Glucagon Like Peptides-1 Modulators as Newer Target for Diabetes

Current Drug Targets

Volumn 9, Issue 10, 2008, Pages 911-920

  Vaidya, H B ^a   Goyal, R K ^a  

^a L M COLLEGE OF PHARMACY   (India)

Author keywords

Antihyperglycemic; Diabetes mellitus; Dipeptidyl peptidase IV; Enteroendocrine derived peptide; Glucagon like peptide; Glucosedependent insulinotropic polypeptide; Glycated haemoglobin; Hypoglycemia

Indexed keywords

GLUCAGON LIKE PEPTIDE 1;

AMINO ACID SEQUENCE; ANIMAL; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; HUMAN; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; DIABETES MELLITUS, TYPE 2; DRUG DELIVERY SYSTEMS; GLUCAGON-LIKE PEPTIDE 1; HUMANS; MOLECULAR SEQUENCE DATA;

EID: 65849187460     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945008785909284     Document Type: Review

References (135)

1. Joe, M. C.; Arshag, D.M. (2000) Drugs, 60, 95-113.
2. Prevention of "Diabetes Mellitus", World Health Organization Technical Report Series 1994, No.844.
3. "Diabetes Mellitus", (1999) World Health Organization Fact Sheet, No. 138.
4. "Diabetes Mellitus", (1999) American Diabetes Association-General Fact Sheet
5. Harris, M.I.; Flegal, K.M.; Cowie, C.C.; Eberhardt, M.S.; Goldstein, D.E.; Little, R.R.; et al. (1998) Diabetes Care, 21, 518-54.
6. International Diabetes Federation. Diabetes Atlas, Second Edition. International Diabetes Federation; Brussells, 2003.
7. Atkinson, M.A.; Eisenbarth, G.S. (2001) Lancet, 358, 221-229.
8. Report of the expert committee on the diagnosis and classification of diabetes mellitus. (1997) Diabet. Care, 20, 1183-1197.
9. UK Prospective Diabetes Study (UKPDS) Group (1998) Lancet, 352, 854-65.
10. Emslie-Smith, A.M.; Boyle, D.I.; Evans, J.M.; Sullivan, F.; Morris, A.D. (2001) Diabetic Med., 18, 483-8.
11. Edwards, C.M.; Barton, M.A.; Snook, J.; David, M.; Mak, V.H.; Chowdhury, T.A. (2003) J. Med., 96, 315-16.
12. Lebovitz, H.E.; Melander, A. International Textbook of Diabetes Mellitus, (1992) 1st edn. Oxford: Alden Press,. Pp. 745-772.
13. Coniff, R.F.; Shapiro, J.A.; Seaton, T.B.; Bray, G.A. (1995) Am. J. Med., 98, 443-51.
14. Nolan, J.J.; Ludvik, B.; Beerdsen, P.; Joyce, M.; Olefsky, J. (1994) N. Engl. J. Med., 331, 1188-93.
15. Lebovitz, H.E.; Dole, J.F.; Patwardhan, R.; Rappaport, E.B.; Freed, M.I. (2001) J. Clin. Endocrinol. Metab., 86, 280-8.
16. Aronoff, S.; Rosenblatt, S.; Braithwaite, S.; Egan, J.W.; Mathisen, A.L.; Schneider, R.L. (2000) Diabetes Care, 23, 1605-11.
