Utility of lymphoblastoid cell lines

Journal of Neuroscience Research

Volumn 87, Issue 9, 2009, Pages 1953-1959

  Sie, L ^a   Loong, S ^b   Tan, Eng King ^a,c  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Lymphoblastoid cell lines; Neurological research

Indexed keywords

CALCIUM; DOUBLE STRANDED DNA; MICRORNA;

CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL TRANSFORMATION; DNA HELIX; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC SCREENING; HUMAN; LYMPHOBLASTOID CELL LINE; MEDICAL RESEARCH; MITOCHONDRION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; SHORT SURVEY; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS;

CELL CULTURE TECHNIQUES; CELL LINE, TRANSFORMED; GENE EXPRESSION PROFILING; GENETIC SCREENING; LYMPHOID PROGENITOR CELLS; MOLECULAR BIOLOGY; PROTEIN ARRAY ANALYSIS; PROTEOMICS; SIGNAL TRANSDUCTION;

EID: 65849518449     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22000     Document Type: Short Survey

References (65)

1. Abe K, St George-Hyslop PH, Tanzi RE, Kogure K. 1991. Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells. Neurosci Lett 125:169-171.
2. Abu-Elneel K, Liu T, Gazzaniga FS, Nishimura Y, Wall DP, Geschwind DH, Lao K, Kosik KS. 2008. Heterogeneous dysregulation of micro-RNAs across the autism spectrum. Neurogenetics 9:153-161.
3. Amoli MM, Carthy D, Platt H, Ollier WER. 2008. EBV Immortalization of human B lymphocytes separated from small volumes of cryopreserved whole blood. Intl J Epidemiol 37(Suppl 1):i41-i45.
4. Arosio B, Annoni G, Vergani C, Solano DC, Racchi M, Govoni S. 1998. Fibroblasts from Alzheimer's disease donors do not differ from controls in response to heat shock. Neurosci Lett 256:25-28.
5. Babar IA, Slack FJ, Weidhaas JB. 2008. miRNA modulation of the cellular stress response. Future Oncol 4:289-298.
6. Baron CA, Liu SY, Hicks C, Gregg JP. 2006. Utilization of lymphoblastoid cell lines as a system for the molecular modeling of autism. J Autism Dev Disord 36:973-982.
7. Bartel DP. 2004. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281-297.
8. Beck JC, Beiswanger CM, John EM, Satariano E, West D. 2001. Successful transformation of cryopreserved lymphocytes: a resource for epidemiological studies. Cancer Epidemiol Biomarkers Prev 10:551-554.
9. Beit-Ya'acov A, Mizrahi-Meissonnier L, Obolensky A, Landau C, Blumenfeld A, Rosenmann A, Banin E, Sharon D. 2007. Homozygosity for a novel ABCA4 founder splicing mutation is associated with progressive and severe Stargardt-like disease. Invest Ophthalmol Vis Sci 48:4308-4314.
10. Ben-Shachar D. 2002. Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine. J Neurochem 83:1241-1251.
11. Bernacki SH, Beck JC, Muralidharan K, Schaefer FV, Shrimpton AE, Richie KL, Levin BC, Pont-Kingdon G, Stenzel TT. 2005. Characterization of publicly available lymphoblastoid cell lines for disease-associated mutations in 11 genes. Clin Chem 51:2156-2159.
12. Bernacki SH, Stankovic AK, Williams LO, Beck JC, Herndon JE, Snow-Bailey K, Prior TW, Matteson KJ, Wasserman LM, Cole EC, Stenzel TT. 2003. Establishment of stably EBV-transformed cell lines from residual clinical blood samples for use in performance evaluation and quality assurance in molecular genetic testing. J Mol Diag 5:227-230.
