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Volumn 150, Issue 17, 2009, Pages 771-780

Molecular mechanisms of insulin resistance in obesity and type 2 diabetes mellitus;Molekuláris tényezok szerepe az inzulinrezisztencia- elhízás-2-es típusú diabetes patogenetikai kapcsolatban

Author keywords

Adipocytokines; Insulin receptor; Insulin resistance; Obesity; Signal transduction; Type 2 diabetes mellitus

Indexed keywords

ADIPONECTIN; APELIN; INSULIN RECEPTOR; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PLASMINOGEN ACTIVATOR INHIBITOR; RESISTIN; RETINOL BINDING PROTEIN 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

EID: 67249111262     PISSN: 00306002     EISSN: 17886120     Source Type: Journal    
DOI: 10.1556/OH.2009.28608     Document Type: Review
Times cited : (10)

References (39)
  • 1
    • 39149099952 scopus 로고    scopus 로고
    • Goldfi ne, I. D., Maddux, B. A., Youngren, J. F. és mtsai: The role of membrane glycoprotein PC-1/ENPP1 in the pathogenesis of insulin resistance and related abnormalities. Endocr. Rev., 2008, 29, 62-75.
    • Goldfi ne, I. D., Maddux, B. A., Youngren, J. F. és mtsai: The role of membrane glycoprotein PC-1/ENPP1 in the pathogenesis of insulin resistance and related abnormalities. Endocr. Rev., 2008, 29, 62-75.
  • 2
    • 84873236400 scopus 로고    scopus 로고
    • Az inzulinrezisztencia zsírszö veti tényezoi.
    • In press
    • Winkler G., Cseh K.: Az inzulinrezisztencia zsírszö veti tényezoi. Diabetol. Hung. In press.
    • Diabetol. Hung
    • Winkler, G.1    Cseh, K.2
  • 3
    • 0344305782 scopus 로고    scopus 로고
    • Insulin signaling in health and disease
    • White, F. M.: Insulin signaling in health and disease. Science, 2003, 302, 1710-1711.
    • (2003) Science , vol.302 , pp. 1710-1711
    • White, F.M.1
  • 5
    • 0034633993 scopus 로고    scopus 로고
    • Ottensmeyer, F. P., Beniac, D. R., Luo, RZ-T. és mtsa: Mechanism of transmembrane signaling: insulin binding and the insulin receptor. Biochemistry, 2000, 39, 12103-12112.
    • Ottensmeyer, F. P., Beniac, D. R., Luo, RZ-T. és mtsa: Mechanism of transmembrane signaling: insulin binding and the insulin receptor. Biochemistry, 2000, 39, 12103-12112.
  • 6
    • 57249094212 scopus 로고    scopus 로고
    • Temofonte, N., Sajan, M. P., Nimal, S. és mtsai: Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle. Diabetologia, 2009, 52, 60-64.
    • Temofonte, N., Sajan, M. P., Nimal, S. és mtsai: Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle. Diabetologia, 2009, 52, 60-64.
  • 7
  • 9
    • 84873219050 scopus 로고    scopus 로고
    • Cseh K., Winkler G.: A zsírszöveti endokrin szabályozó rendszer és szerepe az inzulinrezisztencia kialakulásában. In Halmos T., Jermendy, Gy. (szerk.): Diabetes mellitus. Elmélet és klinikum. Medicina Kiadó, Budapest, 2002, 98-112.
    • Cseh K., Winkler G.: A zsírszöveti "endokrin" szabályozó rendszer és szerepe az inzulinrezisztencia kialakulásában. In Halmos T., Jermendy, Gy. (szerk.): Diabetes mellitus. Elmélet és klinikum. Medicina Kiadó, Budapest, 2002, 98-112.
  • 10
    • 34548406102 scopus 로고    scopus 로고
    • Adiponectin, obesity and atherosclerosis
    • Behre, C. J.: Adiponectin, obesity and atherosclerosis. Scand J. Clin. Lab. Invest., 2007, 67, 449-458.
    • (2007) Scand J. Clin. Lab. Invest , vol.67 , pp. 449-458
    • Behre, C.J.1
  • 11
    • 34248187069 scopus 로고    scopus 로고
    • Genetic infl uences of adiponectin on insulin resistance, type 2 diabetes and cardiovascular disease
