Scratching behavior and Fos expression in superficial dorsal horn elicited by protease-activated receptor agonists and other itch mediators in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 3, 2009, Pages 945-951

  Akiyama, Tasuku ^a   Merrill, Austin W ^a   Zanotto, Karen ^a   Carstens, Mirela Iodi ^a   Carstens, Earl ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANYLTYROSYLPROLYLGLYCYLLYSYLPHENYLALANINAMIDE; CAPSAICIN; HISTAMINE; MORPHINE; NALTREXONE; POLYPEPTIDE; PROTEIN FOS; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 4; SEROTONIN; SERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCINAMIDE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CIRCLING BEHAVIOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PRURITUS; SCRATCHING; SPINAL CORD DORSAL HORN; TACHYPHYLAXIS;

ANIMALS; BEHAVIOR, ANIMAL; CAPSAICIN; HISTAMINE; INJECTIONS, INTRADERMAL; MICE; MORPHINE; NALTREXONE; OLIGOPEPTIDES; POSTERIOR HORN CELLS; PROTO-ONCOGENE PROTEINS C-FOS; PRURITUS; RECEPTOR, PAR-2; RECEPTORS, OPIOID, MU; RECEPTORS, PROTEINASE-ACTIVATED; SEROTONIN; SPINAL CORD; TACHYPHYLAXIS;

EID: 66749159292     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.152256     Document Type: Article

References (40)