17. Elrick, H.; Stimmler, L.; Hlad, C.J.; Arai, Y. (1964) J. Clin. Endocrinol. Metab., 24, 1076-1082.
18. McIntyre, N.; Holdsworth, C.D.; Turner, D.S. (1965) J. Clin. Endocrinol. Metab., 25, 1317-1324.
19. Dupre, J.; Beck, J.C. (1966) Diabetes, 15, 555-559.
20. Nielsen, L.L.; Young, A.A.; Parkes, D.G. (2004) Regul. Pept., 117, 77-88.
21. Perley, M.J.; Kipnis, D.M. (1967) J. Clin. Invest., 46, 1954-1962.
22. McIntyre, N.; Holsworth, D.C. (1964) Lancet, 2, 20-21.
23. Arnould, Y.; Bellens, R.; Franckson, J.R.M.; Conard, V. (1963) Metabol., 12, 1122-1131.
24. Dupre, J.; Beck, J.C. (1966) Diabetes, 15, 555-559.
25. Mojsov, S.; Weir, G. C.; Habener, J. F. (1987) J. Clin. Invest., 79, 616-619.
26. Meier, J. J.; Nauck, M. A.; Schmidt, W. E.; Gallwitz, B. (2002) Regul. Pept., 107, 1-13.
27. Dhanvantari, S.; Izzo, A.; Jansen, E.; Brubaker, P. L. (2001) Endocrinology, 142, 37-42.
28. Orskov, C.; Rabenhoj, L.; Wettergren, A.; Kofod, H.; Holst, J. J. (1994) Diabetes, 43, 535-539.
29. Nauck, M.A.; Niedereich-Holz, U.; Ettler, R.; Holst, J.J.; Orskov, C.; Ritzel, R. (1997) Am. J. Physiol., 273, E981-E988.
30. Orskov, C.; Holst, J.J.; Nielsen, O.V. (1988) Endocrinology, 123, 2009-2013.
31. Stoffers, D.A.; Kieffer, T.J.; Hussain, M.A.; Drucker, D.J.; Bonner-Weir, S.; Habener, J.F.; Egan, J.M. (2000) Diabet, 49, 741-748.
32. Zhou, J.; Wang, X.; Pineyro, M.A.; Egan, J.M. (1999) Diabetes, 48, 2358-2366.
33. Tang-Christensen, M.; Larsen, P.J.; Goke, R.; Fink-Jensen, A.; Jessop, D.S.; Moller, M.; Sheikh, S.P. (1996) Am. J. Physiol., 271, R848-R856.
34. Layer, P.; Holst, J.J.; Grandt, D.; Goebell, H. (1995) Dig. Dis. Sci., 40, 1074-1082.
35. Elliott, R.M.; Morgan, L.M.; Tredger, J.A.; Deacon, S.; Wright, J.; Marks, V. (1993) J. Endocrinol., 138, 159-166.
36. Eissele, R.; Goke, R.; Willemer, S.; Harthus, H.-P.; Vermeer, H; Arnold, R.; Goke, B. (1992) Eur. J. Clin. Invest., 22, 283-291.
37. Thorens, B. (1992) Proc. Natl. Acad. Sci. USA, 89, 8641-8645.
38. Fehmann, H-C.; Habener, J.F. (1992) Endocrinology, 130, 159-166.
39. Fehmann, H.C.; Habener, J.F. (1991) FEBS Lett., 279, 335-340.
40. Göke, R.; Conlon, J.M. (1988) J. Endocrinol., 116(471), 357-363.
41. Gallwitz, B.; Witt, M.; Fölsch, U.R.; Creutzfeldt, W.; Schmidt, W.E. (1988) J. Mol. Endocrinol., 10 (472), 259-268.
42. Ørskov, C.; Nielsen, J.H. (1988) FEBS. Lett., 229 (473), 175-178.
43. Göke, R.; Cole, T.; Conlon, J.M. (1989) J. Mol. Endocrinol., 2(474), 93-98.
44. Fehmann, H.C.; Habener, J.F. (1991) Endocrinology, 128 (475), 2880-2888.