13. Bilen J, Liu N, Burnett BG, Pittman RN, Bonini NM. 2006. Micro-RNA pathways modulate polyglutamine-induced neurodegeneration. Mol Cell 24:157-163.
14. Bushati N, Cohen SM. 2008. microRNAs in neurodegeneration. Curr Opin Neurobiol [Epub ahead of print].
15. Cai X, Schäfer A, Lu S, Bilello JP, Desrosiers RC, Edwards R, Raab-Traub N, Cullen BR. 2006. Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathog 2:e23.
16. Cao Y, Espinola JA, Fossale E, Massey AC, Cuervo AM, MacDonald ME, Cotman SL. 2006. Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem 281:20483-20493.
17. Caron M, Imam-Sghiouar N, Poirier F, Le Caër JP, Labas V, Joubert-Caron R. 2002. Proteomic map and database of lymphoblastoid proteins. J Chromatogr B Analyt Technol Biomed Life Sci 771:197-209.
18. Dirksen EHC, Cloos J, Braakhuis BJM, Brakenhoff RH, Heck AJR, Slijper M. 2006. Human lymphoblastoid proteome analysis reveals a role for the inhibitor of acetyltransferases complex in DNA double-strand break response. Cancer Res 66:1473-1480.
19. Dodson MW, Gou M. 2007. Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease. Curr Opin Neurobiol 17:331-337.
20. Gao J, Luo X, Tang K, Li X, Li G. 2006. Epstein-Barr virus integrates frequently into chromosome 4q, 2q, 1q and 7q of Burkitt's lymphoma cell line (Raji). J Virol Methods 136:193-199.
21. Glaser V. 2008. Tapping miRNA-regulated pathways: expression profiling ramps up to support diagnostics and drug discovery. Genet Eng Biotechnol News 28.
22. Gualandi G, Santolinin E, Calef E. 1992. Epstein-Barr virus DNA recombines via latent origin of replication with the human genome in the lymphoblastoid cell line RGN1. J Virol 66:5677-5681.
23. Gutekunst CA, Levey AI, Heilman CJ, Whaley WL, Yi H, Nash NR, Rees HD, Madden JJ, Hersch SM. 1995. Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with antifusion protein antibodies. Proc Natl Acad Sci U S A 92:8710-8714.
24. Hammond SM. 2006. MicroRNA therapeutics: a new niche for antisense nucleic acids. Trends Mol Med 12:99-101.
25. Hand CK, Devon RS, Gros-Louis F, Rochefort D, Khoris J, Meininger V, Bouchard J-P, Camu W, Hayden MR, Rouleau GA. 2003. Mutation screening of the ALS2 gene in sporadic and familial amyotrophic lateral sclerosis. Arch Neurol 60:1768-1771.
26. Hu VW, Frank BC, Heine S, Lee NH, Quackenbush J. 2006. Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes. BMC Genomics 7:118.
27. Hughes S, Arneson N, Done S, Squire J. 2005. The use of whole genome amplification in the study of human disease. Prog Biophys Mol Biol 88:173-189.
28. Iaccarino C, Crosio C, Vitale C, Sanna G, Carri MT, Barone P. 2007. Apoptotic mechanisms in mutant LRRK2-mediated cell death. Hum Mol Genet 16:1319-1326.
29. Iwamoto K, Bundo M, Kato T. 2005. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet 14:241-253.
30. Jiang J, Lee EJ, Schmittgen TD. 2005. Increased expression of micro-RNA-155 in Epstein-Barr virus transformed lymphoblastoid cell lines. Genes Chromosomes Cancer 45:103-106.
