Peripheral cytokine profile in Chilean patients with Crohn's disease and ulcerative colitis

European Cytokine Network

Volumn 20, Issue 1, 2009, Pages 33-38

  Beltrán, Caroll J ^a,b   Candia, Enzo ^a   Erranz, Benjamín ^a   Figueroa, Carolina ^b   Gonzalez, Maria J ^c   Quera, Rodrigo ^b,d   Hermoso, Marcela A ^a,c  

^a UNIVERSITY OF CHILE   (Chile)

^b HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

^c UNIVERSITY OF CHILE   (Chile)

^d CLÍNICA LAS CONDES   (Chile)

Author keywords

Crohn disease; Cytokines; Inflammatory bowel disease; Interferon gamma; Th17; Ulcerative colitis

Indexed keywords

CALCIMYCIN; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 5; PHORBOL ESTER;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CELL LEVEL; CELL POPULATION; CELLULAR IMMUNITY; CHILE; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; MESENCHYMAL STEM CELL; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; TH1 CELL; TH17 CELL; TH2 CELL; ULCERATIVE COLITIS; UNIVERSITY HOSPITAL;

ADULT; AGED; CHILE; COLITIS, ULCERATIVE; CROHN DISEASE; CYTOKINES; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERFERON-GAMMA; INTERLEUKIN-17; MALE; MIDDLE AGED; TH1 CELLS; TH17 CELLS; TH2 CELLS;

EID: 66249138836     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: 10.1684/ecn.2009.0142     Document Type: Article

References (40)