45. Gros, L.; Demiprince, E.; Bataille, D.; Kervran, A. (1992) Biomed. Res., 13(Suppl 2),143-150.
46. Ørskov, C.; Poulsen, S.S. (1991) Diabetes, 40, 1292-1296.
47. Kanse, S.M.; Kreymann, B.; Ghatei, M.A.; Bloom, S.R. (1988) FEBS. Lett., 241(388), 209-212.
48. Richter, G.; Göke, R.; Göke, B.; Arnold, R. (1990) FEBS Lett., 267, 78-80.
49. Richter, G.; Goke, R.; Goke, B.; Schmidt, H.; Arnold, R. (1991) FEBS Lett., 280, 247-250.
50. Uttenthal, L.O.; Blazquez, E. (1990) FEBS Lett., 262, 139-141.
51. Shimizu, I.; Hirota, M.; Ohboshi, C.; Shima, K. (1987) Endocrinology, 121, 1076-1082.
52. Mayo, I. E. (1992) Mol. Endocrinol., 6, 1734-1744.
53. Thorens, B.; Porret, A.; Bü hler, L.; Deng, S.P.; Morel, P.; Widman, C. (1993) Diabetes, 42, 1678-1682.
54. Dillon, J.S.; Tanizawa, T.; Wheeler, M.B.; Leng, X.H.; Ligon, B.B.; Rabin, D.U.; Warren, H.Y.; Permutt, M.A. Boyd III, A.E. Endocrinology, 133, 1907-1910.
55. Graziano, M.P.; Hey, P.J.; Borkowski, D.; Chicci, C.; Strader, C.D. (1993) Biochem. Biophys. Res. Commun., 196, 141-146.
56. Jelinek, L.J.; Lok, S.; Rosenberg, G.B. (1993) Science, 259, 1614-1616.
57. Ishihara, T.; Shigemoto, R.; Mori, K.; Takkahashi, K.; Nagata, S. (1992) Neuron, 8, 811-819.
58. Ishihara, T.; Nakamura, S.; Kaziro, Y. (1991) EMBO J., 10, 1635-1641.
59. Usdin, T.B.; Mezey, E.;Button, D.C. (1993) Endocrinology, 133, 2861-2870.
60. Spengler, D.; Waeber, C.; Pataloni, C.; Holsboer, F.; Bockaert, J.; Seeburg, P.H.; Journot, L. (1993) Nature, 365, 170-175.
61. Mayo, I.E. (1992) Mol. Endocrinol., 6, 1734-1744.
62. Lin, H.Y.; Harris, T.T.L.; Flannery, M.S.; Aruffo, A.; Kaji, E.H., Gorn, A.; Kolakowski, L.F.; Lodish, H.F.; Goldring, S.R. (1991) Science, 254, 1022-1024.
63. Jü ppner, H.; Abou-Samra, A.B.; Freeman, M. (1991) Science, 254, 1024-1026.
64. Buggy, J.J.; Livingston, J.N.; Rabin, D.U.; Yoo-Warren, H. (1995) J. Biol. Chem., 270, 7474-7478.
65. Dupre, J.; Ross, S.A.; Watson, D.; Brown, J.C. (1973) J. Clin. Endocrinol. Metab., 37, 826-828.
66. Rocca, A.S.; Brubaker, P.L. (1999) Endocrinology, 140, 1687-1694.
67. Brubaker, P.L.; Anini, Y. (2003) Can. J. Physiol. Pharmacol., 81, 1005-1012.
68. Hansen, L.; Lampert, S.; Mineo, H.; Holst, J.J. (2004) Am. J. Physiol. Endocrinol. Metab., 287, E939-E947.
69. Drucker, D.J., Philippe, J., Mojsov, S., Chick, W.L., Habener, J.F. (1987) Proc. Nat. Acad. Sci. U. SA., 84, 3434-3438.
70. Beguin, P., Nagashima, K., Nishimura, M., Gonoi, T., Seino, S. (1999) EMBO J., 4722-4732.
71. Holz, G.G.; Kuhtreiber, W.M.; Habener, J.F. (1993) Nature, 361, 362-365.
