Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle

Diabetologia

Volumn 52, Issue 1, 2009, Pages 60-64

  Temofonte, N ^a,b   Sajan, M P ^a,b   Nimal, S ^c   Pastoor, T ^c   Fumero, C ^a,b   Casaubon, L ^a,b   Powe, J L ^a,b   Standaert, M L ^a,b   Farese, R V ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c ROSKAMP INSTITUTE   (United States)

Author keywords

Atypical protein kinase C; Diabetes; Insulin; Insulin resistance; Muscle; Protein kinase B; Protein kinase C

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; ROSIGLITAZONE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; HUMAN TISSUE; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; MALE; MUSCLE; MUSCLE BIOPSY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; VASTUS LATERALIS MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BODY MASS INDEX; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIABETES MELLITUS; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RECEPTOR SUBSTRATE PROTEINS; MALE; METFORMIN; MIDDLE AGED; MUSCLE, SKELETAL; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; THIAZOLIDINEDIONES; TRIGLYCERIDES;

EID: 57249094212     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-008-1180-z     Document Type: Article

References (11)

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