-
1
-
-
0023107555
-
Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
-
S. Mojsov et al. Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas J. Clin. Invest. 79 1987 616-619
-
(1987)
J. Clin. Invest.
, vol.79
, pp. 616-619
-
-
Mojsov, S.1
-
2
-
-
0023638829
-
Glucagon-like peptide-17-36: A physiological incretin in man
-
B. Kreymann et al. Glucagon-like peptide-17-36: A physiological incretin in man Lancet 2 1987 1300-1304
-
(1987)
Lancet
, vol.2
, pp. 1300-1304
-
-
Kreymann, B.1
-
3
-
-
0026535588
-
Insulinotropic hormone glucagon-like peptide-I (7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma betaTC-1 cells
-
H.C. Fehmann et al. Insulinotropic hormone glucagon-like peptide-I (7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma betaTC-1 cells Endocrinology 130 1992 159-166
-
(1992)
Endocrinology
, vol.130
, pp. 159-166
-
-
Fehmann, H.C.1
-
4
-
-
0033513455
-
Exendin-4 stimulates both [beta]-cell replication and neogenesis, resulting in increased [beta]-cell mass and improved glucose tolerance in diabetic rats
-
G. Xu et al. Exendin-4 stimulates both [beta]-cell replication and neogenesis, resulting in increased [beta]-cell mass and improved glucose tolerance in diabetic rats Diabetes 48 1999 2270-2276
-
(1999)
Diabetes
, vol.48
, pp. 2270-2276
-
-
Xu, G.1
-
5
-
-
0024515406
-
Glucagon-like peptide I (7-37) actions on endocrine pancreas
-
G.C. Weir et al. Glucagon-like peptide I (7-37) actions on endocrine pancreas Diabetes 38 1989 338-342
-
(1989)
Diabetes
, vol.38
, pp. 338-342
-
-
Weir, G.C.1
-
6
-
-
0030798846
-
Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans
-
H. Larsson et al. Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans Acta Physiol. Scand. 160 1997 413-422
-
(1997)
Acta Physiol. Scand.
, vol.160
, pp. 413-422
-
-
Larsson, H.1
-
7
-
-
0030031146
-
Gastric emptying and release of incretin hormones after glucose ingestion in humans
-
J. Schirra et al. Gastric emptying and release of incretin hormones after glucose ingestion in humans J. Clin. Invest. 97 1996 92-103
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 92-103
-
-
Schirra, J.1
-
8
-
-
0027533758
-
Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man
-
A. Wettergren et al. Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man Dig. Dis. Sci. 38 1993 665-673
-
(1993)
Dig. Dis. Sci.
, vol.38
, pp. 665-673
-
-
Wettergren, A.1
-
9
-
-
0037045845
-
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
-
M. Zander et al. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study Lancet 359 2002 824-830
-
(2002)
Lancet
, vol.359
, pp. 824-830
-
-
Zander, M.1
-
10
-
-
13344282056
-
A role for glucagon-like peptide-1 in the central regulation of feeding
-
M.D. Turton et al. A role for glucagon-like peptide-1 in the central regulation of feeding Nature 379 1996 69-72
-
(1996)
Nature
, vol.379
, pp. 69-72
-
-
Turton, M.D.1
-
11
-
-
0035723503
-
Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes
-
M.K. Gutniak et al. Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes J. Intern. Med. 250 2001 81-87
-
(2001)
J. Intern. Med.
, vol.250
, pp. 81-87
-
-
Gutniak, M.K.1
-
12
-
-
0031033531
-
Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM
-
J. Rachman et al. Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM Diabetologia 40 1997 205-211
-
(1997)
Diabetologia
, vol.40
, pp. 205-211
-
-
Rachman, J.1
-
13
-
-
0026596851
-
Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus
-
M. Gutniak et al. Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus N. Engl. J. Med. 326 1992 1316-1322
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 1316-1322
-
-
Gutniak, M.1
-
14
-
-
0028803336
-
2-terminus in type II diabetic patients and in healthy subjects
-
2 -terminus in type II diabetic patients and in healthy subjects Diabetes 44 1995 1126-1131
-
(1995)
Diabetes
, vol.44
, pp. 1126-1131
-
-
Deacon, C.F.1
-
15
-
-
0027215348
-
Dipeptidyl-peptidase IV hydrolyzes gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36) amide, peptide histidine methionine and is responsible for their degradation in human serum
-
R. Mentlein et al. Dipeptidyl-peptidase IV hydrolyzes gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36) amide, peptide histidine methionine and is responsible for their degradation in human serum Eur. J. Biochem. 214 1993 829-835
-
(1993)
Eur. J. Biochem.
