Determination of cellular strains by combined atomic force microscopy and finite element modeling

Biophysical Journal

Volumn 83, Issue 2, 2002, Pages 858-879

  Charras, Guillaume T ^a   Horton, Mike A ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ANIMAL CELL; ARTICLE; ATOMIC FORCE MICROSCOPY; CELL; CONTROLLED STUDY; ELASTICITY; FINITE ELEMENT ANALYSIS; GENE EXPRESSION; MATHEMATICAL MODEL; MECHANICAL STRESS; NEWBORN; NONHUMAN; OSTEOBLAST; RAT; STRESS STRAIN RELATIONSHIP; ANIMAL; BIOPHYSICS; CELL CULTURE; COMPUTER PROGRAM; CONFOCAL MICROSCOPY; CYTOLOGY; CYTOSKELETON; MAGNETISM; METABOLISM; METHODOLOGY; POISSON DISTRIBUTION; SIGNAL TRANSDUCTION; THEORETICAL MODEL;

ANIMALIA;

ACTIN;

ACTINS; ANIMALS; BIOPHYSICS; CELLS, CULTURED; CYTOSKELETON; MAGNETICS; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, CONFOCAL; MODELS, THEORETICAL; OSTEOBLASTS; POISSON DISTRIBUTION; RATS; SIGNAL TRANSDUCTION; SOFTWARE; STRESS, MECHANICAL;

EID: 0035997021     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(02)75214-4     Document Type: Article

References (79)

1. Relative microelastic mapping of living cells by atomic force microscopy
2. Signal transduction pathways involved in fluid flow-induced PGE2 production by cultured osteocytes
3. Mechanoreception at the cellular level: The detection, interpretation, and diversity of responses to mechanical signals
4. Subcellular distribution of shear stress at the surface of flow-aligned and nonaligned endothelial monolayers
5. Loading paradigms - Intentional and unintentional - For cell culture mechanostimulus
6. Shear stress induces a time- and position-dependent increase in endothelial cell membrane fluidity
7. Assessment of strain field in endothelial cells subjected to uniaxial deformation of their substrate
8. Single cell mechanotransduction and its modulation analyzed by atomic force microscope microindentation
9. Atomic force microscopy can be used to mechanically stimulate osteoblasts and evaluate cellular strain distributions
10. Twisting integrin receptors increases endothelin-1 gene expression in endothelial cells
11. Mechanically induced calcium mobilization in cultured endothelial cells is dependent on actin and phospholipase
12. Hydrodynamics of micropipette aspiration
13. Primary human osteoblast proliferation and prostaglandin E2 release in response to mechanical strain in vitro
14. Endothelial cell signaling and cytoskeletal changes in response to shear stress
15. Calcium ions and tyrosine phosphorylation interact coordinately with actin to regulate cytoprotective responses to stretching
16. A new method for application of force to cells via ferric oxide beads
17. Magnetic fields applied to collagen-coated ferric oxide beads induce stretch-activated Ca2+ flux in fibroblasts
18. A triphasic analysis of negative osmotic flows through charged hydrated soft tissues
19. Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition
20. Volume and surface area measurement of viable chondrocytes in situ using geometric modeling of serial confocal sections
21. The mechanical environment of the chondrocyte: A biphasic finite element model of cell-matrix interactions in articular cartilage
22. An elastic network model based on the structure of the red blood cell membrane skeleton
23. Physiological levels of hydrostatic pressure alter morphology and organization of cytoskeletal and adhesion proteins in MG-63 osteosarcoma cells
24. Dynamic reorientation of cultured cells and stress fibers under mechanical stress from periodic stretching
25. Mechanically activated currents in chick heart cells
26. Intracellular Ca2+ stores and extracellular Ca2+ are required in the real-time Ca2+ response of bone cells experiencing fluid flow
27. Cellular tensegrity: Defining new rules of biological design that govern the cytoskeleton
28. The role of microtubules in the regulation of proteoglycan synthesis in chondrocytes under hydrostatic pressure
29. Cadherins mediate intercellular mechanical signaling in fibroblasts by activation of stretch-sensitive calcium-permeable channels
30. Partners in protection: Interdependence of cytoskeleton and plasma membrane in adaptations to applied forces
31. Integrin and mechanosensitive ion channel-dependent tyrosine phosphorylation of focal adhesion proteins and beta-catenin in human articular chondrocytes after mechanical stimulation
32. New technologies in scanning probe microscopy for the understanding of molecular interactions in cells
33. Adapting atomic force microscopy for cell biology
34. Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis
35. Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress
36. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure
37. A quantitative evaluation of osteoblast-osteocyte relationships on growing endosteal surface of rabbit tibiae
38. Steady and transient fluid shear stress stimulate NO release in osteoblasts through distinct biochemical pathways
39. Experimental method for the measurement of the elastic modulus of trabecular bone tissue
40. Trafficking of matrix collagens through bone-resorbing osteoclasts
41. Mechanically induced calcium movements in astrocytes, bovine aortic endothelial cells and C6 glioma cells
42. Mechanotransduction in bone: Osteoblasts are more responsive to fluid forces than mechanical strain
43. Influence of short-term hydrostatic pressure on organization of stress fibers in cultured chondrocytes
44. Selected contribution: Regulatory pathways involved in mechanical induction of c-fos gene expression in bone cells
45. Actin protofilament orientation in deformation of the erythrocyte membrane skeleton
46. Measuring the elastic properties of biological samples with the AFM
47. Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain
48. Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2)
49. Activation of G proteins mediates flow-induced prostaglandin E2 production in osteoblasts
50. Strain concentrations surrounding an ellipsoid model of lacunae and osteocytes
51. Exposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools
52. Regulation of bone formation by applied dynamic loads
53. Form follows function: How muscle shape is regulated by work
54. i signaling in osteoblastic cells through activation of mechanosensitive and voltage-sensitive Ca2+ channels
55. Mechanosensitive ion channels in nonspecialized cells
56. Fluid shear stress increases transforming growth factor beta 1 expression in human osteoblast-like cells: Modulation by cation channel blockades
57. Electrophysiological responses of human bone cells to mechanical stimulation: Evidence for specific integrin function in mechanotransduction
58. Local mechanical properties measured by atomic force microscopy for cultured bovine endothelial cells exposed to shear stress
59. Device for the application of a dynamic biaxially uniform and isotropic strain to a flexible cell culture membrane
60. Finite element models for arterial wall mechanics
61. A microstructural approach to cytoskeletal mechanics based on tensegrity
62. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels
63. Cytoskeletal mechanics in pressure-overload cardiac hypertrophy
64. Tissue stresses and strain in trabeculae of a canine proximal femur can be quantified from computer reconstructions
65. Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension
66. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
67. Mechanically strained cells of the osteoblast lineage organize their extracellular matrix through unique sites of alphavbeta3-integrin expression
68. Finite element simulation of location- and time-dependent mechanical behavior of chondrocytes in unconfined compression tests
69. Mechanical properties of L929 cells measured by atomic force microscopy: Effects of anticytoskeletal drugs and membrane crosslinking
70. Propagation of a calcium pulse between osteoblastic cells
71. Biomechanical stress-induced signaling and gene expression in the development of arteriosclerosis
72. Mechanisms contributing to fluid-flow -induced Ca2+ mobilization in articular chondrocytes
73. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts
74. Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow
75. Early responses to dynamic strain change and prostaglandins in bone-derived cells in culture
76. Cell mechanics: Mechanical response, cell adhesion, and molecular deformation