Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice

Toxicological Sciences

Volumn 83, Issue 1, 2005, Pages 190-196

  Ito, Yoshiya ^a   Abril, Edward R ^a   Bethea, Nancy W ^a   McCuskey, Robert S ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Hemorrhage; Hepatotoxicity; Microcirculation; Sinusoidal endothelial cells

Indexed keywords

2 [(4 BIPHENYLSULFONYL)AMINO] 3 PHENYLPROPIONIC ACID; ALANINE AMINOTRANSFERASE; GELATINASE A; GELATINASE B; GELATINASE INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; PARACETAMOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KUPFFER CELL; LIVER CELL DAMAGE; LIVER CIRCULATION; MALE; MICROANGIOPATHY; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ANIMALS; ENZYME INHIBITORS; GLUTATHIONE; HEMORRHAGE; HEPATITIS, TOXIC; LIVER; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; MICROCIRCULATION; NECROSIS; PHENYLALANINE; SULFONAMIDES;

EID: 12344292445     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh291     Document Type: Article

References (27)

1. Arthur, M. J. P., Friedman, S. L., Roll, F. J., and Bissell, D. M. (1989). Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J. Clin. Invest. 84, 1076-1085.
2. Dahlin, D. C., Miwa, G. T., Lu, A. Y. H., and Nelson, S. D. (1984). N-acetyl-p-benzoquinone imine: A cytochrome P-450 dependent oxidation product of acetaminophen. Proc. Natl. Acad. Sci. U.S.A. 81, 1327-1331.
3. Deleve, L. D., Ito, Y., Bethea, N. W., McCuskey, M. K., Wang, X., and McCuskey, R. S. (2003a). Embolization by sinusoidal lining cell obstructs the microcirculation in rat sinusoidal obstruction syndrome (hepatic venoocclusive disease). Am. J. Physiol. Gastrointest. Liver Physiol. 284, G1045-G1052.
4. Deleve, L. D., McCuskey, R. S., Wang, X., Hu, L., McCuskey, M. K., Epstein, R. B., and Kanel, G. (1999). Characterization of a reproductive rat model of hepatic veno-occlusive disease. Hepatology 29, 1779-1791.
5. Deleve, L. D., Wang, X., Kaplowitz, N., Shulman, H. M., Bart, J. A., and van der Hoek, A. (1997). Sinusoidal endothelial cells as a target for acetaminophen toxicity. Biochem. Pharmacol. 53, 1339-1345.
6. Deleve, L. D., Wang, X., Tsai, J., Kanel, G., Strasberg, S., and Tokes, Z. A. (2003b). Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology 125, 882-890.
7. Gardner, C. R., Laskin, J. D., Dambach, D. M., Sacco, M., Durham, S. K., Bruno, M. K., Cohen, S. D., Gordon, M. K., Gerecke, D. R., Zhou, P., et al. (2002). Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: Potential role of tumor necrosis factor-α and interleukin-10. Toxicol. Appl. Pharmacol. 184, 27-36.
8. Gerard-Monnier, D., Fougeat, S., and Chaudiere, J. (1992). Glutathione and cysteine depletion in rats and mice following acute intoxication with diethylmaleate. Biochem. Pharmacol. 43, 451-456.
9. Hanumegowda, U. M., Copple, B. L., Shibuya, M., Malle, E., Ganey, P. E., and Roth, R. A. (2003). Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury. Toxicol. Sci. 76, 237-246.
10. Ito, Y., Abril, E. R., Bethea, N. W., and McCuskey, R. S. (2004). Role of nitric oxide in hepatic microvascular injury elicited by acetaminophen in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 286, G60-G67.
11. Ito, Y., Bethea, N. W., Abril, E. R., and McCuskey, R. S. (2003). Early hepatic microvascular injury in response to acetaminophen toxicity. Microcirculation 10, 391-400.
