Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4583-4594

  Markl, Christian ^a   Attia, Mohamed I ^a   Julius, Justin ^b   Sethi, Shalini ^b   Witt Enderby, Paula A ^b   Zlotos, Darius P ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b DUQUESNE UNIVERSITY   (United States)

Author keywords

Melatonin receptor ligands

Indexed keywords

1,2,3,4 TETRAHYDROPYRAZINO[1,2 A]INDOLE; 2 [(PHENYLMETHYLAMINO)METHYL] 1H INDOLE; MELATONIN DERIVATIVE; N [2 (8 METHOXY 2 METHYL 1,2,3,4 TETRAHYDROPYRAZINO[1,2 A]INDOL 10 YL)ETHYL]ACETAMIDE; N [2 (8 METHOXY 2 METHYL 1,2,3,4 TETRAHYDROPYRAZINO[1,2 A]INDOL 10 YL)ETHYL]BUTANAMIDE; N [2 [5 METHOXY 2 [[METHYL(PHENYL)AMINO]METHYL] 1H INDOL 3 YL]ETHYL]ACETAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; LIGANDS; MELATONIN; PROTEIN BINDING; RECEPTOR, MELATONIN, MT1; RECEPTOR, MELATONIN, MT2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66449119473     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.068     Document Type: Article

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