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Volumn 31, Issue 3, 1997, Pages 207-224

Lead-induced abnormalities in blood-brain barrier permeability in experimental chronic toxicity

Author keywords

Blood brain barrier; Capillaries; Endothelial cells; HRP; Lead; Phospholipids; Synaptosomes; Tight junctions

Indexed keywords

FAT DROPLET; HORSERADISH PEROXIDASE; LEAD ACETATE; PHOSPHOLIPID;

EID: 0030866111     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02815125     Document Type: Article
Times cited : (77)

References (44)
  • 1
    • 12644278590 scopus 로고
    • Difference in mitochondrial content and cytochrome oxidase activity between pericytes and endothelial cells of rat brain capillaries
    • (Cervos-Navarro, J. and Ferszt R. eds.), Raven, New York
    • Bär T. (1987) Difference in mitochondrial content and cytochrome oxidase activity between pericytes and endothelial cells of rat brain capillaries, in Stroke and Microcirculation (Cervos-Navarro, J. and Ferszt R. eds.), Raven, New York, pp. 27-33.
    • (1987) Stroke and Microcirculation , pp. 27-33
    • Bär, T.1
  • 2
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh E. G. and Dyer W. J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 3
    • 0018070988 scopus 로고
    • A rapid method for the preparation of relatively pure, metabolically competent synaptosomes from rat brain
    • Booth R. F. G. and Clark J. B. (1978) A rapid method for the preparation of relatively pure, metabolically competent synaptosomes from rat brain. Biochem. J. 176, 365-370.
    • (1978) Biochem. J. , vol.176 , pp. 365-370
    • Booth, R.F.G.1    Clark, J.B.2
  • 5
    • 0027445847 scopus 로고
    • Current issues in human lead exposure and regulation of lead
    • Davies I. M., Elias R. W., and Grant L. D. (1993) Current issues in human lead exposure and regulation of lead. NeuroToxicology 14(2-3), 15-28.
    • (1993) NeuroToxicology , vol.14 , Issue.2-3 , pp. 15-28
    • Davies, I.M.1    Elias, R.W.2    Grant, L.D.3
  • 7
    • 0025213452 scopus 로고
    • Transport of lead-203 at the blood-brain barrier during short cerebrovascular perfusion with saline in the rat
    • Deane R. and Bradbury M. W. B. (1990) Transport of lead-203 at the blood-brain barrier during short cerebrovascular perfusion with saline in the rat. J. Neurochem. 54, 905-914.
    • (1990) J. Neurochem. , vol.54 , pp. 905-914
    • Deane, R.1    Bradbury, M.W.B.2
  • 8
    • 0026096003 scopus 로고
    • Molecular anatomy of the blood-brain barrier as defined by immunocytochemistry
    • (Jeon K. W. and Friedlander M., eds.), Academic, San Diego, CA
    • Dermietzel R. and Krause D. (1991) Molecular anatomy of the blood-brain barrier as defined by immunocytochemistry, in International Review of Cytology. A Survey of Cell Biology, vol. 127 (Jeon K. W. and Friedlander M., eds.), Academic, San Diego, CA, pp. 57-109.
    • (1991) International Review of Cytology. A Survey of Cell Biology , vol.127 , pp. 57-109
    • Dermietzel, R.1    Krause, D.2
  • 9
    • 0019861796 scopus 로고
    • Synaptosomes from rat brain: Morphology, compartmentation and transmembrane pH and electrical gradients
    • Deutsch C., Drown C., Rafałowska U., and Silver I. A. (1981) Synaptosomes from rat brain: morphology, compartmentation and transmembrane pH and electrical gradients. J. Neurochem. 36, 2063-2071.
    • (1981) J. Neurochem. , vol.36 , pp. 2063-2071
    • Deutsch, C.1    Drown, C.2    Rafałowska, U.3    Silver, I.A.4
  • 10
    • 0027190761 scopus 로고
    • Mini review. Is lead toxicosis a reflection of altered fatty acid composition of membranes?
    • Donaldson W. E. and Knowles S. O. (1993) Mini review. Is lead toxicosis a reflection of altered fatty acid composition of membranes? Comp. Biochem. Physiol. 104C, 3, 377-379.
    • (1993) Comp. Biochem. Physiol. , vol.104 C , Issue.3 , pp. 377-379
    • Donaldson, W.E.1    Knowles, S.O.2
  • 11
    • 0021279860 scopus 로고
    • Dietary lead: Effects on hepatic fatty acid composition in chicks
    • Donaldson W. E. and Leeming T. K. (1984) Dietary lead: effects on hepatic fatty acid composition in chicks. Toxicol. Appl. Pharmacol. 73, 119-123.
    • (1984) Toxicol. Appl. Pharmacol. , vol.73 , pp. 119-123
    • Donaldson, W.E.1    Leeming, T.K.2
  • 12
    • 0029076362 scopus 로고
    • Microglia: Instrinsic immunoeffector cell of the brain
    • Gehrmann J., Matsumoto Y., and Kreutzberg G. W. (1995) Microglia: instrinsic immunoeffector cell of the brain. Brain Res. Rev. 20, 269-287.
    • (1995) Brain Res. Rev. , vol.20 , pp. 269-287
    • Gehrmann, J.1    Matsumoto, Y.2    Kreutzberg, G.W.3
  • 13
    • 0016201292 scopus 로고
    • Pathogenesis of lead encephalopathy: Uptake of lead and reaction of brain capillaries
