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Volumn , Issue SUPPL. 37, 2009, Pages

Preparation of short interfering RNA UNIT 16.2 containing the modified nucleosides 2-thiouridine, pseudouridine, or dihydrouridine

Author keywords

2 thiouridine; Dihydrouridine; Phosphoramidite synthesis; Pseudouridine; RNA synthesis; siRNA; Small interfering RNA

Indexed keywords

2 THIOURIDINE; 3' PHOSPHORAMIDOUS ACID; 5' O (4,4' DIMETHOXYTRITYL) 2' O (TERT BUTYLDIMETHYLSILYL) 3' O [(2 CYANOETHOXY) (N,N DIISOPROPYLAMINO)]PHOSPHINYL 2 THIOURIDINE; 5' O (4,4' DIMETHOXYTRITYL) 2' O (TERT BUTYLDIMETHYLSILYL) 3' O [(2 CYANOETHOXY) (N,N DIISOPROPYLAMINO)]PHOSPHINYL 5,6 DIHYDROURIDINE; DIHYDROURIDINE; OLIGOMER; OLIGONUCLEOTIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; PSEUDOURIDINE; SMALL INTERFERING RNA; TERT BUTYL HYDROPEROXIDE; TRANSFER RNA; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

EID: 66849093631     PISSN: 19349270     EISSN: 19349289     Source Type: Journal    
DOI: 10.1002/0471142700.nc1602s37     Document Type: Review
Times cited : (7)

References (67)
  • 1
    • 0038955181 scopus 로고    scopus 로고
    • Modified nucleosides in RNA structure and function
    • In (D. M. Grant and R.K. Harris, eds.; Chan, S., section ed.) John Wiley & Sons, UK
    • Agris, P.F. 1996. Modified nucleosides in RNA structure and function. In Encyclopedia of NMR (D. M. Grant and R.K. Harris, eds.; Chan, S., section ed.) pp. 4151-4158. John Wiley & Sons, UK.
    • (1996) Encyclopedia of NMR , pp. 4151-4158
    • Agris, P.F.1
  • 2
    • 0000635454 scopus 로고
    • Thiolation of Uridine Carbon-2 Restricts the Motional Dynamics of the Transfer RNA Wobble Position Nucleoside
    • Agris, P.F., Sierzputowska-Gracz, H., Smith, W., Malkiewicz, A., Sochacka, E., and Nawrot, B. 1992. Thiolation of Uridine Carbon-2 Restricts the Motional Dynamics of the Transfer RNA Wobble Position Nucleoside. J. Am. Chem. Soc. 114:2652-2656.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 2652-2656
    • Agris, P.F.1    Sierzputowska-Gracz, H.2    Smith, W.3    Malkiewicz, A.4    Sochacka, E.5    Nawrot, B.6
  • 3
    • 0028915734 scopus 로고
    • Sitespecific introduction of modified purine and pyrimidine ribonucleosides into RNA by automated phosphoramidite chemistry
    • Agris, P.F., Malkiewicz, A., Kraszewski, A., Everett, K., Nawrot, B., Sochacka, E., Jankowska, J., and Guenther, R. 1995. Sitespecific introduction of modified purine and pyrimidine ribonucleosides into RNA by automated phosphoramidite chemistry. Biochimie 77:125-134.
    • (1995) Biochimie , vol.77 , pp. 125-134
    • Agris, P.F.1    Malkiewicz, A.2    Kraszewski, A.3    Everett, K.4    Nawrot, B.5    Sochacka, E.6    Jankowska, J.7    Guenther, R.8
  • 4
    • 49149135789 scopus 로고
    • Deoxynucleoside phosphoramidities - A new class of key intermediates for deoxypolynucleotide synthesis
    • Beaucage, S.L. and Caruthers, M.H. 1981. Deoxynucleoside phosphoramidities - a new class of key intermediates for deoxypolynucleotide synthesis. Tetrahedron Lett. 22:1859-1862.