31. Joubert-Caron R, le Caer J, Montandon F, Poirier F, Imam N, Feuillard J, Bladier D, Rossier J, Caron M. 2000. Protein analysis by mass spectrometry and sequence database searching: a proteomic approach to identify human lymphoblastoid cell line proteins. Electrophoresis 21:2566-2575.
32. Kakiuchi C, Ishiwata M, Nanko S, Ozaki N, Iwata N, Umekage T, Tochigi M, Kohda K, Sasaki T, Imamura A, Okazaki Y, Kato T. 2008. Up-regulation of ADM and SEPX1 in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia. Am J Med Genet B Neuropsychiatr Genet 147B:557-564.
33. Karpuj MV, Garren H, Slunt H, Price DL, Gusella J, Becher MW, Steinman L. 1999. Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei. Proc Natl Acad Sci U S A 96:7388-7393.
34. Kato T, Ishiwata M, Nagai T. 2002. Mitochondrial calcium response in human transformed lymphob lastoid cells. Life Sci 71:581-590.
35. Kobayashi H, Kruger R, Markopoulou K, Wszolek Z, Chase B, Taka H, Mineki R, Murayama K, Riess O, Mizuno Y, Hattori N. 2003. Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease. Brain 126:32-42.
36. Koide R, Kobayashi S, Shimohata T, Ikeuchi T, Maruyama M, Saito M, Yamada M, Takahashi H, Tsuji S. 1999. A neurological disease caused by an expanded CAG trinucleotide repeat in the TAT-binding protein gene: a new polyglutamine disease? Hum Mol Genet 8:2047-2053.
37. Lacelle C, Wang E. 2002. Establishing lymphoblastoid cell lines from frozen blood of extremely old individuals. Mech Ageing Dev 123:1415-1418.
38. Leenman EE, Panzer-Grümayer RE, Fischer S, Leitch HA, Horsman DE, Lion T, Gadner H, Ambros PF, Lestou VS. 2004. Rapid determination of Epstein-Barr virus latent or lytic infection in single human cells using in situ hybridization. Mod Pathol 17:1564-1572.
39. Lestou VS, de Braekeleer M, Strehl S, Ott G, Gadner H, Ambros PF. 1993. Non-random integration of Epstein-Barr virus in lymphoblastoid cell lines. Genes Chromosomes Cancer 8:38-48.
40. Li C-Q, Trudel LJ, Wogan GN. 2002. Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53. Proc Natl Acad Sci U S A 99:10364-10369.
41. Lin CH, Tzen KY, Yu CY, Tai CH, Farrer MJ, Wu RM. 2008. LRRK2 mutation in familial Parkinson's disease in a Taiwanese population: clinical, PET, and functional studies. J Biomed Sci 5:661-667.
42. Lockhart PJ, Lincoln S, Hulihan M, Kachergus J, Wilkes K, Bisceglio G, Mash DC, Farrer MJ. 2004. DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function. J Med Genet 41:e22.
43. Mahal LK. 2008. Glycomics: towards bioinformatic approaches to understanding glycosylation. Anticancer Agents Med Chem 8:37-51.
44. Marchbanks RM, Ryan M, Day IN, Owen M, McGuffin P, Whatley SA. 2003. A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress. Schizophr Res 65:33-38.
45. Masci A, Mastronicola D, Arese M, Piane M, de Amicis A, Blanck TJJ, Chessa L, Sarti P. 2008. Control of cell respiration by nitric oxide in ataxia telangiectasia lymphoblastoid cells. Biochim Biophys Acta 1777:66-1773.
46. Mayeux R, The NIA-LOAD Study Group. 2006. P1-279 Familial Alzheimer's disease: The NIA-LOAD study. Alzheimers Dement 2(Suppl 1):S178-S179.
47. Meschia JF, Brown RD Jr, Brott TG, Chukwudelunzu FE, Hardy J, Rich SS. 2002. The Siblings With Ischemic Stroke Study (SWISS) Protocol. BMC Med Genet 3:1.
