메뉴 건너뛰기




Volumn 7, Issue 5, 2009, Pages 334-342

The diagnosis and managment of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era

Author keywords

Essential thrombocythemia; JAK2 V617F; Polycythemia vera; Primary myelofibrosis

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA INTERFERON; ANAGRELIDE; ANDROGEN; CORTICOSTEROID; DOXEPIN; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; HYDROXYUREA; INTERFERON; JANUS KINASE 2; LENALIDOMIDE; PAROXETINE; PEGINTERFERON; PREDNISONE; PSORALEN; RECOMBINANT ERYTHROPOIETIN; THALIDOMIDE; ENZYME INHIBITOR;

EID: 66349138550     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (22)

References (92)
  • 1
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet. 2005;365:1054-1061.
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3
  • 2
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couedic JP, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434:1144-1148.
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3
  • 3
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005;352:1779-1790.
    • (2005) N Engl J Med , vol.352 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3
  • 4
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7:387-397.
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 5
    • 20744460045 scopus 로고    scopus 로고
    • Identification of an acquired JAK2 mutation in polycythemia vera
    • Zhao R, Xing S, Li Z, et al. Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem. 2005;280:22788-22792.
    • (2005) J Biol Chem , vol.280 , pp. 22788-22792
    • Zhao, R.1    Xing, S.2    Li, Z.3
  • 7
    • 0017812507 scopus 로고
    • Agnogenic myeloid metaplasia: A clonal proliferation of hematopoietic stem cells with secondary myelofibrosis
    • Jacobson RJ, Salo A, Fialkow PJ. Agnogenic myeloid metaplasia: a clonal proliferation of hematopoietic stem cells with secondary myelofibrosis. Blood. 1978;51:189-194.
    • (1978) Blood , vol.51 , pp. 189-194
    • Jacobson, R.J.1    Salo, A.2    Fialkow, P.J.3
  • 8
    • 0019818299 scopus 로고
    • Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell
    • Fialkow PJ, Faguet GB, Jacobson RJ, Vaidya K, Murphy S. Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood. 1981;58:916-919.
    • (1981) Blood , vol.58 , pp. 916-919
    • Fialkow, P.J.1    Faguet, G.B.2    Jacobson, R.J.3    Vaidya, K.4    Murphy, S.5
  • 9
    • 0036786901 scopus 로고    scopus 로고
    • The World Health Organization (WHO) classification of the myeloid neoplasms
    • Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002; 100:2292-2302.
    • (2002) Blood , vol.100 , pp. 2292-2302
    • Vardiman, J.W.1    Harris, N.L.2    Brunning, R.D.3
  • 10
    • 38349101871 scopus 로고    scopus 로고
    • Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms
    • Tefferi A, Vardiman JW. Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia. 2008;22:14-22.
    • (2008) Leukemia , vol.22 , pp. 14-22
    • Tefferi, A.1    Vardiman, J.W.2
  • 11
    • 33745623666 scopus 로고    scopus 로고
    • Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders
    • Bellanne-Chantelot C, Chaumarel I, Labopin M, et al. Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders. Blood. 2006;108:346-352.
    • (2006) Blood , vol.108 , pp. 346-352
    • Bellanne-Chantelot, C.1    Chaumarel, I.2    Labopin, M.3
  • 12
    • 54049129782 scopus 로고    scopus 로고
    • Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24,577 first-degree relatives of 11,039 patients with myeloproliferative neoplasms in Sweden
    • Landgren O, Goldin LR, Kristinsson SY, Helgadottir EA, Samuelsson J, Bjorkholm M. Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24,577 first-degree relatives of 11,039 patients with myeloproliferative neoplasms in Sweden. Blood. 2008;112:2199-204.
    • (2008) Blood , vol.112 , pp. 2199-2204
    • Landgren, O.1    Goldin, L.R.2    Kristinsson, S.Y.3    Helgadottir, E.A.4    Samuelsson, J.5    Bjorkholm, M.6
  • 13
    • 0028055045 scopus 로고
    • Identification of masked polycythemia vera from patients with idiopathic marked thrombocytosis by endogenous erythroid colony assay
    • Shih LY, Lee CT. Identification of masked polycythemia vera from patients with idiopathic marked thrombocytosis by endogenous erythroid colony assay. Blood. 1994;83:744-748.
    • (1994) Blood , vol.83 , pp. 744-748
    • Shih, L.Y.1    Lee, C.T.2
  • 14
    • 0036041873 scopus 로고    scopus 로고
    • Myelofibrosis with myeloid metaplasia following essential thrombocythaemia: Actuarial probability, presenting characteristics and evolution in a series of 195 patients
    • Cervantes F, Alvarez-Larran A, Talarn C, Gomez M, Montserrat E. Myelofibrosis with myeloid metaplasia following essential thrombocythaemia: actuarial probability, presenting characteristics and evolution in a series of 195 patients. Br J Haematol. 2002;118:786-790.