1. Akiyama T, Merrill AW, Carstens MI, and Carstens E (2009) Activation of superficial dorsal horn neurons in the mouse by a PAR-2 agonist and 5-HT: potential role in itch. J Neurosci doi: 10.1523/jneurosci.6103-08.
2. Andrew D and Craig AD (2001) Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch. Nat Neurosci 4:72-77. (Pubitemid 32095528)
3. Bell JK, McQueen DS, and Rees JL (2004) Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice. Br J Pharmacol 142:374-380. (Pubitemid 38750189)
4. Cottrell GS, Amadesi S, Schmidlin F, and Bunnett N (2003) Protease-activated receptor 2: activation, signalling and function. Biochem Soc Trans 31:1191-1197. (Pubitemid 38030937)
5. Cuellar JM, Jinks SL, Simons CT, and Carstens E (2003) Deletion of the preprotachykinin A gene in mice does not reduce scratching behavior elicited by intradermal serotonin. Neurosci Lett 339:72-76. (Pubitemid 36263223)
6. Davidson S, Zhang X, Yoon CH, Khasabov SG, Simone DA, and Giesler GJ Jr (2007) The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci 27:10007-10014. (Pubitemid 47404005)
7. Fjellner B and Hägermark O (1979) Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement. Acta Derm Venereol 59:505-512. (Pubitemid 10173069)
8. Green BG and Shaffer GS (1993) The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency. Pain 53:323-334. (Pubitemid 23172380)
9. Green AD, Young KK, Lehto SG, Smith SB, and Mogil JS (2006) Influence of genotype, dose and sex on pruritogen-induced scratching behavior in the mouse. Pain 124:50-58. (Pubitemid 44177798)
10. Handwerker HO, Forster C, and Kirchhoff C (1991) Discharge patterns of human C-fibers induced by itching and burning stimuli. J Neurophysiol 66:307-315.
11. Heyer G, Dotzer M, Diepgen TL, and Handwerker HO (1997) Opiate and H1 antagonist effects on histamine induced pruritus and allokinesis. Pain 73:239-243. (Pubitemid 27491686)
12. Ikoma A, Steinhoff M, Ständer S, Yosipovitch G, and Schmelz M (2006) The neurobiology of itch. Nat Rev Neurosci 7:535-547. (Pubitemid 43995431)
13. Inagaki N, Nagao M, Igeta K, Kawasaki H, Kim JF, and Nagai H (2001) Scratching behavior in various strains of mice. Skin Pharmacol Appl Skin Physiol 14:87-96. (Pubitemid 32375195)
14. Jinks SL and Carstens E (2002) Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants: comparison with scratching behavior. J Neurophysiol 87:1280-1289. (Pubitemid 34670795)
15. Johanek LM, Meyer RA, Friedman RM, Greenquist KW, Shim B, Borzan J, Hartke T, LaMotte RH, and Ringkamp M (2008) A role for polymodal C-fiber afferents in nonhistaminergic itch. J Neurosci 28:7659-7669.
16. Johanek LM, Meyer RA, Hartke T, Hobelmann JG, Maine DN, LaMotte RH, and Ringkamp M (2007) Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci 27:7490-7497. (Pubitemid 47066576)
17. Kuraishi Y, Nagasawa T, Hayashi K, and Satoh M (1995) Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur J Pharmacol 275:229-233.
18. LaMotte RH, Shain CN, Simone DA, and Tsai EF (1991) Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. J Neurophysiol 66:190-211.
19. Merrill AW, Barter LS, Rudolph U, Eger EI 2nd, Antognini JF, Carstens MI, and Carstens E (2006) Propofol's effects on nociceptive behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric acid-type(A) receptor beta3 subunit. Anesth Analg 103:478-483.
20. Morihisa JM and Glick SK (1977) Morphine-induced rotation (circling behavior) in rats and mice: species differences, persistence of withdrawal-induced rotation and antagonism by naloxone. Brain Res 123:180-187. (Pubitemid 8051284)
21. Nakano T, Andoh T, Lee JB, and Kuraishi Y (2008) Different dorsal horn neurons responding to histamine and allergic itch stimuli. Neuroreport 19:723-726.
22. Namer B, Carr R, Johanek LM, Schmelz M, Handwerker HO, and Ringkamp M (2008) Separate peripheral pathways for pruritus in man. J Neurophysiol 100:2062-2069.
23. Nojima H and Carstens E (2003) 5-Hydroxytryptamine (5-HT)2 receptor involvement in acute 5-HT-evoked scratching but not in allergic pruritus induced by dinitrofluorobenzene in rats. J Pharmacol Exp Ther 306:245-252. (Pubitemid 36734379)
24. Nojima H, Simons CT, Cuellar JM, Carstens MI, Moore JA, and Carstens E (2003) Opioid modulation of scratching and spinal c-fos expression evoked by intradermal serotonin. J Neurosci 23:10784-10790. (Pubitemid 37499684)
25. Ohtsuka E, Kawai S, Ichikawa T, Nojima H, Kitagawa K, Shirai Y, Kamimura K, and Kuraishi Y (2001) Roles of mast cells and histamine in mosquito bite-induced allergic itch-associated responses in mice. Jpn J Pharmacol 86:97-105. (Pubitemid 32529750)
26. Reddy VB, Iuga AO, Shimada SG, LaMotte RH, and Lerner EA (2008) Cowhage-evoked itch is mediated by a novel cysteine protease: a ligand of protease-activated receptors. J Neurosci 28:4331-4335.
27. Schepers RJ, Johanek LM, Hartke TV, Shim B, Borzan J, Meyer RA, and Ringkamp M (2008) A subpopulation of A-delta nociceptors in monkey is vigorously activated by cowhage spicules. Soc Neurosci Abstr 34:170.3.
28. Schmelz M, Schmidt R, Bickel A, Handwerker HO, and Torebjörk HE (1997) Specific C-receptors for itch in human skin. J Neurosci 17:8003-8008. (Pubitemid 27426235)
29. Schmelz M, Schmidt R, Weidner C, Hilliges M, Torebjork HE, and Handwerker HO (2003) Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. J Neurophysiol 89:2441-2448. (Pubitemid 36570208)
30. Shimada SG and Lamotte RH (2008) Behavioral differentiation between itch and pain in mouse. Pain 139:681-687.
31. Shimada SG, Shimada KA, and Collins JG (2006) Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2. Eur J Pharmacol 530:281-283. (Pubitemid 43075500)
32. Ståhle-Bäckdahl M, Hägermark O, and Lins LE (1988) The sensitivity of uremic and normal human skin to histamine. Acta Derm Venereol 68:230-235. (Pubitemid 18147705)
33. Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS, Luger TA, and Schmelz M (2003) Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 23:6176-6180. (Pubitemid 36875617)
34. Sun YG and Chen ZF (2007) A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448:700-703. (Pubitemid 47236861)
35. Thomsen JS, Petersen MB, Benfeldt E, Jensen SB, and Serup J (2001) Scratch induction in the rat by intradermal serotonin: a model for pruritus. Acta Derm Venereol 81:250-254. (Pubitemid 32977102)
36. Tsujii K, Andoh T, Lee JB, and Kuraishi Y (2008) Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and -independent pathways in mice. J Pharmacol Sci 108:385-388.
37. Twycross R, Greaves MW, Handwerker H, Jones EA, Libretto SE, Szepietowski JC, and Zylicz Z (2003) Itch: scratching more than the surface. QJM 96:7-26. (Pubitemid 36163807)
38. Ui H, Andoh T, Lee JB, Nojima H, and Kuraishi Y (2006) Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice. Eur J Pharmacol 530:172-178. (Pubitemid 43037138)
39. Weisshaar E, Ziethen B, and Gollnick H (1997) Can a serotonin type 3 (5-HT3) receptor antagonist reduce experimentally-induced itch. Inflamm Res 46:412-416. (Pubitemid 27478600)
40. Yamaguchi T, Nagasawa T, Satoh M, and Kuraishi Y (1999) Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice. Neurosci Res 35:77-83. (Pubitemid 29518398)