메뉴 건너뛰기




Volumn 61, Issue 1, 2009, Pages 13-21

Effect of blockage of the endocannabinoid system by CB1 antagonism on cardiovascular risk

Author keywords

Cardiovascular risk; Endocannabinoids; Rimonabant

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR ANTAGONIST; ENDOCANNABINOID; METFORMIN; PLACEBO; RIMONABANT; SULFONYLUREA;

EID: 66949122760     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(09)70003-9     Document Type: Conference Paper
Times cited : (11)

References (41)
  • 2
    • 34547892637 scopus 로고    scopus 로고
    • Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase
    • Bátkai S, Rajesh M, Mukhopadhyay P, Haskó G, Liaudet L, Cravatt BF, Csiszár A et al.: Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol, 2007, 293, H909-918.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Bátkai, S.1    Rajesh, M.2    Mukhopadhyay, P.3    Haskó, G.4    Liaudet, L.5    Cravatt, B.F.6    Csiszár, A.7
  • 4
    • 0034616066 scopus 로고    scopus 로고
    • Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid
    • Braud S, Bon C, Touqui L, Mounier C: Activation of rabbit blood platelets by anandamide through its cleavage into arachidonic acid. FEBS Lett, 2000, 471, 12-16.
    • (2000) FEBS Lett , vol.471 , pp. 12-16
    • Braud, S.1    Bon, C.2    Touqui, L.3    Mounier, C.4
  • 5
    • 34548121876 scopus 로고    scopus 로고
    • Adipose tissue, inflammation and endothelial dysfunction
    • Chudek J, Wiecek A: Adipose tissue, inflammation and endothelial dysfunction. Pharmacol Rep, 2006, 58, Suppl, 81-88.
    • (2006) Pharmacol Rep , vol.58 , Issue.SUPPL. , pp. 81-88
    • Chudek, J.1    Wiecek, A.2
  • 6
    • 1842611887 scopus 로고    scopus 로고
    • The endocannabinoid system: A general view and latest additions
    • De Petrocellis L, Cascio MG, Di Marzo V: The endocannabinoid system: a general view and latest additions. Br J Pharmacol, 2004, 141, 765-774.
    • (2004) Br J Pharmacol , vol.141 , pp. 765-774
    • De Petrocellis, L.1    Cascio, M.G.2    Di Marzo, V.3
  • 7
    • 27844463517 scopus 로고    scopus 로고
    • Rimonabant in Obesity-Lipids Study Group: Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Després JP, Golay A, Sj-dsoström L: Rimonabant in Obesity-Lipids Study Group: Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med, 2005, 353, 2121-2134.
    • (2005) N Engl J Med , vol.353 , pp. 2121-2134
    • Després, J.P.1    Golay, A.2    Sj-dsoström, L.3
  • 8
    • 58149265073 scopus 로고    scopus 로고
    • The endocannabinoid system and cardiometabolic risk: Effects of CB1 receptor blockade on lipid metabolism
    • Deedwania P: The endocannabinoid system and cardiometabolic risk: Effects of CB1 receptor blockade on lipid metabolism. Int J Cardiol, 2009, 131, 305-312.
    • (2009) Int J Cardiol , vol.131 , pp. 305-312
    • Deedwania, P.1
  • 9
    • 0033567190 scopus 로고    scopus 로고
    • Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages
    • Di Marzo V, Bisogno T, De Petrocellis L, Melck D, Orlando P, Wagner JA, Kunos G: Biosynthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in circulating and tumoral macrophages. Eur J Biochem, 1999, 264, 258-267.
    • (1999) Eur J Biochem , vol.264 , pp. 258-267
    • Di Marzo, V.1    Bisogno, T.2    De Petrocellis, L.3    Melck, D.4    Orlando, P.5    Wagner, J.A.6    Kunos, G.7
  • 10
    • 33947128224 scopus 로고    scopus 로고
    • Endocannabinoids and the regulation of their levels in health and disease
    • Di Marzo V, Petrosino S: Endocannabinoids and the regulation of their levels in health and disease. Curr Opin Lipidol, 2007, 18, 129-140.
    • (2007) Curr Opin Lipidol , vol.18 , pp. 129-140
    • Di Marzo, V.1    Petrosino, S.2
  • 12
    • 31044436262 scopus 로고    scopus 로고
    • Platelets in inflammation and atherogenesis
    • Gawaz M, Langer H, May AE: Platelets in inflammation and atherogenesis. J Clin Invest, 2005, 115, 3378-3384.
    • (2005) J Clin Invest , vol.115 , pp. 3378-3384
    • Gawaz, M.1    Langer, H.2    May, A.E.3
  • 13
    • 2942675088 scopus 로고    scopus 로고
    • Obesity, metabolic syndrome, and cardiovascular disease