    • Menzaghi, C., Trischitta, V., Doria, A.: Genetic infl uences of adiponectin on insulin resistance, type 2 diabetes and cardiovascular disease. Diabetes, 2007, 56, 1198-1209.
    • (2007) Diabetes , vol.56 , pp. 1198-1209
    • Menzaghi, C.1    Trischitta, V.2    Doria, A.3
  • 12
    • 37549040190 scopus 로고    scopus 로고
    • The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS
    • Kadowaki, T., Yamauchi, T., Kubota, N.: The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS. FEBS Letters, 2008, 582, 74-80.
    • (2008) FEBS Letters , vol.582 , pp. 74-80
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3
  • 13
    • 34347255023 scopus 로고    scopus 로고
    • Kubota, N., Yano, W., Kubota, T. és mtsai: Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab., 2007, 6, 55-68.
    • Kubota, N., Yano, W., Kubota, T. és mtsai: Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab., 2007, 6, 55-68.
  • 14
    • 40849120765 scopus 로고    scopus 로고
    • Obesity and lipodystrophy - Where do the circles intersect?
    • Chehab, F. F.: Obesity and lipodystrophy - Where do the circles intersect? Endocrinology, 2008, 149, 925-934.
    • (2008) Endocrinology , vol.149 , pp. 925-934
    • Chehab, F.F.1
  • 15
    • 2342444310 scopus 로고    scopus 로고
    • Leptin receptor signaling and regulation of mammalian physiology
    • Myers, M. G.: Leptin receptor signaling and regulation of mammalian physiology. Rec. Progr. Horm. Res., 2004, 59, 287-304.
    • (2004) Rec. Progr. Horm. Res , vol.59 , pp. 287-304
    • Myers, M.G.1
  • 16
    • 33745106645 scopus 로고    scopus 로고
    • Drug insight: The role of leptin in human physiology and pathophysiology - emerging clinical applications
    • Brennan, A. M., Mantzoros, C. S.: Drug insight: the role of leptin in human physiology and pathophysiology - emerging clinical applications. Nat. Clin. Pract. Endocrinol. Metab., 2006, 2, 318-327.
    • (2006) Nat. Clin. Pract. Endocrinol. Metab , vol.2 , pp. 318-327
    • Brennan, A.M.1    Mantzoros, C.S.2
  • 17
    • 57449099877 scopus 로고    scopus 로고
    • Jiang, L., Jia, Y., Yu, X. és mtsai: Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. PNAS, 2008, 105, 18619-18624.
    • Jiang, L., Jia, Y., Yu, X. és mtsai: Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. PNAS, 2008, 105, 18619-18624.
  • 18
    • 55949108685 scopus 로고    scopus 로고
    • Kassem, H. S., Arabi, A., Zantout, M. S. és mtsa: Negative effect of leptin on bone mass in type 1 diabetes. Acta Diabetol., 2008, 45, 237-241.
    • Kassem, H. S., Arabi, A., Zantout, M. S. és mtsa: Negative effect of leptin on bone mass in type 1 diabetes. Acta Diabetol., 2008, 45, 237-241.
  • 19
    • 39149143637 scopus 로고    scopus 로고
    • Antuna-Puente, B., Fevec, B., Fellahi, S. és mtsa: Adipokines: the missing link between insulin resistance and obesity. Diabetes & Metabolism., 2008, 34, 2-11.
    • Antuna-Puente, B., Fevec, B., Fellahi, S. és mtsa: Adipokines: the missing link between insulin resistance and obesity. Diabetes & Metabolism., 2008, 34, 2-11.
  • 20
    • 34249911241 scopus 로고    scopus 로고
    • Muse, E. D., Lam, T. K., Scherer, P. E. és mtsa: Hypothalamic re-sistin induces hepatic insulin resistance. J. Clin. Invest., 2007, 117, 1670-1678.
    • Muse, E. D., Lam, T. K., Scherer, P. E. és mtsa: Hypothalamic re-sistin induces hepatic insulin resistance. J. Clin. Invest., 2007, 117, 1670-1678.
  • 21
    • 34948836879 scopus 로고    scopus 로고
    • Goralski, K. B., McCarthy, T. C., Hanniman, E. A. és mtsai: Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J. Biol. Chem., 2007, 282, 28175-28188.