    • (2002) Br J Haematol , vol.118 , pp. 786-790
    • Cervantes, F.1    Alvarez-Larran, A.2    Talarn, C.3    Gomez, M.4    Montserrat, E.5
  • 15
    • 0001068989 scopus 로고
    • Myelofibrosis. Clinical, hematologic and pathologic study of 110 patients
    • Bouroncle BA, Doan CA. Myelofibrosis. Clinical, hematologic and pathologic study of 110 patients. Am J Med Sci. 1962;243:697-715.
    • (1962) Am J Med Sci , vol.243 , pp. 697-715
    • Bouroncle, B.A.1    Doan, C.A.2
  • 17
    • 47649121826 scopus 로고    scopus 로고
    • The revised World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: An alternative proposal
    • Spivak JL, Silver RT. The revised World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: an alternative proposal. Blood. 2008;112:231-239.
    • (2008) Blood , vol.112 , pp. 231-239
    • Spivak, J.L.1    Silver, R.T.2
  • 18
    • 0035760303 scopus 로고    scopus 로고
    • Diagnostic and clinical relevance of the number of circulating CD34(+) cells in myelofibrosis with myeloid metaplasia
    • Barosi G, Viarengo G, Pecci A, et al. Diagnostic and clinical relevance of the number of circulating CD34(+) cells in myelofibrosis with myeloid metaplasia. Blood. 2001;98:3249-3255.
    • (2001) Blood , vol.98 , pp. 3249-3255
    • Barosi, G.1    Viarengo, G.2    Pecci, A.3
  • 19
    • 0242299235 scopus 로고    scopus 로고
    • Clinical utility of the absolute number of circulating CD34-positive cells in patients with chronic myeloproliferative disorders
    • Passamonti F, Vanelli L, Malabarba L, et al. Clinical utility of the absolute number of circulating CD34-positive cells in patients with chronic myeloproliferative disorders. Haematologica. 2003;88:1123-1129.
    • (2003) Haematologica , vol.88 , pp. 1123-1129
    • Passamonti, F.1    Vanelli, L.2    Malabarba, L.3
  • 20
    • 33846660947 scopus 로고    scopus 로고
    • JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
    • Scott LM, Tong W, Levine RL, et al. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med. 2007;356:459-468.
    • (2007) N Engl J Med , vol.356 , pp. 459-468
    • Scott, L.M.1    Tong, W.2    Levine, R.L.3
  • 21
    • 35448963775 scopus 로고    scopus 로고
    • Phenotypic variations and new mutations in JAK2 V617F-negative polycythemia vera, erythrocytosis, and primary myelofibrosis
    • Williams DM, Kim AH, Rogers O, Spivak JL, Moliterno AR. Phenotypic variations and new mutations in JAK2 V617F-negative polycythemia vera, erythrocytosis, and primary myelofibrosis. Exp Hematol. 2007;35:1641-1646.
    • (2007) Exp Hematol , vol.35 , pp. 1641-1646
    • Williams, D.M.1    Kim, A.H.2    Rogers, O.3    Spivak, J.L.4    Moliterno, A.R.5
  • 22
    • 21344467318 scopus 로고    scopus 로고
    • Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
    • Jones AV, Kreil S, Zoi K, et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood. 2005;106:2162-2168.
    • (2005) Blood , vol.106 , pp. 2162-2168
    • Jones, A.V.1    Kreil, S.2    Zoi, K.3
  • 23
    • 25844447519 scopus 로고    scopus 로고
    • JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia
    • Jelinek J, Oki Y, Gharibyan V, et al. JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood. 2005;106:3370-3373.
    • (2005) Blood , vol.106 , pp. 3370-3373
    • Jelinek, J.1    Oki, Y.2    Gharibyan, V.3
  • 24
    • 38549176801 scopus 로고    scopus 로고
    • JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis
    • Schmitt-Graeff AH, Teo SS, Olschewski M, et al. JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis. Haematologica. 2008;93:34-40.
    • (2008) Haematologica , vol.93 , pp. 34-40
    • Schmitt-Graeff, A.H.1    Teo, S.S.2    Olschewski, M.3
  • 25
    • 33750534561 scopus 로고    scopus 로고
    • MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients
    • Pardanani AD, Levine RL, Lasho T, et al. MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients. Blood. 2006; 108:3472-3476.
    • (2006) Blood , vol.108 , pp. 3472-3476
    • Pardanani, A.D.1    Levine, R.L.2    Lasho, T.3
  • 26
    • 33845239214 scopus 로고    scopus 로고
    • Molecular mimicry in the chronic myeloproliferative disorders: Reciprocity between quantitative JAK2 V617F and Mpl expression
    • Moliterno AR, Williams DM, Rogers O, Spivak JL. Molecular mimicry in the chronic myeloproliferative disorders: reciprocity between quantitative JAK2 V617F and Mpl expression. Blood. 2006;108:3913-3915.
