Matrix strains induced by cells: Computing how far cells can feel

Cellular and Molecular Bioengineering

Volumn 2, Issue 1, 2009, Pages 39-48

  Sen, Shamik ^a   Engler, Adam J ^b   Discher, Dennis E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell prestress; Substrate stiffness

Indexed keywords

ARTICLE; CELL SPREADING; CELL STRAIN; CELL STRESS; CELL STRUCTURE; COMPUTER MODEL; ELASTICITY; EXPERIMENTAL STUDY; EXTRACELLULAR MATRIX; FINITE ELEMENT ANALYSIS; FOCAL ADHESION; GEL; MEMBRANE CHANNEL; MOLECULAR DYNAMICS; MUSCLE CONTRACTILITY; MYOBLAST; OSTEOBLAST; PRIORITY JOURNAL; STEM CELL; STIMULUS RESPONSE; TACTILE STIMULATION; THREE DIMENSIONAL IMAGING;

EID: 67349108659     PISSN: 18655025     EISSN: 18655033     Source Type: Journal    
DOI: 10.1007/s12195-009-0052-z     Document Type: Article

References (42)

1. N. Q. Balaban U. S. Schwarz D. Riveline 2001 Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates Nat. Cell Biol. 3 5 466 472
2. K. A. Beningo M. Dembo I. Kaverina J. V. Small Y.-L. Wang 2001 Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts J. Cell Biol. 153 4 881 888
3. I. B. Bischofs S. A. Safran U. S. Schwarz 2003 Elastic interactions of active cells with soft materials Phys. Rev. E 60 2 021911
4. I. B. Bischofs U. S. Schwarz 2003 Cell organization in soft media due to active mechanosensing PNAS 100 16 9274 9279
5. J. P. Butler I. M. Tolic-Norrelykke B. Fabry J. J. Fredberg 2002 Traction fields, moments, and strain energy that cells exert on their surroundings Am. J. Physiol. Cell Physiol. 282 3 C595 C605
6. Y. Cai N. Biais G. Giannone 2006 Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow Biophys. J. 91 10 3907 3920
7. G. T. Charras M. A. Horton 2002 Determination of cellular strains by combined atomic force microscopy and finite element modeling Biophys. J. 83 2 858 879
8. E. Cukierman R. Pankov D. R. Stevens K. M. Yamada 2001 Taking cell-matrix adhesions to the third dimension Science 294 5547 1708 1712
9. M. Dembo Y.-L. Wang 1999 Stresses at the cell-to-substrate interface during locomotion of fibroblasts Biophys. J. 76 4 2307 2316
10. P. A. DiMilla K. Barbee D. A. Lauffenburger 1991 Mathematical model for the effects of adhesion and mechanics on cell migration speed Biophys. J. 60 1 15 37
11. A. J. Engler L. Bacakova C. Newman A. Hategan M. Griffin D. E. Discher 2004 Substrate compliance versus ligand density in cell on gel responses Biophys. J. 86 1 617 628
12. A. J. Engler M. A. Griffin S. Sen C. G. Bonnemann H. L. Sweeney D. E. Discher 2004 Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments J. Cell Biol. 166 6 877 887
13. A. J. Engler R. Richert J. Y. Wong C. Picart D. E. Discher 2004 Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: correlations between substrate stiffness and cell adhesion J. Surf. Sci. 570 142 154
14. A. J. Engler S. Sen H. L. Sweeney D. E. Discher 2006 Matrix elasticity directs stem cell lineage specification Cell 126 4 677 689
15. L. A. Flanagan Y. E. Ju B. Marg M. Osterfield P. A. Janmey 2002 Neurite branching on deformable substrates NeuroReport 13 18 2411 2415
16. A. J. García C. D. Reyes 2005 Bio-adhesive surfaces to promote osteoblast differentiation and bone formation J. Dent. Res. 84 5 407 413
17. M. A. Griffin S. Sen H. L. Sweeney D. E. Discher 2004 Adhesion-contractile balance in myocyte differentiation J. Cell Sci. 117 24 5855 5863
18. F. Guilak V. C. Mow 2000 The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage J. Biomech. 33 12 1663 1673
19. F. Guilak G. R. Erickson H. P. Ting-Beall 2002 The effects of osmotic stress on the viscoelastic and physical properties of articular chondrocytes Biophys. J. 82 2 720 727