72. Yada, T.; Itoh, K.; Nakata, M. (1993) Endocrinology, 133, 1685-1692.
73. Bode, H.-P.; Moorman, B.; Dabew, R.; Goke, B. (1999) Endocrinology, 140, 3919-3927.
74. Gromada, J.; Holst, J.J.; Rorsman, P. (1998) P. Jugers. Arch., 435, 583-594.
75. Byrne, M.M.;Goke, B. (1996) Diabetes Med., 1, 854-860.
76. Turner, R.C.; Cull, C.A.; Frighi, V.; Holman, R.R. (1999) JAMA, 281, 2005-2012.
77. Nauck, M.A.; Sauerwald, A.; Ritzel, R.; Holst, J.J.; Schmiegel, W. (1998) Diabetes Care, 21, 1925-1931.
78. Rodriquez, de Fonseca, F.; Navarro, M.; Alvarez, E.; Roncero, I.; Chowen, A.J.; Maestre, O.; Gomez, R.; Munoz, M.R.; Eng, J. (2000) Metab, 42, 709-717.
79. Gutzwiller, J.P.; Drewe, J.; Goke, B.; Schmidt, H.; Rohrer, B.; Larieda, J., Beglinger, C. (1999) Am. J. Physiol., 276, (5, pt 2), R1541-R1544.
80. Navarro, M.; Rodriquez, de Fonseca, F.; Alvarez, E.; Chowen, A.J.; Zueco, A.J.; Gomez, R.; Eng, J. (1996) J. Neurochem., 67, 1982-1991.
81. MacLusky, N.J.; Cook, S.; Scrocchi. L.; Shin, J.; Kim, J.; Vaccarino, F.; Asa, L.S.; Drucker, J.D. (2000) Endocrinology, 141, 752-762.
82. Young, A.A.; Gedulin, B.R.; Bhavsar, S.; Bodkin, N.; Jodka, C.; Hansen, B.; Denaro, M. (1999) Diabetes, 48, 1026-1034.
83. Xu, G.; Stoffers, D.A.; Habener, J.F.; Bonner-Weir, S. (1999) Diabetes., 48, 2270-2276.
84. Edwards, C.M.; Todd, J.F.; Mahmoudi, M.; Wang, Z.; Wang, R.M.; Ghatei, M.A.; Bloom, S.R. (1999) Diabetes, 48, 86-93.
85. Deacon, C.F.; Knudsen, L.B.; Madsen, K.; Wiberg, F.C.; Jacobsen, O.; Holst, J.J. (1998) Diabetologia, 41, 271-278.
86. Burcelin, R.; Dolci, W.; Thorens, B. (1999) Metab., 48, 252-258.
87. Egan, J.M.; Clocquet, A.R.; Elahi, D. (2002) J. Clin. Endocrinol. Metab., 87, 1282-1290.
88. Edwards, C.M.; Stanley, S.A.; Davis, R.; Brynes, E.A.; Frost, S.G.; Seal, J.L.; Ghatei, A.M.; Bloom, S.R. (2001) Am. J. Physiol. Endocrinol. Metab., 281, E155-E161.
89. Nielsen, L. (2005) Drug Discov. Today, 10, 703-710.
90. Trautmann, M.E.; Chen, C.F.; Chappell, J.; Danaberg, J.; Patterson, B.; Klausmann, G.; Kapitza, C. (2003) Diabetes, 52(Suppl. 1), A136.
91. Knudsen, L.B.; Nielsen, P.F.; Huusfeldt, P.O.; Johansen, N.L.; Madsen, K.; Pedersen, F.Z.; Thogersen, H.; Wilken, M.; Agerso, H. (2002) J. Med. Chem., 41, 1664-1669.
92. Juhl, C.B.; Hollingdal, M.; Sturis, J.; Jakobsen, G.; Agerso, H.; Veldhuis, J.; Porksen, N.; Schmitz, O. (2002) Diabetes, 51, 424-429.
93. Rolin, B.; Larsen, M.O.; Gotfredsen, C.F.; Deacon, C.F.; Carr, R.D.; Wilken, M.; Knudsen, L.B. (2002) Am. J. Physiol., 283, E745-E752.
