKINES; ADIPONECTIN; ADIPOSE TISSUE, WHITE; ADIPOSITY; ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; BODY WEIGHT; CHEMOKINE CCL2; CHOLESTEROL; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ENERGY METABOLISM; HYPOGLYCEMIC AGENTS; LIPID PEROXIDATION; LIPOLYSIS; LIVER; MACROPHAGES; MALE; MICE; MICE, MUTANT STRAINS; MORUS; NADPH OXIDASE; OBESITY; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT LEAVES; PROTEIN SUBUNITS; THIAZOLIDINEDIONES; TIME FACTORS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67349121226     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.10.021     Document Type: Article

References (26)

1. Spiegelman B.M., and Flier J.S. Obesity and the regulation of energy balance. Cell 104 (2001) 531-543
2. Matsuzawa Y., Funahashi T., Kihara S., et al. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 24 (2004) 29-33
3. Kanda H., Tateya S., Tamori Y., et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116 (2006) 1494-1505
4. Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (1993) 87-91
5. Okamoto Y., Kihara S., Ouchi N., et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 106 (2002) 2767-2770
6. Yamauchi T., Kamon J., Minokoshi Y., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8 (2002) 1288-1295
7. Houstis N., Rosen E.D., and Lander E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440 (2006) 944-948
8. Furukawa S., Fujita T., Shimabukuro M., et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114 (2004) 1752-1761
9. Babior B.M. NADPH oxidase. Curr Opin Immunol 16 (2004) 42-47
10. Weisberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112 (2003) 1796-1808
11. Evans J.L., and Goldfine I.D. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Ther 2 (2000) 401-413
12. Park M.Y., Lee K.S., and Sung M.K. Effects of dietary mulberry, Korean red ginseng, and banaba on glucose homeostasis in relation to PPAR-alpha, PPAR-gamma, and LPL mRNA expressions. Life Sci 77 (2005) 3344-3354
13. Harauma A., Murayama T., Ikeyama K., et al. Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun 358 (2007) 751-756
14. Enkhmaa B., Shiwaku K., Katsube T., et al. Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr 135 (2005) 729-734
15. Shibata Y., Kume N., Arai H., et al. Mulberry leaf aqueous fractions inhibit TNF-alpha-induced nuclear factor kappaB (NF-kappaB) activation and lectin-like oxidized LDL receptor-1 (LOX-1) expression in vascular endothelial cells. Atherosclerosis 193 (2007) 20-27
16. Oike Y., Akao M., Yasunaga K., et al. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med 11 (2005) 400-408
17. Tomimoto S., Tsujita M., Okazaki M., et al. Effect of probucol in lecithin-cholesterol acyltransferase-deficient mice: inhibition of 2 independent cellular cholesterol-releasing pathways in vivo. Arterioscler Thromb Vasc Biol 21 (2001) 394-400
18. Tsuda M., Iwai M., Li J.M., et al. Inhibitory effects of AT1 receptor blocker, olmesartan, and estrogen on atherosclerosis via anti-oxidative stress. Hypertension 45 (2005) 545-551
19. Enerback S., Jacobsson A., Simpson E.M., et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387 (1997) 90-94
20. Browning J.D., and Horton J.D. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114 (2004) 147-152
21. Kong W.H., Oh S.H., Ahn Y.R., et al. Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models. J Agric Food Chem 56 (2008) 2613-2619
22. Fonseca V. Effect of thiazolidinediones on body weight in patients with diabetes mellitus. Am J Med 115 Suppl. 8A (2003) 42S-48S
23. de Souza C.J., Eckhardt M., Gagen K., et al. Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes 50 (2001) 1863-1871
24. Guan Y., Hao C., Cha D.R., et al. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med 11 (2005) 861-866
25. Yamakoshi J., Fukuda S., Satoh T., et al. Antihypertensive and natriuretic effects of less-sodium soy sauce containing gamma-aminobutyric acid in spontaneously hypertensive rats. Biosci Biotechnol Biochem 71 (2007) 165-173
26. Kang T.H., Oh H.R., Jung S.M., et al. Enhancement of neuroprotection of mulberry leaves (Morus alba L.) prepared by the anaerobic treatment against ischemic damage. Biol Pharm Bull 29 (2006) 270-274