    • (1981) Tetrahedron Lett. , vol.22 , pp. 1859-1862
    • Beaucage, S.L.1    Caruthers, M.H.2
  • 5
    • 0036603595 scopus 로고    scopus 로고
    • Recent advances in the in vitro evolution of nucleic acids
    • Bittker, J.A., Philips, K.J., and Liu, D.R. 2002. Recent advances in the in vitro evolution of nucleic acids. Curr. Opin. Chem. Biol. 6:367-374.
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 367-374
    • Bittker, J.A.1    Philips, K.J.2    Liu, D.R.3
  • 6
    • 0002063670 scopus 로고
    • Modern machine-aided methods of oligodeoxyribonucleotide synthesis
    • In (F. Eckstein, ed.) Oxford University Press, Oxford
    • Brown, T. and Brown, D.J.S. 1991. Modern machine-aided methods of oligodeoxyribonucleotide synthesis. In Oligonucleotides and Analogues. A Practical Approach (F. Eckstein, ed.) pp. 1-25. Oxford University Press, Oxford.
    • (1991) Oligonucleotides and Analogues. A Practical Approach , pp. 1-25
    • Brown, T.1    Brown, D.J.S.2
  • 7
    • 0024436646 scopus 로고
    • Solid phase synthesis of the 5-half of the initiator t-RNA from B. subtilis
    • Chaix, C., Duplaa, A.M.,Molko, D., and Teoule, R. 1989. Solid phase synthesis of the 5-half of the initiator t-RNA from B. subtilis. Nucleic Acids Res. 17:7381-7393.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 7381-7393
    • Chaix, C.1    Duplaa, A.M.2    Molko, D.3    Teoule, R.4
  • 8
    • 0041331496 scopus 로고    scopus 로고
    • siRNA function in RNAi: A chemical modification analysis
    • Chiu, Y.L. and Rana, T.M. 2003. siRNA function in RNAi: A chemical modification analysis. RNA 9:1034-1048.
    • (2003) RNA , vol.9 , pp. 1034-1048
    • Chiu, Y.L.1    Rana, T.M.2
  • 9
    • 0029077840 scopus 로고
    • Characterization of fully 2′-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity
    • Cummins, L.L., Owen, S.R., Risen, L.M., Lesnik, E.A., Freier, S.M., McGee, D., Guinosso, C.J., and Cook, P.D. 1995. Characterization of fully 2′-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity. Nucleic Acids Res. 23:2019-2024.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 2019-2024
    • Cummins, L.L.1    Owen, S.R.2    Risen, L.M.3    Lesnik, E.A.4    Freier, S.M.5    McGee, D.6    Guinosso, C.J.7    Cook, P.D.8
  • 11
    • 0002841715 scopus 로고    scopus 로고
    • Biophysical and conformational properties of modified nucleosides in RNA (magnetic resonance studies)
    • In (H. Grosjean and B. Benne, eds.) ASM Press,Washingon D.C
    • Davis, D. 1998. Biophysical and conformational properties of modified nucleosides in RNA (magnetic resonance studies). In Modification and Editing of RNA (H. Grosjean and B. Benne, eds.) pp. 85-102. ASM Press,Washingon D.C.
    • (1998) Modification and Editing of RNA , pp. 85-102
    • Davis, D.1
  • 12
    • 7944238357 scopus 로고    scopus 로고
    • Introduction of hypermodified nucleotides in RNA
    • Davis, D.R. and Bajji, A.C. 2005. Introduction of hypermodified nucleotides in RNA. Methods Mol. Biol. 288:187-204.
    • (2005) Methods Mol. Biol. , vol.288 , pp. 187-204
    • Davis, D.R.1    Bajji, A.C.2
  • 13
    • 0031861474 scopus 로고    scopus 로고
    • An RNA model system for investigation of pseudouridine stabilization of the codon-anticodon interaction in tRNALys, tRNAHis and tRNATyr
    • Davis, D.R., Veltri, C.A., and Nielsen, L. 1998. An RNA model system for investigation of pseudouridine stabilization of the codon-anticodon interaction in tRNALys, tRNAHis and tRNATyr. J. Biomol. Struct. Dyn. 15:1121-1132.