    • Grundy SM: Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab, 2004, 89, 2595-2600.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2595-2600
    • Grundy, S.M.1
  • 14
    • 42549161100 scopus 로고    scopus 로고
    • Prostacyclin among prostanoids
    • Gryglewski RJ. Prostacyclin among prostanoids. Pharmacol Rep, 2008, 60, 3-11.
    • (2008) Pharmacol Rep , vol.60 , pp. 3-11
    • Gryglewski, R.J.1
  • 15
    • 33745571976 scopus 로고    scopus 로고
    • The immune response in atherosclerosis: A double-edged sword
    • Hansson GK, Libby P: The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol, 2006, 6, 508-519.
    • (2006) Nat Rev Immunol , vol.6 , pp. 508-519
    • Hansson, G.K.1    Libby, P.2
  • 17
    • 52049119316 scopus 로고    scopus 로고
    • Pleiotropic effects of angiotensin-converting enzyme inhibitors in normotensive patients with coronary artery disease
    • Krysiak R, Okopień B: Pleiotropic effects of angiotensin-converting enzyme inhibitors in normotensive patients with coronary artery disease. Pharmacol Rep, 2008, 60, 514-523.
    • (2008) Pharmacol Rep , vol.60 , pp. 514-523
    • Krysiak, R.1    Okopień, B.2
  • 18
    • 58849116267 scopus 로고    scopus 로고
    • Synthesis and characterization of a peripherally restricted CB(1) cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice
    • doi:10.1016/j.bmcl.2008.12.059
    • Loverme J, Duranti A, Tontini A, Spadoni G, Mor M, Rivara S, Stella N et al.: Synthesis and characterization of a peripherally restricted CB(1) cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorg Med Chem Lett, 2008, doi:10.1016/j.bmcl.2008.12.059.
    • (2008) Bioorg Med Chem Lett
    • Loverme, J.1    Duranti, A.2    Tontini, A.3    Spadoni, G.4    Mor, M.5    Rivara, S.6    Stella, N.7
  • 19
    • 0032973268 scopus 로고    scopus 로고
    • Anandamide activates human platelets through a pathway independent of the arachidonate cascade
    • Maccarrone M, Bari M, Menichelli A, Del Principe D, Finazzi Agrò A: Anandamide activates human platelets through a pathway independent of the arachidonate cascade. FEBS Lett, 1999, 447, 277-282.
    • (1999) FEBS Lett , vol.447 , pp. 277-282
    • Maccarrone, M.1    Bari, M.2    Menichelli, A.3    Del Principe, D.4    Finazzi Agrò, A.5
  • 20
    • 0034825356 scopus 로고    scopus 로고
    • Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor
    • Maccarrone M, Bari M, Menichelli A, Giuliani E, Del Principe D, Finazzi Agrò A: Human platelets bind and degrade 2-arachidonoylglycerol, which activates these cells through a cannabinoid receptor. Eur J Biochem, 2001, 268, 819-825.
    • (2001) Eur J Biochem , vol.268 , pp. 819-825
    • Maccarrone, M.1    Bari, M.2    Menichelli, A.3    Giuliani, E.4    Del Principe, D.5    Finazzi Agrò, A.6
  • 21
    • 33845673559 scopus 로고    scopus 로고
    • Endocannabinoids and the control of energy balance
    • Matias I, Di Marzo V: Endocannabinoids and the control of energy balance. Trends Endocrinol Metab, 2007, 18, 27-37.
    • (2007) Trends Endocrinol Metab , vol.18 , pp. 27-37
    • Matias, I.1    Di Marzo, V.2
  • 23
    • 28344439657 scopus 로고    scopus 로고
    • Platelets in atherothrombosis: Lessons from mouse models
    • Nieswandt B, Aktas B, Moers A, Sachs UJ: Platelets in atherothrombosis: lessons from mouse models. J Thromb Haemost, 2005, 3, 1725-1736.
    • (2005) J Thromb Haemost , vol.3 , pp. 1725-1736
    • Nieswandt, B.1    Aktas, B.2    Moers, A.3    Sachs, U.J.4
  • 24
    • 41649090426 scopus 로고    scopus 로고
    • STRADI-VARIUS Investigators: Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial
    • Nissen SE, Nicholls SJ, Wolski K, Rodés-Cabau J, Cannon CP, Deanfield JE, Després JP et al.: STRADI-VARIUS Investigators: Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial. JAMA, 2008, 299, 1547-1560.
    • (2008) JAMA , vol.299 , pp. 1547-1560
    • Nissen, S.E.1    Nicholls, S.J.2    Wolski, K.3    Rodés-Cabau, J.4    Cannon, C.P.5    Deanfield, J.E.6    Després, J.P.7
  • 26
    • 19444369394 scopus 로고    scopus 로고
    • Blood pressure regulation by endocannabinoids and their receptors
    • Pacher P, Batkai S, Kunos G: Blood pressure regulation by endocannabinoids and their receptors. Neuropharmacology, 2005, 48, 1130-1138.
