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Volumn 15, Issue 2, 2008, Pages 85-93

Cancer immunotherapy based on recombinant Salmonella enterica serovar Typhimurium aroA strains secreting prostate-specific antigen and cholera toxin subunit B

Author keywords

Bacterial cancer vaccines; Cancer immunotherapy; Cholera toxin subunit B; Hemolysin (HlyA) secretion system (T1SS); Prostate specific antigen

Indexed keywords

CANCER VACCINE; CHOLERA TOXIN B SUBUNIT; PROSTATE SPECIFIC ANTIGEN;

EID: 38349037623     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/sj.cgt.7701109     Document Type: Article
Times cited : (73)

References (51)
  • 2
    • 0023392052 scopus 로고
    • Seminal vesicle-secreted proteins and their reactions during gelation and liquefaction of human semen
    • Lilja H, Oldbring J, Rannevik G, Laurell CB. Seminal vesicle-secreted proteins and their reactions during gelation and liquefaction of human semen. J Clin Invest 1987; 80: 281-285.
    • (1987) J Clin Invest , vol.80 , pp. 281-285
    • Lilja, H.1    Oldbring, J.2    Rannevik, G.3    Laurell, C.B.4
  • 3
    • 0031785612 scopus 로고    scopus 로고
    • Clinical implications of prostate-specific antigen (PSA)
    • Oakley N. Clinical implications of prostate-specific antigen (PSA). Curr Opin Urol 1998; 8: 401-406.
    • (1998) Curr Opin Urol , vol.8 , pp. 401-406
    • Oakley, N.1
  • 4
    • 0036167308 scopus 로고    scopus 로고
    • Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors
    • Heiser A, Coleman D, Dannull J, Yancey D, Maurice MA, Lallas CD et al. Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors. J Clin Invest 2002; 109: 409-417.
    • (2002) J Clin Invest , vol.109 , pp. 409-417
    • Heiser, A.1    Coleman, D.2    Dannull, J.3    Yancey, D.4    Maurice, M.A.5    Lallas, C.D.6
  • 5
    • 2342640119 scopus 로고    scopus 로고
    • Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA
    • Barrou B, Benoit G, Ouldkaci M, Cussenot O, Salcedo M, Agrawal S et al. Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. Cancer Immunol Immunother 2004; 53: 453-460.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 453-460
    • Barrou, B.1    Benoit, G.2    Ouldkaci, M.3    Cussenot, O.4    Salcedo, M.5    Agrawal, S.6
  • 6
  • 7
    • 33644760431 scopus 로고    scopus 로고
    • A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer
    • Arlen PM, Gulley JL, Parker C, Skarupa L, Pazdur M, Panicali D et al. A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer. Clin Cancer Res 2006; 12: 1260-1269.
    • (2006) Clin Cancer Res , vol.12 , pp. 1260-1269
    • Arlen, P.M.1    Gulley, J.L.2    Parker, C.3    Skarupa, L.4    Pazdur, M.5    Panicali, D.6
  • 8
    • 21844444548 scopus 로고    scopus 로고
    • Immune monitoring in a phase 1 trial of a PSA DNA vaccine in patients with hormone-refractory prostate cancer
    • Miller AM, Ozenci V, Kiessling R, Pisa P. Immune monitoring in a phase 1 trial of a PSA DNA vaccine in patients with hormone-refractory prostate cancer. J Immunother 2005; 28: 389-395.
    • (2005) J Immunother , vol.28 , pp. 389-395
    • Miller, A.M.1    Ozenci, V.2    Kiessling, R.3    Pisa, P.4
  • 9
    • 0036324470 scopus 로고    scopus 로고
    • Gene therapy of prostate cancer: Current and future directions
    • Mabjeesh NJ, Zhong H, Simons JW. Gene therapy of prostate cancer: current and future directions. Endocr Relat Cancer 2002; 9: 115-139.
