Reduced expression of the cell-cycle inhibitor p27(Kip1) is associated with progression and lymph node metastasis of gastric carcinoma

Histopathology

Volumn 36, Issue 3, 2000, Pages 245-251

  Kim, D H ^a,c   Lee, H I ^a   Nam, E S ^a   Shin, H S ^a   Sohn, J H ^a   Park, C H ^a,b   Yoon, D S ^a,b   Song, S Y ^a   Park, Y E ^a  

^a Hallym University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c Kangdong Sacred Heart Hospital   (South Korea)

Author keywords

Gastric carcinoma; Immunohistochemistry; Lymph node metastasis; p27(kip1)

Indexed keywords

KI 67 ANTIGEN; PROTEIN P27;

ADVANCED CANCER; ARTICLE; CANCER GRADING; CANCER RECURRENCE; CELL CYCLE; DISEASE COURSE; EARLY CANCER; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CARCINOMA; TUMOR VOLUME;

CARCINOMA; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MICROTUBULE-ASSOCIATED PROTEINS; PROGNOSIS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS;

EID: 0034055554     PISSN: 03090167     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2559.2000.00842.x     Document Type: Article

References (39)

1. 1. Morgan DO. Principles of CDK regulation. Nature 1995; 374; 131-134.
2. 2. Hengst L, Dulic V, Slingerland JM. Lees E, Reed SI. A cell cycle-regulated inhibitor of cyclin-dependent kinases. Proc: Natl. Acad. Sci. USA 1994; 91; 5291-5295.
3. 3. Sherr CJ. Cancer cell cycles. Science 1996; 274; 1672-1677.
4. 4. Hassussian CJ. Struewing JP, Goldstein AM et al. Germline p16 mutations in familial melanoma. Nat. Genet. 1994; 8; 15-21.
5. INK4B genes in gastric carcinomas. Cancer 1997; 80; 1889-1896.
6. 6. Toyoshima H, Hunter T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 1994; 78; 67-74.
7. KIP1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Gene Dev. 1994; 8; 9-22.
8. KIP1, a cyclin-dependent kinase and a potent mediator of extracellular antimilogenic signals. Cell 1994; 78; 59-66.
9. KIP1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. Cancer Res. 1995; 55; 1211-1214.
10. Kip1 gene to 12p13 and its analysis in leukemias. Cancer Res. 1995; 55; 1206-1210.
11. KIP1, to regions involved in human cancer. Cancer Res. 1995; 55; 1199-1205.
12. 12. Pagano M, Tam SW, Theodoras AM et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 1995; 269; 682-685.
13. Kip1 protein: prognostic implications in primary breast cancer. Nature Med. 1997; 3; 227-230.
14. 14. Loda M, Cukor B, Tam SW et al. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nature Med. 1997; 3; 231-234.
15. 15. Mori M, Mimori K, Shiraishi T et al. p27 expression and gastric carcinoma. Nature Med. 1997; 3; 593.
16. 16. Esposito V, Baldi A, Luca AD et al. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res. 1997; 57; 3381-3385.
17. 17. Fleming ID, Cooper JS, Henson DE et al. Manual for Staging of Cancer, 5th edn. Philadelphia. JB Lippincott., 1997: 71-76.
18. 18. Watanabe H, Jass JR, Sabin LH. Histological typing of oesophageal and gastric tumors. World Health Organization International Histological Classification of Tumours. Berlin: Springer, 1989: 20-26.
19. 19. Lauren P. The two histological main types of gastric carcinoma. Diffuse and so-called intestinal type carcinoma. An attempt at histoclinical classification. Acta Pathol. Microbiol Scand. 1965; 64; 31-49.
20. Kip1 is associated with advanced stage and invasiveness of gastric carcinomas. Jpn. J. Cancer Res. 1997; 88; 625-629.
21. KIP1 shows prognostic value in gastric carcinoma. J. Korean Med. Sci. 1998; 13; 369-376.
22. 22. Piva R, Cavalla P, Bortolotto S, Cordera S, Richiardi P, Schiffer D. p27/kip1 expression in human astrocytic gliomas. Neurosci. Lett. 1997; 234; 127-130.
23. Kip1 is a novel prognostic factor in localized human prostatic adenocarcinoma. Cancer Res. 1998; 58; 542-548.
24. Kip1 in malignant melanoma. Inverse correlation with disease-free survival. Am. J. Surg. Pathol. 1998; 153; 305-312.
25. Kip1 in epithelial dysplasia and carcinoma of the oral cavity. Am. J. Pathol. 1998; 152; 585-590.
26. Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells. Oncogene 1999; 18; 103-115.
27. KIP1 and degree of malignancy in human breast and colorectal cancers. Proc. Natl. Acad. Sci. USA 1997; 94; 6380-6385.
28. 28. Resnick MB, Schacter P, Finkelstein Y, Kellner Y, Cohen O. Immunohistochemical analysis of p27/kip1 expression in thyroid carcinoma. Mod. Pathol. 1998; 11; 735-739.
29. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996; 85; 707-720.
30. Kip1. Cell 1996; 85; 721-732.
31. Kip1-deficient mice. Cell 1996; 85; 733-744.
32. 32. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 1984; 133; 1710-1715.
33. 33. Kamel OW, Franklin WA, Ringus JC, Mayer JS. Thymidine labeling index and Ki-67 growth fraction in lesions of the breast. Am. J. Pathol. 1989; 134; 107-113.
34. kip1 expression in endocrine and other tumors. Am. J. Pathol. 1997; 150; 401-407.
35. KIP1 expression is inversely proportional to the proliferative index. Am. J. Pathol. 1997; 151; 151-160.
36. 36. Thomas GV, Szigeti K, Murphy M, Draetta G, Pagano M, Loda M. Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases. Am. J. Pathol. 1998; 153; 681-687.
37. KIP1 on adhesion-dependent resistance of tumor cells to anticancer agents. Nature Med. 1996; 2; 1204-1210.
38. 38. Fang F, Orend G, Watanabe N, Hunter T, Ruoslathi E, Dependence of cyclin E-Cdk2 kinase activity on cell anchorage. Science 1996; 271; 499-502.
39. 39. Zhu X, Ohtsubo M, Mohmer RM, Roberts JM, Assoian RK. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J. Cell. Biol. 1996; 133; 391-403.