Medullary thyroid cancer responsiveness to pentagastrin stimulation: An early surrogate parameter of tumor dissemination?

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 6, 2008, Pages 2234-2238

  Machens, Andreas ^a   Hauptmann, Steffen ^a   Dralle, Henning ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN; CARCINOEMBRYONIC ANTIGEN; PENTAGASTRIN;

ADULT; ARTICLE; CONTROLLED STUDY; DISTANT METASTASIS; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROVOCATION TEST; THYROID CANCER; THYROIDECTOMY;

EID: 45149095297     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-2792     Document Type: Article

References (20)

1. Osamura RY, Yasuda O, Kawakami T, Itoh Y, Inada K, Kakudo K 1997 Immunoelectron microscopic demonstration of regulated pathway for calcitonin and constitutive pathway for carcinoembryonic antigen in the same cells of human medullary carcinomas of thyroid glands. Mod Pathol 10: 7-11
2. Reubi JC, Schaer JC, Waser B 1997 Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors. Cancer Res 57:1377-1386
3. Behr TM, Béhé MP 2002 Cholecystokinin-B/gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies. Semin Nucl Med 32:97-109
4. Reubi JC, Waser B 1996 Unexpected high incidence of cholecystokinin-B/gastrin receptors in human medullary thyroid carcinomas. Int J Cancer 67: 644-647
5. 2-receptor mediates calcitonin secretion, gene expression, and proliferation in the human medullary thyroid carcinoma cell line, TT. Regul Pept 118:111-117
6. Machens A, Schneyer U, Holzhausen HJ, Dralle H 2005 Prospects of remission in medullary thyroid carcinoma according to basal calcitonin level. J Clin Endocrinol Metab 90:2029-2034
7. Barbet J, Campion L, Kraeber-Bodéré F, Chatal JF; GTE Study Group 2005 Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma. J Clin Endocrinol Metab 90:6077-6084
8. 2-receptor in normal human thyroid gland and medullary thyroid carcinoma. Eur J Endocrinol 146:89-96
9. Gotthardt M, Béhé MP, Beuter D, Battmann A, Bauhofer A, Schurrat T, Schipper M, Pollum H, Oyen WJG, Behr TM 2006 Improved tumour detection by gastrin receptor scintigraphy in patients with metastasised medullary thyroid carcinoma. Eur J Nucl Med Mol Imaging 33:1273-1279
10. Machens A, Hinze R, Thomusch O, Dralle H 2002 Pattern of nodal metastasis for primary and reoperative thyroid cancer. World J Surg 26:22-28
11. Röher HD, Simon D, Goretzki PE 1997 Guidelines in oncologic surgery: malignant thyroid tumors. Langenbecks Arch Surg 114 (Suppl 2):142
12. Hinze R, Holzhausen HJ, Gimm O, Dralle H, Rath FW 1998 Primary hereditary medullary thyroid carcinoma - C-cell morphology and correlation with preoperative calcitonin levels. Virchows Arch 433:203-208
13. Machens A, Gimm O, Ukkat J, Hinze R, Schneyer U, Dralle H 2000 Improved prediction of calcitonin normalization in medullary thyroid carcinoma patients by quantitative lymph node analysis. Cancer 88:1909-1915
14. Weber T, Schilling T, Frank-Raue K, Colombo-Benkmann M, Hinz U, Ziegler R, Klar E 2001 Impact of modified radical neck dissection on biochemical cure in medullary thyroid carcinomas. Surgery 130:1044-1049
15. Scollo C, Baudin E, Travagli JP, Caillou B, Bellon N, Leboulleux S, Schlumberger M 2003 Rationale for central and bilateral lymph node dissection in sporadic and hereditary medullary thyroid cancer. J Clin Endocrinol Metab 88:2070-2075
16. Machens A, Hofmann C, Hauptmann S, Dralle H 2007 Locoregional recurrence and death from medullary thyroid carcinoma in a contemporaneous series: 5-year results. Eur J Endocrinol 157:85-93
17. Oskam IM, Hoebers F, Balm AJM, van Coevorden F, Bais EM, Hart AM, van den Brekel MW 2008 Neck management in medullary thyroid carcinoma. Eur J Surg Oncol 34:71-76
18. Machens A, Ukkat J, Hauptmann S, Dralle H 2007 Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression. A multivariate analysis. Arch Surg 142:289-293
19. Machens A, Haedecke J, Holzhausen HJ, Thomusch O, Schneyer U, Dralle H 2000 Differential diagnosis of calcitonin-secreting neuroendocrine carcinoma of the foregut by pentagastrin stimulation. Langenbecks Arch Surg 385:398-401
20. Kwekkeboom DJ, Bakker WH, Kooij PPM, Erion J, Srinivasan A, de Jong M, Reubi JC, Krenning EP 2000 Cholecystokinin receptor imaging using an octapeptide DTPA-CCK analogue in patients with medullary thyroid carcinoma. Eur J Mol Med 27:1312-1317