Is toluene diamine a sensitizer and is there cross-reactivity between toluene diamine and toluene diisocyanate?

Toxicological Sciences

Volumn 109, Issue 2, 2009, Pages 256-264

  Vanoirbeek, Jeroen A J ^a   De Vooght, Vanessa ^a   Synhaeve, Nicholas ^a   Nemery, Benoit ^a   Hoet, Peter H M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Cross reactivity; Murine model; Occupational asthma; TDA; TDI

Indexed keywords

ACETONE; CD19 ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 4; OLIVE OIL; TOLUENE DERIVATIVE; TOLUENE DIAMINE; TOLUENE DIISOCYANATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BAGG ALBINO MOUSE; BRONCHITIS; BRONCHUS HYPERREACTIVITY; CHEMICAL INJURY; CHEMICAL REACTION; CONTROLLED STUDY; CROSS REACTION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREACTIVITY; LOCAL LYMPH NODE ASSAY; LUNG LAVAGE; LUNG TOXICITY; MALE; MOUSE; NONHUMAN; SENSITIZATION; T LYMPHOCYTE; TOXICITY TESTING;

ANIMALS; ANTIGENS, CD; ASTHMA; CELLS, CULTURED; CROSS REACTIONS; CYTOKINES; DISEASE MODELS, ANIMAL; IMMUNOGLOBULINS; LOCAL LYMPH NODE ASSAY; LYMPHOCYTES; MALE; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; PHENYLENEDIAMINES; STATISTICS, NONPARAMETRIC; TOLUENE 2,4-DIISOCYANATE;

MURINAE; MUS;

EID: 66149156502     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp065     Document Type: Article

References (42)