    • (2006) Blood , vol.108 , pp. 3913-3915
    • Moliterno, A.R.1    Williams, D.M.2    Rogers, O.3    Spivak, J.L.4
  • 27
    • 53749103194 scopus 로고    scopus 로고
    • Phenotypic variability within the JAK2 V617F-positive MPD: Roles of progenitor cell and neutrophil allele burdens
    • Epub ahead of print
    • Moliterno AR, Williams DM, Rogers O, Isaacs MA, Spivak JL. Phenotypic variability within the JAK2 V617F-positive MPD: Roles of progenitor cell and neutrophil allele burdens. Exp Hematol. 2008; Epub ahead of print
    • (2008) Exp Hematol
    • Moliterno, A.R.1    Williams, D.M.2    Rogers, O.3    Isaacs, M.A.4    Spivak, J.L.5
  • 28
    • 34548136101 scopus 로고    scopus 로고
    • Prospective identification of high-risk polycythemia vera patients based on JAK2(V617F) allele burden
    • Vannucchi AM, Antonioli E, Guglielmelli P, et al. Prospective identification of high-risk polycythemia vera patients based on JAK2(V617F) allele burden. Leukemia. 2007;21:1952-1959.
    • (2007) Leukemia , vol.21 , pp. 1952-1959
    • Vannucchi, A.M.1    Antonioli, E.2    Guglielmelli, P.3
  • 29
    • 28244442441 scopus 로고    scopus 로고
    • Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: A prospective study
    • Campbell PJ, Scott LM, Buck G, et al. Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study. Lancet. 2005;366:1945-1953.
    • (2005) Lancet , vol.366 , pp. 1945-1953
    • Campbell, P.J.1    Scott, L.M.2    Buck, G.3
  • 30
    • 34347394712 scopus 로고    scopus 로고
    • Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation
    • Theocharides A, Boissinot M, Girodon F, et al. Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation. Blood. 2007;110:375-79.
    • (2007) Blood , vol.110 , pp. 375-379
    • Theocharides, A.1    Boissinot, M.2    Girodon, F.3
  • 31
    • 33747199312 scopus 로고    scopus 로고
    • Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders
    • Kralovics R, Teo SS, Li S, et al. Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders. Blood. 2006;108:1377-1380.
    • (2006) Blood , vol.108 , pp. 1377-1380
    • Kralovics, R.1    Teo, S.S.2    Li, S.3
  • 32
    • 33845755386 scopus 로고    scopus 로고
    • Polycythemia vera is not initiated by JAK2V617F mutation
    • Nussenzveig RH, Swierczek SI, Jelinek J, et al. Polycythemia vera is not initiated by JAK2V617F mutation. Exp Hematol. 2007;35:32-38.
    • (2007) Exp Hematol , vol.35 , pp. 32-38
    • Nussenzveig, R.H.1    Swierczek, S.I.2    Jelinek, J.3
  • 33
    • 0141574207 scopus 로고    scopus 로고
    • The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis
    • Ruggeri M, Tosetto A, Frezzato M, Rodeghiero F. The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis. Ann Intern Med. 2003; 139:470-475.
    • (2003) Ann Intern Med , vol.139 , pp. 470-475
    • Ruggeri, M.1    Tosetto, A.2    Frezzato, M.3    Rodeghiero, F.4
  • 34
    • 33645461067 scopus 로고    scopus 로고
    • The incidence of the JAK2 V617F mutation in patients with idiopathic erythrocytosis
    • Percy MJ, Jones FG, Green AR, Reilly JT, McMullin MF. The incidence of the JAK2 V617F mutation in patients with idiopathic erythrocytosis. Haematologica. 2006;91:413-414.
    • (2006) Haematologica , vol.91 , pp. 413-414
    • Percy, M.J.1    Jones, F.G.2    Green, A.R.3    Reilly, J.T.4    McMullin, M.F.5
  • 35
    • 0023631485 scopus 로고
    • The contracted plasma volume syndromes (relative polycythaemias) and their haemorheological significance
    • Isbister JP. The contracted plasma volume syndromes (relative polycythaemias) and their haemorheological significance. Baillieres Clin Haematol. 1987;1: 665-693.
    • (1987) Baillieres Clin Haematol , vol.1 , pp. 665-693
    • Isbister, J.P.1
  • 36
    • 0021140690 scopus 로고
    • Interpretation of measured red cell mass and plasma volume in males with elevated venous, PCV values
    • Pearson TC, Botterill CA, Glass UH, Wetherley-Mein G. Interpretation of measured red cell mass and plasma volume in males with elevated venous, PCV values. Scand J Haematol. 1984;33:68-74.
