DNA-targeting pyrroloquinoline-linked butenone and chalcones: Synthesis and biological evaluation

European Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2009, Pages 2854-2861

  Via, Lisa Dalla ^a   Gia, Ornella ^a   Chiarelotto, Gianfranco ^a   Ferlin, Maria Grazia ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Antiproliferative activity; Chalcones; Pyrroloquinoline; Topoisomerase II

Indexed keywords

1 (4' (3H PYRROLO[3,2 F]QUINOLIN 9 YLAMINO)PHENYL) 3 ( 4'' NITROPHENYL)PROP 2 EN 1 ONE; 1 (4' (3H PYRROLO[3,2 F]QUINOLIN 9 YLAMINO)PHENYL) 3 (1H PYRROL 2'' YL)PROP 2 EN 1 ONE; 1 (4' (3H PYRROLO[3,2 F]QUINOLIN 9 YLAMINO)PHENYL) 3 (THIOPHEN 2'' YL)PROP 2 EN 1 ONE; 1 PHENYL 3 (1H PYRROL 2 YL)PROP 2 EN 1 ONE; 1 PHENYL 3 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 3 (4 NITRO PHENYL) 1 PHENYLPROP 2 EN 1 ONE; 4 (4' (3H PYRROLO[3,2 F]QUINOLIN 9 YLAMINO)PHENYL)BUT 3 EN 2 ONE; BUTENONE; BUTENONE DERIVATIVE; CHALCONE; CHALCONE DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); ELLIPTICINE; KETONE DERIVATIVE; PYRROLOQUINOLINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CELL DEATH; CELL GROWTH; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE TARGETING; HUMAN; HUMAN CELL; MELANOMA CELL; SUBSTITUTION REACTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BUTANONES; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONES; DNA; DNA TOPOISOMERASES, TYPE II; HUMANS; PYRROLES; QUINOLINES;

EID: 67349103403     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.12.011     Document Type: Article

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