Thromboxane A2 stimulates mitogen-activated protein kinase and arachidonic acid liberation in rabbit platelets

Prostaglandins

Volumn 52, Issue 5, 1996, Pages 403-413

  Ohkubo, Satoko ^a   Nakahata, Norimichi ^a   Ohizumi, Yasushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

arachidonic acid; cytosolic phospholipase A2; mitogen activated protein kinase; thromboxane A2; tyrosine kinase

Indexed keywords

ARACHIDONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; THROMBOXANE A2; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; CALCIUM; DRUG DERIVATIVE; HYDRAZINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHORUS; PROSTAGLANDIN ENDOPEROXIDE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN TYROSINE KINASE; VASOCONSTRICTOR AGENT;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNOBLOTTING; MALE; NONHUMAN; RABBIT; THROMBOCYTE; ANIMAL; DRUG EFFECT; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; TIME; WESTERN BLOTTING;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ARACHIDONIC ACID; BLOOD PLATELETS; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; HYDRAZINES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORUS RADIOISOTOPES; PHOSPHORYLATION; PROSTAGLANDIN ENDOPEROXIDES, SYNTHETIC; PROTEIN-TYROSINE KINASES; RABBITS; THROMBOXANE A2; TIME FACTORS; VASOCONSTRICTOR AGENTS;

EID: 0030273915     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(96)00105-0     Document Type: Article

References (28)

1. 1. Hamberg, M., Svensson, J. and Samuelsson, B. Thromboxanes: A new group of biologically active compound derived from prostaglandin endoperoxides. Proc. Natl. Acad. Sci. USA: 72, 2994. 1975.
2. 2+ pathway in rabbit platelets. Brit. J. Pharmacol.: 117, 1095, 1996.
3. 2 receptor in human platelets is a member of the novel Gq family. J. Biol. Chem.: 266, 9309. 1991.
4. 2 receptors communicate with Gq/11 in human astrocytoma cells and rabbit astroytes as well as human platelets. Res. Commun. Mol. Pathol. Pharmacol.: 87, 243. 1995.
5. 2 receptor-stimulated phosphoinositide hydrolysis in isolated platelet membranes: involvement of phosphomositide-specific phospholipase C-β and GTP-binding protein Gq. Biochem. J.: 291, 235. 1993.
6. 6. Brass, L.F., Shaller, C.C. and Belmonte, E.J. Inositol 1,4,5-trisphosphate-induced granule secretion in platelets: evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin. J. Clin. Invest: 79, 1269. 1987.
7. 2 receptors. J. Biol. Chem.: 268, 26011. 1993.
8. 2 receptor. J. Biol. Chem.: 269, 19256. 1994.
9. 2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies. J. Biol. Chem.: 269, 6109. 1994.
10. 10. Clark, E.A., Shattil, S.C. and Brugge, J.S. Regulation of protein tyrosine kinases in platelets. Trend. Biochem. Sci.: 19, 464. 1994.
11. 11. Derijard, B., Raingeaud, J., Barrett, T., Wu, I-H., Han, J., Ulevitch, R.J. and Davis, R.J. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science: 267, 682. 1995.
12. 12. Davis, R.J. MAPKs: new JNK expands the group. Trend. Biochem. Sci.: 19, 470. 1994.
13. 2 phosphorylation and cicosanoid production by colony-stimulating factor 1, Biol. Chem.: 269, 31693. 1994.
14. 14. Nakashima, S., Chatani, Y., Nakamura, M., Miyoshi, M., Kohno, M. and Nozawa, Y. Tyrosine phosphorylation and activation of mitogen-activated protein kinase by thrombin in human platelets: possible involvement in late arachidonic acid release. Biochem. Biophys. Res. Commun.: 198, 497. 1994.
15. 2-stimulated mitogenesis of coronary artery smooth muscle cells involves activation of mitogen-activated protein kinase and S6 kinase. J. Biol. Chem.: 269, 5693. 1994.
16. 2+ mobilization in rabbit platelets. Eur. J. Pharmacol.: 298, 175. 1996.
17. 2+-dependent arachidonic acid liberation in collagen-stimulated rabbit platelets. Biochem. Pharmacol.: 38, 1841. 1989.
18. 18. Samiei, W., Sanghera, J.S. and Pelech, S.L. Activation of myelin basic protein and S6 peptide kinase in phorbol ester-and PAF-treated sheep platelets. Biochim. Biophys. Acta: 1176, 287. 1993.
19. ras. Proc. Natl. Acad. Sci. USA: 91, 12706. 1994.
20. 20. Winitz, S., Russell, M., Qian, N., Gardner, A., Dwyer, L. and Johnson, G.L. Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase. J. Biol. Chem.: 268, 19196. 1993.
21. 21. Lapetina, E.G., Lacal, J.C., Reep, B.R. and Vedia, L.M.Y. A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets. Proc. Natl. Acad. Sci. USA: 86, 3131. 1989.
22. 22. Golden, A., Nemeth, S.P. and Brugge, J.S. Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets. Proc. Natl. Acad. Sci. USA: 86, 901. 1989.
23. c-src to integrin-dependent cytoskeletal complexs in thrombin-stimulated platelets. Mol. Cell. Biol.: 13, 1863. 1993.
24. 24. Gupta, S.K., Gallego, C., Johnson, G.L. and Heasley, L.E. MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts. J. Biol. Chem.: 267, 7987. 1992.
25. v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase. Proc. Natl. Acad. Sci. USA: 89, 2922. 1992.
26. 26. Papkoff, J., Chen, R-H., Blenis, J. and Forsman, J. p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Mol. Cell. Biol.: 14, 463. 1994.
27. 27. Bennett, J.S., Hoxie, J.A., Leitman, S.F., Vilaire, G. and Cines, D.B. Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody. Proc. Natl. Acad. Sci. USA: 80, 2417. 1983.
28. 28. Gartner, T.K. and Bennett, J.S. The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets. J. Biol. Chem.: 260, 11891. 1985.