Characterization of relaxin receptor (RXFP1) desensitization and internalization in primary human decidual cells and RXFP1-transfected HEK293 cells

Endocrinology

Volumn 150, Issue 5, 2009, Pages 2419-2428

  Kern, Andras ^a,b   Bryant Greenwood, Gillian D ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF HAWAII   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN 2; PROTEIN RXFP1; RECEPTOR PROTEIN; RELAXIN; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; RECEPTOR; RETINA S ANTIGEN; RXFP1 PROTEIN, HUMAN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL STIMULATION; CELL STRAIN HEK293; CONTROLLED STUDY; DECIDUA; DESENSITIZATION; DIMERIZATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERNALIZATION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; AUTOCRINE EFFECT; BIOLOGICAL MODEL; CELL CULTURE; CELL LINE; CHEMISTRY; CULTURE TECHNIQUE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENE EXPRESSION; GENETICS; METABOLISM; PARACRINE SIGNALING; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ARRESTINS; AUTOCRINE COMMUNICATION; CELL CULTURE TECHNIQUES; CELL LINE; CELLS, CULTURED; DECIDUA; DIMERIZATION; FEMALE; GENE EXPRESSION; HUMANS; MODELS, BIOLOGICAL; PARACRINE COMMUNICATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RELAXIN; TRANSFECTION;

EID: 66449122003     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1385     Document Type: Article

References (52)