, vol.214
, pp. 829-835
-
-
Mentlein, R.1
-
16
-
-
0038178058
-
Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes
-
J.M. Egan et al. Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes Am. J. Physiol. 284 2003 E1072-E1079
-
(2003)
Am. J. Physiol.
, vol.284
-
-
Egan, J.M.1
-
17
-
-
0037098963
-
Gastric inhibitory polypeptide: The neglected incretin revisited
-
J.J. Meier et al. Gastric inhibitory polypeptide: The neglected incretin revisited Regul. Pept. 107 2002 1-13
-
(2002)
Regul. Pept.
, vol.107
, pp. 1-13
-
-
Meier, J.J.1
-
18
-
-
0027391607
-
Preserved incretin activity of glucagon-like peptide 1 (7-36 amide) but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
-
M.A. Nauck et al. Preserved incretin activity of glucagon-like peptide 1 (7-36 amide) but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus J. Clin. Invest. 91 1993 301-307
-
(1993)
J. Clin. Invest.
, vol.91
, pp. 301-307
-
-
Nauck, M.A.1
-
19
-
-
0035041250
-
Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
-
F.C. Lynn et al. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats Diabetes 50 2001 1004-1011
-
(2001)
Diabetes
, vol.50
, pp. 1004-1011
-
-
Lynn, F.C.1
-
20
-
-
0033619675
-
Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
-
R. Mentlein Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides Regul. Pept. 85 1999 9-24
-
(1999)
Regul. Pept.
, vol.85
, pp. 9-24
-
-
Mentlein, R.1
-
21
-
-
0034612348
-
Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
-
D. Marguet et al. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26 Proc. Natl. Acad. Sci. USA 97 2000 6874-6879
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6874-6879
-
-
Marguet, D.1
-
22
-
-
0034811909
-
Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats
-
T. Nagakura et al. Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats Biochem. Biophys. Res. Commun. 284 2001 501-506
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.284
, pp. 501-506
-
-
Nagakura, T.1
-
23
-
-
20244385394
-
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPPIV inhibitors
-
T. Hansotia et al. Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPPIV inhibitors Diabetes 53 2004 1326-1335
-
(2004)
Diabetes
, vol.53
, pp. 1326-1335
-
-
Hansotia, T.1
-
24
-
-
0037974604
-
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
-
S.L. Conarello et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance Proc. Natl. Acad. Sci. USA 100 2003 6825-6830
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6825-6830
-
-
Conarello, S.L.1
-
25
-
-
0034522773
-
Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
-
R. Perfetti et al. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats Endocrinology 141 2000 4600-4605
-
(2000)
Endocrinology
, vol.141
, pp. 4600-4605
-
-
Perfetti, R.1
-
26
-
-
0036828227
-
Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
-
L. Farilla et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats Endocrinology 143 2002 4397-4408
-
(2002)
Endocrinology
, vol.143
, pp. 4397-4408
-
-
Farilla, L.1
-
27
-
-
0033512486
-
Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
-
J. Zhou et al. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells Diabetes 48 1999 2358-2366
-
(1999)
Diabetes
, vol.48
, pp. 2358-2366
-
-
Zhou, J.1
-
28
-
-
0036107064
-
Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice
-
M.K. Reimer et al. Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice Eur. J. Endocrinol. 146 2002 717-727
-
(2002)
Eur. J. Endocrinol.