    • (1984) Scand J Haematol , vol.33 , pp. 68-74
    • Pearson, T.C.1    Botterill, C.A.2    Glass, U.H.3    Wetherley-Mein, G.4
  • 38
    • 0037114625 scopus 로고    scopus 로고
    • Polycythemia vera: Myths, mechanisms and management
    • Spivak, JL. Polycythemia vera: myths, mechanisms and management. Blood. 2002; 100:4272-90.
    • (2002) Blood , vol.100 , pp. 4272-4290
    • Spivak, J.L.1
  • 39
    • 0022703827 scopus 로고
    • Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and second hematologic malignancies
    • Ellis JT, Peterson P, Geller SA, Rappaport H. Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and second hematologic malignancies. Semin Hematol. 1986;23:144-155.
    • (1986) Semin Hematol , vol.23 , pp. 144-155
    • Ellis, J.T.1    Peterson, P.2    Geller, S.A.3    Rappaport, H.4
  • 40
    • 2342631195 scopus 로고    scopus 로고
    • Congenital disorder of oxygen-sensing: Association of the homozygous Chuvash polycythernia VHL mutation with thrombosis and vascular abnormalities but not tumors
    • Gordeak VR, Sergueeva AI, Miasnikova GY, et al. Congenital disorder of oxygen-sensing: association of the homozygous Chuvash polycythernia VHL mutation with thrombosis and vascular abnormalities but not tumors. Blood. 2004;103:3924-3932.
    • (2004) Blood , vol.103 , pp. 3924-3932
    • Gordeak, V.R.1    Sergueeva, A.I.2    Miasnikova, G.Y.3
  • 41
    • 0031051391 scopus 로고    scopus 로고
    • Inapparent polycythemia vera: An unrecognized diagnosis
    • Lamy T, Devillers A, Bernard M, et al. Inapparent polycythemia vera: an unrecognized diagnosis. Am J Med. 1997;102:14-20.
    • (1997) Am J Med , vol.102 , pp. 14-20
    • Lamy, T.1    Devillers, A.2    Bernard, M.3
  • 42
    • 39149090683 scopus 로고    scopus 로고
    • Classification of myeloproliferative disorders in the JAK2 era: Is there a role for red cell mass?
    • Cassinat B, Laguillier C, Gardin C, et al. Classification of myeloproliferative disorders in the JAK2 era: is there a role for red cell mass? Leukemia. 2008;22: 452-453.
    • (2008) Leukemia , vol.22 , pp. 452-453
    • Cassinat, B.1    Laguillier, C.2    Gardin, C.3
  • 43
    • 34548042964 scopus 로고    scopus 로고
    • Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycytherma vera, essential dirombocythemia, and primary myelofibrosis: Recommendations from an ad hoc international expert panel
    • Tefferi A, Thiele J, Orazi A, et al. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycytherma vera, essential dirombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood. 2007;110:1092-1097.
    • (2007) Blood , vol.110 , pp. 1092-1097
    • Tefferi, A.1    Thiele, J.2    Orazi, A.3
  • 44
    • 38049188368 scopus 로고    scopus 로고
    • Bone marrow pathology in essential thrombocythemia: Interobserver reliability and utility for identifying disease subtypes
    • Wilkins BS, Erber WN, Bareford D, et al. Bone marrow pathology in essential thrombocythemia: interobserver reliability and utility for identifying disease subtypes. Blood. 2008;111:60-70.
    • (2008) Blood , vol.111 , pp. 60-70
    • Wilkins, B.S.1    Erber, W.N.2    Bareford, D.3
  • 46
    • 8344229870 scopus 로고    scopus 로고
    • Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia
    • Passamonti F, Rumi E, Pungofino E, et al. Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia. Am J Med. 2004;117:755-761.
    • (2004) Am J Med , vol.117 , pp. 755-761
    • Passamonti, F.1    Rumi, E.2    Pungofino, E.3
  • 47
    • 0025820104 scopus 로고
    • Life expectancy of patients with chronic nouleukemic myeloproliferative disorders
    • Rozman C, Giralt M, Feliu E, Rubio D, Cortes MT. Life expectancy of patients with chronic nouleukemic myeloproliferative disorders. Cancer. 1991;67:2658-2663.
    • (1991) Cancer , vol.67 , pp. 2658-2663
    • Rozman, C.1    Giralt, M.2    Feliu, E.3    Rubio, D.4    Cortes, M.T.5
  • 48
    • 0029767865 scopus 로고    scopus 로고
    • Prognostic factors in agnogenic myeloid metaplasia: A report on 195 cases with a new scoring system
    • Dupriez B, Morel P, Demory JL, et al. Prognostic factors in agnogenic myeloid metaplasia: a report on 195 cases with a new scoring system. Blood. 1996;88: 1013-1018.
