Severe metabolic complications from theophylline intoxication

Nephrology

Volumn 8, Issue 5, 2003, Pages 239-242

  Charytan, David ^a   Jansen, Kevin ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Acidosis; Aminophyllines; Hypokalaemia; Overdose; Theophylline

Indexed keywords

AZATHIOPRINE; HYDROCHLOROTHIAZIDE PLUS TRIAMTERENE; INSULIN; LEVOFLOXACIN; MECLOZINE; METRONIDAZOLE; MORPHINE; NARCOTIC AGENT; SALBUTAMOL; THEOPHYLLINE;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; AGED; ANAMNESIS; ARTERIAL GAS; ARTICLE; ASTHMA; BLOOD EXAMINATION; BREATHING DISORDER; BREATHING RATE; CASE REPORT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL EXAMINATION; CLINICAL FEATURE; CONFUSION; DELIRIUM; DEMENTIA; DIABETIC KETOACIDOSIS; EMERGENCY WARD; HOSPITAL ADMISSION; HUMAN; HYPOKALEMIA; ILEUS; INTENSIVE CARE UNIT; KETONURIA; LABORATORY TEST; MALE; METABOLIC ACIDOSIS; METABOLIC DISORDER; NEPHROTOXICITY; PRIORITY JOURNAL; RESPIRATORY ALKALOSIS; SEPSIS; SIDE EFFECT; STARVATION; TACHYCARDIA; THORAX RADIOGRAPHY; URINALYSIS;

ACIDOSIS, LACTIC; AGED, 80 AND OVER; BICARBONATES; CARBON DIOXIDE; HUMANS; HYPOKALEMIA; KETOSIS; MALE; OXYGEN; PHOSPHODIESTERASE INHIBITORS; POISONING; THEOPHYLLINE;

EID: 0242574416     PISSN: 13205358     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1797.2003.00181.x     Document Type: Article

References (25)

1. Schiff GD, Hegde HK, LaCloche L, Hryhorczuk DO. Inpatient theophylline toxicity: Preventable factors. Ann. Intern. Med. 1991; 114: 748-53.
2. Aitken ML, Martin TR. Life threatening theophylline toxicity is predictable by serum levels. Chest 1987; 91: 10-14.
3. Ryan T, Coughlan G, McGing P, Phelan D. Ketosis a complication of theophylline toxicity. J. Int. Med. 1989; 226: 277-8.
4. Polak M, Rolon MA, Chouchana A, Czernichow P. Theophylline intoxication mimicking diabetic ketoacidosis in a child. Diabetes Metab. 1999; 25: 513-15.
5. Vaucher Y, Lightner ES, Walson PD. Theophyllie poisoning. J. Pediatrics 1977; 90: 827-30.
6. Bernard S. Severe lactic acidosis following theophylline overdose. Ann. Emerg. Med. 1991; 20: 1135-7.
7. Leventhal LJ, Kochar G, Feldman NH, Podolsky SM, Stanek MS. Lactic acidosis in theophylline overdose. Am. J. Emerg. Med. 1989; 7: 417-18.
8. Hagley MT, Traeger SM, Schuckman H. Pronounced metabolic response to modest theophylline overdose. Ann. Pharmacother. 1994; 28: 195-6.
9. Assadi FK. Therapy of acute bronchospasm: Complicated by lactic acidosis and hypokalemia. Clin. Pediatr. 1989; 28: 258-60.
10. Shannon M. Predictors of major toxicity after theophylline overdose. Ann. Intern. Med. 1993; 119: 1161-7.
11. Sessler CN. Theophylline toxicity: clinical features of 116 consecutive cases. Am. J. Med. 1990; 88: 567-76.
12. Hall KW, Dobson KE, Dalton JG, Ghignone MC, Penner SB. Metabolic abnormalities associated with intentional theophylline overdose. Ann. Intern. Med. 1984; 101: 457-62.
13. Wingo CS, Weiner ID. Disorders of potassium balance. In: Brenner BM, ed. Brenner and Rector's the Kidney, 6th edn. Philadelphia: W.B. Saunders and Co., 2000; 998-1036.
14. Kokko JP. Disturbances of potassium balance. In: Goldman L, Bennet SC, eds. Cecil Textbook of Medicine, 21st edn. Philadelphia: W.B. Saunders and Co., 2000; 553-8.
15. McFadden ER. Methylxanthines in the treatment of asthma: The rise, the fall, and the possible rise again. Ann. Intern. Med. 1991; 115: 241.
16. Mountain RD, Neff TA. Oral theophylline intoxication: a serious error of patient and physician understanding. Arch. Intern. Med. 1984; 144: 724-7.
17. Bertino JS Jr, Walker JW. Reassessment of theophyliine toxicity. Serum concentrations, clinical course, and treatment. Arch. Intern. Med. 1987; 147: 757-60.
18. Vestal RE, Eiriksson CE, Musser B, Ozaki LK, Halter J. Effect of intravenous aminophylline on plasma levels of catecholamines and related cardiovascular and metabolic responses in man. Circulation 1983; 67: 162-70.
19. Higbee MD, Kumar M, Galant SP. Stimulation of endogenous catecholamine release by theophylline: a proposed additional mechanism of action for theophylline efects. J. Allergy Clin. Immunol. 1982; 70: 377-82.
20. Curry SC, Vance MV, Requa R, Armstead R. The effects of toxic concentrations of theophylline on oxygen consumption, ventricular work, acid base balance and plasma catecholamine levels in the dog. Ann. Emerg. Med. 1985; 14: 554-61.
21. Buckley BM, Braithwaite RA, Vale JA. Theophylline poisoning. Lancet 1983; 2: 618.
22. Amitai Y, Lovejoy FH. Hypokalemia in acute theophylline poisoning. Am. J. Emerg. Med. 1988; 6: 214-18.
23. Kolendorf K, Moller BB. Lactic acidosis in ephinephrine poisoning. Acta Med. Scand. 1974; 196: 465-6.
24. Spergel G, Bleicher SJ, Ertel NH. Carbohydrate and fat metabolism in patients with pehochromocytoma. N. Engl. J. Med. 1968; 278: 803-9.
25. Bornemann M, Hill SC, Kidd GS. Lactic acidosis in pheochromocytoma. Ann. Intern. Med. 1986; 105: 880-2.