1. James R, Niall H, Kwok S, Bryant-Greenwood GD 1977 Primary structure of porcine relaxin: homology with insulin and related growth factors. Nature 267:544-546
2. Sherwood OD 2004 Relaxin's physiological roles and other diverse actions. Endocr Rev 25:205-234
3. Hombach-Klonisch S, Bialek J, Trojanowicz B, Weber E, Holzhausen HJ, Silvertown JD, Summerlee AJ, Dralle H, Hoang-Vu C, Klonisch T 2006 Re- laxinenhancestheoncogenicpotentialofhumanthyroidcarcinomacells.AmJ Pathol 169:617-632
4. Samuel CS, Hewitson TD 2006 Relaxin in cardiovascular and renal disease. Kidney Int 69:1498-1502
5. Mookerjee I, Solly NR, Royce SG, Tregear GW, Samuel CS, ML. T 2006 Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease. Endocrinology 147:754-761
6. Feng S, AgoulnikIU, Bogatcheva NV, Kamat AA, Kwabi-Addo B, Li R, Ayala G, Ittmann MM, Agoulnik AI 2007 Relaxin promotes prostate cancer progression. Clin Cancer Res 13:1695-1702
7. Smith MC, Danielson LA, Conrad KP, Davison JM 2006 Influence of recom- binant human relaxin on renal hemodynamics in healthy volunteers. J Am Soc Nephrol 17:3192-3197
8. Bogic LV, Yamamoto SY, Millar LK, Bryant-Greenwood GD 1997 Developmental regulation of the human relaxin genes in the decidua and placenta: overexpression in the preterm premature rupture of the fetal membranes. Biol Reprod 57:908 -920
9. Koay ES, Bryant-Greenwood GD, Yamamoto SY, Greenwood FC 1986 The human fetal membranes: a target tissue for relaxin. J Clin Endocrinol Metab 62:513-521
10. Garibay-Tupas JL, A. Maaskant R, Greenwood FC, Bryant-Greenwood GD 1995 Characteristics of the binding of 32P-labelled human relaxins to the human fetal membranes. J Endocrinol 145:441-448
11. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ 2002 Activation of orphan receptors by the hormone relaxin. Science 295: 671-674
12. HsuSY,KudoM,ChenT,NakabayashiK,BhallaA,vanderSpekPJ,vanDuin M, Hsueh AJ 2000 The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol 14:1257-1271
13. Kern A, Agoulnik AI, Bryant-Greenwood GD 2007 The low-density lipopro- tein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane. Endocrinology 148:1181-1194
14. Bogatcheva NV, Ferlin A, Feng S, Truong A, Gianesello L, Foresta C, Agoulnik AI 2007 T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane. Am J Physiol Endocrinol Metab 292:E138-E144
15. Hsu SY 2003 New insights into the evolution of the relaxin-LGR signaling system. Trends Endocrinol Metab 14:303-309
16. Ferguson SS 2001 Evolving concepts in G protein-coupled receptor endocy- tosis: the role in receptor desensitization and signaling. Pharmacol Rev 53: 1-24
17. Moore CA, Milano SK, Benovic JL 2007 Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol 69:451-482
18. LefkowitzRJ,Shenoy SK 2005 Transduction of receptor signals by /3-arrestins. Science 308:512-517
19. Oakley RH, Laporte SA, Holt JA, Caron MG, Barak LS 2000 Differential affinities of visual arrestin, β arrestin1, and β arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem 275:17210-17210
20. Nakamura K, Lazari MF, Li S, Korgaonkar C, Ascoli M 1999 Role of the rate of internalization of the agonist-receptor complex on the agonist-induced down-regulation of the lutropin/choriogonadotropin receptor. Mol Endocrinol 13:1295-1304
21. Lazari MF, Liu X, Nakamura K, Benovic JL, Ascoli M 1999 Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor. Mol Endocrinol 13:866-876
22. Frenzel R, Voigt C, Paschke R 2006 The human thyrotropin receptor is predom- inantlyinternalized by β-arrestin 2. Endocrinology147:3114-3122
23. LowndesK, AmanoA,YamamotoS,Bryant-GreenwoodGD2006Thehuman relaxin receptor (LGR7): expression in the fetal membranes and placenta. Placenta 27:610-618
24. Tashima LS, Yamamoto SY, Yasuda M, Millar LK, Bryant-Greenwood GD 2002 Decidual relaxins: gene and protein up-regulation in preterm premature rupture of the membranes by complementary DNA arrays and quantitative immunocytochemistry. Am J Obstet Gynecol 187:785-797
25. Kern A, Hubbard D, Amano A, Bryant-Greenwood GD 2008 Cloning, expression, and functional characterization of relaxin receptor (leucine-rich repeat-containing G protein-coupled receptor 7) splice variants from human fetal membranes. Endocrinology 149:1277-1294
26. Simhan HN, Chura JC, Rauk PN 2004 The effect of the anti-inflammatory cytokines interleukin-4 and interleukin-10 on lipopolysaccharide-stimulated production of prostaglandin E2 by cultured human decidual cells. J Reprod Immunol 64:1-7
27. Cakmak H, Schatz F, Huang ST, Buchwalder L, Rahman M, Arici A, Lockwood CJ 2005 Progestin suppresses thrombin- and interleukin-1 β-induced interleu- kin-11 production in term decidual cells: implications for preterm delivery. JClin Endocrinol Metab 90:5279-5286
