Intracellular bacterial vectors that induce CD8+ T cells with similar cytolytic abilities but disparate memory phenotypes provide contrastingtumor protection

Cancer Research

Volumn 69, Issue 10, 2009, Pages 4327-4334

  Stark, Felicity C ^a   Sad, Subash ^a,b   Krishnan, Lakshmi ^a,b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VECTOR; CANCER VACCINE; CD8 ANTIGEN; GAMMA INTERFERON; HERMES ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 7 RECEPTOR ALPHA; L SELECTIN; OVALBUMIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CANCER GROWTH; CANCER IMMUNIZATION; CANCER PREVENTION; CD8+ T LYMPHOCYTE; CELL FATE; CELL KILLING; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; DENDRITIC CELL; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; FEMALE; HEMOSTASIS; IN VIVO STUDY; INTERFERON PRODUCTION; INTRACELLULAR SPACE; LISTERIA MONOCYTOGENES; LYMPHATIC DRAINAGE; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; MELANOMA B16; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SALMONELLA TYPHI; T LYMPHOCYTE ACTIVATION; TARGET CELL; TREATMENT RESPONSE;

ADOPTIVE TRANSFER; ANIMALS; AUTOANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CROSSES, GENETIC; FEMALE; GENETIC VECTORS; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; IMMUNOTHERAPY; LISTERIA MONOCYTOGENES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, TRANSGENIC; NEOPLASMS; OVALBUMIN; RECEPTORS, ANTIGEN, T-CELL; SALMONELLA TYPHIMURIUM; T-CELL ANTIGEN RECEPTOR SPECIFICITY;

EID: 66249133416     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-3160     Document Type: Article

References (47)

