Requirement of Fut8 for the expression of vascular endothelial growth factor receptor-2: A new mechanism for the emphysema-like changes observed in Fut8-deficient mice

Journal of Biochemistry

Volumn 145, Issue 5, 2009, Pages 643-651

  Wang, Xiangchun ^a   Fukuda, Tomohiko ^b   Li, Wenzhe ^c,d   Gao, Cong Xiao ^a   Kondo, Akihiro ^c   Matsumoto, Akio ^a   Miyoshi, Eiji ^e   Taniguchi, Naoyuki ^a,f   Gu, Jianguo ^b  

^a OSAKA UNIVERSITY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d DALIAN UNIVERSITY   (China)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f RIKEN   (Japan)

Author keywords

Apoptosis; Emphysema; Fucosylation; Fut8; VEGFR 2 expression

Indexed keywords

ALPHA 1,6 FUCOSYLTRANSFERASE; CERAMIDE; SMALL INTERFERING RNA; TRANSFERASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EMPHYSEMA; FUCOSYLATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS WALL; NICK END LABELING; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CELL LINE; CERAMIDES; DOWN-REGULATION; EMPHYSEMA; FUCOSYLTRANSFERASES; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; IN SITU NICK-END LABELING; LUNG; MICE; MODELS, BIOLOGICAL; ORGAN SPECIFICITY; PROTO-ONCOGENE PROTEINS C-FOS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

MUS;

EID: 66749177948     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvp022     Document Type: Article

References (38)