, vol.146
, pp. 717-727
-
-
Reimer, M.K.1
-
29
-
-
0037342614
-
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
-
J.A. Pospisilik et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats Diabetes 52 2003 741-750
-
(2003)
Diabetes
, vol.52
, pp. 741-750
-
-
Pospisilik, J.A.1
-
30
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
A.E. Butler et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes Diabetes 52 2003 102-110
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
-
31
-
-
9444285818
-
Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
-
B. Ahrén et al. Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes Diabetes Care 27 2004 2874-2880
-
(2004)
Diabetes Care
, vol.27
, pp. 2874-2880
-
-
Ahrén, B.1
-
32
-
-
4544227213
-
Inhibition of DPP8/9 results in toxicity in preclinical species: Potential importance of selective dipeptidyl peptidase IV inhibition for the treatment of type 2 DM
-
Pages: A2(7-OR)
-
G. Lankas et al. Inhibition of DPP8/9 results in toxicity in preclinical species: Potential importance of selective dipeptidyl peptidase IV inhibition for the treatment of type 2 DM Diabetes 53 Suppl. 2 2004 A2(7-OR)
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 2
-
-
Lankas, G.1
-
35
-
-
0036583164
-
Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
-
B. Ahrén et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes Diabetes Care 25 2002 869-875
-
(2002)
Diabetes Care
, vol.25
, pp. 869-875
-
-
Ahrén, B.1
-
36
-
-
0037777695
-
1-3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
-
E.B. Villhauer et al. 1- 3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties J. Med. Chem. 46 2003 2774-2789
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2774-2789
-
-
Villhauer, E.B.1
-
37
-
-
2442482515
-
Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagons levels in type 2 diabetes
-
B. Ahrén et al. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagons levels in type 2 diabetes J. Clin. Endocrinol. Metab. 89 2004 2078-2084
-
(2004)
J. Clin. Endocrinol. Metab.
, vol.89
, pp. 2078-2084
-
-
Ahrén, B.1
-
38
-
-
7444243454
-
Effects of Exenatide (synthetic exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
-
Orlando, FL, USA 2004 (abstract 6-LB) 4-8 June (abstract 6-LB)
-
R. Defronzo Effects of Exenatide (synthetic exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes Proceedings of the American Diabetes Association 64th Scientific Sessions 4-8 June 2004, Orlando, FL, USA 2004 (abstract 6-LB)
-
(2004)
Proceedings of the American Diabetes Association 64th Scientific Sessions
-
-
Defronzo, R.1
-
39
-
-
7444228521
-
Effects of Exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
-
J.B. Buse et al. Effects of Exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes Diabetes Care 27 2004 2628-2635
-
(2004)
Diabetes Care
, vol.27
, pp. 2628-2635
-
-
Buse, J.B.1
-
40
-
-
4544302130
-
The DP-IV inhibitor MK-0431 enhances active GLP-1 and reduces glucose following an OGTT in type 2 diabetes
-
(abstract 353-OR)
-
G.A. Herman et al. The DP-IV inhibitor MK-0431 enhances active GLP-1 and reduces glucose following an OGTT in type 2 diabetes Diabetes 53 Suppl. 2 2004 A82 (abstract 353-OR)
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 2
-
-
Herman, G.A.1
-
41
-
-
14044264798
-
Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus
-
J.J. Holst et al. Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus Curr. Opin. Pharmacol. 4 2004 589-596
-
(2004)
Curr. Opin. Pharmacol.
, vol.4
, pp. 589-596
-
-
Holst, J.J.1
-
42
-
-
85039660639
-
Design, synthesis, and pharmacology of BMS-477118: A long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type II diabetes
-
Philadelphia, PA, USA 2004 (abstract MEDI-207) 22-26 August
-
L.G. Hamann et al. Design, synthesis, and pharmacology of BMS-477118: A long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type II diabetes Proceedings of the 228th American Chemical Society National Meeting 22-26 August 2004, Philadelphia, PA, USA 2004 (abstract MEDI-207)
-
(2004)
Proceedings of the 228th American Chemical Society National Meeting
-
-
Hamann, L.G.1
-
43
-
-
22244457035
-
Synthesis and biological evaluation of potent, selective, orally active 4-fluoro-2-cyanopyrrolidine inhibitors of DPP-IV
-
Philadelphia, PA, USA 2004 (abstract MEDI-205) 22-26 August
-
C.D. Haffner et al. Synthesis and biological evaluation of potent, selective, orally active 4-fluoro-2-cyanopyrrolidine inhibitors of DPP-IV Proceedings of the 228th American Chemical Society National Meeting 22-26 August 2004, Philadelphia, PA, USA 2004 (abstract MEDI-205)
-
(2004)
Proceedings of the 228th American Chemical Society National Meeting
-
-
Haffner, C.D.1
|