    • (1996) Blood , vol.88 , pp. 1013-1018
    • Dupriez, B.1    Morel, P.2    Demory, J.L.3
  • 49
    • 0031003622 scopus 로고    scopus 로고
    • Identification of 'short-lived' and 'long-lived' patients at presentation of primary myelofibrosis
    • Cervantes F, Pereira A. Esteve J, et al. Identification of 'short-lived' and 'long-lived' patients at presentation of primary myelofibrosis. Br J Haematol. 1997;97:635-640.
    • (1997) Br J Haematol , vol.97 , pp. 635-640
    • Cervantes, F.1    Pereira, A.2    Esteve, J.3
  • 50
    • 61749095586 scopus 로고    scopus 로고
    • A new prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treaunent
    • Cervantes F, Dupriez B, Pereira A et al. A new prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treaunent. Blood. 2008.
    • (2008) Blood
    • Cervantes, F.1    Dupriez, B.2    Pereira, A.3
  • 51
    • 13444256042 scopus 로고    scopus 로고
    • Thrombosis and haemorrhage in polycythaemia vera and essential dirombocythaemia
    • Elliott MA, Tefferi A. Thrombosis and haemorrhage in polycythaemia vera and essential dirombocythaemia. Br J Haematol. 2005;128:275-90.
    • (2005) Br J Haematol , vol.128 , pp. 275-290
    • Elliott, M.A.1    Tefferi, A.2
  • 52
    • 0030784247 scopus 로고    scopus 로고
    • Treatment of polycythemia vera: The use of hydroxyurea and pipobroman in 292 patients under the age of 65 years
    • Najean Y, Rain JD. Treatment of polycythemia vera: the use of hydroxyurea and pipobroman in 292 patients under the age of 65 years. Blood. 1997;90: 370-3377.
    • (1997) Blood , vol.90 , pp. 370-3377
    • Najean, Y.1    Rain, J.D.2
  • 53
    • 33745714754 scopus 로고    scopus 로고
    • Long-term incidence of hematological evolution in three French prospective studies of hydroxyurea and pipobroman in polycythemia vera and essential thrombocythemia
    • Kiladjian JJ, Rain JD, Bernard JF, Briere J, Chomientic C, Fenaux R Long-term incidence of hematological evolution in three French prospective studies of hydroxyurea and pipobroman in polycythemia vera and essential thrombocythemia. Semin Thromb Hemost. 2006;32:417-421.
    • (2006) Semin Thromb Hemost , vol.32 , pp. 417-421
    • Kiladjian, J.J.1    Rain, J.D.2    Bernard, J.F.3    Briere, J.4    Chomientic, C.5    Fenaux, R.6
  • 54
    • 0016793754 scopus 로고
    • Diagnosis and classification of the polycythemias
    • Berlin NI. Diagnosis and classification of the polycythemias. Semin Hematol. 1975;12:339-351.
    • (1975) Semin Hematol , vol.12 , pp. 339-351
    • Berlin, N.I.1
  • 55
    • 0028844554 scopus 로고
    • Polycythemia vera: The natural history of 1213 patients followed for 20 years. Gruppo Italiano Studio Policitemia
    • Polycythemia vera: the natural history of 1213 patients followed for 20 years. Gruppo Italiano Studio Policitemia. Ann Intern Med. 1995;123:656-664.
    • (1995) Ann Intern Med , vol.123 , pp. 656-664
  • 56
    • 20444502966 scopus 로고    scopus 로고
    • Risk-adapted therapy in essential thrombocythemia and polycydiemia vera
    • Finazzi G, Barbui T. Risk-adapted therapy in essential thrombocythemia and polycydiemia vera. Blood Rev. 2005;19:243-252.
    • (2005) Blood Rev , vol.19 , pp. 243-252
    • Finazzi, G.1    Barbui, T.2
  • 57
    • 0027227873 scopus 로고
    • Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution in plasma
    • Budde U, Scharf RE, Franke P, Hartmann-Budde K, Dent J, Ruggeri ZM. Elevated platelet count as a cause of abnormal von Willebrand factor multimer distribution in plasma. Blood 1993;82:1749-1757.
    • (1993) Blood , vol.82 , pp. 1749-1757
    • Budde, U.1    Scharf, R.E.2    Franke, P.3    Hartmann-Budde, K.4    Dent, J.5    Ruggeri, Z.M.6
  • 58
    • 0018181405 scopus 로고
    • Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia
    • Pearson TC, Weatherly-Mein G. Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia. Lancet. 1978;2:1219-1221.
    • (1978) Lancet , vol.2 , pp. 1219-1221
    • Pearson, T.C.1    Weatherly-Mein, G.2
  • 60
    • 0027328511 scopus 로고
    • The efficacy of psoralen photochemotherapy in the treatment of aquagenic, pruritus
    • Menagé HD, Norris PG, Hawk JL, Graves MW. The efficacy of psoralen photochemotherapy in the treatment of aquagenic, pruritus. Br J Dermatol. 1993; 129:163-165.