1. Wilson, J.R., Williams, D., and Schachter, H. (1976) The control of glycoprotein synthesis: N-acetylglucosamine linkage to a mannose residue as a signal for the attachment of L-fucose to the asparagine-linked N-acetylglucosamine residue of glycopeptide from alpha1-acid glycoprotein. Biochem. Biophys. Res. Commun. 72, 909-916
2. Miyoshi, E., Noda, K., Yamaguchi, Y., Inoue, S., Ikeda, Y., Wang, W., Ko, J.H., Uozumi, N., Li, W., and Taniguchi, N. (1999) The alpha1-6- fucosyltransferase gene and its biological significance. Biochim. Biophys. Acta 1473, 9-20
3. Noda, K., Miyoshi, E., Gu, J., Gao, C.X., Nakahara, S., Kitada, T., Honke, K., Suzuki, K., Yoshihara, H., Yoshikawa, K., Kawano, K., Tonetti, M., Kasahara, A., Hori, M., Hayashi, N., and Taniguchi, N. (2003) Relationship between elevated FX expression and increased production of GDP-L-fucose, a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines. Cancer Res. 63, 6282-6289
4. Shields, R.L., Lai, J., Keck, R., O'Connell, L.Y., Hong, K., Meng, Y.G., Weikert, S.H., and Presta, L.G. (2002) Lack of fucose on human IgG1N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity. J. Biol. Chem. 277, 26733-26740
5. Shinkawa, T., Nakamura, K., Yamane, N., Shoji-Hosaka, E., Kanda, Y., Sakurada, M., Uchida, K., Anazawa, H., Satoh, M., Yamasaki, M., Hanai, N., and Shitara, K. (2003) The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity. J. Biol. Chem. 278, 3466-3473
6. Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asahi, M., Takahashi, M., Uozumi, N., Ihara, S., Lee, S.H., Ikeda, Y., Yamaguchi, Y., Aze, Y., Tomiyama, Y., Fujii, J., Suzuki, K., Kondo, A., Shapiro, S.D., Lopez-Otin, C., Kuwaki, T., Okabe, M., Honke, K., and Taniguchi, N. (2005) Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc. Natl Acad. Sci. USA 102, 15791-15796
7. Wang, X., Gu, J., Ihara, H., Miyoshi, E., Honke, K., and Taniguchi, N. (2006) Core fucosylation regulates epidermal growth factor receptor-mediated intracellular signaling. J. Biol. Chem. 281, 2572-2577
8. Zhao, Y., Itoh, S., Wang, X., Isaji, T., Miyoshi, E., Kariya, Y., Miyazaki, K., Kawasaki, N., Taniguchi, N., and Gu, J. (2006) Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions. J. Biol. Chem. 281, 38343-38350
9. Kondo, A., Li, W., Nakagawa, T., Nakano, M., Koyama, N., Wang, X., Gu, J., Miyoshi, E., and Taniguchi, N. (2006) From glycomics to functional glycomics of sugar chains: identification of target proteins with functional changes using gene targeting mice and knock down cells of FUT8 as examples. Biochim. Biophys. Acta 1764, 1881-1889
10. Taniguchi, N., Miyoshi, E., Gu, J., Honke, K., and Matsumoto, A. (2006) Decoding sugar functions by identifying target glycoproteins. Curr. Opin. Struct. Biol. 16, 561-566
11. Hautamaki, R.D., Kobayashi, D.K., Senior, R.M., and Shapiro, S.D. (1997) Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277, 2002-2004
12. Morris, D.G., Huang, X., Kaminski, N., Wang, Y., Shapiro, S.D., Dolganov, G., Glick, A., and Sheppard, D. (2003) Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature 422, 169-173
13. Kasahara, Y., Tuder, R.M., Cool, C.D., Lynch, D.A., Flores, S.C., and Voelkel, N.F. (2001) Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am. J. Respir. Crit. Care Med. 163, 737-744
14. Kasahara, Y., Tuder, R.M., Taraseviciene-Stewart, L., Le Cras, T.D., Abman, S., Hirth, P.K., Waltenberger, J., and Voelkel, N.F. (2000) Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J. Clin. Invest. 106, 1311-1319
15. Petrache, I., Natarajan, V., Zhen, L., Medler, T.R., Richter, A., Berdyshev, E.V., and Tuder, R.M. (2006) Ceramide causes pulmonary cell apoptosis and emphysema: a role for sphingolipid homeostasis in the maintenance of alveolar cells. Proc. Am. Thorac. Soc. 3, 510
16. Petrache, I., Natarajan, V., Zhen, L., Medler, T.R., Richter, A.T., Cho, C., Hubbard, W.C., Berdyshev, E.V., and Tuder, R.M. (2005) Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat. Med. 11, 491-498
17. Tang, K., Rossiter, H.B., Wagner, P.D., and Breen, E.C. (2004) Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice. J. Appl. Physiol. 97, 1559-1566; discussion 1549
18. Suzuki, M., Betsuyaku, T., Nagai, K., Fuke, S., Nasuhara, Y., Kaga, K., Kondo, S., Hamamura, I., Hata, J., Takahashi, H., and Nishimura, M. (2008) Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients. Inhal. Toxicol. 20, 349-359
19. Tuder, R.M., Petrache, I., Elias, J.A., Voelkel, N.F., and Henson, P.M. (2003) Apoptosis and emphysema: the missing link. Am. J. Respir. Cell Mol. Biol. 28, 551-554
20. Alon, T., Hemo, I., Itin, A., Pe'er, J., Stone, J., and Keshet, E. (1995) Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med. 1, 1024-1028
21. Gerber, H.P., McMurtrey, A., Kowalski, J., Yan, M., Keyt, B.A., Dixit, V., and Ferrara, N. (1998) Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal trans-duction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 273, 30336-30343
22. Uozumi, N., Teshima, T., Yamamoto, T., Nishikawa, A., Gao, Y.E., Miyoshi, E., Gao, C.X., Noda, K., Islam, K.N., Ihara, Y., Fujii, S., Shiba, T., and Taniguchi, N. (1996) A fluorescent assay method for GDP-L-Fuc:N-acetyl-beta-D- glucosaminide alpha 1-6fucosyltransferase activity, involving high performance liquid chromatography. J. Biochem. 120, 385-392
23. Li, W., Nakagawa, T., Koyama, N., Wang, X., Jin, J., Mizuno-Horikawa, Y., Gu, J., Miyoshi, E., Kato, I., Honke, K., Taniguchi, N., and Kondo, A. (2006) Down-regulation of trypsinogen expression is associated with growth retardation in alpha1,6-fucosyltransferase-deficient mice: attenuation of proteinase-activated receptor 2 activity. Glycobiology 16, 1007-1019
24. Inamori, K., Gu, J., Ohira, M., Kawasaki, A., Nakamura, Y., Nakagawa, T., Kondo, A., Miyoshi, E., Nakagawara, A., and Taniguchi, N. (2006) High expression of N-acetylglucosami-nyltransferase V in favorable neuroblastomas: involvement of its effect on apoptosis. FEBS Lett. 580, 627-632
25. Massague, J., Blain, S.W., and Lo, R.S. (2000) TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103, 295-309
26. Hannun, Y.A. and Luberto, C. (2000) Ceramide in the eukaryotic stress response. Trends Cell Biol. 10, 73-80
27. Hannun, Y.A. and Obeid, L.M. (2002) The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 277, 25847-25850
28. Reunanen, N., Westermarck, J., Hakkinen, L., Holmstrom, T.H., Elo, I., Eriksson, J.E., and Kahari, V.M. (1998) Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways. J. Biol. Chem. 273, 5137-5145
29. Ashwell, G. and Harford, J. (1982) Carbohydrate-specific receptors of the liver. Annu. Rev. Biochem. 51, 531-554
30. Ohtsubo, K., Takamatsu, S., Minowa, M.T., Yoshida, A., Takeuchi, M., and Marth, J.D. (2005) Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 123, 1307-1321
31. Partridge, E.A., Le Roy, C., Di Guglielmo, G.M., Pawling, J., Cheung, P., Granovsky, M., Nabi, I.R., Wrana, J.L., and Dennis, J.W. (2004) Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306, 120-124
32. Lau, K.S., Partridge, E.A., Grigorian, A., Silvescu, C.I., Reinhold, V.N., Demetriou, M., and Dennis, J.W. (2007) Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell 129, 123-134
33. Tuder, R.M., Flook, B.E., and Voelkel, N.F. (1995) Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. J. Clin. Invest. 95, 1798-1807
34. Patterson, C., Perrella, M.A., Endege, W.O., Yoshizumi, M., Lee, M.E., and Haber, E. (1996) Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells. J. Clin. Invest. 98, 490-496
35. Angel, P. and Karin, M. (1991) The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072, 129-157
36. Jochum, W., Passegue, E., and Wagner, E.F. (2001) AP-1 in mouse development and tumorigenesis. Oncogene 20, 2401-2412
37. Holmes, D.I. and Zachary, I. (2004) Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors. FEBS Lett. 557, 93-98
38. Chen, D.B. and Davis, J.S. (2003) Epidermal growth factor induces c-fos and c-jun mRNA via Raf-1/MEK1/ERK-dependent and -independent pathways in bovine luteal cells. Mol. Cell Endocrinol. 200, 141-154