Early lead exposure increases the leakage of the blood-cerebrospinal fluid barrier, in vitro

Human and Experimental Toxicology

Volumn 26, Issue 3, 2007, Pages 159-167

  Lewis, Zhichang Shi ^a   Zheng, Wei ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Blood CSF barrier; Blood brain barrier; Claudin 1; Lead (Pb); Permeability

Indexed keywords

CLAUDIN 1; LEAD; OCCLUDIN;

ANIMAL CELL; BLOOD CEREBROSPINAL FLUID BARRIER; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; IN VITRO STUDY; LIQUORRHEA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIGHT JUNCTION;

ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; CEREBROSPINAL FLUID; CHOROID PLEXUS; ENVIRONMENTAL POLLUTANTS; EPITHELIAL CELLS; LEAD; MEMBRANE PROTEINS; PERMEABILITY; PHOSPHOPROTEINS; RATS; RNA, MESSENGER; SUCROSE; TIGHT JUNCTIONS;

EID: 33947427428     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327107070560     Document Type: Conference Paper

References (48)

1. Goyer RA. Lead toxicity: current concerns. Environ Health Perspect 1993; 100: 177-87.
2. Zheng W, Aschner M, Ghersi-Egea JF. Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol Appl Pharmacol 2003; 192: 1-11.
3. Fiume MZ. Final report on the safety assessment of Acid Violet 43. Int J Toxicol 2001; 20: 1-6.
4. Zeichner A, Ehrlich S, Shoshani E, Halicz L. Application of lead isotope analysis in shooting incident investigations. Forensic Sci Int 2006; 158: 52-64.
5. Leggett RW. An age-specific kinetic model of lead metabolism in humans. Environ Health Perspect 1993; 101: 598-616.
6. Dietert RR, Lee JE, Hussain I, Piepenbrink M. Developmental immunotoxicology of lead. Toxicol Appl Pharmacol 2004; 198: 86-94.
7. Landrigan PJ, Baker EL Jr, Feldman RG, Cox DH, Eden KV, Orenstein WA, Mather JA, Yankel AJ, Von Lindern IH. Increased lead absorption with anemia and slowed nerve conduction in children near a lead smelter. J Pediatr 1976; 89: 904-10.
8. Counter SA, Buchanan LH, Ortega F. Neurocognitive impairment in lead-exposed children of Andean lead-glazing workers. J Occup Environ Med 2005; 47: 306-12.
9. US Centers for Disease Control. Preventing lead poisoning in young children. USCDC, 1991.
10. Pentschew A, Garro F. Lead encephalo-myelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseases. With special reference to the permeability disorders of the nervous system's capillaries. Acta Neuropathol 1966; 6: 266-78.
11. Press MF. Lead encephalopathy in neonatal Long-Evans rats: morphologic studies. J Neuropathol Exp Neurol 1977; 36: 169-93.
12. Silbergeld EK. Mechanisms of lead neurotoxicity, or looking beyond the lamppost. FASEB J 1992; 6: 3201-206.
13. Dyatlov VA, Platoshin AV, Lawrence DA, Carpenter DO. Lead potentiates cytokine- and glutamate-mediated increases in permeability of the blood-brain barrier. Neurotoxicology 1998; 19: 283-91.
14. Sundstrom R, Muntzing K, Kalimo H, Sourander P. Changes in the integrity of the blood-brain barrier in suckling rats with low dose lead encephalopathy. Acta Neuropathol 1985; 68: 1-9.
15. McMichael AJ, Baghurst PA, Wigg NR, Vimpani GV, Robertson EF, Roberts RJ. Port Pirie Cohort Study: environmental exposure to lead and children's abilities at the age of four years. N Engl J Med 1988; 319: 468-75.
16. Friedheim E, Corvi C, Graziano J, Donnelli T, Breslin D. Choroid plexus as a protective sink for heavy metals? Lancet 1983; 1: 981-82.
17. Zheng W, Perry DF, Nelson DL, Aposhian HV. Choroid plexus protects cerebrospinal fluid against toxic metals. FASEB J 1991; 5: 2188-93.
18. Zheng W, Lu YM, Lu GY, Zhao Q, Cheung O, Blaner WS. Transthyretin, thyroxine, and retinol-binding protein in human cerebrospinal fluid: effect of lead exposure. Toxicol Sci 2001; 61: 107-14.
19. Zheng W, Shen H, Blaner WS, Zhao Q, Ren X, Graziano JH. Chronic lead exposure alters transthyretin concentration in rat cerebrospinal fluid: the role of the choroid plexus. Toxicol Appl Pharmacol 1996; 139: 445-50.
20. Zheng W, Blaner WS, Zhao Q. Inhibition by lead of production and secretion of transthyretin in the choroid plexus: its relation to thyroxine transport at blood-CSF barrier. Toxicol Appl Pharmacol 1999; 155: 24-31.
