Amino acids allosterically regulate the thiamine diphosphate-dependent α-keto acid decarboxylase from Mycobacterium tuberculosis

Journal of Biological Chemistry

Volumn 283, Issue 9, 2008, Pages 5344-5354

  Werther, Tobias ^a   Spinka, Michael ^a   Tittmann, Kai ^a   Schütz, Anja ^a,b   Golbik, Ralph ^a   Mrestani Klaus, Carmen ^a   Hübner, Gerhard ^a   König, Stephan ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINO ACIDS; CARBOXYLATION; ENZYMES; ORGANIC ACIDS;

ACID DEGRADATIONS; BROAD SPECTRUMS; FLOW KINETICS; KETO ACID DECARBOXYLASE; KETO ACIDS; KINETIC EXPERIMENTS; METABOLIC FLOWS; MYCOBACTERIAL ENZYMES; MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS STRAINS; POTENT ACTIVATORS; STEADY STATES; SUBSTRATE SPECIFICITIES; THIAMINE DIPHOSPHATE;

AMINES;

2 OXOACID; AMINO ACID; BACTERIAL ENZYME; CARBOXYLYASE; COCARBOXYLASE; PROTEIN MTKDC; UNCLASSIFIED DRUG; 2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); BACTERIAL PROTEIN; OXOACID;

ALLOSTERISM; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CATALYSIS; CHEMICAL REACTION; DECARBOXYLATION; EHRLICH REACTION; ENZYME ACTIVATION; ENZYME REGULATION; ENZYME SPECIFICITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; RV0853C GENE; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; PHYSIOLOGY;

MYCOBACTERIUM TUBERCULOSIS;

3-METHYL-2-OXOBUTANOATE DEHYDROGENASE (LIPOAMIDE); ALLOSTERIC REGULATION; AMINO ACIDS; BACTERIAL PROTEINS; ENZYME ACTIVATION; KETO ACIDS; KINETICS; MYCOBACTERIUM TUBERCULOSIS; THIAMINE PYROPHOSPHATE;

EID: 41949116525     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706569200     Document Type: Article

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