Preparation and evaluation of self-microemulsifying drug delivery system containing vinpocetine

Drug Development and Industrial Pharmacy

Volumn 35, Issue 5, 2009, Pages 603-611

  Cui, Shu Xia ^a   Nie, Shu Fang ^a   Li, Li ^a   Wang, Chang Guang ^a   Pan, Wei San ^a   Sun, Jian Ping ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHENYANG JIANZHU UNIVERSITY   (China)

Author keywords

Bioavailability; Microemulsion; Self microemulsifying drug delivery system; Vinpocetine

Indexed keywords

DIETHYLENE GLYCOL MONOETHYL ETHER; LABRASOL; OLEIC ACID ETHYL ESTER; SOLUTOL HS 15; VINPOCETINE; EXCIPIENT; NOOTROPIC AGENT; OIL; SURFACTANT; VINCA ALKALOID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG SCREENING; DRUG SOLUBILITY; IN VITRO STUDY; NONHUMAN; SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM; TABLET; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DOG; DRUG FORMULATION; EMULSION; PARTICLE SIZE; SOLUBILITY;

ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DOGS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EMULSIONS; EXCIPIENTS; NOOTROPIC AGENTS; OILS; PARTICLE SIZE; SOLUBILITY; SURFACE-ACTIVE AGENTS; VINCA ALKALOIDS;

EID: 67049143460     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040802488089     Document Type: Article

References (45)