20. A. K. Harris D. Stopak P. Wild 1981 Fibroblast traction as a mechanism for collagen morphogenesis Nature 290 5803 249 251
21. A. K. Harris P. Wild D. Stopak 1980 Silicone rubber substrata: a new wrinkle in the study of cell locomotion Science 208 4440 177 179
22. H. Karcher J. Lammerding H. Huang R. T. Lee R. D. Kamm M. R. Kaazempur-Mofrad 2003 A three-dimensional viscoelastic model for cell deformation with experimental verification Biophys. J. 85 5 3336 3349
23. C. B. Khatiwala S. R. Peyton A. J. Putnam 2006 Intrinsic mechanical properties of the extracellular matrix affect the behavior of pre-osteoblastic MC3T3-E1 cells Am. J. Physiol. Cell Physiol. 290 6 C1640 C1650
24. S. Kumar I. Z. Maxwell A. Heisterkamp 2006 Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics Biophys. J. 90 10 3762 3773
25. J. Maloney E. B. Walton C. M. Bruce K. J. Van Vliet 2008 Influence of finite thickness and stiffness on cellular adhesion-induced deformation of compliant substrata Phys. Rev. E 78 041923 1 15
26. R. McBeath D. M. Pirone C. M. Nelson K. Bhadriraju C. S. Chen 2004 Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment Dev. Cell 6 4 483 495
27. J. G. McGarry P. J. Prendergast 2004 A three-dimensional finite element model of an adherent eukaryotic cell Eur. Cell Mater. 7 27 34
28. R. Merkel N. Kirchgessner C. M. Cesa B. Hoffmann 2007 Cell force microscopy on elastic layers of finite thickness Biophys. J. 93 9 3314 3323
29. M. J. Paszek N. Zahir K. R. Johnson 2005 Tensional homeostasis and the malignant phenotype Cancer Cell 8 3 241 254
30. R. J. Pelham Jr. Y.-L. Wang 1997 Cell locomotion and focal adhesions are regulated by substrate flexibility PNAS 94 25 13661 13665
31. S. R. Peyton A. J. Putnam 2005 Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion J. Cell. Physiol. 204 1 198 209
32. P. Rajagopalan W. A. Marganski X. Q. Brown J. Y. Wong 2004 Direct comparison of the spread area, contractility, and migration of balb/c 3T3 fibroblasts adhered to fibronectin- and RGD-modified substrata Biophys. J. 87 4 2818 2827
33. D. Raucher M. P. Sheetz 1999 Characteristics of a membrane reservoir buffering membrane tension Biophys. J. 77 4 1992 2002
34. U. S. Schwarz N. Q. Balaban D. Riveline A. Bershadsky B. Geiger S. A. Safran 2002 Calculation of forces at focal adhesions from elastic substrate data: the effect of localized force and the need for regularization Biophys. J. 83 3 1380 1394
35. U. S. Schwarz S. A. Safran 2002 Elastic interactions of cells Phys. Rev. Lett. 88 4 048102
36. H. H. Stedman H. L. Sweeney J. B. Shrager 1991 The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy Nature 352 6335 536 539
37. K. R. Stenmark R. P. Mecham 1997 Cellular and molecular mechanisms of pulmonary vascular remodeling Ann. Rev. Physiol. 59 1 89 144
38. H. B. Wang M. Dembo Y. L. Wang 2000 Substrate flexibility regulates growth and apoptosis of normal but not transformed cells Am. J. Physiol. Cell Physiol. 279 5 C1345 C1350
39. N. Wang I. M. Tolic-Norrelykke J. Chen 2002 Cell prestress I Stiffness and prestress are closely associated in adherent contractile cells Am. J. Physiol. Cell Physiol. 282 3 C606 C616
40. K. T. Weber Y. Sun S. E. Campbell 1995 Chronic mineralocorticoid excess and cardiovascular remodeling Steroids 60 1 125 132
41. T. Yeung P. C. Georges L. A. Flanagan 2005 Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion Cell Motil. Cytoskeleton 60 1 24 34
42. M. H. Zaman L. M. Trapani A. L. Sieminski 2006 Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis Proc. Natl. Acad. Sci. U.S.A. 103 29 10889 10894