    • (1993) Br J Dermatol , vol.129 , pp. 163-165
    • Menagé, H.D.1    Norris, P.G.2    Hawk, J.L.3    Graves, M.W.4
  • 61
    • 0027254816 scopus 로고
    • Relief of intractable pruritus in polycydiemia vera with recombinant interferon alla
    • Finelli C, Gugliotta L, Gamberi B, Vianelli N, Visani G, Tura S. Relief of intractable pruritus in polycydiemia vera with recombinant interferon alla. Am J Hematol. 1993;43:316-318.
    • (1993) Am J Hematol , vol.43 , pp. 316-318
    • Finelli, C.1    Gugliotta, L.2    Gamberi, B.3    Vianelli, N.4    Visani, G.5    Tura, S.6
  • 62
    • 34249983486 scopus 로고    scopus 로고
    • How I treat patients with polycythemia vera
    • Finazzi G, Barbui T. How I treat patients with polycythemia vera. Blood. 2007;109:5104-5111.
    • (2007) Blood , vol.109 , pp. 5104-5111
    • Finazzi, G.1    Barbui, T.2
  • 64
    • 55549132620 scopus 로고    scopus 로고
    • Frequent reduction or absence of detection of the JAK2-mutated done in JAK2V617F-positive patients within the first years of hydroxyurea therapy
    • Girodon F, Schaeffer C, Cleyrat C et al. Frequent reduction or absence of detection of the JAK2-mutated done in JAK2V617F-positive patients within the first years of hydroxyurea therapy. Haematologica. 2008;93:1723-1727.
    • (2008) Haematologica , vol.93 , pp. 1723-1727
    • Girodon, F.1    Schaeffer, C.2    Cleyrat, C.3
  • 65
    • 67349105550 scopus 로고    scopus 로고
    • Hydrgxyufea (HU) is effective in reducing JAK2V617F mutated done size in the peripheral blood of essential thrombocythernia (ET) and polycythemia vera (PV) patients
    • Dec 19. Epub ahead of print
    • Spanoudakis E, Bazdiara I, Kotsianidis I et al. Hydrgxyufea (HU) is effective in reducing JAK2V617F mutated done size in the peripheral blood of essential thrombocythernia (ET) and polycythemia vera (PV) patients. Ann Hematol 2008 Dec 19. Epub ahead of print.
    • (2008) Ann Hematol
    • Spanoudakis, E.1    Bazdiara, I.2    Kotsianidis, I.3
  • 66
    • 54049141336 scopus 로고    scopus 로고
    • Pegylated interferon-affa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera
    • Kiladrian JJ, Cassinat B, Chevret S, et al. Pegylated interferon-affa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera. Blood. 2008;112:3065-3072.
    • (2008) Blood , vol.112 , pp. 3065-3072
    • Kiladrian, J.J.1    Cassinat, B.2    Chevret, S.3
  • 67
    • 33947208087 scopus 로고    scopus 로고
    • Leukocytosis as a major thrombodc risk factor in patients with polycydiemia vera
    • Landolfi R, Di Gennaro L, Barbui T, et al. Leukocytosis as a major thrombodc risk factor in patients with polycydiemia vera. Blood. 2007;109:2446-2452.
    • (2007) Blood , vol.109 , pp. 2446-2452
    • Landolfi, R.1    Di Gennaro, L.2    Barbui, T.3
  • 68
    • 43549125836 scopus 로고    scopus 로고
    • A dynamic prognostic model to predict survival in post-polycythemia vera myclofibrosis
    • Passamonti F, Rumi E, Caramella M, et al. A dynamic prognostic model to predict survival in post-polycythemia vera myclofibrosis. Blood. 2008;111:3383-3387.
    • (2008) Blood , vol.111 , pp. 3383-3387
    • Passamonti, F.1    Rumi, E.2    Caramella, M.3
  • 69
    • 21444434751 scopus 로고    scopus 로고
    • Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia
    • Harrison CN, Campbell PJ, Buck G, et al. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med. 2005;353: 33-45.
    • (2005) N Engl J Med , vol.353 , pp. 33-45
    • Harrison, C.N.1    Campbell, P.J.2    Buck, G.3
  • 70
    • 0028913012 scopus 로고
    • Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis
    • Cortelazzo S, Finazzi G, Ruggeri M, et al. Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. N Engl J Med. 1995; 332:1132-1136.
    • (1995) N Engl J Med , vol.332 , pp. 1132-1136
    • Cortelazzo, S.1    Finazzi, G.2    Ruggeri, M.3
  • 71
    • 0346727336 scopus 로고    scopus 로고
    • Efficacy and safety of low-dose aspirin in polycythemia vera
    • Landolfi R, Marchioli R, Kutti J, et al. Efficacy and safety of low-dose aspirin in polycythemia vera. N Engl J Med. 2004;350:114-124.