    • (2002) Endocr Relat Cancer , vol.9 , pp. 115-139
    • Mabjeesh, N.J.1    Zhong, H.2    Simons, J.W.3
  • 10
    • 0032213387 scopus 로고    scopus 로고
    • Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma
    • Paglia P, Medina E, Arioli I, Guzman CA, Colombo MP. Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma. Blood 1998; 92: 3172-3176.
    • (1998) Blood , vol.92 , pp. 3172-3176
    • Paglia, P.1    Medina, E.2    Arioli, I.3    Guzman, C.A.4    Colombo, M.P.5
  • 11
    • 0035284897 scopus 로고    scopus 로고
    • Prophylactic tumor vaccination: Comparison of effector mechanisms initiated by protein versus DNA vaccination
    • Zoller M, Christ O. Prophylactic tumor vaccination: comparison of effector mechanisms initiated by protein versus DNA vaccination. J Immunol 2001; 166: 3440-3450.
    • (2001) J Immunol , vol.166 , pp. 3440-3450
    • Zoller, M.1    Christ, O.2
  • 12
    • 0041305904 scopus 로고    scopus 로고
    • Transcription factor Fos-related antigen 1 is an effective target for a breast cancer vaccine
    • Luo Y, Zhou H, Mizutani M, Mizutani N, Reisfeld RA, Xiang R. Transcription factor Fos-related antigen 1 is an effective target for a breast cancer vaccine. Proc Natl Acad Sci USA 2003; 100: 8850-8855.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8850-8855
    • Luo, Y.1    Zhou, H.2    Mizutani, M.3    Mizutani, N.4    Reisfeld, R.A.5    Xiang, R.6
  • 13
    • 12544259115 scopus 로고    scopus 로고
    • A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication
    • Xiang R, Mizutani N, Luo Y, Chiodoni C, Zhou H, Mizutani M et al. A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication. Cancer Res 2005; 65: 553-561.
    • (2005) Cancer Res , vol.65 , pp. 553-561
    • Xiang, R.1    Mizutani, N.2    Luo, Y.3    Chiodoni, C.4    Zhou, H.5    Mizutani, M.6
  • 14
    • 14144251067 scopus 로고    scopus 로고
    • Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium
    • Zhao M, Yang M, Li XM, Jiang P, Baranov E, Li S et al. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc Natl Acad Sci USA 2005; 102: 755-760.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 755-760
    • Zhao, M.1    Yang, M.2    Li, X.M.3    Jiang, P.4    Baranov, E.5    Li, S.6
  • 15
    • 20044365044 scopus 로고    scopus 로고
    • Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA
    • Holmgren J, Adamsson J, Anjuere F, Clemens J, Czerkinsky C, Eriksson K et al. Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA. Immunol Lett 2005; 97: 181-188.
    • (2005) Immunol Lett , vol.97 , pp. 181-188
    • Holmgren, J.1    Adamsson, J.2    Anjuere, F.3    Clemens, J.4    Czerkinsky, C.5    Eriksson, K.6
  • 16
    • 24144483089 scopus 로고    scopus 로고
    • Targeted vaccine adjuvants based on modified cholera toxin
    • Lycke N. Targeted vaccine adjuvants based on modified cholera toxin. Curr Mol Med 2005; 5: 591-597.
    • (2005) Curr Mol Med , vol.5 , pp. 591-597
    • Lycke, N.1
  • 17
    • 0036278571 scopus 로고    scopus 로고
    • Genetic fusion of human insulin B-chain to the B-subunit of cholera toxin enhances in vitro antigen presentation and induction of bystander suppression in vivo
    • Sadeghi H, Bregenholt S, Wegmann D, Petersen JS, Holmgren J, Lebens M. Genetic fusion of human insulin B-chain to the B-subunit of cholera toxin enhances in vitro antigen presentation and induction of bystander suppression in vivo. Immunology 2002; 106: 237-245.