1. Abhijit, A. D., & Nagarsenker, M. S. (2007). Design and evaluation of selfnanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int. J. Pharm., 329, 166-172
2. Bachynsky, M. O., Shah, N. H., Patel, C. I., & Malick, A. W. (1997). Factors affecting the efficiency of self-emulsifying oral delivery system. Drug Dev. Ind. Pharm., 23, 809-816
3. Bok, K. K., Jin, S. L., & Se, K. C. (2004). Development of self-microemulsifying drug delivery systems (SMEDDS) for bioavailability enhancement of simvastatin in beagle dogs. Int. J. Pharm., 274, 65-73
4. Buszello, K., Harnisch, S., Müller, R. H., & Müller, B. W. (2000). The influence of alkali fatty acids on the properties and the stability of parenteral O/ W emulsions modified with Solutol HS 15. Eur. J. Pharm. Biopharm., 49, 143-149
5. Caitriona, M., & O'Driscoll, C. M. (2002). Lipid-based formulations for intestinal lymphatic delivery. Eur. J. Pharm. Sci., 15, 405-415
6. Charman, S. A., Charman, W. N., Rogge, M. C., Wilson, T. D., Dutko, F. J., & Pouton, C. W. (1992). Self-emulsifying drug delivery systems: Formulation and biopharmaceutical evaluation of an investigational lipophilic compound. Pharm. Res., 9, 87-93
7. Chen, J., Cai, J., Tao, W., Mei, Ni., Cao, S., & Jiang, X. G. (2006). Determination of apovincaminic acid in human plasma by high-performance liquid chromatography using solid-phase extraction and ultraviolet detection. J. Chromatogr. B, 830, 201-206
8. Constantinides, P. P. (1995). Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects. Pharm. Res., 12, 1561-1571
9. Craig, D. Q. M., Barker, S. A., Banning, D., & Booth, S. W. (1995). An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int. J. Pharm., 114, 103-110
10. Cui, S. M., Zhao, C. S., Chen, D. W., & He, Z. G. (2005). Self-microemulsifying drug delivery systems (SMEDDS) for improving in-vitro dissolution and oral absorption of pueraria obata isoflavone. Drug Dev. Ind. Pharm., 31, 349-356
11. Cuiné, J. F., Charman, W. N., & Pouton, C. W. (2007). Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagles dogs. Pharm. Res., 24, 748-757
12. Diplock, A. T. (1985). Vitamin E. In A. T. Diplock (Ed.), Fat-soluble vitamins; their biochemistry and applications (pp. 154-217). London: William Heinemann
13. Feigin, V. L., Doronin, B. M., Popova, T. F., Gribatcheva, E. V., & Tchernov, D. V. (2001). Vinpocetine treatment in acute ischaemic stroke: A pilot single-blind randomized clinical trial. Eur. J. Neurol., 8, 81-85
14. Flemming, S. N., Kamilla, B. P., & Anette, M. (2008). Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state. Eur. J. Pharm. Biopharm., 69, 553-562
15. Gao, Z. G., Choi, H. G., Shin, H. J., Park, K. M., Lim, S. J., Hwang, K. J., & Kim, C. K. (1998). Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A. Int. J. Pharm., 161, 75-86
16. Gershanik, T., & Benita, S. (2000). Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur. J. Pharm. Biopharm., 50, 179-188
17. Holm, R., Müllertz, A., Christensen, E., Hoy, C. E., & Kristensen, H. G. (2001). Comparison of total oral bioavailability and the lymphatic transport of halofantrine from three different unsaturated triglycerides in lymphcannulated conscious rats. Eur. J. Pharm. Sci., 14, 331-337
18. Holm, R., Porter, C. J. H., Müllertz, A., Kristensen, H. G., & Charman, W. N. (2002). Structured triglyceride vehicles for oral delivery of halofantrine: Examination of intestinal lymphatic transport and boiavailability in conscious rats. Pharm. Res., 19, 1354-1361
19. Khoo, S. M., Humberstone, A. J., Porter, C. J. H., Edwards, G. A., & Charman, W. N. (1998). Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine. Int. J. Pharm., 167, 155-164
20. Kommuru, T. R., Gurley, B., Khan, M. A., & Reddy, I. K. (2006). Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: Formulation development and bioavailability assessment. Int. J. Pharm., 212, 233-246
21. Levy, M. Y., & Benita, S. (1990). Drug release from submicronized o/w emulsion: A new in vitro kinetic evaluation model. Int. J. Pharm., 66, 29-37
22. Lindmark, T., Nikkila, T., & Artursson, P. (1995). Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 monolayers. J. Pharmacol. Exp. Ther., 275, 958-964
23. Ljiljana, D., & Marija, P. (2008). The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/ capric glycerides. Int. J. Pharm., 352, 231-239
24. Malcolmson, C., Sidhu, A., Satra, C., Kantaria, S., & Lawrence, M. J. (1998). Effect of the nature of oil on the incorporation of testosterone propionate into nonionic oil-in-water microemulsions. J. Pharm. Sci., 87, 109-116
25. Mette, G., Anette, M., & Jeanet, L. N. (2006). Bioavailability of seocalcitol II: Development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides. Eur. J. Pharm. Res., 28, 233-242
26. Miskolczi, P., Kozma, K., Polgar, M., & Vereczkey, L. (1990). Pharmacokinetics of VP and its main metabolite apovincaminic acid before and after the chronic oral administration of VP to humans. Eur. J. Drug Metab. Pharmacokinet., 15, 1-5
27. Morazzoni, P., Montalbetti, A., Malandrino, S., & Pifferi, G. (1993). Comparative pharmacokinetics of silipide and silymarin in rats. Eur. J. Drug Metab. Pharmacokinet., 18, 289-297
28. Nazzal, S., Guven, N., Reddy, I. K., & Khan, M. A. (2002). Preparation and characterization of Coenzyme Q10-Eudragit® solid dispersion. Drug Dev. Ind. Pharm., 28, 49-57
29. Neslihan, G. R., & Simon, B. (2004). Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Bio. Pharm., 58, 173-182
30. O'Driscoll, C. M. (2002). Lipid-based formulations for intestinal lymphatic delivery. Eur. J. Pharm. Sci., 15, 405-415
31. Perng, C. H., Kearney, A. S., Patel, K., Palepu, N. R., & Zuber, G. (1998). Investigation of formulation approaches to improve the dissolution of SB- 210661, a poorly water soluble 5-lipoxygenase inhibitor. Int. J. Pharm., 176, 31-38
32. Pouton, C. W. (1997). Formulation of self-emulsifying drug delivery systems. Adv. Drug Deliv. Rev., 25, 47-58
33. P outon, C. W. (2000). Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and "selfmicroemulsifying" drug delivery systems. Eur. J. Pharm. Sci., 2(Suppl), S93-S98
34. Ruchatz, F., & Schuch, H. (1998). Physicochemical properties of Solutol HS 15 and its solubilizates. BASF ExAct, 1, 6-7
35. Shah, N. H., Carvajal, M. T., Patel, C. I., Infeld, M. H., & Malick, A. W. (1994). Self-emulsifying drug delivery systems (SEDDS) with polyglycolysed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int. J. Pharm., 106, 15-23
36. Six, K., Verreck, G., Peeters, J., Brewster, M., & Van Den Mooter, G. (2004). Increased physical stability and improved dissolution properties of itraconazole, a class II drug, by solid dispersions that combine fast- and slow-dissolving polymers. J. Pharm. Sci., 93, 124-131
37. Song, K. H., Chung, S. J., & Shim, C. K. (2005). Enhanced intestinal absorption of salmon calcitonin (SCT) from proliposomes containing bile salts. J. Control. Release, 106, 298-308
38. Szakács, T., Veres, Z., & Vereczkey, L. (2001). In vitro-in vivo correlation of the pharmacokinetics of VP. Pol. J. Pharmacol., 53(6), 623-628
39. Trotta, M., Pattarino, F., & Grosa, G. (1998). Formation of lecithin-based microemulsions containing n-alkanol phosphocholines. Int. J. Pharm., 174, 253-259
40. Venkatesan, N., Uchino, K., Amagase, K., Ito, Y., Shibata, N., & Takada, K. (2006). Gastrointestinal patch system for the delivery of erythropoietin. J. Control. Release, 111, 19-26
41. Warisnoicharoen, W., Lansley, A. B., & Lawrence, M. J. (2000). Nonionic oilin- water microemulsions: The effect of oil type on phase behavior. Int. J. Pharm., 198, 7-27
42. Wei, L. L., Sun, P. N., Nie, S. F., & Pan, W. S. (2005). Preparation and evaluation of SEDDS and SMEDDS containing Carvedilol. Drug Dev. Ind. Pharm., 31, 785-794
43. Wu, W., Wang, Y., & Que, L. (2006). Enhanced bioavailability of silymarin by selfmicroemulsifying drug delivery system. Eur. J. Pharm. Biopharm., 63, 288-294
44. Zhang, Y. C., & Benet, L. Z. (2001). The gut as a barrier to drug absorption combined role of cytochrome P450 3A and P-glycoprotein. Clin. Pharmacokinet., 40(3), 159-168
45. Zhang, P., Liu, Y., Feng, N. P., & Xu, J. (2008). Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int. J. Pharm., 355, 269-276