Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain

Brain Research Bulletin

Volumn 70, Issue 4-6, 2006, Pages 457-466

  Christophersen, Nicolaj S ^a,b   Meijer, Xia ^c   Jørgensen, Jesper R ^a   Englund, Ulrica ^b   Grønborg, Mette ^a   Seiger, Åke ^c   Brundin, Patrik ^b   Wahlberg, Lars U ^a  

^a NsGene AS   (Denmark)

^b LUND UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Differentiation method; Dopaminergic; Human; Neural progenitor; Neural stem cell; Neurospheres; Parkinson's disease; Tyrosine hydroxylase

Indexed keywords

ACIDIC FIBROBLAST GROWTH FACTOR; CARBOXYLYASE; CYCLIC AMP; DOPAMINE BETA MONOOXYGENASE; GROWTH FACTOR; MESSENGER RNA; OXYGENASE; PROTEIN KINASE C; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; EMBRYO; FEMALE; FIRST TRIMESTER PREGNANCY; FOREBRAIN; IMMUNOREACTIVITY; IN VITRO STUDY; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL;

ANIMALS; BRAIN INJURIES; CELL COUNT; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CELLS, CULTURED; DOPAMINE; FEMALE; FETUS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NERVE TISSUE PROTEINS; NEURONS; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; TIME FACTORS; TYROSINE 3-MONOOXYGENASE; VENTRAL TEGMENTAL AREA;

EID: 33749242798     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2006.07.001     Document Type: Article

References (41)

