A New Route to 2′-O-Alkyl-2-thiouridine Derivatives via 4-O-Protection of the Uracil Base and Hybridization Properties of Oligonucleotides Incorporating These Modified Nucleoside Derivatives

Journal of Organic Chemistry

Volumn 68, Issue 26, 2003, Pages 9971-9982

  Okamoto, Itaru ^a   Shohda, Koh Ichiroh ^a   Seio, Kohji ^a,b   Sekine, Mitsuo ^a,b  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; DERIVATIVES; NUCLEAR MAGNETIC RESONANCE; RNA;

HYBRIDIZATION PROPERTIES;

BIOCHEMISTRY;

2 THIOURIDINE DERIVATIVE; ADENOSINE; CARBONYL DERIVATIVE; COMPLEMENTARY RNA; DOUBLE STRANDED RNA; GUANOSINE; NUCLEOSIDE DERIVATIVE; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; THIOURIDINE; UNCLASSIFIED DRUG; URACIL DERIVATIVE; URIDINE DERIVATIVE;

ARTICLE; BASE MISPAIRING; CONFORMATION; HYBRIDIZATION; MELTING POINT; PROTECTION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; RNA STABILITY; SYNTHESIS;

MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; NUCLEIC ACID HETERODUPLEXES; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; RNA, COMPLEMENTARY; TEMPERATURE; THIOURIDINE; URACIL;

EID: 0345732095     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo035246b     Document Type: Article

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