Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

Nature Cell Biology

Volumn 7, Issue 10, 2005, Pages 969-976

  Innocenti, Metello ^a,b   Gerboth, Silke ^a,b   Rottner, Klemens ^c   Lai, Frank P L ^c   Hertzog, Maud ^a,b,d   Stradal, Theresia E B ^c   Frittoli, Emanuela ^a,b   Didry, Dominique ^d   Polo, Simona ^a,b   Disanza, Andrea ^a,b   Benesch, Stefanie ^c   Di Fiore, Pier Paolo ^a,b,e   Carlier, Marie France ^d   Scita, Giorgio ^a,b  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN ABI1; PROTEIN CDC42; PROTEIN WAVE; RAC PROTEIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN;

ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CELL SURFACE; CELL TRANSPORT; CELL VACUOLE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MEGALOCYTOSIS; MOLECULAR DYNAMICS; MOLECULAR GENETICS; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; REGULATORY MECHANISM;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CDC42 GTP-BINDING PROTEIN; CELL MEMBRANE; CYTOSKELETAL PROTEINS; HELA CELLS; HUMANS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, TRANSFERRIN; TRANSPORT VESICLES; WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL;

EID: 27144493410     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1304     Document Type: Article

References (43)

1. Pantaloni, D., Le Clainche, C. & Carlier, M. F. Mechanism of actin-based motility. Science 292, 1502-1506 (2001).
2. Pollard, T. D. & Borisy, G. G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112, 453-465 (2003).
3. Qualmann, B. & Kessels, M. M. Endocytosis and the cytoskeleton. Int. Rev. Cytol. 220, 93-144 (2002).
4. Takenawa, T. & Milki, H. WASP and WAVE family proteins: Key molecules for rapid rearrangement of cortical actin filaments and cell movement. J. Cell Sci. 114, 1801-1809 (2001).
5. Moreau, V. et al. A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization. Nature Cell Biol. 2, 441-448 (2000).
6. Stradal, T. E. et al. Regulation of actin dynamics by WASP and WAVE family proteins. Trends Cell Biol. 14, 303-311 (2004).
7. Kitamura, T. et al. Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck. Biochem. Biophys. Res. Commun. 219, 509-514 (1996).
8. Kobayashi, K. et al. P140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J. Biol. Chem. 273, 291-295 (1998).
9. Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M. & Kirschner, M. W. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418, 790-793 (2002).
10. Shi, Y., Alin, K. & Goff, S. P. Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. Genes Dev. 9, 2583-2597 (1995).
11. Innocenti, M. et al. Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Nature Cell Biol. 6, 319-327 (2004).
12. Gautreau, A. et al. Purification and architecture of the ubiquitous Wave complex. Proc. Natl Acad. Sci. USA 101, 4379-4383 (2004).
13. Parsons, M. et al. Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol. Cell Biol. 25, 1680-1695 (2005).
14. Suetsugu, S., Yamazaki, D., Kurisu, S. & Takenawa, T. Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration. Dev. Cell 5, 595-609 (2003).
15. Steffen, A. et al. Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J. 23, 749-759 (2004).
16. Innocenti, M. et al. Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. J. Cell Biol. 160, 17-23 (2003).
17. Disanza, A. et al. Eps8 controls actin-based motility by capping the barbed ends of actin filaments. Nature Cell Biol. 6, 1180-1188 (2004).
18. Lorenz, M., Yamaguchi, H., Wang, Y., Singer, R. H. & Condeelis, J. Imaging sites of N-Wasp activity in lamellipodia and invadopodia of carcinoma cells. Curr. Biol. 14, 697-703 (2004).
19. Bogdan, S. & Klambt, C. Kette regulates actin dynamics and genetically interacts with Wave and Wasp. Development 130, 4427-4437 (2003).
20. Carlier, M. F. et al. GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex. J. Biol. Chem. 275, 21946-21952 (2000).
21. Innocenti, M. et al. Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J. Cell Biol. 156, 125-136 (2002).
22. Fukuoka, M. et al. A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42. J. Cell Biol. 152, 471-482 (2001).
23. Snapper, S. B. et al. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nature Cell Biol. 3, 897-904 (2001).
24. Lommel, S. et al. Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells. EMBO Rep. 2, 850-857 (2001).
25. Taunton, J. Actin filament nucleation by endosomes, lysosomes and secretory vesicles. Curr. Opin. Cell Biol. 13, 85-91 (2001).
26. Rozelle, A. L. et al. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr. Biol. 10, 311-320 (2000).
27. Bogdan, S., Stephan, R., Löbke, C., Mertens, A. & Klämbt, C. Abi activates WASP to promote sensory organ development. Nature Cell Biol. 7, DOI: 10.1038/ncb1305 (2005).
28. Kessels, M. M. & Qualmann, B. Syndapins integrate N-WASP in receptor-mediated endocytosis. EMBO J. 21, 6083-6094 (2002).
29. Naqvi, S. N., Zahn, R., Mitchell, D. A., Stevenson, B. J. & Munn, A. L. The WASp homologue Las17p functions with the WIP homologue End5p/ verprolin and is essential for endocytosis in yeast. Curr. Biol. 8, 959-962 (1998).
30. Conner, S. D. & Schmid, S. L. Regulated portals of entry into the cell. Nature 422, 37-44 (2003).
31. Merrifield, C. J., Feldman, M. E., Wan, L. & Almers, W. Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits. Nature Cell Biol. 4, 691-698 (2002).
32. Merrifield, C. J., Qualmann, B., Kessels, M. M. & Almers, W. Neural Wiskott Aldrich Syndrome Protein (N-WASP) and the Arp2/3 complex are recruited to sites of clathrin-mediated endocytosis in cultured fibroblasts. Eur. J. Cell Biol. 83, 13-18 (2004).
33. Benesch, S. et al. N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits. J. Cell Sci. 118, 3103-3115 (2005).
34. Yarar, D., Waterman-Storer, C. M. & Schmid, S. L. A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis. Mol. Biol. Cell 16, 964-975 (2005).
35. Merrifield, C. J., Perrais, D. & Zenisek, D. Coupling between clathrin-coated-pit invagination, cortactin recruitment, and membrane scission observed in live cells. Cell 121, 593-606 (2005).
36. Wiley, H. S. Trafficking of the ErbB receptors and its influence on signaling. Exp. Cell Res. 284, 78-88 (2003).
37. Suetsugu, S., Miki, H. & Takenawa, T. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. Biochem. Biophys. Res. Commun. 260, 296-302 (1999).
38. Kunda, P., Craig, G., Dominguez, V. & Baum, B. Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions. Curr. Biol. 13, 1867-1875 (2003).
39. Pantaloni, D., Boujemaa, R., Didry, D., Gounon, P. & Carlier, M. F. The Arp2/3 complex branches filament barbed ends: Functional antagonism with capping proteins. Nature Cell Biol. 2, 385-391 (2000).
40. Loisel, T. P., Boujemaa, R., Pantaloni, D. & Carlier, M. F. Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. Nature 401, 613-616 (1999).
41. Egile, C. et al. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. J. Cell Biol. 146, 1319-1332 (1999).
42. Rubinson, D. A. et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nature Genet. 33, 401-406 (2003).
43. Haglund, K. et al. Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nature Cell Biol. 5, 461-466 (2003).