1. Arsenijevic Y., and Weiss S. Insulin-like growth factor-I is a differentiation factor for postmitotic CNS stem cell-derived neuronal precursors: distinct actions from those of brain-derived neurotrophic factor. J. Neurosci. 18 (1998) 2118-2128
2. Bjorklund A., Dunnett S.B., Brundin P., Stoessl A.J., Freed C.R., Breeze R.E., Levivier M., Peschanski M., Studer L., and Barker R. Neural transplantation for the treatment of Parkinson's disease. Lancet Neurol. 2 (2003) 437-445
3. Bouvier M.M., and Mytilineou C. Basic fibroblast growth factor increases division and delays differentiation of dopamine precursors in vitro. J. Neurosci. 15 (1995) 7141-7149
4. Brederlau A., Correia A.S., Anisimov S.V., Elmi M., Roybon L., Paul G., Morizane A., Bergquist F., Riebe I., Nannmark U., Carta M., Hanse E., Takahashi J., Sasai Y., Funa K., Brundin P., Eriksson P.S., and Li J.Y. Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells (2006)
5. Carpenter M.K., Cui X., Hu Z.Y., Jackson J., Sherman S., Seiger A., and Wahlberg L.U. In vitro expansion of a multipotent population of human neural progenitor cells. Exp. Neurol. 158 (1999) 265-278
6. Correia A.S., Anisimov S.V., Li J.Y., and Brundin P. Stem cell-based therapy for Parkinson's disease. Ann. Med. 37 (2005) 487-498
7. Du X., and Iacovitti L. Multiple signaling pathways direct the initiation of tyrosine hydroxylase gene expression in cultured brain neurons. Brain Res. Mol. Brain Res. 50 (1997) 1-8
8. Du X., and Iacovitti L. Protein kinase C activators work in synergy with specific growth factors to initiate tyrosine hydroxylase expression in striatal neurons in culture. J. Neurochem. 68 (1997) 564-569
9. Du X., and Iacovitti L. Synergy between growth factors and transmitters required for catecholamine differentiation in brain neurons. J. Neurosci. 15 (1995) 5420-5427
10. Du X., Stull N.D., and Iacovitti L. Novel expression of the tyrosine hydroxylase gene requires both acidic fibroblast growth factor and an activator. J. Neurosci. 14 (1994) 7688-7694
11. Engele J., and Franke B. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell Tissue Res. 286 (1996) 235-240
12. Ernsberger U., and Rohrer H. Neuronal precursor cells in chick dorsal root ganglia: differentiation and survival in vitro. Dev. Biol. 126 (1988) 420-432
13. Feng L., Wang C.Y., Jiang H., Oho C., Mizuno K., Dugich-Djordjevic M., and Lu B. Differential effects of GDNF and BDNF on cultured ventral mesencephalic neurons. Brain Res. Mol. Brain Res. 66 (1999) 62-70
14. Freed C.R., Greene P.E., Breeze R.E., Tsai W.Y., DuMouchel W., Kao R., Dillon S., Winfield H., Culver S., Trojanowski J.Q., Eidelberg D., and Fahn S. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 344 (2001) 710-719
15. Hagell P., and Cenci M.A. Dyskinesias and dopamine cell replacement in Parkinson's disease: a clinical perspective. Brain Res. Bull. 68 (2005) 4-15
16. Huang S., Saint-Jeannet J.P., Kan P., and Duprat A.M. Extracellular matrix: an immunological and biochemical (CAT and TOH activity) survey of in vitro differentiation of isolated amphibian neuroblasts. Cell Differ. Dev. 30 (1990) 219-233
17. Hyman C., Hofer M., Barde Y.A., Juhasz M., Yancopoulos G.D., Squinto S.P., and Lindsay R.M. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350 (1991) 230-232
18. Hyman C., Juhasz M., Jackson C., Wright P., Ip N.Y., and Lindsay R.M. Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. J. Neurosci. 14 (1994) 335-347
19. Iacovitti L., and Stull N.D. Expression of tyrosine hydroxylase in newly differentiated neurons from a human cell line (hNT). Neuroreport 8 (1997) 1471-1474
20. Iacovitti L., Stull N.D., and Jin H. Differentiation of human dopamine neurons from an embryonic carcinomal stem cell line. Brain Res. 912 (2001) 99-104
21. Kirik D., Rosenblad C., and Bjorklund A. Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor. Eur. J. Neurosci. 12 (2000) 3871-3882
22. Kumer S.C., and Vrana K.E. Intricate regulation of tyrosine hydroxylase activity and gene expression. J. Neurochem. 67 (1996) 443-462
23. Ling Z.D., Potter E.D., Lipton J.W., and Carvey P.M. Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines. Exp. Neurol. 149 (1998) 411-423
24. Mena M.A., Casarejos M.J., Bonin A., Ramos J.A., and Garcia Yebenes J. Effects of dibutyryl cyclic AMP and retinoic acid on the differentiation of dopamine neurons: prevention of cell death by dibutyryl cyclic AMP. J. Neurochem. 65 (1995) 2612-2620
25. Michel P.P., and Agid Y. Chronic activation of the cyclic AMP signaling pathway promotes development and long-term survival of mesencephalic dopaminergic neurons. J. Neurochem. 67 (1996) 1633-1642
26. Nishino H., Hida H., Takei N., Kumazaki M., Nakajima K., and Baba H. Mesencephalic neural stem (progenitor) cells develop to dopaminergic neurons more strongly in dopamine-depleted striatum than in intact striatum. Exp. Neurol. 164 (2000) 209-214
27. Olanow C.W., Goetz C.G., Kordower J.H., Stoessl A.J., Sossi V., Brin M.F., Shannon K.M., Nauert G.M., Perl D.P., Godbold J., and Freeman T.B. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann. Neurol. 54 (2003) 403-414
28. Ostenfeld T., Joly E., Tai Y.T., Peters A., Caldwell M., Jauniaux E., and Svendsen C.N. Regional specification of rodent and human neurospheres. Brain Res. Dev. Brain Res. 134 (2002) 43-55
29. Pliego Rivero F.B., McCormack W.J., Jauniaux E., Stern G.M., and Bradford H.F. Forskolin-induced expression of tyrosine hydroxylase in human foetal brain cortex. Brain Res. Dev. Brain Res. 114 (1999) 201-206
30. Poltorak M., Shimoda K., and Freed W.J. L1 substrate enhances outgrowth of tyrosine hydroxylase-immunoreactive neurites in mesencephalic cell culture. Exp. Neurol. 117 (1992) 176-184
31. Potter E.D., Ling Z.D., and Carvey P.M. Cytokine-induced conversion of mesencephalic-derived progenitor cells into dopamine neurons. Cell Tissue Res. 296 (1999) 235-246
32. Savettieri G., Licata L., Catania C., Raneri R., Di Liegro I., and Cestelli A. Synergistic effects of laminin and thyroid hormones on neuron polarity in culture. Neuroreport 10 (1999) 1269-1272
33. Studer L., Spenger C., Seiler R.W., Othberg A., Lindvall O., and Odin P. Effects of brain-derived neurotrophic factor on neuronal structure of dopaminergic neurons in dissociated cultures of human fetal mesencephalon. Exp. Brain Res. 108 (1996) 328-336
34. Treanor J.J., Goodman L., de Sauvage F., Stone D.M., Poulsen K.T., Beck C.D., Gray C., Armanini M.P., Pollock R.A., Hefti F., Phillips H.S., Goddard A., Moore M.W., Buj-Bello A., Davies A.M., Asai N., Takahashi M., Vandlen R., Henderson C.E., and Rosenthal A. Characterization of a multicomponent receptor for GDNF. Nature 382 (1996) 80-83
35. Ungerstedt U. Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour. Acta Physiol. Scand. Suppl. 367 (1971) 49-68
36. Winkler C., Bentlage C., Nikkhah G., Samii M., and Bjorklund A. Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants. Exp. Neurol. 155 (1999) 165-186
37. Yan J., Studer L., and McKay R.D. Ascorbic acid increases the yield of dopaminergic neurons derived from basic fibroblast growth factor expanded mesencephalic precursors. J. Neurochem. 76 (2001) 307-311
38. Yang M., Donaldson A.E., Marshall C.E., Shen J., and Iacovitti L. Studies on the differentiation of dopaminergic traits in human neural progenitor cells in vitro and in vivo. Cell Transplant 13 (2004) 535-547
39. Zetterstrom R.H., Solomin L., Jansson L., Hoffer B.J., Olson L., and Perlmann T. Dopamine neuron agenesis in Nurr1-deficient mice. Science 276 (1997) 248-250
40. Zhou J., Bradford H.F., and Stern G.M. Induction of dopaminergic neurotransmitter phenotype in rat embryonic cerebrocortex by the synergistic action of neurotrophins and dopamine. Eur. J. Neurosci. 8 (1996) 2328-2339
41. Zhou J., Pliego-Rivero B., Bradford H.F., Stern G.M., and Jauniaux E.R. Induction of tyrosine hydroxylase gene expression in human foetal cerebral cortex. Neurosci. Lett. 252 (1998) 215-217