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Volumn 2, Issue 2, 2005, Pages 143-149

Dipeptidyl peptidase IV inhibitors for type 2 diabetes and metabolic syndrome

Author keywords

[No Author keywords available]

Indexed keywords

6 [[2 [[2 (2 CYANO 1 PYRROLIDINYL) 2 OXOETHYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GSK 23A; INSULIN; METFORMIN; PLACEBO; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; UNCLASSIFIED DRUG; VILDAGLIPTIN;

EID: 22244482444     PISSN: 17406773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddstr.2005.05.020     Document Type: Review
Times cited : (7)

References (43)
  • 1
    • 0023107555 scopus 로고
    • Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • S. Mojsov et al. Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas J. Clin. Invest. 79 1987 616-619
    • (1987) J. Clin. Invest. , vol.79 , pp. 616-619
    • Mojsov, S.1
  • 2
    • 0023638829 scopus 로고
    • Glucagon-like peptide-17-36: A physiological incretin in man
    • B. Kreymann et al. Glucagon-like peptide-17-36: A physiological incretin in man Lancet 2 1987 1300-1304
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1
  • 3
    • 0026535588 scopus 로고
    • Insulinotropic hormone glucagon-like peptide-I (7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma betaTC-1 cells
    • H.C. Fehmann et al. Insulinotropic hormone glucagon-like peptide-I (7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma betaTC-1 cells Endocrinology 130 1992 159-166
    • (1992) Endocrinology , vol.130 , pp. 159-166
    • Fehmann, H.C.1
  • 4
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both [beta]-cell replication and neogenesis, resulting in increased [beta]-cell mass and improved glucose tolerance in diabetic rats
    • G. Xu et al. Exendin-4 stimulates both [beta]-cell replication and neogenesis, resulting in increased [beta]-cell mass and improved glucose tolerance in diabetic rats Diabetes 48 1999 2270-2276
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1
  • 5
    • 0024515406 scopus 로고
    • Glucagon-like peptide I (7-37) actions on endocrine pancreas
    • G.C. Weir et al. Glucagon-like peptide I (7-37) actions on endocrine pancreas Diabetes 38 1989 338-342
    • (1989) Diabetes , vol.38 , pp. 338-342
    • Weir, G.C.1
  • 6
    • 0030798846 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans
    • H. Larsson et al. Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans Acta Physiol. Scand. 160 1997 413-422
    • (1997) Acta Physiol. Scand. , vol.160 , pp. 413-422
    • Larsson, H.1
  • 7
    • 0030031146 scopus 로고    scopus 로고
    • Gastric emptying and release of incretin hormones after glucose ingestion in humans
    • J. Schirra et al. Gastric emptying and release of incretin hormones after glucose ingestion in humans J. Clin. Invest. 97 1996 92-103
    • (1996) J. Clin. Invest. , vol.97 , pp. 92-103
    • Schirra, J.1
  • 8
    • 0027533758 scopus 로고
    • Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man
    • A. Wettergren et al. Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man Dig. Dis. Sci. 38 1993 665-673
    • (1993) Dig. Dis. Sci. , vol.38 , pp. 665-673
    • Wettergren, A.1
  • 9
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • M. Zander et al. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study Lancet 359 2002 824-830
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1
  • 10
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • M.D. Turton et al. A role for glucagon-like peptide-1 in the central regulation of feeding Nature 379 1996 69-72
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1
  • 11
    • 0035723503 scopus 로고    scopus 로고
    • Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes
    • M.K. Gutniak et al. Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes J. Intern. Med. 250 2001 81-87
    • (2001) J. Intern. Med. , vol.250 , pp. 81-87
    • Gutniak, M.K.1
  • 12
    • 0031033531 scopus 로고    scopus 로고
    • Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM
    • J. Rachman et al. Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM Diabetologia 40 1997 205-211
    • (1997) Diabetologia , vol.40 , pp. 205-211
    • Rachman, J.1
  • 13
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus
    • M. Gutniak et al. Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus N. Engl. J. Med. 326 1992 1316-1322
    • (1992) N. Engl. J. Med. , vol.326 , pp. 1316-1322
    • Gutniak, M.1
  • 14
    • 0028803336 scopus 로고
    • 2-terminus in type II diabetic patients and in healthy subjects
    • 2 -terminus in type II diabetic patients and in healthy subjects Diabetes 44 1995 1126-1131
