Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting

Journal of Biological Chemistry

Volumn 282, Issue 40, 2007, Pages 29230-29240

  Plaza Menacho, Iván ^a   Mologni, Luca ^b   Sala, Elisa ^b   Gambacorti Passerini, Carlo ^b   Magee, Anthony I ^c   Links, Thera P ^d   Hofstra, Robert M W ^d   Barford, David ^a   Isacke, Clare M ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; DEGRADATION; GENE TRANSFER; SIGNAL TRANSDUCTION; TUMORS;

ENDOCRINE NEOPLASIA; PROTEASOMAL TARGETING; PROTEIN DEGRADATION;

ENZYME ACTIVITY;

PROTEASOME; PROTEIN RET; SORAFENIB;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; CANCER SUSCEPTIBILITY; CELL ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG INHIBITION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME PURIFICATION; HUMAN; HUMAN CELL; IC 50; LYSOSOME MEMBRANE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIPPLE SYNDROME; TUMOR CELL CULTURE; WILD TYPE;

BENZENESULFONATES; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; LYSOSOMES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RET; PYRIDINES;

PYRONIA TITHONUS;

EID: 35748958721     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703461200     Document Type: Article

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