Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats

Food and Chemical Toxicology

Volumn 44, Issue 8, 2006, Pages 1424-1431

  Hung, Ming Yu ^a   Fu, Timothy Yu Chi ^b   Shih, Ping Hsiao ^a   Lee, Chia Pu ^a   Yen, Gow Chin ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b Jen Ai General Hospital   (Taiwan)

Author keywords

Antioxidant effects; Carbon tetrachloride; Eucommia ulmoides Oliv.; Hepatic damage; Protocatechuic acid

Indexed keywords

CARBON TETRACHLORIDE; EUCOMMIA ULMOIDES EXTRACT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; PLANT EXTRACT; PROTOCATECHUIC ACID; TROLOX C; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL VACUOLE; CONNECTIVE TISSUE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; KIDNEY MASS; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER WEIGHT; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PLANT; PLANT LEAF; RAT; TU CHUNG;

ANIMALS; ANTIOXIDANTS; CARBON TETRACHLORIDE POISONING; CHROMANS; EUCOMMIACEAE; GLUTATHIONE; HYDROXYBENZOIC ACIDS; KIDNEY; LIPID PEROXIDATION; LIVER; LIVER DISEASES; MALE; ORGAN SIZE; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR;

EUCOMMIA ULMOIDES; RATTUS NORVEGICUS;

EID: 33745190246     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.03.009     Document Type: Article

References (47)