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1
  • 15
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyzes gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36) amide, peptide histidine methionine and is responsible for their degradation in human serum
    • R. Mentlein et al. Dipeptidyl-peptidase IV hydrolyzes gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36) amide, peptide histidine methionine and is responsible for their degradation in human serum Eur. J. Biochem. 214 1993 829-835
    • (1993) Eur. J. Biochem. , vol.214 , pp. 829-835
    • Mentlein, R.1
  • 16
    • 0038178058 scopus 로고    scopus 로고
    • Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes
    • J.M. Egan et al. Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes Am. J. Physiol. 284 2003 E1072-E1079
    • (2003) Am. J. Physiol. , vol.284
    • Egan, J.M.1
  • 17
    • 0037098963 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide: The neglected incretin revisited
    • J.J. Meier et al. Gastric inhibitory polypeptide: The neglected incretin revisited Regul. Pept. 107 2002 1-13
    • (2002) Regul. Pept. , vol.107 , pp. 1-13
    • Meier, J.J.1
  • 18
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 (7-36 amide) but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • M.A. Nauck et al. Preserved incretin activity of glucagon-like peptide 1 (7-36 amide) but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus J. Clin. Invest. 91 1993 301-307
    • (1993) J. Clin. Invest. , vol.91 , pp. 301-307
    • Nauck, M.A.1
  • 19
    • 0035041250 scopus 로고    scopus 로고
    • Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    • F.C. Lynn et al. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats Diabetes 50 2001 1004-1011
    • (2001) Diabetes , vol.50 , pp. 1004-1011
    • Lynn, F.C.1
  • 20
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
    • R. Mentlein Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides Regul. Pept. 85 1999 9-24
    • (1999) Regul. Pept. , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 21
    • 0034612348 scopus 로고    scopus 로고
    • Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
    • D. Marguet et al. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26 Proc. Natl. Acad. Sci. USA 97 2000 6874-6879
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6874-6879
    • Marguet, D.1
  • 22
    • 0034811909 scopus 로고    scopus 로고
    • Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats
    • T. Nagakura et al. Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats Biochem. Biophys. Res. Commun. 284 2001 501-506
    • (2001) Biochem. Biophys. Res. Commun. , vol.284 , pp. 501-506
    • Nagakura, T.1
  • 23
    • 20244385394 scopus 로고    scopus 로고
    • Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPPIV inhibitors
    • T. Hansotia et al. Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPPIV inhibitors Diabetes 53 2004 1326-1335
    • (2004) Diabetes , vol.53 , pp. 1326-1335
    • Hansotia, T.1
  • 24
    • 0037974604 scopus 로고    scopus 로고
    • Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
    • S.L. Conarello et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance Proc. Natl. Acad. Sci. USA 100 2003 6825-6830
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6825-6830
    • Conarello, S.L.1
  • 25
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • R. Perfetti et al. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats Endocrinology 141 2000 4600-4605
    • (2000) Endocrinology , vol.141 , pp. 4600-4605
    • Perfetti, R.1
  • 26
    • 0036828227 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
    • L. Farilla et al. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats Endocrinology 143 2002 4397-4408
    • (2002) Endocrinology , vol.143 , pp. 4397-4408
    • Farilla, L.1
  • 27
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • J. Zhou et al. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells Diabetes 48 1999 2358-2366
    • (1999) Diabetes , vol.48 , pp. 2358-2366
    • Zhou, J.1
  • 28
    • 0036107064 scopus 로고    scopus 로고
    • Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice
    • M.K. Reimer et al. Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice Eur. J. Endocrinol. 146 2002 717-727
    • (2002) Eur. J. Endocrinol. , vol.146 , pp. 717-727
    • Reimer, M.K.1
  • 29
    • 0037342614 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
    • J.A. Pospisilik et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats Diabetes 52 2003 741-750
    • (2003) Diabetes , vol.52 , pp. 741-750
    • Pospisilik, J.A.1
  • 30
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • A.E. Butler et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes Diabetes 52 2003 102-110