1. Austin, S. (2007). Biological monitoring of TDI-derived amines in polyurethane foam production. Occup. Med. (Lond.) 57, 444-448.
2. Basketter, D. A., Evans, P., Fielder, R. J., Gerberick, G. F., Dearman, R. J., and Kimber, I. (2002). Local lymph node assay - validation, conduct and use in practice. Food Chem. Toxicol. 40, 593-598.
3. Bello, D., Herrick, C. A., Smith, T. J., Woskie, S. R., Streicher, R. P., Cullen, M. R., Liu, Y., and Redlich, C. A. (2007). Skin exposure to isocyanates: Reasons for concern. Environ. Health Perspect. 115 328-335.
4. Briatico-Vangosa, G., Braun, C. L., Cookman, G., Hofmann, T., Kimber, I., Loveless, S. E., Morrow, T., Pauluhn, J., Sorensen, T., and Niessen, H. J. (1994). Respiratory allergy: Hazard identification and risk assessment. Fundam. Appl. Toxicol. 23, 145-158.
5. Chan-Yeung, M., and Malo, J. L. (1994). Aetiological agents in occupational asthma. Eur. Respir. J. 7, 346-371.
6. Chan-Yeung, M., Malo, J. L., Tarlo, S. M., Bernstein, L., Gautrin, D., Mapp, C., Newman-Taylor, A., Swanson, M. C., Perrault, G., Jaques, L., et al. (2003). Proceedings of the first Jack Pepys Occupational Asthma Symposium. Am. J. Respir. Crit. Care Med. 167, 450-471.
7. Dearman, R. J., and Kimber, I. (2001). Cytokine fingerprinting and hazard assessment of chemical respiratory allergy. J. Appl. Toxicol. 21, 153-163.
8. Farraj, A. K., Boykin, E., Haykal-Coates, N., Gavett, S. H., Doerfler, D., and Selgrade, M. (2007). Th2 cytokines in skin draining lymph nodes and serum IgE do not predict airway hypersensitivity to intranasal isocyanate exposure in mice. Toxicol. Sci. 100, 99-108.
9. Gerberick, G. F., Robinson, M. K., Ryan, C. A., Dearman, R. J., Kimber, I., Basketter, D. A., Wright, Z., and Marks, J. G. (2001). Contact allergenic potency: Correlation of human and local lymph node assay data. Am. J. Contact Dermat. 12, 156-161.
10. Kimber, I., Basketter, D. A., Butler, M., Gamer, A., Garrigue, J. L., Gerberick, G. F., Newsome, C., Steiling, W., and Vohr, H. W. (2003). Classification of contact allergens according to potency: Proposals. Food Chem. Toxicol. 41, 1799-1809.
11. Kimber, I., Bernstein, I. L., Karol, M. H., Robinson, M. K., Sarlo, K., and Selgrade, M. K. (1996). Workshop overview. Identification of respiratory allergens. Fundam. Appl. Toxicol. 33, 1-10.
12. Kimber, I., and Dearman, R. J. (1991). Investigation of lymph node cell proliferation as a possible immunological correlate of contact sensitizing potential. Food Chem. Toxicol. 29, 125-129.
13. Kimber, I., Dearman, R. J., Basketter, D. A., Ryan, C. A., and Gerberick, G. F. (2002). The local lymph node assay: Past, present and future. Contact Dermatitis 47, 315-328.
14. Kimber, I., Hilton, J., and Weisenberger, C. (1989). The murine local lymph node assay for identification of contact allergens: A preliminary evaluation of in situ measurement of lymphocyte proliferation. Contact Dermatitis 21, 215-220.
15. Kimber, I., Mitchell, J. A., and Griffin, C. (1986). Development of a murine local lymph node assay for the determination of sensitizing potential. Food Chem. Toxicol. 24, 585-586.
16. Kimber, I., and Weisenberger, C. (1989). A murine local lymph node assay for the identification of contact allergens. Assay development and results of an initial validation study. Arch. Toxicol. 63, 274-282.
17. Lange, R. W., Lantz, R. C., Stolz, D. B., Watkins, S. C., Sundareshan, P., Lemus, R., and Karol, M. H. (1999). Toluene diisocyanate colocalizes with tubulin on cilia of differentiated human airway epithelial cells. Toxicol. Sci. 50, 64-71.
18. Lind, P., Dalene, M., Skarping, G., and Hagmar, L. (1996). Toxicokinetics of 2,4- and 2,6-toluenediamine in hydrolysed urine and plasma after occupational exposure to 2,4- and 2,6-toluene diisocyanate. Occup. Environ. Med. 53, 94-99.
19. Matheson, J. M., Johnson, V. J., Vallyathan, V., and Luster, M. I. (2005). Exposure and immunological determinants in a murine model for toluene diisocyanate (TDI) asthma. Toxicol. Sci. 84, 88-98.
20. Matheson, J. M., Lange, R. W., Lemus, R., Karol, M. H., and Luster, M. I. (2001). Importance of inflammatory and immune components in a mouse model of airway reactivity to toluene diisocyanate (TDI). Clin. Exp. Allergy 31, 1067-1076.
21. Pauluhn, J. (2008a). Brown Norway rat asthma model of diphenylmethane-4, 4′-diisocyanate (MDI): Analysis of the elicitation dose-response relationship. Toxicol. Sci. 104, 320-331.
22. Pauluhn, J. (2008b). Brown Norway rat asthma model of diphenylmethane-4, 4′-diisocyanate (MDI): Impact of vehicle for topical induction. Regul. Toxicol. Pharmacol. 50, 144-154.