    • (1998) J. Biomol. Struct. Dyn. , vol.15 , pp. 1121-1132
    • Davis, D.R.1    Veltri, C.A.2    Nielsen, L.3
  • 15
    • 0031771568 scopus 로고    scopus 로고
    • Modified oligoribonucleotides as site-specific probes of RNA structure and function
    • Earnshaw, D.J. and Gait, M.J. 1998. Modified oligoribonucleotides as site-specific probes of RNA structure and function. Biopolymers 48:39-55.
    • (1998) Biopolymers , vol.48 , pp. 39-55
    • Earnshaw, D.J.1    Gait, M.J.2
  • 16
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    • Elbashir, S.M., Martinez, J., Patkaniowska, A., Lendecel, W., and Tuschl, T. 2001a. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20:6877-6888.
    • (2001) EMBO J. , vol.20 , pp. 6877-6888
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendecel, W.4    Tuschl, T.5
  • 17
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference ismediated by 21- and 22-nucleotide RNAs
    • Elbashir, S.M., Lendeckel, W., and Tuschl, T. 2001b. RNA interference ismediated by 21- and 22-nucleotide RNAs. Genes Dev. 15:188-200.
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 18
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S.M., Harborth, J., Lendeckel,W., Yalcin, A.,Weber,K., and Tuschl, T. 2001c.Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494- 498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 19
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    • Elbashir, S.M., Martinez, J., Patkaniowska, A., Lendecel, W., and Tuschl, T. 2001d. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20:6877-6888.
    • (2001) EMBO J. , vol.20 , pp. 6877-6888
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendecel, W.4    Tuschl, T.5
  • 20
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by doublestranded RNA in Caenorhabitis elegans
    • Fire, A., Xu, S.Q., Montgomery, M.K., Kostas, S.A., Driver, S.E., and Mello, C.C. 1998. Potent and specific genetic interference by doublestranded RNA in Caenorhabitis elegans. Nature 391:806-813.
    • (1998) Nature , vol.391 , pp. 806-813
    • Fire, A.1    Xu, S.Q.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 21
    • 11844251207 scopus 로고    scopus 로고
    • RNA interference in vivo: Towards synthetic small inhibitory RNA based therapeutics
    • Fougerolles, A., Manoharan, M., Meyers, R., and Vornlocher, H-P. 2005. RNA interference in vivo: Towards synthetic small inhibitory RNA based therapeutics. Methods Enzymol. 392:278- 296.
    • (2005) Methods Enzymol. , vol.392 , pp. 278-296
    • Fougerolles, A.1    Manoharan, M.2    Meyers, R.3    Vornlocher, H.-P.4
  • 23
    • 0028630551 scopus 로고
    • Synthetic oligoribonucleotides carrying site-specific modifications for RNA structure-function analysis
    • Grasby, J.A. and Gait, M.J. 1994. Synthetic oligoribonucleotides carrying site-specific modifications for RNA structure-function analysis. Biochimie 76:1223-1234.
    • (1994) Biochimie , vol.76 , pp. 1223-1234
    • Grasby, J.A.1    Gait, M.J.2
  • 25
    • 0000168697 scopus 로고
    • New catalysts and procedures for the dimethoxytritylation and selective silylation of ribonucleosides
    • Hakimelahi, G.H., Proba, Z.A., and Ogilvie, K.K. 1982. New catalysts and procedures for the dimethoxytritylation and selective silylation of ribonucleosides. Can. J. Chem. 60:1106- 1113.
    • (1982) Can. J. Chem. , vol.60 , pp. 1106-1113
    • Hakimelahi, G.H.1    Proba, Z.A.2    Ogilvie, K.K.3
  • 26
    • 0014194626 scopus 로고
    • Nucleic acids. IV. The catalytic reduction of pyrimidine nucleosides (human liver deaminase inhibitors)
    • Hanze, A.R. 1967. Nucleic acids. IV. The catalytic reduction of pyrimidine nucleosides (human liver deaminase inhibitors). J. Am. Chem. Soc. 89:6720-6725.
    • (1967) J. Am. Chem. Soc. , vol.89 , pp. 6720-6725
    • Hanze, A.R.1
  • 27
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • Karikó, K., Buckstein, M., Ni, H., and Weissman, D. 2005. Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23:165-175.