94. Sturis, J.; Gotfredsen, C.F.; Romer, J.; Rolin, B.; Ribel, U.; Brand, C.L.; Wilken, M.; Wassermann, K.; Deacon, C.F.; Carr, R.D.; Knudsen, L.B. (2003) Br. J. Pharmacol., 140, 123-132.
95. Ginnoukakis, N. (2003) Conju. Chem. Curr. Opin. Invest. Drugs, 4, 1245-1249.
96. Kim, J.G.; Baggio, L.L.; Bridon, D.P.; Castaigne, J.P.; Robitaille, M.F.; Jette, L.; Benquet, C.; Drucker, D.J. (2003) Diabetes, 52, 751-759.
97. Knudsen, L.B. (2004) J. Med. Chem., 47, 4128-4134.
98. Yamamoto, H.; Kishi, T.; Lee, C.E.; Choi, B.J.; Fang, H.; Hollenberg, A.N.; Drucker, D.J.; Elmquist, J.K. (2003) J. Neurosci., 23, 2939-2946.
99. Hopsu-Havu, V.K.; Glenner, C.G. (1966) Histochemistry, 7, 197-201.
100. Kettman, U.; Humbel, B.; Holzhausen, H.J. (1992) Acta Histochem., 92, 225-227.
101. Mentlein, R. (1999) Regul. Pept., 85, 9-24.
102. Ludwig, K.; Yan, S.; Fan, H.; Reutter, W.; Bottcher, C. (2003) Biochim. Biophys. Res. Commun., 304, 73-77.
103. Naush, I.; Mentlein, R., Heymann, E. (1990) Biol. Chem. Hoppe. Seyler, 371, 1113-1118.
104. Mitani, H.; Takimoto, M.; Hughes, T.E.; Kimura, M. (2002) Jpn. J. Pharmacol., 88, 442-450.
105. Marguet, D.; Baggio, L.; Kobayashi, T.; Bernard, A.M.; Pierrers, M.; Nielsen, P.F.; Ribel, U.; Watanabe, T.; Drucker, D.J.; Wagtmann, N. (2000) Proc. Natl. Acad. Sci. U.S.A., 97, 6874-6879.
106. Drucker, D.J. (2006) Cell Metab., 3, 153-65.
107. Deacon, C. (2004) Diabetes, 53, 2181-9.
108. Rosenblum, J.S.; Kozarich, J.W. (2003) Curr. Opin. Chem. Biol., 7, 496-504.
109. Holst, J. J.; Deacon, C. F. (1998) Diabetes, 47(11), 1663-1670.
110. Lenhard, J. M.; Gottschalk, W. K. (2002) Adv. Drug Delivery Rev., 54, 1199-1212.
111. McIntosh, C. H. S.; Demuth, H.-U.; Pospisilik, J. A.; Pederson, R. A. (2005) Regulat. Peptide, 128(2), 159-165.
112. Augustyns, K., Bal, G.; Thonus, G.; Belyaev, A.; Zhang, X. M.; Bollaert, W.; Lambeir, M.A.; Durinx, C.; Goossens, F.; Haemers, A. (1999) Curr. Med. Chem., 6(4), 311-327.
113. Evans, D. M. (2002) I. Drugs, 5(6), 577-585.
114. Weber, A. E. (2004) J. Med. Chem., 47(17), 4135-4141.
115. Wiedeman, P. E.; Trevillyan, J. M. (2005) Drug Dis. Today Ther. Strat., 2(2), 143-149.
116. Mannucci, E.; Ognibene, A.; Cremasco, F.; Bardini, G.; Mencucci, A.; Pierazzuoli, E.; Ciani, S.; Messeri, G.; Rotella, C.M. (2001) Diabetes Care, 24, 489-94.
117. Lindsay, J. R; Duffy, N.A.; McKillop, A.M.; Ardill, J.; O'Harte, F.P.M.; Flatt, P.R.; Bell, P.M. (2005) Diabetes Med., 22, 654-7.
118. Drucker, D.J.; Nauck, M.A. (2006) Lancet, 368, 1696-1705.