    • (2005) Neuropharmacology , vol.48 , pp. 1130-1138
    • Pacher, P.1    Batkai, S.2    Kunos, G.3
  • 28
    • 85136411745 scopus 로고    scopus 로고
    • Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J; RIO-North America Study Group: Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA, 2006, 295, 761-775.
    • Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J; RIO-North America Study Group: Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA, 2006, 295, 761-775.
  • 29
    • 2542555018 scopus 로고    scopus 로고
    • The complexities of the cardiovascular actions of cannabinoids
    • Randall MD, Kendall DA, O'Sullivan S: The complexities of the cardiovascular actions of cannabinoids. Br J Pharmacol, 2004, 142, 20-26.
    • (2004) Br J Pharmacol , vol.142 , pp. 20-26
    • Randall, M.D.1    Kendall, D.A.2    O'Sullivan, S.3
  • 30
    • 59049104050 scopus 로고    scopus 로고
    • Rosenstock J, Hollander P, Chevalier S, Iranmanesh A; SERENADE Study Group: SERENADE: the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients: effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes. Diabetes Care, 2008, 31, 2169-2176.
    • Rosenstock J, Hollander P, Chevalier S, Iranmanesh A; SERENADE Study Group: SERENADE: the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients: effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes. Diabetes Care, 2008, 31, 2169-2176.
  • 31
    • 17144426964 scopus 로고    scopus 로고
    • Pharmacology: Marijuana and your heart
    • Roth MD: Pharmacology: marijuana and your heart. Nature, 2005, 434, 708-709.
    • (2005) Nature , vol.434 , pp. 708-709
    • Roth, M.D.1
  • 33
    • 33751001942 scopus 로고    scopus 로고
    • RIO-Diabetes Study Group: Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study
    • Scheen AJ, Finer N, Hollander P, Jensen MD, Van Gaal LF; RIO-Diabetes Study Group: Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet, 2006, 368, 1660-1672.
    • (2006) Lancet , vol.368 , pp. 1660-1672
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3    Jensen, M.D.4    Van Gaal, L.F.5
  • 34
    • 17144400758 scopus 로고    scopus 로고
    • Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
    • Steffens S, Veillard NR, Arnaud C, Pelli G, Burger F, Staub C, Karsak M et al.: Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature, 2005, 434, 782-786.
    • (2005) Nature , vol.434 , pp. 782-786
    • Steffens, S.1    Veillard, N.R.2    Arnaud, C.3    Pelli, G.4    Burger, F.5    Staub, C.6    Karsak, M.7
  • 36
    • 17144382751 scopus 로고    scopus 로고
    • RIO-Europe Study Group: Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
    • Van Gaal LF, Rissanen AM, Scheen AJ, Ziegler O, Rossner S: RIO-Europe Study Group: Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet, 2005, 365, 1389-1397.
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3    Ziegler, O.4    Rossner, S.5
  • 38
    • 0032924113 scopus 로고    scopus 로고
    • Mesenteric vasodilation mediated by endothelial anandamide receptors
    • Wagner JA, Varga K, Jarai Z, Kunos G: Mesenteric vasodilation mediated by endothelial anandamide receptors. Hypertension, 1999, 33, 429-434.
    • (1999) Hypertension , vol.33 , pp. 429-434
    • Wagner, J.A.1    Varga, K.2    Jarai, Z.3    Kunos, G.4
  • 39
    • 16444364523 scopus 로고    scopus 로고
    • Platelets and chemokines in atherosclerosis: Partners in crime
    • Weber C: Platelets and chemokines in atherosclerosis: partners in crime. Circ Res, 2005, 96, 612-616.
    • (2005) Circ Res , vol.96 , pp. 612-616
    • Weber, C.1
  • 40
    • 33847047729 scopus 로고    scopus 로고
    • Role of the endocannabinoid system in regulating cardiovascular and metabolic risk factors
    • Woods SC: Role of the endocannabinoid system in regulating cardiovascular and metabolic risk factors. Am J Med, 2007, 120, S19-25.
    • (2007) Am J Med , vol.120
    • Woods, S.C.1
  • 41
    • 0020527558 scopus 로고
    • The hospital anxiety and depression scale
    • Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand, 1983, 67, 361-370.
    • (1983) Acta Psychiatr Scand , vol.67 , pp. 361-370
    • Zigmond, A.S.1    Snaith, R.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.