    • (2005) Immunity , vol.23 , pp. 165-175
    • Karikó, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 28
    • 0035887005 scopus 로고    scopus 로고
    • Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
    • Ketting, R.F., Fischer, S.E., Bernstein, E., Sijen, T., Hannon, G.J., and Plasterk, R.H. 2001. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev. 15:2654-2659.
    • (2001) Genes Dev. , vol.15 , pp. 2654-2659
    • Ketting, R.F.1    Fischer, S.E.2    Bernstein, E.3    Sijen, T.4    Hannon, G.J.5    Plasterk, R.H.6
  • 29
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova, A., Reynolds, A., and Jayasena, S.D. 2003. Functional siRNAs and miRNAs exhibit strand bias. Cell 115:209-216.
    • (2003) Cell , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 30
    • 0028885841 scopus 로고
    • Synthesis of oligoribonucleotides containing 2-thiouridine: Incorporation of 2-thiouridine phosphoramidite without base protection
    • Kumar, R.K. and Davis, D.R. 1995. Synthesis of oligoribonucleotides containing 2-thiouridine: Incorporation of 2-thiouridine phosphoramidite without base protection. J. Org. Chem. 60:7726-7727.
    • (1995) J. Org. Chem. , vol.60 , pp. 7726-7727
    • Kumar, R.K.1    Davis, D.R.2
  • 31
    • 0030839446 scopus 로고    scopus 로고
    • Synthesis and studies on the effect of 2-thiouridine and 4- thiouridine on sugar conformation and RNA duplex stability
    • Kumar, R.K. and Davis, D.R. 1997. Synthesis and studies on the effect of 2-thiouridine and 4- thiouridine on sugar conformation and RNA duplex stability. Nucleic Acids Res. 25:1272- 1280.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 1272-1280
    • Kumar, R.K.1    Davis, D.R.2
  • 33
    • 33745126327 scopus 로고    scopus 로고
    • The naturally occurring N6-threonyl adenine in anticodon loop of Schizosaccharomyces pombe tRNAi causes of a unique U-turn motif
    • Lescrinier, E., Nauwelaerts, K., Zanier, K., Poesen, K., Sattier, M., and Herdewijn, P. 2006. The naturally occurring N6-threonyl adenine in anticodon loop of Schizosaccharomyces pombe tRNAi causes of a unique U-turn motif. Nucleic Acids Res. 34:2878-2886.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 2878-2886
    • Lescrinier, E.1    Nauwelaerts, K.2    Zanier, K.3    Poesen, K.4    Sattier, M.5    Herdewijn, P.6
  • 34
    • 0013571179 scopus 로고
    • Appendix 1: Structures of modified nucleosides
    • In (D. Söll and U. Raj Bhandary, eds.). American Society for Microbiology, Washington D.C
    • Limbach, P.A., Crain, P.F., Pomerantz, S.C., and McCloskey, J.A. 1995. Appendix 1: Structures of modified nucleosides. In tRNA: Structure, Biosynthesis and Function. (D. Söll and U. Raj Bhandary, eds.). American Society for Microbiology, Washington D.C.
    • (1995) TRNA: Structure, Biosynthesis and Function
    • Limbach, P.A.1    Crain, P.F.2    Pomerantz, S.C.3    McCloskey, J.A.4
  • 35
    • 0032122430 scopus 로고    scopus 로고
    • Hybridization properties of base-modified oligonucleotides within the double and triple helix motif
    • Luyten, I. and Herdewijn, P. 1998. Hybridization properties of base-modified oligonucleotides within the double and triple helix motif. Eur. J. Med. Chem. 33:515-576.
    • (1998) Eur. J. Med. Chem. , vol.33 , pp. 515-576
    • Luyten, I.1    Herdewijn, P.2
  • 36
    • 8844262560 scopus 로고    scopus 로고
    • RNA interference and chemically modified small interfering RNAs
    • Manoharan, M. 2004. RNA interference and chemically modified small interfering RNAs. Curr. Opin. Chem. Biol. 8:570-579.