21. 125I]thyroxine by in situ perfused ovine choroid plexus: inhibition by lead exposure. J Toxicol Environ Health. Part A 2003; 66: 435-51.
22. Stevenson BR, Siliciano JD, Mooseker MS, Goodenough DA. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol 1986; 103: 755-66.
23. Willott E, Balda MS, Heintzelman M, Jameson B, Anderson JM. Localization and differential expression of two isoforms of the tight junction protein ZO-1. Am J Physiol 1992; 262: C1119-24.
24. Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 1993; 123: 1777-88.
25. Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998; 141: 1539-50.
26. 2+ resorption. Science 1999; 285: 103-106.
27. Furuse M, Furuse K, Sasaki H, Tsukita S. Conversion of Zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol 2001; 153: 263-72.
28. Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol 1994; 127: 1617-26.
29. Wittchen ES, Haskins J, Stevenson BR. Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J Biol Chem 1999; 274: 35179-85.
30. Shi LZ, Zheng W. Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological study. Brain Res 2005; 1057: 37-48.
31. Zheng W, Zhao Q. Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus. Brain Res 2002; 958: 371-80.
32. Zheng W, Zhao Q. The blood-CSF barrier in culture. Development of a primary culture and transepithelial transport model from choroidal epithelial cells. Methods Mol Biol 2002; 188: 99-114.
33. Strazielle N, Preston JE. Transport across the choroid plexuses in vivo and in vitro. Methods Mol Med 2003; 89: 291-304.
34. Jou TS, Schneeberger EE, Nelson WJ. Structural and functional regulation of tight junctions by RhoA and Racl small GTPases. J Cell Biol 1998; 142: 101-15.
35. Fleming TP, Papenbrock T, Fesenko I, Hausen P, Sheth B. Assembly of tight junctions during early vertebrate development. Semin Cell Dev Biol 2000; 11: 291-99.
36. Virgintino D, Errede M, Robertson D, Capobianco C, Girolamo F, Vimercati A, Bertossi M, Roncali L. Immunolocalization of tight junction proteins in the adult and developing human brain. Histochem Cell Biol 2004; 122: 51-59.
37. Hertz MM, Bolwig TG, Grandjean P, Westergaard E. Lead poisoning and the blood-brain barrier. Acta Neurol Scand 1981; 63: 286-96.
38. Bressler JP, Goldstein GW. Mechanisms of lead neurotoxicity. Biochem Pharmacol 1991; 41: 479-84.
39. Hossain MA, Bouton CM, Pevsner J, Laterra J. Induction of vascular endothelial growth factor in human astrocytes by lead. Involvement of a protein kinase C/ activator protein-1 complex-dependent and hypoxia-inducible factor 1-independent signaling pathway. J Biol Chem 2000; 275: 27874-82.
40. Hossain MA, Russell JC, Miknyoczki S, Ruggeri B, Lal B, Laterra J. Vascular endothelial growth factor mediates vasogenic edema in acute lead encephalopathy. Ann Neurol 2004; 55: 660-67.
41. Zheng W. Toxicology of choroid plexus: special reference to metal-induced neurotoxicities. Microsc Res Tech 2001; 52: 89-103.
42. Saunders NR. Ontogeny of the blood-brain barrier. Exp Eye Res 1977; 25: 523-50.
43. Schulze C, Firth JA. Interendothelial junctions during blood-brain barrier development in the rat: morphological changes at the level of individual tight junctional contacts. Brain Res Dev Brain Res 1992; 69: 85-95.
44. Davson H, Segal MB. Physiology of the CSF and blood-brain barriers. CRC Press, 1996.
45. Chakraborti T, Kim KA, Goldstein GG, Bressler JP. Increased AP-1 DNA binding activity in PC12 cells treated with lead. J Neurochem 1999; 73: 187-94.
46. Kim KA, Chakraborti T, Goldstein GW, Bressler JP. Immediate early gene expression in PC12 cells exposed to lead: requirement for protein kinase C. J Neurochem 2000; 74: 1140-46.
47. Zhao Q, Slavkovich V, Zheng W. Lead exposure promotes translocation of protein kinase C activities in rat choroid plexus in vitro, but not in vivo. Toxicol Appl Pharmacol 1998; 149: 99-106.
48. Furuse M, Sasaki H, Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 1999; 147: 891-903.