1. Figueroa C, Quera R, Valenzuela J, Jensen C. Enfermedad Inflamatoria Intestinal: Experiencia de Dos Centros. Rev Med Chil 2005; 133: 1295-1304
2. Sandborn WJ. Serologic markers in inflammatory bowel disease: state of the art. Rev Gastroenterol Disord 2004; 4: 167-174 (Pubitemid 40012216)
3. Guindi M, Riddell RH. Indeterminate colitis. J Clin Pathol 2004; 57: 1233-1244 (Pubitemid 39611504)
4. Russel MG, Stockbrugger RW. Epidemiology of inflammatory bowel disease: an update. Scand J Gastroenterol 1996; 31: 417-427 (Pubitemid 26153633)
5. Sepulveda SE, Beltran CJ, Peralta A, et al. Rev Med Chil 2008; 136: 367-375 [Inflammatory bowel diseases: an immunological approach].
6. Duchmann R, Kaiser I, Hermann E, Mayet W, Ewe K, Meyer zum Buschenfelde KH. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 1995; 102: 448-455
7. Rogler G. Update in inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol 2004; 20: 311-317 (Pubitemid 38813671)
8. Stagg AJ, Hart AL, Knight SC, Kamm MA. The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut 2003; 52: 1522-1529 (Pubitemid 37176736)
9. Neurath MF, Finotto S, Glimcher LH. The role of Th1/Th2 polarization in mucosal immunity. Nat Med 2002; 8: 567-573 (Pubitemid 34633433)
10. Del Prete G. The concept of type-1 and type-2 helper T cells and their cytokines in humans. Int Rev Immunol 1998; 16: 427-455 (Pubitemid 28102263)
11. Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nature reviews 2002; 2: 933-944 (Pubitemid 37323214)
12. Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6: 1123-1132 (Pubitemid 41541790)
13. Zhang XL, Komada Y, Chipeta J, Li QS, Inaba H, Azuma E, et al. Intracellular cytokine profile of T cells from children with acute lymphoblastic leukemia. Cancer Immunol Immunother 2000; 49: 165-172 (Pubitemid 30430066)
14. Cheng X, Liao YH, Ge H, et al. TH1/TH2 functional imbalance after acute myocardial infarction: coronary arterial inflammation or myocardial inflammation. J Clin Immunol 2005; 25: 246-253 (Pubitemid 40884051)
15. Kawashima M, Miossec P. mRNA quantification of T-bet, GATA-3, IFN-gamma, and IL-4 shows a defective Th1 immune response in the peripheral blood from rheumatoid arthritis patients: link with disease activity. J Clin Immunol 2005; 25: 209-214 (Pubitemid 40884046)
16. Holland N, Dong J, Garnett E, et al. Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohn's disease and age-related changes in Th1/Th2 cytokine profiles. Pediatr Res 2008; 63: 257-262
17. Pene J, Chevalier S, Preisser L, et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008; 180: 7423-7430
18. Fuss IJ, Neurath M, Boirivant M, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 1996; 157: 1261-1270 (Pubitemid 126449643)
19. Plevy SE, Landers CJ, Prehn J, Carramanzana NM, Deem RL, Shealy D, et al. A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease. J Immunol 1997; 159: 6276-6282 (Pubitemid 127471570)
20. Annunziato F, Cosmi L, Santarlasci V, et al. Phenotypic and functional features of human Th17 cells. J Exp Med 2007; 204: 1849-1861 (Pubitemid 47240944)
21. Sventoraityte J, Zvirbliene A, Kiudelis G, et al. Immune system alterations in patients with inflammatory bowel disease during remission. Medicina (Kaunas) 2008; 44: 27-33.
22. Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003; 52: 65-70. (Pubitemid 36020767)
23. Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005; 19(Suppl. A): 5-36.
24. Duramad P, McMahon CW, Hubbard A, Eskenazi B, Holland NT. Flow cytometric detection of intracellular TH1/TH2 cytokines using whole blood: validation of immunologic biomarker for use in epidemiologic studies. Cancer Epidemiol Biomarkers Prev 2004; 13: 1452-1458 (Pubitemid 39202311)
25. Kaminishi K, Soma Y, Kawa Y, Mizoguchi M. Flow cytometric analysis of IL-4, IL-13 and IFN-gamma expression in peripheral blood mononuclear cells and detection of circulating IL-13 in patients with atopic dermatitis provide evidence for the involvement of type 2 cytokines in the disease. J Dermatol Sci 2002; 29: 19-25. (Pubitemid 34462188)
26. Schuerwegh AJ, De Clerck LS, De Schutter L, et al. Flow cytometric detection of type 1 (IL-2, IFN-gamma) and type 2 (IL-4, IL-5) cytokines in T-helper and T-suppressor/cytotoxic cells in rheumatoid arthritis, allergic asthma and atopic dermatitis. Cytokine 1999; 11: 783-788 (Pubitemid 29460477)
27. Nistala K, Moncrieffe H, Newton KR, et al. Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum 2008; 58: 875-887
28. Camoglio L, Te Velde AA, Tigges AJ, Das PK, Van Deventer SJ. Altered expression of interferon-gamma and interleukin-4 in inflammatory bowel disease. Inflamm Bowel Dis 1998; 4: 285-290 (Pubitemid 128699868)
29. Breese E, Braegger CP, Corrigan CJ, Walker-Smith JA, MacDonald TT. Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993; 78: 127-131 (Pubitemid 23035859)
30. Niessner M, Volk BA. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995; 101: 428-435
31. Bamias G, Martin 3rd C, Marini M, Hoang S, Mishina M, Ross WG, et al. Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J Immunol 2003; 171: 4868-4874
32. Fais S, Capobianchi MR, Pallone F, et al. Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers. Gut 1991; 32: 403-407
33. Jurjus AR, Khoury NN, Reimund JM. Animal models of inflammatory bowel disease. J Pharmacol Toxicol Methods 2004; 50: 81-92. (Pubitemid 39286320)
34. Beltrán C, Maass C, Figueroa C, Quera R, Hermoso MA. Th1 Cytokine Pattern Determination in Patients with Inflammatory Bowel Disease: A Novel Tool for Differential Diagnosis. Falk Symposium 151 Emerging Issues in Inflammatory Bowel Diseases. Sidney: Australia: Springer, 2006.
35. Zhang Z, Zheng M, Bindas J, Schwarzenberger P, Kolls JK. Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm Bowel Dis 2006; 12: 382-388 (Pubitemid 43756199)
36. Fina D, Sarra M, Fantini MC, et al. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 2008; 134: 1038-1048
37. Kobayashi T, Okamoto S, Hisamatsu T, et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 2008; 57: 1682-1689
38. Vainer B, Nielsen OH, Hendel J, Horn T, Kirman I. Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease. Cytokine 2000; 12: 1531-1536
39. West GA, Matsuura T, Levine AD, Klein JS, Fiocchi C. Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity. Gastroenterology 1996; 110: 1683-1695 (Pubitemid 26169204)
40. Fuss IJ, Heller F, Boirivant M, et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 2004; 113: 1490-1497 (Pubitemid 39071705)