    • (2004) Curr. Opin. Chem. Biol. , vol.8 , pp. 570-579
    • Manoharan, M.1
  • 37
    • 0037031576 scopus 로고    scopus 로고
    • Singlestranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez, J., Patkaniowska, A., Urlaub, H., Luhrmann, R., and Tuschl, T. 2002. Singlestranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110:563-574.
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Luhrmann, R.4    Tuschl, T.5
  • 38
    • 27744590896 scopus 로고    scopus 로고
    • Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
    • Matranga, C., Tomari, Y., Shin, C., Bartel, D.P., and Zamore, P.D. 2005. Passenger-strand cleavage facilitates assembly of siRNA into Ago2- containing RNAi enzyme complexes. Cell. 123:607-620.
    • (2005) Cell. , vol.123 , pp. 607-620
    • Matranga, C.1    Tomari, Y.2    Shin, C.3    Bartel, D.P.4    Zamore, P.D.5
  • 39
    • 66849137056 scopus 로고    scopus 로고
    • RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acids (siNA)
    • McSwinggen, J. and Beigelman, L. 2003. RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acids (siNA). US Patent WO 03/070895.
    • (2003) US Patent WO 03/070895
    • McSwinggen, J.1    Beigelman, L.2
  • 40
    • 33744503652 scopus 로고    scopus 로고
    • Chemical and structural diversity of siRNA molecules
    • Nawrot, B. and Sipa, K. 2006. Chemical and structural diversity of siRNA molecules, Curr. Top. Med. Chem. 6:913-925.
    • (2006) Curr. Top. Med. Chem. , vol.6 , pp. 913-925
    • Nawrot, B.1    Sipa, K.2
  • 41
    • 33750978172 scopus 로고    scopus 로고
    • The discovery of modified nucleosides from the early days to the present: A personal perspective
    • Nishimura, S. and Watanabe, K. 2006. The discovery of modified nucleosides from the early days to the present: A personal perspective. J. Biosci. 31:465-475.
    • (2006) J. Biosci. , vol.31 , pp. 465-475
    • Nishimura, S.1    Watanabe, K.2
  • 42
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering RNA structure in the RNA interference pathway
    • Nykanen, A., Haley, B., and Zamore, P.D. 2001. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 107:309-321.
    • (2001) Cell , vol.107 , pp. 309-321
    • Nykanen, A.1    Haley, B.2    Zamore, P.D.3
  • 43
    • 0001756111 scopus 로고
    • The synthesis of oligoribonucleotides. II. The use of silyl protecting groups in nucleoside and nucleotide chemistry. VIII
    • Ogilvie, K.K., Beaucage, S.L., Schifman, A.L., Theriault, N.Y., and Sadana, K.J. 1978. The synthesis of oligoribonucleotides. II. The use of silyl protecting groups in nucleoside and nucleotide chemistry. VIII. Can. J. Chem. 56:2768-2780.
    • (1978) Can. J. Chem. , vol.56 , pp. 2768-2780
    • Ogilvie, K.K.1    Beaucage, S.L.2    Schifman, A.L.3    Theriault, N.Y.4    Sadana, K.J.5
  • 44
    • 0345732095 scopus 로고    scopus 로고
    • A new route to 2′-O-alkyl-2-thiouridine derivatives via 4-protection of uracil base and hybridization properties of oligonucleotides incorporating these modified nucleoside derivatives
    • Okamoto, I., Shohda, K., Seio, K., and Sekine, M. 2003. A new route to 2′-O-alkyl-2-thiouridine derivatives via 4-protection of uracil base and hybridization properties of oligonucleotides incorporating these modified nucleoside derivatives. J. Org. Chem. 68:9971-9982.
    • (2003) J. Org. Chem. , vol.68 , pp. 9971-9982
    • Okamoto, I.1    Shohda, K.2    Seio, K.3    Sekine, M.4
  • 45
    • 0033634682 scopus 로고    scopus 로고
    • Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference
    • Parrish, S., Fleenor, J., Xu, S., Mello, C., and Fire, A. 2000. Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference. Mol. Cell 6:1077-1087.