    • (2002) Immunology , vol.106 , pp. 237-245
    • Sadeghi, H.1    Bregenholt, S.2    Wegmann, D.3    Petersen, J.S.4    Holmgren, J.5    Lebens, M.6
  • 18
    • 0035811858 scopus 로고    scopus 로고
    • Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis
    • Yuki Y, Byun Y, Fujita M, Izutani W, Suzuki T, Udaka S et al. Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis. Biotechnol Bioeng 2001; 74: 62-69.
    • (2001) Biotechnol Bioeng , vol.74 , pp. 62-69
    • Yuki, Y.1    Byun, Y.2    Fujita, M.3    Izutani, W.4    Suzuki, T.5    Udaka, S.6
  • 19
    • 0031762753 scopus 로고    scopus 로고
    • A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes
    • Arakawa T, Yu J, Chong DK, Hough J, Engen PC, Langridge WH. A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes. Nat Biotechnol 1998; 16: 934-938.
    • (1998) Nat Biotechnol , vol.16 , pp. 934-938
    • Arakawa, T.1    Yu, J.2    Chong, D.K.3    Hough, J.4    Engen, P.C.5    Langridge, W.H.6
  • 20
    • 0030574284 scopus 로고    scopus 로고
    • Development of antigen-delivery systems, based on the Escherichia coli hemolysin secretion pathway
    • Gentschev I, Mollenkopf H, Sokolovic Z, Hess J, Kaufmann SH, Goebel W. Development of antigen-delivery systems, based on the Escherichia coli hemolysin secretion pathway. Gene 1996; 179: 133-140.
    • (1996) Gene , vol.179 , pp. 133-140
    • Gentschev, I.1    Mollenkopf, H.2    Sokolovic, Z.3    Hess, J.4    Kaufmann, S.H.5    Goebel, W.6
  • 21
    • 0030007941 scopus 로고    scopus 로고
    • Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis
    • Hess J, Gentschev I, Miko D, Welzel M, Ladel C, Goebel W et al. Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis. Proc Natl Acad Sci USA 1996; 93: 1458-1463.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1458-1463
    • Hess, J.1    Gentschev, I.2    Miko, D.3    Welzel, M.4    Ladel, C.5    Goebel, W.6
  • 22
    • 0030837709 scopus 로고    scopus 로고
    • Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal antiamebic and anti-V. cholerae antibody responses in mice
    • Ryan ET, Butterton JR, Zhang T, Baker MA, Stanley Jr SL, Calderwood SB. Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal antiamebic and anti-V. cholerae antibody responses in mice. Infect Immun 1997; 65: 3118-3125.
    • (1997) Infect Immun , vol.65 , pp. 3118-3125
    • Ryan, E.T.1    Butterton, J.R.2    Zhang, T.3    Baker, M.A.4    Stanley Jr, S.L.5    Calderwood, S.B.6
  • 23
    • 0035142760 scopus 로고    scopus 로고
    • Expression, extracellular secretion, and immunogenicity of the Plasmodium falciparum sporozoite surface protein 2 in Salmonella vaccine strains
    • Gomez-Duarte OG, Pasetti MF, Santiago A, Sztein MB, Hoffman SL, Levine MM. Expression, extracellular secretion, and immunogenicity of the Plasmodium falciparum sporozoite surface protein 2 in Salmonella vaccine strains. Infect Immun 2001; 69: 1192-1198.
    • (2001) Infect Immun , vol.69 , pp. 1192-1198
    • Gomez-Duarte, O.G.1    Pasetti, M.F.2    Santiago, A.3    Sztein, M.B.4    Hoffman, S.L.5    Levine, M.M.6
  • 24
    • 0036149305 scopus 로고    scopus 로고
    • The E. coli alphahemolysin secretion system and its use in vaccine development
    • Gentschev I, Dietrich G, Goebel W. The E. coli alphahemolysin secretion system and its use in vaccine development. Trends Microbiol 2002; 10: 39-45.
