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Volumn 30, Issue 6, 2009, Pages 1058-1063

Endocrine dysfunction in p27Kip1 deficient mice and susceptibility to Wnt-1 driven breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; ESTRADIOL; PROGESTERONE; WNT1 PROTEIN; WNT1 PROTEIN, MOUSE;

EID: 66849141218     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp089     Document Type: Article
Times cited : (6)

References (46)
  • 1
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr,C.J. et al. (1999) CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev., 13, 1501-1512.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1
  • 2
    • 41149150219 scopus 로고    scopus 로고
    • The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
    • Chu,I.M. et al. (2008) The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat. Rev. Cancer, 8, 253-267.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 253-267
    • Chu, I.M.1
  • 3
    • 33845640614 scopus 로고    scopus 로고
    • p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy
    • Porter,P.L. et al. (2006) p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy. J. Natl Cancer Inst., 98, 1723-1731.
    • (2006) J. Natl Cancer Inst , vol.98 , pp. 1723-1731
    • Porter, P.L.1
  • 4
    • 0142008438 scopus 로고    scopus 로고
    • High p27Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin
    • Pohl,G. et al. (2003) High p27Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin. J. Clin. Oncol., 21, 3594-3600.
    • (2003) J. Clin. Oncol , vol.21 , pp. 3594-3600
    • Pohl, G.1
  • 5
    • 0027304028 scopus 로고
    • Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk
    • Pike,M.C. et al. (1993) Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol. Rev., 15 17-35.
    • (1993) Epidemiol. Rev , vol.15 , pp. 17-35
    • Pike, M.C.1
  • 6
    • 0142135033 scopus 로고    scopus 로고
    • Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway
    • Foster,J.S. et al. (2003) Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway. J. Biol. Chem., 278, 41355-41366.
    • (2003) J. Biol. Chem , vol.278 , pp. 41355-41366
    • Foster, J.S.1
  • 7
    • 0034238115 scopus 로고    scopus 로고
    • Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells
    • Cariou,S. et al. (2000) Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells. Proc. Natl Acad. Sci. USA, 97, 9042-9046.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 9042-9046
    • Cariou, S.1
  • 8
    • 0028986931 scopus 로고
    • Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias
    • Pietenpol,J.A. et al. (1995) Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias. Cancer Res., 55, 1206-1210.
    • (1995) Cancer Res , vol.55 , pp. 1206-1210
    • Pietenpol, J.A.1
  • 9
    • 0029007867 scopus 로고
    • Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies
    • Kawamata,N. et al. (1995) Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies. Cancer Res., 55, 2266-2269.
    • (1995) Cancer Res , vol.55 , pp. 2266-2269
    • Kawamata, N.1
  • 10
    • 0030002553 scopus 로고    scopus 로고
    • p27 mutation found in breast cancer
    • Spirin,K.S. et al. (1996) p27 mutation found in breast cancer. Cancer Res., 56, 2400-2404.
    • (1996) Cancer Res , vol.56 , pp. 2400-2404
    • Spirin, K.S.1
  • 11
    • 0032511848 scopus 로고    scopus 로고
    • The murine gene p27Kip1 is haplo-insufficient for tumour suppression
    • Fero,M.L. et al. (1998) The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature, 396, 177-180.
    • (1998) Nature , vol.396 , pp. 177-180
    • Fero, M.L.1
  • 12
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
    • Nakayama,K. et al. (1996) Mice lacking p27 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell, 85, 707-720.
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1
  • 13
    • 15844415946 scopus 로고    scopus 로고
    • Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
    • Kiyokawa,H. et al. (1996) Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell, 85, 721-732.
    • (1996) Cell , vol.85 , pp. 721-732
    • Kiyokawa, H.1
  • 14
    • 15844384256 scopus 로고    scopus 로고
    • A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27-deficient mice
    • Fero,M.L. et al. (1996) A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27-deficient mice. Cell, 85, 733-744.
    • (1996) Cell , vol.85 , pp. 733-744
    • Fero, M.L.1
  • 15
    • 1342280369 scopus 로고    scopus 로고
    • Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development
    • Philipp-Staheli,J. et al. (2004) Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development. Oncogene, 23, 905-913.
    • (2004) Oncogene , vol.23 , pp. 905-913
    • Philipp-Staheli, J.1
  • 16
    • 0037143726 scopus 로고    scopus 로고
    • Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis
    • Hwang,H.C. et al. (2002) Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis. Proc. Natl Acad. Sci. USA, 99, 11293-11298.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 11293-11298
    • Hwang, H.C.1
  • 17
    • 0037099496 scopus 로고    scopus 로고
    • Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis
    • Martins,C.P. et al. (2002) Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis. EMBO J., 21, 3739-3748.