1. Overwijk WW, Lee DS, Surman DR, et al. Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes. Proc Natl Acad Sci U S A 1999;96:2982-2987
2. Rosenberg SA, Yang JC, Schwartzentruber DJ, et al. Recombinant fowlpox viruses encoding the anchor-modified gp100 melanoma antigen can generate antitumor immune responses in patients with metastatic melanoma. Clin Cancer Res 2003;9:2973-2980 (Pubitemid 36993255)
3. Klebanoff CA, Gattinoni L, Restifo NP. CD8+ T-cell memory in tumor immunology and immunotherapy. Immunol Rev 2006;211:214-224 (Pubitemid 43882974)
4. Angel J, Chaperot L, Molens JP, et al. Virosome-mediated delivery of tumor antigen to plasmacytoid dendritic cells. Vaccine 2007;25:3913-3921 (Pubitemid 46613829)
5. Odunsi K, Qian F, Matsuzaki J, et al. Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer. Proc Natl Acad Sci U S A 2007;104:12837-12842 (Pubitemid 47255241)
6. Naslund TI, Uyttenhove C, Nordstrom EK, et al. Comparative prime-boost vaccinations using Semliki Forest virus, adenovirus, and ALVAC vectors demonstrate differences in the generation of a protective central memory CTL response against the P815 tumor. J Immunol 2007;178:6761-6769 (Pubitemid 46847400)
7. Finn OJ. Cancer vaccines: between the idea and the reality. Nat Rev Immunol 2003;3:630-641 (Pubitemid 37328666)
8. Anichini A, Vegetti C, Mortarini R. The paradox of T-cell-mediated antitumor immunity in spite of poor clinical outcome in human melanoma. Cancer Immunol Immunother 2004;53:855-864 (Pubitemid 39312653)
9. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999;401:708-712 (Pubitemid 129515761)
10. Usherwood EJ, Hogan RJ, Crowther G, et al. Functionally heterogeneous CD8(+) T-cell memory is induced by Sendai virus infection of mice. J Virol 1999;73:7278-7286 (Pubitemid 29383210)
11. Sad S, Krishnan L. Maintenance and attrition of T-cell memory. Crit Rev Immunol 2003;23:129-147
12. Arbones ML, Ord DC, Ley K, et al. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1994;1:247-260 (Pubitemid 2114850)
13. Wherry EJ, Teichgraber V, Becker TC, et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 2003;4:225-234 (Pubitemid 36322131)
14. Weninger W, Crowley MA, Manjunath N, von Andrian UH. Migratory properties of naive, effector, and memory CD8(+) T cells. J Exp Med 2001;194:953-966 (Pubitemid 32953264)
15. Roberts AD, Ely KH, Woodland DL. Differential contributions of central and effector memory T cells to recall responses. J Exp Med 2005;202:123-133 (Pubitemid 41002915)
16. Castiglioni P, Gerloni M, Zanetti M. Genetically programmed B lymphocytes are highly efficient in inducing anti-virus protective immunity mediated by central memory CD8 T cells. Vaccine 2004;23:699-708. (Pubitemid 39473202)
17. Vaccari M, Trindade CJ, Venzon D, Zanetti M, Franchini G. Vaccine-induced CD8+ central memory T cells in protection from simian AIDS. J Immunol 2005;175:3502-3507 (Pubitemid 41292007)
18. Kaech SM, Wherry EJ, Ahmed R. Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol 2002;2:251-262 (Pubitemid 37323225)
19. + T cell turnover during mycobacterial infection: comparison with Listeria monocytogenes . J Immunol 2004;172:3491-3500
20. + T Cell response during infection with virulent Salmonella typhimurium. J Immunol 2006;177:1516-1525
21. Jelley-Gibbs DM, Dibble JP, Brown DM, et al. Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. J Immunol 2007;178:7563-7570 (Pubitemid 46898025)
22. Dudani R, Chapdelaine Y, Faassen HH, et al. Multiple mechanisms compensate to enhance tumor-protective CD8(+) T cell response in the long-term despite poor CD8(+) T cell priming initially: comparison between an acute versus a chronic intracellular bacterium expressing a model antigen. J Immunol 2002;168:5737-5745 (Pubitemid 34556158)
23. high) subset. J Immunol 2005;174:5341-5350
24. Barber DL, Wherry EJ, Ahmed R. Cutting edge: rapid in vivo killing by memory CD8 T cells. J Immunol 2003;171:27-31. (Pubitemid 36745269)
25. Busch DH, Kerksiek K, Pamer EG. Processing of Listeria monocytogenes antigens and the in vivo T- cell response to bacterial infection. Immunol Rev 1999;172:163-169 (Pubitemid 30000477)
26. Ahmed R, Gray D. Immunological memory and protective immunity: understanding their relation. Science 1996;272:54. (Pubitemid 26110754)
27. Sad S, Dudani R, Gurnani K, et al. Pathogen proliferation governs the magnitude but compromises the function of CD8 T cells. J Immunol 2008;180:5853-5861
28. Kaech SM, Tan JT, Wherry EJ, et al. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol 2003;4:1191-1198 (Pubitemid 37540688)
29. Klebanoff CA, Gattinoni L, Torabi-Parizi P, et al. Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. Proc Natl Acad Sci U S A 2005;102:9571-9576 (Pubitemid 40981722)
30. June CH. Adoptive T cell therapy for cancer in the clinic. J Clin Invest 2007;117:1466-1476 (Pubitemid 46871329)
31. + T cells. Proc Natl Acad Sci U S A 2004;101:1969-1974.
32. + T cell lineage commitment. Nat Immunol 2005;6:793-799
33. + T effector to memory transition in adoptive T-cell antitumor immunotherapy. Cancer Res 2008;68:2984-2992
34. Zajac AJ, Blattman JN, Murali KK, et al. Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med 1998;188:2205-2213 (Pubitemid 29028493)
35. Fuller MJ, Khanolkar A, Tebo AE, Zajac AJ. Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J Immunol 2004;172:4204-4214 (Pubitemid 38375233)
36. Zhou S, Ou R, Huang L, Price GE, Moskophidis D. Differential tissue-specific regulation of antiviral CD8+ T-cell immune responses during chronic viral infection. J Virol 2004;78:3578-3600 (Pubitemid 38568300)
37. - memory T cells do not differ in immediate effector cell functions. J Immunol 2002;169:638-641
38. + CTL after reinfection. J Immunol 2005;174:3590-3597
39. Schluns KS, Lefrancois L. Cytokine control of memory T-cell development and survival. Nat Rev Immunol 2003;3:269-279 (Pubitemid 37328680)
40. + cells. J Exp Med 2002;195:1523-1532
41. Fensterle J, Bergmann B, Yone CL, et al. Cancer immunotherapy based on recombinant Salmonella enterica serovar Typhimurium aroA strains secreting prostate-specific antigen and cholera toxin subunit B. Cancer Gene Ther 2008;15:85-93.
42. Medina E, Guzman CA, Staendner LH, Colombo MP, Paglia P. Salmonella vaccine carrier strains: effective delivery system to trigger anti-tumor immunity by oral route. Eur J Immunol 1999;29:693-699 (Pubitemid 29078532)
43. Loeffler M, Le'Negrate G, Krajewska M, Reed JC. Attenuated Salmonella engineered to produce human cytokine LIGHT inhibit tumor growth. Proc Natl Acad Sci U S A 2007;104:12879-12883 (Pubitemid 47255248)
44. Zhong Z, Kazmierczak RA, Dino A, et al. Salmonellahost cell interactions, changes in host cell architecture, and destruction of prostate tumor cells with genetically altered Salmonella . Microsc Microanal 2007;13:372-383 (Pubitemid 47528709)
45. Hussain SF, Paterson Y. What is needed for effective antitumor immunotherapy? Lessons learned using Listeria monocytogenes as a live vector for HPV-associated tumors. Cancer Immunol Immunother 2005;54:577-586 (Pubitemid 40603197)
46. Hamilton SE, Badovinac VP, Khanolkar A, Harty JT. Listeriolysin O-deficient Listeria monocytogenes as a vaccine delivery vehicle: antigen-specific CD8 T cell priming and protective immunity. J Immunol 2006;177:4012-4020 (Pubitemid 44359934)
47. Bruhn KW, Craft N, Nguyen BD, Yip J, Miller JF. Characterization of anti-self CD8 T-cell responses stimulated by recombinant Listeria monocytogenes expressing the melanoma antigen TRP-2. Vaccine 2005;23:4263-4272 (Pubitemid 40984787)