    • Goralski, K. B., McCarthy, T. C., Hanniman, E. A. és mtsai: Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J. Biol. Chem., 2007, 282, 28175-28188.
  • 22
    • 34748817386 scopus 로고    scopus 로고
    • Bozaoglu, K., Bolton, K., McMillan, J. és mtsai: Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology, 2007, 148, 4687-4694.
    • Bozaoglu, K., Bolton, K., McMillan, J. és mtsai: Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology, 2007, 148, 4687-4694.
  • 23
    • 39649114784 scopus 로고    scopus 로고
    • Takahashi, M., Takahashi, Y., Takahashi, K. és mtsai: Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Letters, 2008, 582, 573-578.
    • Takahashi, M., Takahashi, Y., Takahashi, K. és mtsai: Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Letters, 2008, 582, 573-578.
  • 24
    • 22944434929 scopus 로고    scopus 로고
    • Yang, Q., Graham, T. E., Mody, N. és mtsai: Serum retinol binding protein-4 contributes to insulin resistance in obesity and type 2 diabetes. Nature, 2005, 436, 356-362.
    • Yang, Q., Graham, T. E., Mody, N. és mtsai: Serum retinol binding protein-4 contributes to insulin resistance in obesity and type 2 diabetes. Nature, 2005, 436, 356-362.
  • 25
    • 33745095399 scopus 로고    scopus 로고
    • Graham, T. E., Yang, Q., Blüher, M. és mtsai: Retinol-binding protein-4 and insulin resistance in lean, obese and diabetic subjects. NEJM, 2006, 354, 2552-2563.
    • Graham, T. E., Yang, Q., Blüher, M. és mtsai: Retinol-binding protein-4 and insulin resistance in lean, obese and diabetic subjects. NEJM, 2006, 354, 2552-2563.
  • 26
    • 40749155505 scopus 로고    scopus 로고
    • Youn, B.-S., Klöting, N., Kratzsch, J. és mtsai: Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes, 2008, 57, 372-377.
    • Youn, B.-S., Klöting, N., Kratzsch, J. és mtsai: Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes, 2008, 57, 372-377.
  • 27
    • 52949093160 scopus 로고    scopus 로고
    • Jenkins, A., Zhang, S. X., Gosmanova, A. és mtsai: Increased serum pigment epithelium-derived factor levels in type 2 diabetes. Diab. Res. Clin. Pract., 2008, 82, E5-E7.
    • Jenkins, A., Zhang, S. X., Gosmanova, A. és mtsai: Increased serum pigment epithelium-derived factor levels in type 2 diabetes. Diab. Res. Clin. Pract., 2008, 82, E5-E7.
  • 28
    • 33748312291 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor: A multimodal tumor inhibitor
    • Ek, E. T. H., Dass, C. R., Choong, P. F. N.: Pigment epithelium-derived factor: a multimodal tumor inhibitor. Mol. Cancer Ther, 2006, 5, 1641-1646.
    • (2006) Mol. Cancer Ther , vol.5 , pp. 1641-1646
    • Ek, E.T.H.1    Dass, C.R.2    Choong, P.F.N.3
  • 29
    • 52049098545 scopus 로고    scopus 로고
    • Visfatin, structure, function and relation to diabetes mellitus and other dysfunctions
    • Adeghate, E.: Visfatin, structure, function and relation to diabetes mellitus and other dysfunctions. Curr. Med. Chem., 2008, 15, 1851-1862.
    • (2008) Curr. Med. Chem , vol.15 , pp. 1851-1862
    • Adeghate, E.1
  • 30
    • 19944433652 scopus 로고    scopus 로고
    • Fukuhara, A., Matsuda, M., Nishizawa, M. és mtsai: A protein secreted by visceral fat that mimics the effects of insulin. Science, 2005, 307, 426-430.
    • Fukuhara, A., Matsuda, M., Nishizawa, M. és mtsai: A protein secreted by visceral fat that mimics the effects of insulin. Science, 2005, 307, 426-430.
  • 31
    • 85133384976 scopus 로고    scopus 로고
    • Song, H. K., Lee, M. H., Kim, B. K. és mtsai: Visfatin: a new player in mesangial cell physiology and diabetic nephropathy. Am. J. Physiol. Renal. Physiol., 2008, 295, F1485-F1494.