    • (2004) N Engl J Med , vol.350 , pp. 114-124
    • Landolfi, R.1    Marchioli, R.2    Kutti, J.3
  • 72
    • 3042513955 scopus 로고    scopus 로고
    • A prospective analysis of thrombotic events in the European collaboration study on low-dose aspirin in polycythemia (ECLAP)
    • Finazzi G. A prospective analysis of thrombotic events in the European collaboration study on low-dose aspirin in polycythemia (ECLAP). Pathol Biol (Paris). 2004;52:285-288.
    • (2004) Pathol Biol (Paris) , vol.52 , pp. 285-288
    • Finazzi, G.1
  • 73
    • 44949094483 scopus 로고    scopus 로고
    • Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia
    • CD006503
    • Squizzato A. Romualdi E, Middeldorp S. Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia. Cochrane Database Syst Rev. 2008;(2): CD006503.
    • (2008) Cochrane Database Syst Rev , Issue.2
    • Squizzato, A.1    Romualdi, E.2    Middeldorp, S.3
  • 74
    • 0030887759 scopus 로고    scopus 로고
    • Prevention and treatment of thrombotic complications in essential thrombocythaemia: Efficacy and safety of aspirin
    • van Genderen PJ, Mulder PG, Waleboer M, van de Moesdijk D, Michiels JJ. Prevention and treatment of thrombotic complications in essential thrombocythaemia: efficacy and safety of aspirin. Br J Haematol. 1997;97:179-184.
    • (1997) Br J Haematol , vol.97 , pp. 179-184
    • van Genderen, P.J.1    Mulder, P.G.2    Waleboer, M.3    van de Moesdijk, D.4    Michiels, J.J.5
  • 76
    • 54049086618 scopus 로고    scopus 로고
    • Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythernia
    • Carobbio A, Finazzi G, Antonioli E, et al. Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythernia. Blood. 2008;112:3135-3137.
    • (2008) Blood , vol.112 , pp. 3135-3137
    • Carobbio, A.1    Finazzi, G.2    Antonioli, E.3
  • 77
    • 33749351784 scopus 로고    scopus 로고
    • Management of extreme dirombocytosis in otherwise low-risk essential thrombocythemia; does number matter?
    • Tefferi A, Gangat N, Wolanskyj AP. Management of extreme dirombocytosis in otherwise low-risk essential thrombocythemia; does number matter? Blood. 2006;108:2493-2494.
    • (2006) Blood , vol.108 , pp. 2493-2494
    • Tefferi, A.1    Gangat, N.2    Wolanskyj, A.P.3
  • 78
    • 0034988764 scopus 로고    scopus 로고
    • Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia
    • Tefferi A, Mesa RA, Schroeder G, Hanson CA, Li CY, Dewald GW. Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia. Br J Haematol. 2001;113:763-771.
    • (2001) Br J Haematol , vol.113 , pp. 763-771
    • Tefferi, A.1    Mesa, R.A.2    Schroeder, G.3    Hanson, C.A.4    Li, C.Y.5    Dewald, G.W.6
  • 79
    • 10744230038 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation for myelofibrosis
    • Deeg HJ, Gooley TA, Flowers ME, et al. Allogeneic hematopoietic stem cell transplantation for myelofibrosis. Blood. 2003;102:3912-3918.
    • (2003) Blood , vol.102 , pp. 3912-3918
    • Deeg, H.J.1    Gooley, T.A.2    Flowers, M.E.3
  • 80
    • 0033135848 scopus 로고    scopus 로고
    • Allogeneic stein cell transplantation for agnogenic myeloid metaplasia: A European Group for Blood and Marrow Transplantation, Societe Francaise dc Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study
    • Guardiola P, Anderson JE, Bandini G, et al. Allogeneic stein cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Societe Francaise dc Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study. Blood. 1999;93:2831-2838.
    • (1999) Blood , vol.93 , pp. 2831-2838
    • Guardiola, P.1    Anderson, J.E.2    Bandini, G.3
  • 81
    • 20844457922 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediate-or high-risk patients with myelofibrosis with myeloid mccaplasia
    • Rondelli D, Barosi G, Bacigalupo A, et al. Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediate-or high-risk patients with myelofibrosis with myeloid mccaplasia. Blood. 2005; 105:4115-4119.
    • (2005) Blood , vol.105 , pp. 4115-4119
    • Rondelli, D.1    Barosi, G.2    Bacigalupo, A.3
  • 82
    • 33745811661 scopus 로고    scopus 로고
    • Palliative goals, patient selection, and perioperative platelet management: Outcomes and lessons from 3 decades of splenectomy for myelofibrosis with mycloid metaplasia at the Mayo Clinic
    • Mesa RA, Nagorney DS, Schwager S, Allred J, Tefferi A. Palliative goals, patient selection, and perioperative platelet management: outcomes and lessons from 3 decades of splenectomy for myelofibrosis with mycloid metaplasia at the Mayo Clinic. Cancer. 2006;107:361-370.