    • (2002) EMBO J , vol.21 , pp. 3739-3748
    • Martins, C.P.1
  • 18
    • 0037456996 scopus 로고    scopus 로고
    • Loss of p27(Kip1) cooperates with cyclin E in T-cell lymphomagenesis
    • Geisen,C. et al. (2003) Loss of p27(Kip1) cooperates with cyclin E in T-cell lymphomagenesis. Oncogene, 22, 1724-1729.
    • (2003) Oncogene , vol.22 , pp. 1724-1729
    • Geisen, C.1
  • 19
    • 0034746302 scopus 로고    scopus 로고
    • Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse
    • Di Cristofano,A. et al. (2001) Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nat. Genet., 27 222-224.
    • (2001) Nat. Genet , vol.27 , pp. 222-224
    • Di Cristofano, A.1
  • 20
    • 39649093873 scopus 로고    scopus 로고
    • Susceptibility of p27 kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine may not simply be due to enhanced proliferation
    • Hikosaka,A. et al. (2008) Susceptibility of p27 kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine may not simply be due to enhanced proliferation. Int. J. Cancer, 122, 1222-1228.
    • (2008) Int. J. Cancer , vol.122 , pp. 1222-1228
    • Hikosaka, A.1
  • 21
    • 33750361636 scopus 로고    scopus 로고
    • Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans
    • Pellegata,N.S. et al. (2006) Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc. Natl Acad. Sci. USA, 103, 15558-15563.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 15558-15563
    • Pellegata, N.S.1
  • 22
    • 0036124467 scopus 로고    scopus 로고
    • ErbB2/Neu-induced cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells
    • Muraoka,R.S. et al. (2002) ErbB2/Neu-induced cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. Mol. Cell. Biol., 22, 2204-2219.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 2204-2219
    • Muraoka, R.S.1
  • 23
    • 10344230979 scopus 로고    scopus 로고
    • A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis
    • Gao,H. et al. (2004) A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis. Proc. Natl Acad. Sci. USA, 101, 17204-17209.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 17204-17209
    • Gao, H.1
  • 24
    • 0036559462 scopus 로고    scopus 로고
    • Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice
    • Philipp-Staheli,J. et al. (2002) Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. Cancer Cell, 1, 355-368.
    • (2002) Cancer Cell , vol.1 , pp. 355-368
    • Philipp-Staheli, J.1
  • 25
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis,P. (2000) Wnt signaling and cancer. Genes Dev., 14, 1837-1851.
    • (2000) Genes Dev , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 26
    • 0024162530 scopus 로고
    • Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
    • Tsukamoto,A.S. et al. (1988) Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell, 55, 619-625.
    • (1988) Cell , vol.55 , pp. 619-625
    • Tsukamoto, A.S.1
  • 27
    • 0036733656 scopus 로고    scopus 로고
    • Pathway pathology: Histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors
    • Rosner,A. et al. (2002) Pathway pathology: Histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am. J. Pathol., 161, 1087-1097.
    • (2002) Am. J. Pathol , vol.161 , pp. 1087-1097
    • Rosner, A.1
  • 28
    • 20544474499 scopus 로고    scopus 로고
    • Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations
    • Zhang,X. et al. (2005) Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations. Oncogene, 24, 4220-4231.
    • (2005) Oncogene , vol.24 , pp. 4220-4231
    • Zhang, X.1
  • 29
    • 0033561743 scopus 로고    scopus 로고
    • A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha
    • Bocchinfuso,W.P. et al. (1999) A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha. Cancer Res., 59, 1869-1876.
    • (1999) Cancer Res , vol.59 , pp. 1869-1876
    • Bocchinfuso, W.P.1
  • 30
    • 0034696279 scopus 로고    scopus 로고
    • Cardiff,R.D. et al. (2000) The mammary pathology of genetically engineered mice: The consensus report and recommendations from the Annapolis meeting. Oncogene, 19, 968-988.
    • Cardiff,R.D. et al. (2000) The mammary pathology of genetically engineered mice: The consensus report and recommendations from the Annapolis meeting. Oncogene, 19, 968-988.
  • 31
    • 34548066245 scopus 로고    scopus 로고
    • Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice
    • Huang,S. et al. (2005) Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. Genome Biol., 6, R84.
    • (2005) Genome Biol , vol.6
    • Huang, S.1
  • 32
    • 0034696336 scopus 로고    scopus 로고
    • Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer
    • Li,Y. et al. (2000) Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene, 19, 1002-1009.