    • (2002) Trends Microbiol , vol.10 , pp. 39-45
    • Gentschev, I.1    Dietrich, G.2    Goebel, W.3
  • 25
    • 0037490068 scopus 로고    scopus 로고
    • Effect of in situ expression of human interleukin-6 on antibody responses against Salmonella typhimurium antigens
    • Li Y, Reichenstein K, Ullrich R, Danner T, von Specht BU, Hahn HP. Effect of in situ expression of human interleukin-6 on antibody responses against Salmonella typhimurium antigens. FEMS Immunol Med Microbiol 2003; 37: 135-145.
    • (2003) FEMS Immunol Med Microbiol , vol.37 , pp. 135-145
    • Li, Y.1    Reichenstein, K.2    Ullrich, R.3    Danner, T.4    von Specht, B.U.5    Hahn, H.P.6
  • 26
    • 26844506638 scopus 로고    scopus 로고
    • Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice
    • Gentschev I, Fensterle J, Schmidt A, Potapenko T, Troppmair J, Goebel W et al. Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice. BMC Cancer 2005; 5: 15.
    • (2005) BMC Cancer , vol.5 , pp. 15
    • Gentschev, I.1    Fensterle, J.2    Schmidt, A.3    Potapenko, T.4    Troppmair, J.5    Goebel, W.6
  • 27
    • 0030986250 scopus 로고    scopus 로고
    • Tissue-specific expression of the human prostatespecific antigen gene in transgenic mice: Implications for tolerance and immunotherapy
    • Wei C, Willis RA, Tilton BR, Looney RJ, Lord EM, Barth RK et al. Tissue-specific expression of the human prostatespecific antigen gene in transgenic mice: implications for tolerance and immunotherapy. Proc Natl Acad Sci USA 1997; 94: 6369-6374.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6369-6374
    • Wei, C.1    Willis, R.A.2    Tilton, B.R.3    Looney, R.J.4    Lord, E.M.5    Barth, R.K.6
  • 28
    • 0034612342 scopus 로고    scopus 로고
    • One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
    • Datsenko KA, Wanner BL. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci USA 2000; 97: 6640-6645.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6640-6645
    • Datsenko, K.A.1    Wanner, B.L.2
  • 29
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 30
    • 38349047547 scopus 로고    scopus 로고
    • Animal models for DNA vaccination against prostate cancer using PSA encoding plasmids
    • Fensterle J, Schwartz V, Riedmiller H, Rapp UR. Animal models for DNA vaccination against prostate cancer using PSA encoding plasmids. Onkologie 2005; 28(Suppl 2): 52.
    • (2005) Onkologie , vol.28 , Issue.SUPPL. 2 , pp. 52
    • Fensterle, J.1    Schwartz, V.2    Riedmiller, H.3    Rapp, U.R.4
  • 31
    • 0032828966 scopus 로고    scopus 로고
    • Effective DNA vaccination against listeriosis by prime/boost inoculation with the gene gun
    • Fensterle J, Grode L, Hess J, Kaufmann SHE. Effective DNA vaccination against listeriosis by prime/boost inoculation with the gene gun. J Immunol 1999; 163: 4510-4518.
    • (1999) J Immunol , vol.163 , pp. 4510-4518
    • Fensterle, J.1    Grode, L.2    Hess, J.3    Kaufmann, S.H.E.4
  • 32
    • 0031064825 scopus 로고    scopus 로고
    • The Escherichia coli hemolysin secretion apparatus-a versatile antigen delivery system in attenuated Salmonella
    • Gentschev I, Dietrich G, Mollenkopf HJ, Sokolovic Z, Hess J, Kaufmann SH et al. The Escherichia coli hemolysin secretion apparatus-a versatile antigen delivery system in attenuated Salmonella. Behring Inst Mitt 1997; 95: 103-113.
    • (1997) Behring Inst Mitt , vol.95 , pp. 103-113
    • Gentschev, I.1    Dietrich, G.2    Mollenkopf, H.J.3    Sokolovic, Z.4    Hess, J.5    Kaufmann, S.H.6
  • 33
    • 0025346159 scopus 로고    scopus 로고
    • Gentschev I, Hess J, Goebel W. Change in the cellular localization of alkaline phosphatase by alteration of its carboxy-terminal sequence. Mol Gen Genet 1990; 222: 211-216.