    • (2006) Cancer , vol.107 , pp. 361-370
    • Mesa, R.A.1    Nagorney, D.S.2    Schwager, S.3    Allred, J.4    Tefferi, A.5
  • 83
    • 0031784441 scopus 로고    scopus 로고
    • Splenic irradiation for symptomatic splenomegaly associated with myelofibrosis with myeloid metaplasia
    • Elliott MA, Chen MG, Silverstein MN, Tefferi A. Splenic irradiation for symptomatic splenomegaly associated with myelofibrosis with myeloid metaplasia. Br J Haematol. 1998;103:505-511.
    • (1998) Br J Haematol , vol.103 , pp. 505-511
    • Elliott, M.A.1    Chen, M.G.2    Silverstein, M.N.3    Tefferi, A.4
  • 85
    • 8844269106 scopus 로고    scopus 로고
    • Erythropoietin treatment of the anaernia of myelofibrosis with myeloid metaplasia: Results in 20 patients and review of the literature
    • Cervantes F, Alvarez-Larran A, Hernandez-Boluda JC, Sureda A, Torrebadell M, Montserrat E. Erythropoietin treatment of the anaernia of myelofibrosis with myeloid metaplasia: results in 20 patients and review of the literature. Br J Haematol. 2004;127:399-403.
    • (2004) Br J Haematol , vol.127 , pp. 399-403
    • Cervantes, F.1    Alvarez-Larran, A.2    Hernandez-Boluda, J.C.3    Sureda, A.4    Torrebadell, M.5    Montserrat, E.6
  • 86
    • 0012889254 scopus 로고    scopus 로고
    • A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia
    • Mesa RA, Steensma DR Pardanani A. et al. A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia. Blood. 2003;101:2534-2541.
    • (2003) Blood , vol.101 , pp. 2534-2541
    • Mesa, R.A.1    Steensma, D.R.2    Pardanani, A.3
  • 87
    • 33747167338 scopus 로고    scopus 로고
    • Lenalidomide therapy in myelofibrosis with myeloid metaplasia
    • Tefferi A, Cortes J, Verstovsek S, et al. Lenalidomide therapy in myelofibrosis with myeloid metaplasia. Blood. 2006;108:1158-1164.
    • (2006) Blood , vol.108 , pp. 1158-1164
    • Tefferi, A.1    Cortes, J.2    Verstovsek, S.3
  • 88
    • 33745714752 scopus 로고    scopus 로고
    • Essential thrombocythemia/ polycythemia vera and pregnancy: The need for an observational study in Europe
    • Griesshammer M, Struve S, Harrison CM. Essential thrombocythemia/ polycythemia vera and pregnancy: the need for an observational study in Europe. Semin Thromb Hemost. 2006;32:422-429.
    • (2006) Semin Thromb Hemost , vol.32 , pp. 422-429
    • Griesshammer, M.1    Struve, S.2    Harrison, C.M.3
  • 89
    • 34547130084 scopus 로고    scopus 로고
    • Thrombocytosis, pregnancy, and regression toward the mean
    • Spivak JL. Thrombocytosis, pregnancy, and regression toward the mean. Blood. 2008;110:472-473.
    • (2008) Blood , vol.110 , pp. 472-473
    • Spivak, J.L.1
  • 90
    • 34547122759 scopus 로고    scopus 로고
    • Increased risk ofpregnancy complications in patients with essential dirombocythemia carrying the JAK2 (617V>F) mutation
    • Passamond F, Randi ML, Rumi E, et al. Increased risk ofpregnancy complications in patients with essential dirombocythemia carrying the JAK2 (617V>F) mutation. Blood. 2007;110:485-489.
    • (2007) Blood , vol.110 , pp. 485-489
    • Passamond, F.1    Randi, M.L.2    Rumi, E.3
  • 91
    • 0023945705 scopus 로고
    • Transient suppression of clonal hemopoiesis associated with pregnancy in a patient with a myeloproliferative disorder
    • Turhan AG, Humphries RK, Cashman JD, Cuthbert DA, Eaves CJ, Eaves AC. Transient suppression of clonal hemopoiesis associated with pregnancy in a patient with a myeloproliferative disorder. J Chn Invest. 1988;81:1999-2003.
    • (1988) J Chn Invest , vol.81 , pp. 1999-2003
    • Turhan, A.G.1    Humphries, R.K.2    Cashman, J.D.3    Cuthbert, D.A.4    Eaves, C.J.5    Eaves, A.C.6
  • 92
    • 0036178744 scopus 로고    scopus 로고
    • The optimal management of polycythemia vera
    • Spivak JL. The optimal management of polycythemia vera. Br J Haematol. 2002;116:243.
    • (2002) Br J Haematol , vol.116 , pp. 243
    • Spivak, J.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.