    • (2000) Mol. Cell , vol.6 , pp. 1077-1087
    • Parrish, S.1    Fleenor, J.2    Xu, S.3    Mello, C.4    Fire, A.5
  • 46
    • 27744506761 scopus 로고    scopus 로고
    • Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation
    • Rand, T.A., Petersen, S., Du, F., and Wang, X. 2005. Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell 123:621- 629.
    • (2005) Cell , vol.123 , pp. 621-629
    • Rand, T.A.1    Petersen, S.2    Du, F.3    Wang, X.4
  • 48
  • 49
    • 0034698866 scopus 로고    scopus 로고
    • Synthesis and properties of 2′-O-methyl-2-thiouridine and Oligoribonucleotides containing 2′-O-methyl-2-thiouridine
    • Shohda, K., Okamoto, I., Wada, T., Seio, K., and Sekine, M. 2000. Synthesis and properties of 2′-O-methyl-2-thiouridine and Oligoribonucleotides containing 2′-O-methyl-2-thiouridine. Bioorg. Med. Chem. Lett. 10:1795-1798.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 1795-1798
    • Shohda, K.1    Okamoto, I.2    Wada, T.3    Seio, K.4    Sekine, M.5
  • 50
    • 34447507937 scopus 로고    scopus 로고
    • Effect of base modifications on structure, thermodynamic stability and gene silencing activity of short interfering RNA
    • Sipa, K., Sochacka, E., Kazmierczak-Baranska, J., Maszewska, M., Janicka, M., Nowak, G., and Nawrot, B. 2007. Effect of base modifications on structure, thermodynamic stability and gene silencing activity of short interfering RNA. RNA 13:1301-1316.
    • (2007) RNA , vol.13 , pp. 1301-1316
    • Sipa, K.1    Sochacka, E.2    Kazmierczak-Baranska, J.3    Maszewska, M.4    Janicka, M.5    Nowak, G.6    Nawrot, B.7
  • 51
    • 33947473519 scopus 로고
    • Studies on polynucleotides. XVI. Specific synthesis of C3′-C5′ internucleotide linkage. Synthesis of uridyl-(3′- 5′)-uridine and uridyl-(3′-5′)-adenosine
    • Smith, M., Rammler, D.H., Goldberg, I.H., and Khorana, H.G. 1962. Studies on polynucleotides. XVI. Specific synthesis of C3′-C5′ internucleotide linkage. Synthesis of uridyl-(3′- 5′)-uridine and uridyl-(3′-5′)-adenosine. J. Am. Chem. Soc. 84:430-440.
    • (1962) J. Am. Chem. Soc. , vol.84 , pp. 430-440
    • Smith, M.1    Rammler, D.H.2    Goldberg, I.H.3    Khorana, H.G.4
  • 52
    • 0034757789 scopus 로고    scopus 로고
    • Efficient assessment of modified nucleoside stability under conditions of automated oligonucleotide synthesis: Characterization of the oxidation and oxidative desulfurization of 2-thiouridine
    • Sochacka, E. 2001. Efficient assessment of modified nucleoside stability under conditions of automated oligonucleotide synthesis: characterization of the oxidation and oxidative desulfurization of 2-thiouridine. Nucleosides Nucleotides Nucleic Acids 20:1871-1879.
    • (2001) Nucleosides Nucleotides Nucleic Acids , vol.20 , pp. 1871-1879
    • Sochacka, E.1
  • 56
    • 0034680364 scopus 로고    scopus 로고
    • Hypermodified nucleosides in the anticodon of tRNALys stabilize a canonical U-turn structure
    • Sundaram, M., Durant, P.C., and Davis, D.R. 2000. Hypermodified nucleosides in the anticodon of tRNALys stabilize a canonical U-turn structure. Biochemistry 39:12575-12584.
    • (2000) Biochemistry , vol.39 , pp. 12575-12584
    • Sundaram, M.1    Durant, P.C.2    Davis, D.R.3
  • 57
    • 0037224921 scopus 로고    scopus 로고
    • A biochemical framework for RNA silencing in plants
    • Tang, G., Reinhart, B.J., Bartel, D.P., and Zamore, P.D. 2003. A biochemical framework for RNA silencing in plants. Genes Dev. 17:49-63.