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1
  • 31
    • 9444285818 scopus 로고    scopus 로고
    • Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
    • B. Ahrén et al. Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes Diabetes Care 27 2004 2874-2880
    • (2004) Diabetes Care , vol.27 , pp. 2874-2880
    • Ahrén, B.1
  • 32
    • 4544227213 scopus 로고    scopus 로고
    • Inhibition of DPP8/9 results in toxicity in preclinical species: Potential importance of selective dipeptidyl peptidase IV inhibition for the treatment of type 2 DM
    • Pages: A2(7-OR)
    • G. Lankas et al. Inhibition of DPP8/9 results in toxicity in preclinical species: Potential importance of selective dipeptidyl peptidase IV inhibition for the treatment of type 2 DM Diabetes 53 Suppl. 2 2004 A2(7-OR)
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Lankas, G.1
  • 35
    • 0036583164 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
    • B. Ahrén et al. Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes Diabetes Care 25 2002 869-875
    • (2002) Diabetes Care , vol.25 , pp. 869-875
    • Ahrén, B.1
  • 36
    • 0037777695 scopus 로고    scopus 로고
    • 1-3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
    • E.B. Villhauer et al. 1- 3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties J. Med. Chem. 46 2003 2774-2789
    • (2003) J. Med. Chem. , vol.46 , pp. 2774-2789
    • Villhauer, E.B.1
  • 37
    • 2442482515 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagons levels in type 2 diabetes
    • B. Ahrén et al. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagons levels in type 2 diabetes J. Clin. Endocrinol. Metab. 89 2004 2078-2084
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 2078-2084
    • Ahrén, B.1
  • 38
    • 7444243454 scopus 로고    scopus 로고
    • Effects of Exenatide (synthetic exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • Orlando, FL, USA 2004 (abstract 6-LB) 4-8 June (abstract 6-LB)
    • R. Defronzo Effects of Exenatide (synthetic exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes Proceedings of the American Diabetes Association 64th Scientific Sessions 4-8 June 2004, Orlando, FL, USA 2004 (abstract 6-LB)
    • (2004) Proceedings of the American Diabetes Association 64th Scientific Sessions
    • Defronzo, R.1
  • 39
    • 7444228521 scopus 로고    scopus 로고
    • Effects of Exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • J.B. Buse et al. Effects of Exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes Diabetes Care 27 2004 2628-2635
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1
  • 40
    • 4544302130 scopus 로고    scopus 로고
    • The DP-IV inhibitor MK-0431 enhances active GLP-1 and reduces glucose following an OGTT in type 2 diabetes
    • (abstract 353-OR)
    • G.A. Herman et al. The DP-IV inhibitor MK-0431 enhances active GLP-1 and reduces glucose following an OGTT in type 2 diabetes Diabetes 53 Suppl. 2 2004 A82 (abstract 353-OR)
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2
    • Herman, G.A.1
  • 41
    • 14044264798 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus
    • J.J. Holst et al. Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus Curr. Opin. Pharmacol. 4 2004 589-596
    • (2004) Curr. Opin. Pharmacol. , vol.4 , pp. 589-596
    • Holst, J.J.1
  • 42
    • 85039660639 scopus 로고    scopus 로고
    • Design, synthesis, and pharmacology of BMS-477118: A long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type II diabetes
    • Philadelphia, PA, USA 2004 (abstract MEDI-207) 22-26 August
    • L.G. Hamann et al. Design, synthesis, and pharmacology of BMS-477118: A long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type II diabetes Proceedings of the 228th American Chemical Society National Meeting 22-26 August 2004, Philadelphia, PA, USA 2004 (abstract MEDI-207)
    • (2004) Proceedings of the 228th American Chemical Society National Meeting
    • Hamann, L.G.1
  • 43
    • 22244457035 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of potent, selective, orally active 4-fluoro-2-cyanopyrrolidine inhibitors of DPP-IV
    • Philadelphia, PA, USA 2004 (abstract MEDI-205) 22-26 August
    • C.D. Haffner et al. Synthesis and biological evaluation of potent, selective, orally active 4-fluoro-2-cyanopyrrolidine inhibitors of DPP-IV Proceedings of the 228th American Chemical Society National Meeting 22-26 August 2004, Philadelphia, PA, USA 2004 (abstract MEDI-205)
    • (2004) Proceedings of the 228th American Chemical Society National Meeting
    • Haffner, C.D.1


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