    • Song, H. K., Lee, M. H., Kim, B. K. és mtsai: Visfatin: a new player in mesangial cell physiology and diabetic nephropathy. Am. J. Physiol. Renal. Physiol., 2008, 295, F1485-F1494.
  • 32
    • 36049006424 scopus 로고    scopus 로고
    • The emerging role of adipokines as mediators of cardiovascular function: Physiologic and clinical perspectives
    • Gualillo, O., Gonzalez-Juanatey, J. R., Lago, F.: The emerging role of adipokines as mediators of cardiovascular function: physiologic and clinical perspectives. Trend Cardiovasc. Med., 2007, 17, 275-283.
    • (2007) Trend Cardiovasc. Med , vol.17 , pp. 275-283
    • Gualillo, O.1    Gonzalez-Juanatey, J.R.2    Lago, F.3
  • 33
    • 25844491778 scopus 로고    scopus 로고
    • Berndt, J., Klöting, N., Kralisch, S. és mtsai: Plasma visfatin concentrations and fat depot-specifi c mRNA expression in humans. Diabetes, 2005, 54, 2911-2916.
    • Berndt, J., Klöting, N., Kralisch, S. és mtsai: Plasma visfatin concentrations and fat depot-specifi c mRNA expression in humans. Diabetes, 2005, 54, 2911-2916.
  • 34
    • 85099490462 scopus 로고    scopus 로고
    • Wurm, S., Neumeier, M., Weigert, J. és mtsai: Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. Cardiovasc. Diabetol., 2007, 6, 1-7. (doi: 10.11186/1475-2840-6-7)
    • Wurm, S., Neumeier, M., Weigert, J. és mtsai: Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. Cardiovasc. Diabetol., 2007, 6, 1-7. (doi: 10.11186/1475-2840-6-7)
  • 35
    • 34249674520 scopus 로고    scopus 로고
    • de Souza Batista, C. M., Yang, R.-Z., Lee, N.-J. és mtsai: Omentin plasma levels and gene expression are decreased in obesity. Diabetes, 2007, 56, 1655-1661.
    • de Souza Batista, C. M., Yang, R.-Z., Lee, N.-J. és mtsai: Omentin plasma levels and gene expression are decreased in obesity. Diabetes, 2007, 56, 1655-1661.
  • 36
    • 0035015269 scopus 로고    scopus 로고
    • Reaux, A., DeMota, N., Skultetyova, I. és mtsai: Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain. J. Neurochemistry, 2001, 77, 1085-1096.
    • Reaux, A., DeMota, N., Skultetyova, I. és mtsai: Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain. J. Neurochemistry, 2001, 77, 1085-1096.
  • 37
    • 64549113076 scopus 로고    scopus 로고
    • Tan, B. K., Adya, R., Shan, X. és mtsai: Ex vivo and in vivo regulation of lipocalin-2, a novel adipokine by insulin. Diabetes Care, 2009, 32, 129-131.
    • Tan, B. K., Adya, R., Shan, X. és mtsai: Ex vivo and in vivo regulation of lipocalin-2, a novel adipokine by insulin. Diabetes Care, 2009, 32, 129-131.
  • 38
    • 0035827558 scopus 로고    scopus 로고
    • Caenorhabditis elegans PIAK, a phospholipid-independent kinase deactivates the Akt-PKB survival kinase
    • Li, Y., Dowbenko, D., Lasky, L. A.: Caenorhabditis elegans PIAK, a phospholipid-independent kinase deactivates the Akt-PKB survival kinase. J. Biol. Chem., 2001, 276, 20323-20329.
    • (2001) J. Biol. Chem , vol.276 , pp. 20323-20329
    • Li, Y.1    Dowbenko, D.2    Lasky, L.A.3
  • 39
    • 58149339613 scopus 로고    scopus 로고
    • Narbonne, P., Roy, R.: Caenorhabditis elegans dauers need LKB1/AMP to ration lipid reserves and ensure long term survival. Nature, doi:10.1038/nature07536; Published online 3 December 2008.
    • Narbonne, P., Roy, R.: Caenorhabditis elegans dauers need LKB1/AMP to ration lipid reserves and ensure long term survival. Nature, doi:10.1038/nature07536; Published online 3 December 2008.


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