Low glucocorticoid receptor α/β ratio in T-cell lymphoblastic leukemia

Hormone and Metabolic Research

Volumn 32, Issue 10, 2000, Pages 401-406

  Longui, C A ^a,b   Vottero, A ^a   Adamson, P C ^c   Cole, D E ^c   Kino, T ^a   Monte, O ^b   Chrousos, G P ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b Medical Sciences School of Santa Casa of São Paulo   (Brazil)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Acute Leukemia; Glucocorticoid Receptor; Glucocorticoid Resistance; Glucocorticoid Sensitivity

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; CELL LINEAGE; CHILD; CLINICAL ARTICLE; FEMALE; HORMONE RESISTANCE; HUMAN; IMMUNOPHENOTYPING; LYMPHATIC LEUKEMIA; MALE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; T CELL LEUKEMIA; WESTERN BLOTTING;

EID: 0033753883     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-978661     Document Type: Article

References (45)

1. Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukaemia
2. Glucocorticoid-induced apoptosis and treatment sensitivity in acute lymphoblastic leukemia of children
3. Apoptosis and acute lymphocytic leukemia in children
4. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86
5. Prednisolone resistance in childhood acute lymphoblastic leukemia: Vitro-vivo correlations and cross-resistance to other drugs
6. Phenotypes of acute leukemia and disease prognosis, 1979
7. Cellular drug resistance profiles that might explain the prognostic value of immunophenotype and age in childhood acute lymphoblastic leukemia
8. Glucocorticoid receptors in normal and leukaemic human leukocytes
9. High glucocorticoid receptor content of leukemic blasts is a favorable prognostic factor in childhood acute lymphoblastic leukemia
10. The relationship of blast cell glucocorticoid receptor levels to response to single-agent steroid trial and remission response in children with acute lymphoblastic leukemia
11. Glucocorticoid receptor β, a potential endogenous inhibitor of glucocorticold action in humans
12. The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function
13. The genomic structure of the human glucocorticoid receptor
14. Primary structure and expression of functional human glucocorticoid cDNA
15. Functional domains of human glucocorticoid receptor
16. Molecular mechanisms of glucocorticoid resistance/hypersensitivity - Potential clinical implications
17. The non-ligand binding β-isoform of the human glucocorticoid receptor (hGRβ): Tissue levels, mechanism of action, and potential physiologic role
18. Glucocorticoid resistant syndromes - Molecular basis and clinical presentations
19. Evidence that the β-isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor
20. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta
21. Mechanisms of glucocorticoid-resistant asthma
22. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor
23. Glucocorticoid-induced apoptosis and regulation of NK-κB activity in human leukemic T cells
24. Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants
25. Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure
26. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs
27. Steroid-induced conformational changes at ends of the hormone-binding domain in the rat glucocorticoid receptor are independent of agonist versus antagonist activity
28. Glucocorticoid-receptor-gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines
29. Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression
30. Splice site mutation in the glucocorticoid receptor gene causes resistance to glucocorticoid-induced apoptosis in a human acute leukemic cell line
31. Identification of the activation-labile gene: A single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes
32. Resistance of human leukemic CEM-C1 cells is overcome by synergism between glucocorticoid and protein kinase A pathways: Correlation with c-myc suppression
33. Regulation of the human interleukin-2 gene by the α and β isoforms of the glucocorticoid receptor
34. Glucocorticoid-induced apoptosis
35. The biochemistry and molecular biology of glucocorticoid-induced apoptosis in the immune system
36. Role of calcium in glucocorticosteroid-induced apoptosis of thymocytes and lymphoma cells: Resurrection of old theories by new findings
37. Intracellular K+ suppresses the activation of apoptosis in lymphocytes
38. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor β
39. Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia
40. Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia - Implications for treatment of infants
41. DNA binding of the glucocorticoid receptor is not essential for survival
42. The use of glucocorticoids in acute lymphoblastic leukemia of childhood
43. Differences in down-regulation of glucocorticoid receptor mRNA by cortisol prednisolone and dexamethasone in HeLa cells
44. Downregulation of the glucocorticoid receptor. A mechanism for physiological adaptation to hormones
45. Homologous down regulation of the glucocorticoid receptor: The molecular machinery