    • (2000) Oncogene , vol.19 , pp. 1002-1009
    • Li, Y.1
  • 33
    • 0037028208 scopus 로고    scopus 로고
    • Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models
    • Jackson,R.J. et al. (2002) Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models. Oncogene, 21, 8486-8497.
    • (2002) Oncogene , vol.21 , pp. 8486-8497
    • Jackson, R.J.1
  • 34
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • Yu,Q. et al. (2001) Specific protection against breast cancers by cyclin D1 ablation. Nature, 411, 1017-1021.
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1
  • 35
    • 54249086214 scopus 로고    scopus 로고
    • The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis
    • Vaillant,F. et al. (2008) The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res., 68, 7711-7717.
    • (2008) Cancer Res , vol.68 , pp. 7711-7717
    • Vaillant, F.1
  • 36
    • 1642570244 scopus 로고    scopus 로고
    • The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
    • Liu,B.Y. et al. (2004) The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc. Natl Acad. Sci. USA, 101, 4158-4163.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 4158-4163
    • Liu, B.Y.1
  • 37
    • 33645221414 scopus 로고    scopus 로고
    • Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1
    • Chien,W.M. et al. (2006) Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1. Proc. Natl Acad. Sci. USA, 103, 4122-4127.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 4122-4127
    • Chien, W.M.1
  • 38
    • 0031667133 scopus 로고    scopus 로고
    • The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa→ luteal transition
    • Tong,W. et al. (1998) The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa→luteal transition. Cell Growth Differ., 9 787-794.
    • (1998) Cell Growth Differ , vol.9 , pp. 787-794
    • Tong, W.1
  • 39
    • 0035660512 scopus 로고    scopus 로고
    • Morphologic and molecular analysis of estrogen-induced pituitary tumorigenesis in targeted disruption of transforming growth factor-beta receptor type II and/or p27 mice
    • Ikeda,H. et al. (2001) Morphologic and molecular analysis of estrogen-induced pituitary tumorigenesis in targeted disruption of transforming growth factor-beta receptor type II and/or p27 mice. Endocrine, 16, 55-65.
    • (2001) Endocrine , vol.16 , pp. 55-65
    • Ikeda, H.1
  • 40
    • 27744547251 scopus 로고    scopus 로고
    • p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori infected mice
    • Kuzushita,N. et al. (2005) p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori infected mice. Gastroenterology, 129, 1544-1556.
    • (2005) Gastroenterology , vol.129 , pp. 1544-1556
    • Kuzushita, N.1
  • 41
    • 0030855876 scopus 로고    scopus 로고
    • Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas
    • Yasui,W. et al. (1997) Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas. Jpn. J. Cancer Res., 88, 625-629.
    • (1997) Jpn. J. Cancer Res , vol.88 , pp. 625-629
    • Yasui, W.1
  • 42
    • 0030955454 scopus 로고    scopus 로고
    • p27 expression and gastric carcinoma
    • Mori,M. et al. (1997) p27 expression and gastric carcinoma. Nat. Med., 3, 593.
    • (1997) Nat. Med , vol.3 , pp. 593
    • Mori, M.1
  • 43
    • 0034055554 scopus 로고    scopus 로고
    • Reduced expression of the cell-cycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma
    • Kim,D.H. et al. (2000) Reduced expression of the cell-cycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma. Histopathology, 36, 245-251.
    • (2000) Histopathology , vol.36 , pp. 245-251
    • Kim, D.H.1
  • 44
    • 0034729281 scopus 로고    scopus 로고
    • Loss of p16 and p27 is associated with progression of human gastric cancer
    • Myung,N. et al. (2000) Loss of p16 and p27 is associated with progression of human gastric cancer. Cancer Lett., 153, 129-136.
    • (2000) Cancer Lett , vol.153 , pp. 129-136
    • Myung, N.1
  • 45
    • 3442890875 scopus 로고    scopus 로고
    • Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia
    • Min,Y.H. et al. (2004) Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia. Cancer Res., 64, 5225-5231.
    • (2004) Cancer Res , vol.64 , pp. 5225-5231
    • Min, Y.H.1
  • 46
    • 11144235655 scopus 로고    scopus 로고
    • Estrogen and risk of gastric cancer: A protective effect in a nationwide cohort study of patients with prostate cancer in Sweden
    • Lindblad,M. et al. (2004) Estrogen and risk of gastric cancer: A protective effect in a nationwide cohort study of patients with prostate cancer in Sweden. Cancer Epidemiol. Biomarkers Prev., 13, 2203-2207.
    • (2004) Cancer Epidemiol. Biomarkers Prev , vol.13 , pp. 2203-2207
    • Lindblad, M.1


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