Chemical components of Centella asiatica and their bioactivities

Journal of Chinese Integrative Medicine

Volumn 5, Issue 3, 2007, Pages 348-351

  Zheng, Cheng Jian ^a   Qin, Lu Ping ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apiaceae; Biological activity; Centella asiatica; Chemical constituent; Triterpenes

Indexed keywords

ALKALOID; AMINO ACID; ASIATIC ACID; ASIATICOSIDE; AURANTIIN; BICYCLOGERMACRENE; CAROTENOID; CARYOPHYLLENE; CATECHIN; CENTELLA ASIATICA EXTRACT; CHLOROPHYLL; ESSENTIAL OIL; FARNESOL; FATTY ACID; FLAVONOID; FLAVONOL; HUMULENE; KAEMPFEROL; PECTIN; PLACEBO; POLYSACCHARIDE; QUERCETIN; RUTOSIDE; SESQUITERPENE; STEROL; TANNIN; TRITERPENE DERIVATIVE; TRITERPENOID; VINCRISTINE;

ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; CENTELLA ASIATICA; CHEMICAL COMPOSITION; CHEMOPROPHYLAXIS; CLINICAL TRIAL; COGNITION; COLON CARCINOGENESIS; COLON TUMOR; DEPRESSION; HERBAL MEDICINE; HUMAN; LEARNING; LIVER TOXICITY; MEMORY; MICROANGIOPATHY; NONHUMAN; PHYTOTHERAPY; REVIEW; SKIN ALLERGY; SKIN CANCER; STOMACH ULCER; ULCER HEALING; VEIN INSUFFICIENCY; WOUND; WOUND HEALING;

EID: 34249741997     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20070324     Document Type: Review

References (30)

1. Suguna L, Sivakumar P, Chandrakasan G. Effects of Centella asiatica extract on dermal wound healing in rats. Indian J Exp Biol. 1996; 34: 1208-1211.
2. Apparao MVR, Srinivasan K, Rao K, et al. The effect of mandookparni (Centella asiatica) on the general mental ability (Medhya) of mentally retarded children. J Res Indian Med. 1973; 8: 9-16.
3. Oyedeji OA, Afolayan AJ. Chemical composition and antibacterial activity of the essential oil of Centella asiatica growing in South Africa. Pharm Biol. 2005; 43 (3): 249-252.
4. Jayashree G, Kurup MG, Sudarslal VS, et al. Antioxidant activity of Centella asiatica on lymphoma-bearing mice. Fitoterapia. 2003; 74: 431-434.
5. Babu TD, Kuttan G, Padikkala J. Cytotoxic and antitumor properties of certain texa of umbelliferae with specific reference to Centella asiatica (L.) urban. J Ethnopharmacol. 1995; 48: 53-57.
6. Brinkhaus B, Lindner M, Schuppan D. Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica. Phytomedicine. 2000; 7(5): 427-448.
7. Shukla YN, Srivastava R, Tripathi AK, et al. Characterization of an ursane triterpenoid from Centella asiatica with growth inhibitory activity against Spilarctia bliqua. Pharm Biol. 2000; 38(4): 262-267.
8. Matsuda H, Morikawa T, Ueda H, et al. Medicinal foodstuffs. XXVI. Inhibitors of aldose reductase and new triterpene and its oligoglycoside, centellasapogenol A and centellasaponin A, from Centella asiatica (Gotu Kola). Heterocycles. 2001; 55(8): 1499-1504.
9. Matsuda H, Morikawa T, Ueda H, et al. Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka. Chem Pharm Bull (Tokyo). 2001; 49(10): 1368-1371.
10. Kuroda M, Mimaki Y, Harada H, et al. Five new triterpene glycosides from Centella asiatica. Nat Med. 2001; 55(3): 134-138.
11. Jiang ZY, Zhang XM, Zhou J. New triterpenoid glycosides from Centella asiatica. Helv Chim Acta. 2005; 88 (2): 297-303.
12. Monti D, Candido A, Silva MMC. et al. Biocatalyzed generation of molecular diversity: selective modification of the saponin asiaticoside. Adv Synth Catal. 2005; 347 (7-8): 1168-1174.
13. Shetty BS, Udupa SL, Udupa AL, et al. Effect of Centella asiatica L (Umbelliferae) on normal and dexamethasone-suppressed wound healing in Wistar albino rats. Int J Low Extrem Wounds, 2006; 5(3): 137-143.
14. Coldren CD, Hashim P, Ali JM, et al. Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Planta Med, 2003; 69(8): 725-732.
15. Lee J, Jung E, Kim Y, et al. Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI Kinase)-independent smad signaling. Planta Med. 2006; 72(4): 324-328.
16. Rao SB, Chetana M, Uma Devi P. Centella asiatica treatment during postnatal period enhances learning and memory in mice. Physiol Behav. 2005; 86(4): 449-457.
17. Veerendra Kumar MH, Gupta YK. Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats. J Ethnopharmacol. 2002; 79 (2): 253-260.
18. Mohandas Rao KG, Muddanna Rao S, Gurumadhva Rao S. Centella asiatica (linn) induced behavioural changes during growth spurt period in neonatal rats. Neuroanatomy. 2005; 4(1): 18-23.
19. Mohandas Rao KG, Muddanna Rao S, Gurumadhva Rao S. Centella asiatica (L.) leaf extract treatment during the growth spurt period enhances hippocampal CA3 neuronal dendritic arborization in rats. Evid Based Complement Alternat Med. 2006; 3(3): 349-357.
20. De Sanctis MT, Belcaro G, Incandela L, et al. Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial. Angiology. 2001; 52(Suppl 2): S55-59.
21. Cheng CL, Guo JS, Luk J, et al. The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats. Life Sci. 2004; 74(18): 2237-2249.
22. Sairam K, Rao CV, Goel RK. Effect of Centella asiatica Linn on physical and chemical factors induced gastric ulceration and secretion in rats. Indian J Exp Biol. 2001; 39(2): 137-142.
23. Guo JS, Cheng CL, Koo MW. Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats. Planta Med. 2004; 70(12): 1150-1154.
24. Huang YH, Zhang SH, Zhen RX, et al. Asiaticoside inducing apoptosis of tumor cells and enhancing antitumor activity of vincristine. Ai Zheng. 2004; 23(12): 1599-1604. Chinese with abstract in English.
25. Bunpo P, Kataoka K, Arimochi H, et al. Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats. Food Chem Toxicol. 2004; 42 (12): 1987-1997.
26. Park BC, Bosire KO, Lee ES, et al. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 2005; 218(1): 81-90.
27. Qin LP, Ding RX, Zhang WD, et al. Essential oil from Centella asiatica and its antidepressant activity. Di Er Jun Yi Da Xue Xue Bao. 1998; 19(2): 186-187. Chinese.
28. Zainol MK, Abd-Hamid A, Yusof S, et al. Antioxidative activity and total phenolic compounds of leaf, root and petiole of four accessions of Centella asiatica (L.) Urban. Food Chem. 2003; 81(4): 575-581.
29. Hussin M, Abdul-Hamid A, Mohamad S, et al. Protective effect of Centella asiatica extract and powder on oxidative stress in rats. Food Chem. 2007; 100: 535-541.
30. Wong SP, Leong LP, Koh JHW. Antioxidant activities of aqueous extracts of selected plants. Food Chem. 2006; 99(4): 775-783.