1. Al-Shabanah O.A., Alam K., Nagi M.N., Al-Rikabi A.C., and Al-Bekairi A.M. Protective effect of aminoguanidine, a nitric oxides synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sciences 66 (2000) 265-270
2. Arivazhagan S., Balasenthil S., and Nagini S. Garlic and neem leaf extracts enhance hepatic glutathione and glutathione dependent enzymes during N-methyl-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis. Phytotherapy Research 14 (2000) 291-293
3. Arnao M.B., Cano A., Hernandez-Ruiz J., Garcia-Canovas F., and Acosta M. Inhibition by l-ascorbic acid and other antioxidants of the 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) oxidation catalyzed by peroxidase: a new approach for determining total antioxidant status of foods. Analytical Biochemistry 236 (1996) 255-261
4. Bansal A.K., Bansal M., Soni G., and Bhatnagar D. Protective role of vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chemico-Biological Interactions 156 (2005) 101-111
5. Bellomo G., Mirabelli F., Dimonte D., Richelmi P., Thor H., Orrenius C., and Orrenius S. Formation and reduction of glutathione-mixed disulfides during oxidative stress. Biochemical Pharmacology 36 (1987) 1313-1320
6. Bhandarkar M.R., and Khan A. Antihepatotoxic effect of Nymphaea stellata willd., against carbon tetrachloride-induced hepatic damage in albino rats. Journal of Ethnopharmacology 91 (2004) 61-64
7. Buege A.J., and Aust S.D. Microsomal lipid peroxidation. Methods in Enzymology 52 (1978) 302-310
8. Campo G.M., Squadrito F., Ceccarelli S., Calo M., Avenoso A., Campo S., Squadrito G., and Altavilla D. Reduction of carbon tetrachloride-induced rat liver injury by IRFI 042, a novel dual vitamin E-like antioxidant. Free Radical Research 34 (2001) 379-393
9. Cao C., Russell R.M., Lischner N., and Prior R.L. Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly woman. Journal of Nutrition 128 (1998) 2383-2390
10. Carmief-Haggai M., Cederbaum A.I., and Nieto N. Binge ethanol exposure increases liver injury in obese rats. Gastroenterology 125 (2003) 1818-1833
11. Dundar K., Topal T., Ay H., Oter S., and Korkmaz A. Protective effects of exogenously administered or endogenously produced melatonin on hyperbaric oxygen-induced oxidative stress in the rat brain. Clinical and Experimental Pharmacology and Physiology 32 (2005) 926-930
12. French S.W., Miyamoto K., Ohta Y., and Geoffrion Y. Pathogenesis of experimental alcoholic liver disease in the rat. Methods and Achievements in Experimental Pathology 13 (2000) 181-207
13. Gray P. Handbook of Basic Microtechnique. third ed. (1964), McGrawHill, New York pp: 85-145
14. Gupta M., Mazumder U.K., Kumar R.S., Sivakumar T., and Gomathi P. Antioxidant and protective effects of Ervatamia coronaria Stapf., leaves against carbon tetrachloride-induced liver injury. European Bulletin of Drug Research 12 (2004) 13-22
15. Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferase: the first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry 249 (1974) 7130-7139
16. Halliwell B., and Gutteridge J.M.C. Antioxidant defense. Free Radicals in Biology and Medicine (1998), Oxford University Press Inc., New York pp. 105-245
17. Hertog M.G., Feskens E.J., Hollman P.C., Katan M.B., and Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342 (1993) 1007-1011
18. Hosseinzadeh H., and Sadeghnia H.R. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. Journal of Pharmacy and Pharmaceutical Sciences 8 (2005) 394-399
19. Hsieh C.L., and Yen G.C. Antioxidant actions of Du-Zhong (Eucommia ulmoides Oliv.) toward oxidative damage in biomolecules. Life Sciences 66 (2000) 1387-1400
20. Hu M.L. Measurement of plasma protein thiols and GSH. Methods in Enzymology 233 (1994) 380-385
21. Lawerence R.A., and Burk R.F. Glutathione peroxidase activity in selenium-deficient rat's liver. Biochemical and Biophysical Research Communications 71 (1961) 952-958
22. Lin W.L., Hsieh Y.J., Chou F.P., Wang C.J., Cheng M.T., and Tseng T.H. Hibiscus protocatechuic acid inhibits lipopolysaccharide-induced rat hepatic damage. Food and Chemical Toxicology 77 (2003) 42-47
23. Liu C.L., Wang J.M., Chu C.Y., Cheng M.T., and Tseng T.H. In vivo protective effect of protocatechuic acid on tert-butyl hydroperoxide-induced rat hepatotoxicity. Food and Chemical Toxicology 40 (2002) 635-641
24. Mak D.H., Ip S.P., Li P.C., Poon M.K., and Ko K.M. Alterations in tissue glutathione antioxidant system in Streptozotocin-induced diabetic rats. Molecular and Cellular Biochemistry 162 (1996) 153-158
