The structural basis of substrate activation in yeast pyruvate decarboxylase. A crystallographic and kinetic study

European Journal of Biochemistry

Volumn 267, Issue 3, 2000, Pages 861-868

  Lu, Guoguang ^a,c   Dobritzsch, Doreen ^a,b   Baumann, Sabine ^b,d   Schneider, Gunter ^a   König, Stephan ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY OF BERN   (Switzerland)

^d LUND UNIVERSITY   (Sweden)

Author keywords

Conformational change; Enzyme mechanism; Protein crystallography; Thiamine diphosphate

Indexed keywords

COCARBOXYLASE; CYSTEINE; DIMER; PYRUVATE DECARBOXYLASE; TETRAMER;

ARTICLE; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; ENZYME SUBUNIT; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SACCHAROMYCES CEREVISIAE;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ENZYME ACTIVATION; KINETICS; MODELS, MOLECULAR; PROTEIN STRUCTURE, QUATERNARY; PYRUVATE DECARBOXYLASE; PYRUVATES; PYRUVIC ACID; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY; THIAMINE PYROPHOSPHATE;

SACCHAROMYCES CEREVISIAE;

EID: 0033960918     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01070.x     Document Type: Article

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