    • Gentschev I, Hess J, Goebel W. Change in the cellular localization of alkaline phosphatase by alteration of its carboxy-terminal sequence. Mol Gen Genet 1990; 222: 211-216.
  • 35
    • 0035902080 scopus 로고    scopus 로고
    • Progress in human tumour immunology and immunotherapy
    • Rosenberg SA. Progress in human tumour immunology and immunotherapy. Nature 2001; 411: 380-384.
    • (2001) Nature , vol.411 , pp. 380-384
    • Rosenberg, S.A.1
  • 36
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 2004; 21: 137-148.
    • (2004) Immunity , vol.21 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 37
    • 0026636250 scopus 로고
    • Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens
    • Cardenas L, Clements JD. Oral immunization using live attenuated Salmonella spp. as carriers of foreign antigens. Clin Microbiol Rev 1992; 5: 328-342.
    • (1992) Clin Microbiol Rev , vol.5 , pp. 328-342
    • Cardenas, L.1    Clements, J.D.2
  • 38
    • 33645243935 scopus 로고    scopus 로고
    • Use of bacteria in anti-cancer therapies
    • Ryan RM, Green J, Lewis CE. Use of bacteria in anti-cancer therapies. Bioessays 2006; 28: 84-94.
    • (2006) Bioessays , vol.28 , pp. 84-94
    • Ryan, R.M.1    Green, J.2    Lewis, C.E.3
  • 39
    • 0037108604 scopus 로고    scopus 로고
    • The innate immune response differs in primary and secondary Salmonella infection
    • Kirby AC, Yrlid U, Wick MJ. The innate immune response differs in primary and secondary Salmonella infection. J Immunol 2002; 169: 4450-4459.
    • (2002) J Immunol , vol.169 , pp. 4450-4459
    • Kirby, A.C.1    Yrlid, U.2    Wick, M.J.3
  • 40
    • 0347776209 scopus 로고    scopus 로고
    • Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
    • Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol 2003; 4: 1230-1237.
    • (2003) Nat Immunol , vol.4 , pp. 1230-1237
    • Brigl, M.1    Bry, L.2    Kent, S.C.3    Gumperz, J.E.4    Brenner, M.B.5
  • 41
    • 21344461738 scopus 로고    scopus 로고
    • Gammadelta T cells link innate and adaptive immune responses
    • Holtmeier W, Kabelitz D. Gammadelta T cells link innate and adaptive immune responses. Chem Immunol Allergy 2005; 86: 151-183.
    • (2005) Chem Immunol Allergy , vol.86 , pp. 151-183
    • Holtmeier, W.1    Kabelitz, D.2
  • 42
    • 2942581320 scopus 로고    scopus 로고
    • DNA vaccines suppress tumor growth and metastases by the induction of anti-angiogenesis
    • Reisfeld RA, Niethammer AG, Luo Y, Xiang R. DNA vaccines suppress tumor growth and metastases by the induction of anti-angiogenesis. Immunol Rev 2004; 199: 181-190.
    • (2004) Immunol Rev , vol.199 , pp. 181-190
    • Reisfeld, R.A.1    Niethammer, A.G.2    Luo, Y.3    Xiang, R.4
  • 44
    • 33745832268 scopus 로고    scopus 로고
    • In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines
    • Nishikawa H, Sato E, Briones G, Chen LM, Matsuo M, Nagata Y et al. In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines. J Clin Invest 2006; 116: 1946-1954.
    • (2006) J Clin Invest , vol.116 , pp. 1946-1954
    • Nishikawa, H.1    Sato, E.2    Briones, G.3    Chen, L.M.4    Matsuo, M.5    Nagata, Y.6
  • 45
    • 33749471430 scopus 로고    scopus 로고
    • Prophylactic anti-tumor immunity against a murine fibrosarcoma triggered by the Salmonella type III secretion system
    • Panthel K, Meinel KM, Sevil Domenech VE, Geginat G, Linkemann K, Busch DH et al. Prophylactic anti-tumor immunity against a murine fibrosarcoma triggered by the Salmonella type III secretion system. Microbes Infect 2006; 8: 2539-2546.