48. Mohyuddin A, Ayub Q, Siddiqi S, Carvalho-Silva DR, Mazhar K, Rehman S, Firasat S, Dar A, Tyler-Smith C, Mehdi SQ. 2004. Genetic instability in EBV-transformed lymphoblastoid cell lines. Biochim Biophys Acta 1670:81-83.
49. Monnier N, Ferreiro A, Marty I, Labarre-Vila A, Mexin P, Lunardi J. 2003. A homozygous splicing mutation causing a depletion of skeletal muscle RYR1 is associated with multi-minicore disease congenital myopathy with ophthalmoplegia. Hum Mol Genet 12(10):1171-1178.
50. Nelson PT, Wang WX, Rajeev BW. 2008. MicroRNAs (miRNAs) in neurodegenerative diseases. Brain Pathol 18:130-138.
51. Pfeffer S, Zavolan M, Grässer FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T. 2004. Identification of virus-encoded microRNAs. Science 304:734-736.
52. Scriver CR. 2004. After the genome - the phenome? J Inherit Metab Dis 27:305-317.
53. Sugimoto M, Tahara H, Ide T, Furuichi Y. 2004. Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus. Cancer Res 64:3361-3364.
54. Tan EK, Sie L, Loong S. 2008. Growth rate from patient-derived lymphoblastoid cells with LRRK2 mutations. Mol Genet Metab 95:113.
55. Tan EK, Zhao Y, Skipper L, Tan MG, Di Fonzo A, Sun L, Fook-Chong S, Tang S, Chua E, Yuen Y, Tan L, Pavanni R, Wong MC, Kolatkar P, Lu CS, Bonifati V, Liu JJ. 2007. The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence. Hum Genet 120:857-863.
56. Tan EK, Skipper LM. 2007. Pathogenic mutations in Parkinson disease. Hum Mutat 28:641-653.
57. Tan EK. 2006. Re-defining neurological syndromes: the genotype meets the phenotype. Ann Acad Med Singapore 35:63-65.
58. Toda T, Sugimoto M. 2003. Proteome analysis of Epstein-Barr virus-transformed B-lymphoblasts and the proteome database. J Chromatography B 787:197-206.
59. Trenz K, Landgraf J, Speit G. 2003. Mutagen Sensitivity of Human Lymphoblastoid Cells with a BRCA1 Mutation. Breast Cancer Res Treat 78:69-79.
60. van Meer G. 2005. Cellular lipidomics. EMBO J 24:3159-3165.
61. Vilain A, Bernardino J, Gerbault-Seureau M, Vogt N, Niveleau A, Lefrancois D, Malfoy B, Dutrillaux B. 2000. DNA methylation and chromosome instability in lymphoblastoid cell lines. Cytogenet Cell Genet 90:93-101.
62. Washizuka S, Kakiuchi C, Mori K, Kunugi H, Tajima O, Akiyama T, Nanko S, Kato T. 2003. Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 120B:72-78.
63. Washizuka S, Kametani M, Sasaki T, Tochigi M, Umekage T, Kohda K, Kato T. 2006. Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with schizophrenia in the Japanese population. Am J Med Genet B Neuropsychiatr Genet 141B:301-304.
64. Wishart DS, Tzur D, Knox C, Eisner R, Guo AC, Young N, Cheng D, Jewell K, Arndt D, Sawhney S, Fung C, Nikolai L, Lewis M, Coutouly M-A, Forsythe I, Tang P, Shrivastava S, Jeroncic K, Stothard P, Amegbey G, Block D, Hau DD, Wagner J, Miniaci J, Clements M, Gebremedhin M, Guo N, Zhang Y, Duggan GE, Mac-Innis GD, Weljie Am, Dowlatabadi R, Bamforth F, Clive D, Greiner R, Li L, Marrie T, Sykes BD, Vogel HJ, Querengesser L. 2007. HMDB: the Human Metabolome Database. Nuc Acids Res 35:D521-D526.
65. Wu R-M, Bounds R, Lincoln S, Hulihan M, Lin C-H, Hwu W-L, Chen J, Gwinn-Hardy K, Farrer M. 2005. Parkin mutations and early-onset parkinsonism in a Taiwanese cohort. Arch Neurol 62:82-87.