119. Ahren, B.; Pacini, G.; Foley, J. E.; Schweizer. (2005) Diabetes Care, 28, 1936-1940.
120. Ahŕen, B.; Landlin-Olesson, M.; Jansson, P.A.; Svensson, M.; Holmes, D.; Schweizer, A. (2004a) J. Clin. Endocrinol. Metab., 89, 2078-2084.
121. Ahren, B.; Gomis, R.; Standl, E.; Mills, D.; Schweizer, A. (2004b) Diabetes Care, 27, 2874-2880.
122. Ristic, S.; Byiers, S.; Foley, J. Holmes, D. (2005) Diabetes Obes. Metab., 7, 692-698.
123. Kim, D.; Wang, L.; Beconi, M., Eiermann, J.G.; Fisher, H.M.; He, H.; Hickey, J.G.; Kowalchick, E.J.; Leiting, B.; Lyons, K.; Marsilio, F.; McCann, E.M.; Patel, A.R.; Petrov, A; Scapin, G.; Patel, B.S.; Roy, S.R.; Wu, K.J.; Wyvratt, J.M.; Zhang, B.B.; Zhu, L.; Thornberry, A.N.; Weber, E.A. (2005) J. Med. Chem., 48, 141-151.
124. Raz, I.; Hanefeld, M.; Xu, L.; Caria, C.; Williams-Herman, D.; Khatami, H. (2006) Diabetologia, 49, 2564-2571.
125. Aschner, P.; Kipnes, S.M.; Lunceford, K.J.; Sanchez, M.; Mickel, C.; Debora, E. (2006) Diabetes Care, 29, 2632-2637.
126. Charbonnel, B.; Karasik, A.; Liu, J.; Wu, M.; Meininger, G.; For Sitagliptin study 020 group (2006) Diabetes Care, 29, 2638-2643.
127. Rosenstock, J.; Brazg, R.; Andryuk, J.P.; Lu, K.; Stein, P. (2006) Clin. Ther., 28, 1556-1568.
128. Scott, R.; Wu, M.; Sanchez, M.; Stein, P. (2007) Int. J. Clin. Pract., 61, 171-80.
129. Augeri, D.J.; Robl, J.A.; Betebenner, D.A.; Magnin, D.R.; Khanna, A.; Robertson, J.G.; Wang, A.; Simpkins, L.M.; Taunk, P.; Huang, Q.; Han, S.P.; Abboa-Offei, B.; Cap, M.; Xin, L.; Tao, L.; Tozzo, E.; Welzel, G.E.; Egan, D.M.; Marcinkeviciene, J.;Chang, S.Y.; Biller, S.A.; Kirby, M.S.; Parker, R.A.; Hamann, L.G. (2005) J. Med. Chem., 48, 5025-5037.
130. Kim, Y.B.; Kopcho, L.M.; Kirby, M.S.; Hamann, L.G.; Weigelt, C.A.; Metzler, W.J.; Marcinkeviciene, J. (2006) Arch. Biochem. Biophys., 445, 9-18.
131. Pospisilik, J.A.; Stafford, S.G.; Demuth, H.U.; Brownsey, R.; Parkhouse, W.; Finegood, D.T.; McIntosh, C.H.; Pederson, R.A. (2002a) Diabetes, 51, 943-950.
132. Pospisilik, J.A., Stafford, S.G., Demuth, H.U., McIntosh, C.H.S., Pederson, R. A (2002b) Diabetes, 51, 2677-2683.
133. Wargent, E.; Stocker, C.; Augstein, P.; Heinke, P., Meyer, A.; Hoffmann, T.; Subramaniam, A.; Sennitt, M.V.; Demuth, H.U.; Arch, J.R.S.; Cawthorne, M.A. (2005) Diabetes Obes. Metab., 7, 170-181.
134. Demuth, H.U.; McIntosh, C.H.S.; Pederson, R.A. (2005) Biochim. Biophys. Acta, 1751, 33-44.
135. Heins, J.; Glund, K.; Hoffmann, T.; Metzner, J.; Demuth, H.U. (2004) Diabetes, 53(Suppl.2), A128 (Abstract).