28. PawsonAJ, Faccenda E, MaudsleyS, LuZL, Naor Z, Millar RP2008 Mammalian type I gonadotropin-releasing hormone receptors undergo slow, constitutive, agonist-independentinternalization. Endocrinology149:1415-1422
29. Ivell R, Balvers M, Pohnke Y, Telgmann R, Bartsch O, Milde-Langosch K, BambergerAM,Einspanier2003 AImmunoexpressionoftherelaxinreceptor LGR7 in breast and uterine tissues of humans and primates. Reprod Biol Endocrinol 1:114
30. Pippig S, Andexinger S, Daniel K, Puzicha M, Caron MG, Lefkowitz RJ, Lohse MJ 1993 Overexpression of β-arrestin and β-adrenergic receptor kinase augment desensitization of β 2-adrenergic receptors. J Biol Chem 268:3201-3208
31. Gurevich VV, Gurevich EV 2006 The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol Ther 110:465-502
32. Krupnick JG, Gurevich VV, Benovic JL 1997 Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin. J Biol Chem 272:18125-18131
33. Menard L, Ferguson SS, Zhang J, Lin FT, Lefkowitz RJ, CaronMG, Barak LS 1997 Synergistic regulation of β 2-adrenergic receptor sequestration: intracel- lular complement of β-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. Mol Pharmacol 51:800 -808
34. ScottDJ,LayfieldS,YanY,SudoS,HsuehAJ,TregearGW,BathgateRA2006 Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. J Biol Chem 281:34942-34954
35. Zhang J, Barak LS, Anborgh PH, Laporte SA, Caron MG, Ferguson SS 1999 Cellular trafficking of G protein-coupled receptor β-arrestin endocytic complexes. J Biol Chem 274:10999-11006
36. Svendsen AM, Zalesko A, K0nig J, Vrecl M, Heding A, Kristensen JB, Wade JD, Bathgate RA, De Meyts P, N0hr J 2008 Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1. Mol Cell Endocrinol 296:10-17
37. Svendsen AM, Vrecl M, Ellis TM, Heding A, Kristensen JB, Wade JD, Bathgate RA, De Meyts P, N0hr J 2008 Cooperative binding of insulin-like peptide 3 to a dimeric relaxin family peptide receptor 2. Endocrinology 149:1113
38. Bogatcheva NV, Truong A, Feng S, Engel W, Adham IM, AgoulnikAI 2003 GREAT/LGR8 is the only receptor for insulin-like 3 peptide. Mol Endocrinol 17:2639 -2646
39. Paing MM, Stutts AB, Kohout TA, Lefkowitz RJ, Trejo J 2002 β-Arrestins regulate protease-activated receptor-1 desensitization but not internalization or down-regulation. J Biol Chem 277:1292-1300
40. MohammadS,BaldiniG,GranellS,NarducciP,MartelliAM,BaldiniG2007 Constitutive traffic of melanocortin-4 receptor in neuro2A cells and immortalized hypothalamic neurons. J Biol Chem 282:4963-4974
41. McDonald NA, Henstridge CM, Connolly CN, Irving AJ 2007 An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor. Mol Pharmacol 71:976 -984
42. Achour L, Labbe-Jullie C, Scott MG, Marullo S 2008 An escort for GPCRs: implicationsforregulationofreceptordensityatthecellsurface. TrendsPharmacol Sci 29:528-535
43. Chen GA, Huang JR, Tseng L 1988 The effect of relaxin on cyclic adenosine 3',5'-monophosphate concentrations in human endometrial glandular epithelial cells. Hum Reprod Update 4:355-358
44. Nguyen BT, Dessauer CW 2005 Relaxin stimulates protein kinase C£ translocation: requirement for cyclic adenosine 3',5'-monophosphate production. Mol Endocrinol 19:1012-1023
45. Slessareva JE, Routt SM, Temple B, Bankaitis VA, DohlmanHG 2006 Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein α subunit at the endosome. Cell 126:191-203
46. Garcfa-Regalado A, Guzman-Hernandez ML, Ramfrez-Rangel I, Robles-Molina E, Balla T, Vazquez-Prado J, Reyes-Cruz G 2008 GPCR-promoted trafficking of Gβ31γ2 leads to AKT activation at endosomes via a mechanism mediated by G/j1y2-Rab11a interaction. Mol Biol Cell 19:4188-4200
47. Huttenrauch F, Pollok-Kopp B, Oppermann M 2005 G protein-coupled receptor kinases promote phosphorylation and β-arrestin-mediated inter- nalization of CCR5 homo- and hetero-oligomers. JBiol Chem 280:37503-37515
48. Hillion J, Canals M, Torvinen M, Casado V, Scott R, Terasmaa A, Hansson A, Watson S, Olah ME, Mallol J, Canela EI, Zoli M, Agnati LF, Ibanez CF, Lluis C, Franco R, Ferre S, Fuxe K 2002 Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. J Biol Chem 277:18091-18097
49. Stanasila L, Perez J-B, Vogel H, Cotecchia S 2003 Oligomerization of the α1a- and a1b-adrenergic receptor subtypes. JBiol Chem 278:40239-40251
50. Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ2006 Inter-nationalUnionofPharmacologyLVII:recommendationsforthenomenclature of receptors for relaxin family peptides. Pharm Rev 58:7-31
51. Barak LS, Oakley RH, Laporte SA, Caron MG 2001 Constitutive arrestin- mediated desensitization of a human vasopressin receptor mutant associ- atedwith nephrogenicdiabetes insipidus. ProcNatlAcad Sci USA98:93-98
52. Mazella J, Tang M, Tseng L 2004 Disparate effects of relaxin and TGFjj1: relaxin increases, but TGFjj1 inhibits, the relaxin receptor and the production of IGFBP-1 in human endometrial stromal/decidual cells. Hum Reprod 19: 1513-1518