    • (2006) Microbes Infect , vol.8 , pp. 2539-2546
    • Panthel, K.1    Meinel, K.M.2    Sevil Domenech, V.E.3    Geginat, G.4    Linkemann, K.5    Busch, D.H.6
  • 46
    • 1242351554 scopus 로고    scopus 로고
    • Wick MJ. Living in the danger zone: innate immunity to Salmonella. Curr Opin Microbiol 2004; 7: 51-57.
    • Wick MJ. Living in the danger zone: innate immunity to Salmonella. Curr Opin Microbiol 2004; 7: 51-57.
  • 47
    • 0035189087 scopus 로고    scopus 로고
    • Regulated antigen expression in live recombinant Salmonella enterica serovar Typhimurium strongly affects colonization capabilities and specific CD4(+)-T-cell responses
    • Bumann D. Regulated antigen expression in live recombinant Salmonella enterica serovar Typhimurium strongly affects colonization capabilities and specific CD4(+)-T-cell responses. Infect Immun 2001; 69: 7493-7500.
    • (2001) Infect Immun , vol.69 , pp. 7493-7500
    • Bumann, D.1
  • 48
    • 23944432459 scopus 로고    scopus 로고
    • Heteropentameric cholera toxin B subunit chimeric molecules genetically fused to a vaccine antigen induce systemic and mucosal immune responses: A potential new strategy to target recombinant vaccine antigens to mucosal immune systems
    • Harakuni T, Sugawa H, Komesu A, Tadano M, Arakawa T. Heteropentameric cholera toxin B subunit chimeric molecules genetically fused to a vaccine antigen induce systemic and mucosal immune responses: a potential new strategy to target recombinant vaccine antigens to mucosal immune systems. Infect Immun 2005; 73: 5654-5665.
    • (2005) Infect Immun , vol.73 , pp. 5654-5665
    • Harakuni, T.1    Sugawa, H.2    Komesu, A.3    Tadano, M.4    Arakawa, T.5
  • 49
    • 9144241092 scopus 로고    scopus 로고
    • Use of the α-hemolysin secretion system of Escherichia coli for antigen delivery in the Salmonella typhi Ty21a vaccine strain
    • Gentschev I, Dietrich G, Spreng S, Neuhaus B, Maier E, Benz R et al. Use of the α-hemolysin secretion system of Escherichia coli for antigen delivery in the Salmonella typhi Ty21a vaccine strain. Int J Med Microbiol 2004; 294: 363-371.
    • (2004) Int J Med Microbiol , vol.294 , pp. 363-371
    • Gentschev, I.1    Dietrich, G.2    Spreng, S.3    Neuhaus, B.4    Maier, E.5    Benz, R.6
  • 50
    • 34147209717 scopus 로고    scopus 로고
    • Vivotif - a 'magic shield' for protection against typhoid fever and delivery of heterologous antigens
    • Gentschev I, Spreng S, Sieber H, Ures J, Mollet F, Collioud A et al. Vivotif - a 'magic shield' for protection against typhoid fever and delivery of heterologous antigens. Chemotherapy 2007; 53: 177-180.
    • (2007) Chemotherapy , vol.53 , pp. 177-180
    • Gentschev, I.1    Spreng, S.2    Sieber, H.3    Ures, J.4    Mollet, F.5    Collioud, A.6
  • 51
    • 0023180351 scopus 로고
    • Large-scale field trial of Ty21a live oral typhoid vaccine in entericcoated capsule formulation
    • Levine MM, Ferreccio C, Black RE, Germanier R. Large-scale field trial of Ty21a live oral typhoid vaccine in entericcoated capsule formulation. Lancet 1987; 1: 1049-1052.
    • (1987) Lancet , vol.1 , pp. 1049-1052
    • Levine, M.M.1    Ferreccio, C.2    Black, R.E.3    Germanier, R.4


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