25. Mansour M.A. Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life Sciences 66 (2000) 2583-2591
26. Miller N.J., Rice-Evans C., Davies M.J., Goponathan V., and Milner A. A novel method for measuring antioxidant status in premature neonates. Clinical Science 84 (1993) 407-412
27. Nakamura T., Nakazawa Y., Onizuka S., Satoh S., Chibo A., Sekihashi K., Miura A., Yasugahire N., and Sasaki Y.F. Antimutagenicity of Tochu tea (an aqueous extract of Eucommia ulmoides leaves): 1. The clastogen-suppressing effects of Tochu tea in CHO cells and mice. Mutation Research 388 (1997) 7-20
28. Nakazawa Y. Functional and healthy properties of Du-zhong tea and their utilization. Food Industry 40 (1997) 6-15 (in Japanese)
29. Nan J.X., Jiang Y.Z., Park E.J., Ko G., Kim Y.C., and Sohn D.H. Protective effect of Rhodiola sachalinensis extract on carbon tetrachloride-induced liver injury in rats. Journal of Ethnopharmacology 84 (2003) 143-148
30. Natusme M., Tsuji H., Harada A., Akiyama M., Yano T., Ishikura H., Nakanishi I., Matsushima K., Kaneko S., and Mukaida N. Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6 deficient mice. Journal of Leukocyte Biology 66 (1999) 601-608
31. Naziroglu M., Cay M., Ustundag B., Aksakal M., and Yekeler H. Protective effects of vitamin E on carbon tetrachloride-induced liver damage in rats. Cell Biochemistry Function 17 (1999) 253-259
32. Nishida K., Yoshiji O., and Ishiguro I. Preventive effect of g-glutamylcysteinlyethyl ester on carbon tetrachloride-induced hepatic triglyceride accumulation in mice. Toxicology Letters 95 (1998) 141-146
33. Prakash J., Gupta S.K., Kochupillai V., Singh N., Gupta Y.K., and Joshi S. Chemopreventive activity of Withania somnifera in experimentally induced fibrosarcoma tumours in swiss albion mice. Phytotherapy Research 15 (2001) 240-244
34. Recknagel R.O., and Glende E.A. Carbon tetrachloride hepatotoxicity: An example of lethal cleavage. CRC Critical Reviews in Toxicology 2 (1973) 263-297
35. Reitman S., and Frankel S. A colorimetric method for the determination of serum GOT and GPT. American Journal of Clinical Pathology 28 (1957) 57-60
36. Tanaka T., Kojima T., Kawamori T., Yoshimi N., and Mori H. Chemoprevention of diethylnitrosamine-induced hepato carcinogenesis by a simple phenolic acid, protocatechuic acid in rats. Cancer Research 53 (1993) 2775-2779
37. Teocharis S.E., Margelo A.P., Skaltsas S.D., Spiliopoulou C.A., and Koutselinis A.S. Induction of metallothionein in the liver of carbon tetrachloride intoxicated rats: an immunohistochemical study. Toxicology 161 (2001) 129-138
38. Toklu H.Z., Sener G., Jahovic N., Uslu B., Arbak S., and Yegen B.C. beta-glucan protects against burn-induced oxidative organ damage in rats. International Immunopharmacology 6 (2006) 156-169
39. Velmurugan B., Bhuvaneswari V., Balasenthil S., and Nagini S. Lycopene, an antioxidant carotenoid modulates glutathione-dependent hepatic biotransformation enzymes during experimental gastric carcinogenesis. Nutrition Research 21 (2001) 1117-1124
40. Wang G.S., Eriksson L.C., Xia L., Olsson J., and Stal P. Dietary iron overload inhibits carbontetrachloride-induced promotion in chemical hepatocarcinogenesis: effects on cell proliferation, apoptosis and antioxidation. Journal of Hepatology 30 (1999) 689-698
41. Weber L.W.D., Boll M., and Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Critical Reviews in Toxicology 33 (2003) 105-136
42. Yang J., Kato K., Noguchi K., Dairaku N., Koike T., Iijima K., Imatani A., Sekine H., Ohara S., Sasano H., and Shimosegawa T. Tochu (Emcommia ulmoides) leaf extract prevents ammonia and vitamin C deficiency induced gastric mucosal injury. Life Sciences 73 (2003) 3245-3256
43. Yen G.C., and Hsieh C.L. Antioxidant activity of extracts from Du-Zhong (Eucommia ulmoides) towards various lipid peroxidation models in vitro. Journal of Agricultural and Food Chemistry 46 (1998) 3952-3957
44. Yen G.C., and Hsieh C.L. Reactive oxygen species scavenging activity of Du-Zhong (Eucommia ulmoides Oliv.) and its active compounds. Journal of Agricultural and Food Chemistry 48 (2000) 3431-3436
45. Yen G.C., and Hsieh C.L. Inhibitory effect of Du-Zhong (Eucommia ulmoides Oliv.) extracts toward low-density lipoprotein oxidative modification. Food Chemistry 77 (2002) 449-456
46. 2. Teratogenesis, Carcinogenesis and Mutagenesis 23 suppl. 1 (2003) 23-33
47. 4-induced acute liver injury of mice. Free Radical Biology and Medicine 29 (2000) 870-880