    • (2003) Genes Dev. , vol.17 , pp. 49-63
    • Tang, G.1    Reinhart, B.J.2    Bartel, D.P.3    Zamore, P.D.4
  • 58
    • 0033554848 scopus 로고    scopus 로고
    • Thermodynamics of RNARNA duplexes with 2- or 4-thiouridines: Implications for antisense design and targeting a group I intron
    • Testa, S.M., Disney, M.D., Turner, D.H., and Kierzek, R. 1999. Thermodynamics of RNARNA duplexes with 2- or 4-thiouridines: Implications for antisense design and targeting a group I intron. Biochemistry 38:16655-16662.
    • (1999) Biochemistry , vol.38 , pp. 16655-16662
    • Testa, S.M.1    Disney, M.D.2    Turner, D.H.3    Kierzek, R.4
  • 59
    • 26944499005 scopus 로고    scopus 로고
    • The therapeutic potential of RNA interference
    • Uprichard, S.L. 2005. The therapeutic potential of RNA interference. FEBS Lett. 579:5996-6007.
    • (2005) FEBS Lett. , vol.579 , pp. 5996-6007
    • Uprichard, S.L.1
  • 60
    • 4544246204 scopus 로고    scopus 로고
    • T7 RNA polymerase transcription with 5-position modified UTP derivatives
    • Vaught, J.D., Dewey, T., and Eaton, B.E. 2004. T7 RNA polymerase transcription with 5-position modified UTP derivatives. J. Am. Chem. Soc. 126:11231-11337.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 11231-11337
    • Vaught, J.D.1    Dewey, T.2    Eaton, B.E.3
  • 61
    • 0141538236 scopus 로고    scopus 로고
    • Novel phosphoramidite building blocks in synthesis and applications towards modified oligonucleotides
    • Venkatesan, N., Kim, S.J., and Kim, B.H. 2003. Novel phosphoramidite building blocks in synthesis and applications towards modified oligonucleotides. Curr. Med. Chem. 10:1973- 1991.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1973-1991
    • Venkatesan, N.1    Kim, S.J.2    Kim, B.H.3
  • 62
    • 17344372249 scopus 로고    scopus 로고
    • Modified oligonucleotides: Synthesis and strategy for users
    • Verma, S. and Eckstein, F. 1998. Modified oligonucleotides: Synthesis and strategy for users. Annu. Rev. Biochem. 67:99-134.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 99-134
    • Verma, S.1    Eckstein, F.2
  • 63
    • 0038499722 scopus 로고    scopus 로고
    • Functional tuning of nucleic acids by chemical modifications: Tailored oligonucleotides as drug, devices, and diagnostics
    • Verma, S., Jager, S., Thum, O., and Famulok, M. 2003. Functional tuning of nucleic acids by chemical modifications: Tailored oligonucleotides as drug, devices, and diagnostics. Chem. Rec. 3:61-60.
    • (2003) Chem. Rec. , vol.3 , pp. 60-61
    • Verma, S.1    Jager, S.2    Thum, O.3    Famulok, M.4
  • 64
    • 0015868793 scopus 로고
    • Eine einfache Synthese von 2-Thiopyrimidin-nucleosiden
    • Vorbruggen, H. and Strehlke, P. 1973. Eine einfache Synthese von 2-Thiopyrimidin-nucleosiden. Chem. Ber. 106:3039-3061.
    • (1973) Chem. Ber. , vol.106 , pp. 3039-3061
    • Vorbruggen, H.1    Strehlke, P.2
  • 65
    • 0000521158 scopus 로고
    • Restrained refinement of two crystalline forms of yeast aspartic acid and phenylalanine transfer RNA crystals
    • Westhof, E., Dumas, P., and Moras, D. 1988. Restrained refinement of two crystalline forms of yeast aspartic acid and phenylalanine transfer RNA crystals. Acta Cryst. A. 44:112-123.
    • (1988) Acta Cryst. A. , vol.44 , pp. 112-123
    • Westhof, E.1    Dumas, P.2    Moras, D.3
  • 67
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore, P.D., Tuschl, T., Sharp, P.A., and Bartel, D.P. 2000. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101:25-33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.