23. Pons, F., Fischer, A., Frossard, N., and Lugnier, A. (1999). Effect of toluene diisocyanate and its corresponding amines on viability and growth of human lung fibroblasts in culture. Cell Biol. Toxicol. 15, 333-340.
24. Redlich, C. A., and Herrick, C. A. (2008). Lung/skin connections in occupational lung disease. Curr. Opin. Allergy Clin. Immunol. 8 115-119.
25. Sailstad, D. M., Ward, M. D., Boykin, E. H., and Selgrade, M. K. (2003). A murine model for low molecular weight chemicals: Differentiation of respiratory sensitizers (TMA) from contact sensitizers (DNFB). Toxicology 194, 147-161.
26. Sakai, T., Morita, Y., Kim, Y., and Tao, Y. X. (2002). LC-MS determination of urinary toluenediamine in workers exposed to toluenediisocyanate. Toxicol. Lett. 134, 259-264.
27. Selgrade, M., Boykin, E. H., Haykal-Coates, N., Woolhiser, M. R., Wiescinski, C., Andrews, D. L., Farraj, A. K., Doerfler, D. L., and Gavett, S. H. (2006). Inconsistencies between cytokine profiles, antibody responses, and respiratory hyperresponsiveness following dermal exposure to isocyanates. Toxicol. Sci. 94, 108-117.
28. Shanmugam, K., Subrahmanyam, S., Tarakad, S. V., Kodandapani, N., and Stanly, D. F. (2001). 2,4-Toluene diamines - Their carcinogenicity, biodegradation, analytical techniques and an approach towards development of biosensors. Anal. Sci. 17, 1369-1374.
29. Skarping, G., Brorson, T., and Sango, C. (1991). Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate. Int. Arch. Occup. Environ. Health 63 83-88.
30. Tarkowski, M., Vanoirbeek, J. A., Vanhooren, H. M., De Vooght, V., Mercier, C. M., Ceuppens, J., Nemery, B., and Hoet, P. H. (2007). Immunological determinants of ventilatory changes induced in mice by dermal sensitization and respiratory challenge with toluene diisocyanate. Am. J. Physiol. Lung Cell. Mol. Physiol. 292, L207-L214.
31. van Och, F. M., Slob, W., de Jong, W. H., Vandebriel, R. J., and van Loveren, H. (2000). A quantitative method for assessing the sensitizing potency of low molecular weight chemicals using a local lymph node assay: Employment of a regression method that includes determination of the uncertainty margins. Toxicology 146, 49-59.
32. Vandenplas, O., Malo, J. L., Saetta, M., Mapp, C. E., and Fabbri, L. M. (1993). Occupational asthma and extrinsic alveolitis due to isocyanates: Current status and perspectives. Br. J. Ind. Med. 50, 213-228.
33. Vanoirbeek, J. A., De Vooght, V., Nemery, B., and Hoet, P. H. (2009). Multiple challenges in a mouse model of chemical-induced asthma lead to tolerance: Ventilatory and inflammatory responses are blunted, immunologic humoral responses are not. Toxicology 257, 144-152.
34. Vanoirbeek, J. A., De Vooght, V., Vanhooren, H. M., Nawrot, T. S., Nemery, B., and Hoet, P. H. (2008). How long do the systemic and ventilatory responses to toluene diisocyanate persist in dermally sensitized mice? J. Allergy Clin. Immunol. 121, 456-463.
35. Vanoirbeek, J. A., Tarkowski, M., Ceuppens, J. L., Verbeken, E. K., Nemery, B., and Hoet, P. H. (2004). Respiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in mice. Toxicol. Sci. 80, 310-321.
36. Vanoirbeek, J. A., Tarkowski, M., Vanhooren, H. M., De Vooght, V., Nemery, B., and Hoet, P. H. (2006a). Validation of a mouse model of chemical-induced asthma using trimellitic anhydride, a respiratory sensitizer, and dinitrochlorobenzene, a dermal sensitizer. J. Allergy Clin. Immunol. 117, 1090-1097.
37. Vanoirbeek, J. A., Toussaint, G., Nemery, B., and Hoet, P. H. (2006b). Reduced exercise capacity in a mouse model of asthma. Thorax 61 736-737.
38. Vanoirbeek, J. A. J., Rinaldi, M., De Vooght, V., Haenen, S., Bobic, S., Gayan-Ramirez, G., Hoet, P. H. M., Verbeken, E., Decramer, M., Nemery, B., and Janssens, W. (2009). Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases. Am. J. Respir. Cell Mol. Biol. Published ahead of print on April 3, 2009, 10.1165/rcmb.2008-0487OC.
39. Wisnewski, A. V., Lemus, R., Karol, M. H., and Redlich, C. A. (1999). Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma? J. Allergy Clin. Immunol. 104, 341-347.
40. Wisnewski, A. V., Liu, Q., Liu, J., and Redlich, C. A. (2005). Glutathione protects human airway proteins and epithelial cells from isocyanates. Clin. Exp. Allergy 35, 352-357.
41. Wisnewski, A. V., and Redlich, C. A. (2001). Recent developments in diisocyanate asthma. Curr. Opin. Allergy Clin. Immunol. 1, 169-175.
42. Wisnewski, A. V., Srivastava, R., Herick, C., Xu, L., Lemus, R., Cain, H., Magoski, N. M., Karol, M. H., Bottomly, K., and Redlich, C. A. (2000). Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo. Am. J. Respir. Crit Care Med. 162, 2330-2336.