12. Jollow, D. J., Mitchell, J. R., Potter, W. Z., Davis, D. C., Gillette, J. R., and Brodie, B. B. (1973). Acetaminophen-induced hepatic necrosis: II. Role of covalent binding in vivo. J. Pharmacol. Exp. Ther. 187, 195-202.
13. Knittel, T., Mehde, M., Kobold, D., Saile, B., Dinter, C., and Ramadori, G. (1999). Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: Regulation by TNF-α and TGF-β. J. Hepatol. 30, 48-60.
14. McCuskey, R. S. (1986). Microscopic methods for studying the microvasculature of internal organs. In Physical Techniques in Biology and Medicine Microvascular Technology (C. H. Baker and W. F. Nastuk, Eds.), pp. 247-264. Academic Press, New York.
15. McCuskey, R. S., Machen, N. W., Wang, X., McCuskey, M. K., Abril, E. R., Earnest, D. L., and Deleve, L. D. (2001). A single ethanol binge exacerbates early acetaminophen-induced centrilobular injury to the sinusoidal endothelium and alters sinusoidal blood flow. In Cells of the Hepatic Sinusoid VIII, (E. Wisse, D. L. Knook, and Arthur M. Leiden, Eds.), pp 68-70. Kupffer Cell Foundation.
16. Mitchell, J. R., Jollow, D. J., Potter, W. Z., Gillette, J. R., and Brodie, B. B. (1973a). Acetaminophen-induced hepatic necrosis: I. Role of drug metabolism. J. Pharmacol. Exp. Ther. 187, 185-194.
17. Mitchell, J. R., Jollow, D. J., Potter, W. Z., Gillette, J. R., and Brodie, B. B. (1973b). Acetaminophen-induced hepatic necrosis: IV. Protective role of glutathione. J. Pharmacol. Exp. Ther. 187, 211-217.
18. Momii, S., and Koga, A. (1990). Time-related morphological changes in cold-stored rat livers. A comparison of Euro-Collins solution with UW solution. Transplantation 50, 745-50.
19. Redegeld, F. A., Moison, R, M., Koster, A. S., and Noordhoek, J. (1992). Depletion of ATP but not of GSH affectes viability of rat hepatocytes. Eur. J. Pharmocol. 228, 229-236.
20. Tamura, Y., Watanabe, F., Nakatani, T., Yasui, K., Fuji, M., Komurasaki, T., Tsuzuki, H., Maekawa, R., Yoshioka, T., Kawada, K., et al. (1998). Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-Sulfonylamino acid derivatives. J. Med. Chem. 41, 640-649.
21. Theret, N., Lehti, K., Musso, O., and Clement, B. (1999). MMP-2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells. Hepatology 30, 462-468.
22. Thomas, S. H. L. (1993). Paracetamol (acetaminophen) poisoning. Phamacol. Ther. 60, 91-120.
23. Upadhya, A. G., Harvey, R. P., Howard, T. K., Lowell, J. A., Shenoy, S., and Strasberg, S. M. (1997). Evidence of a role of matrix metalloproteinases in cold preservation injury of the liver in humans and in the rat. Hepatology 26, 922-928.
24. Upadhya, A. G., and Strasberg, S. M. (1999). Evidence that actin disassembly is a requirement for matrix metalloproteinase secretion by sinusoidal endothelial cells during cold preservation in the rat. Hepatology 30, 169-176.
25. Visse, R., and Nagase, H. (2003). Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry. Cir. Res. 92, 827-839.
26. Walker, R. M., Racz, W. J., and McElligott, T. F. (1983). Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice. Am J. Pathol. 113, 321-330.
27. Winwood, P. J., Schuppan, D., Iredale, J. P., Kawser, C. A., Docherty, A. J. P., and Arthur, M. J. P. (1995). Kupffer cell-derived 95-kd type IV collagenase/gelatinase B: Characterization and expression in cultured cells. Hepatology 22, 304-315.