    • Goldstein, G. W., Asbury, A. K., and Diamond, I. (1974) Pathogenesis of lead encephalopathy: Uptake of lead and reaction of brain capillaries. Arch. Neurol. 31, 382-389.
    • (1974) Arch. Neurol. , vol.31 , pp. 382-389
    • Goldstein, G.W.1    Asbury, A.K.2    Diamond, I.3
  • 15
    • 0027383865 scopus 로고
    • International perspectives of lead exposure and lead toxicity
    • Grandjean P. (1993) International perspectives of lead exposure and lead toxicity. NeuroToxicology 14(2-3), 9-14.
    • (1993) NeuroToxicology , vol.14 , Issue.2-3 , pp. 9-14
    • Grandjean, P.1
  • 17
    • 0021687518 scopus 로고
    • Naturation of resistance to lead encephalopathy: Cellular and subcellular mechanisms
    • Holtzman D., De Vries C., Ngunyen H., Olsen I., and Bensch V. (1984) Naturation of resistance to lead encephalopathy: Cellular and subcellular mechanisms. NeuroToxicology 5, 97-124.
    • (1984) NeuroToxicology , vol.5 , pp. 97-124
    • Holtzman, D.1    De Vries, C.2    Ngunyen, H.3    Olsen, I.4    Bensch, V.5
  • 18
    • 85036490827 scopus 로고
    • Effect of dimercaptosuccinic acid on lead-induced hypertension
    • (Farmer J. G., ed.), International Conference, Edinburgh
    • Khalil-Manesh F., Gonick H. C., Weiler E., and Saldanha L. (1991) Effect of dimercaptosuccinic acid on lead-induced hypertension, in Heavy Metals in the Environment (Farmer J. G., ed.), International Conference, Edinburgh.
    • (1991) Heavy Metals in the Environment
    • Khalil-Manesh, F.1    Gonick, H.C.2    Weiler, E.3    Saldanha, L.4
  • 19
    • 12644266058 scopus 로고
    • Relationship of blood and brain lead levels to morphologic changes in lead-induced chick embryo encephalopathy. II. Biochemical studies
    • (Roizin L., Shiraki H., and Grčević N., eds.), Raven, New York
    • Kochen J. A., Greener Y., and Hirano A. (1977) Relationship of blood and brain lead levels to morphologic changes in lead-induced chick embryo encephalopathy. II. Biochemical studies, in Neurotoxicologiy (Roizin L., Shiraki H., and Grčević N., eds.), pp. 309-311, Raven, New York.
    • (1977) Neurotoxicologiy , pp. 309-311
    • Kochen, J.A.1    Greener, Y.2    Hirano, A.3
  • 20
    • 0343707279 scopus 로고
    • An appraisal of rodent models of lead encephalopathy
    • (Roizin L., Shiraki H., and Grčević N., eds.), Raven, New York
    • Krigman M. R., Mushak P., and Bouldin T. W. (1977) An appraisal of rodent models of lead encephalopathy, in Neurotoxicology (Roizin L., Shiraki H., and Grčević N., eds.), pp. 299-302, Raven, New York.
    • (1977) Neurotoxicology , pp. 299-302
    • Krigman, M.R.1    Mushak, P.2    Bouldin, T.W.3
  • 21
    • 0025811270 scopus 로고
    • Lead-induced tissue fatty acid alterations and lipid peroxidation
    • Lawton L. J. and Donaldson W. E. (1991) Lead-induced tissue fatty acid alterations and lipid peroxidation. Biol. Trace Elem. Res. 28, 83-97.
    • (1991) Biol. Trace Elem. Res. , vol.28 , pp. 83-97
    • Lawton, L.J.1    Donaldson, W.E.2
  • 23
    • 0022874775 scopus 로고
    • Tridimensional observation of fluorescent granular perithelial (FGP) cells in rat cerebral blood vessels
    • Mato M., Aikawa E., Mato T. K., and Kurihara K. (1986) Tridimensional observation of fluorescent granular perithelial (FGP) cells in rat cerebral blood vessels. Anat. Res. 215, 413-419.
    • (1986) Anat. Res. , vol.215 , pp. 413-419
    • Mato, M.1    Aikawa, E.2    Mato, T.K.3    Kurihara, K.4
  • 24
    • 0018782378 scopus 로고
    • Membrane lipid fluidity and its effects on the activation energy of membrane-associated enzymes
    • McMurche E. J. and Raison J. K. (1979) Membrane lipid fluidity and its effects on the activation energy of membrane-associated enzymes. Biochim. Biophys. Acta 554, 364-374.
    • (1979) Biochim. Biophys. Acta , vol.554 , pp. 364-374
    • McMurche, E.J.1    Raison, J.K.2
  • 26
    • 0023196202 scopus 로고
    • Cerebrovascular permeability to horseradish peroxidase in hypertensive rats: Effects of unilateral locus ceruleus lesion
    • Nag S. and Harik S. I. (1987) Cerebrovascular permeability to horseradish peroxidase in hypertensive rats: effects of unilateral locus ceruleus lesion. Acta Neuropathol. (Berl.) 73, 247-253.
    • (1987) Acta Neuropathol. (Berl.) , vol.73 , pp. 247-253
    • Nag, S.1    Harik, S.I.2
  • 27
    • 0021331907 scopus 로고
    • Fracture faces of cell junctions in cerebral endothelium during normal and hyperosmotic conditions
    • Nagy Z., Peters H., and Huttner J. (1984) Fracture faces of cell junctions in cerebral endothelium during normal and hyperosmotic conditions. Lab. Invest. 50, 313-322.
    • (1984) Lab. Invest. , vol.50 , pp. 313-322
    • Nagy, Z.1    Peters, H.2    Huttner, J.3
  • 28
    • 0028191734 scopus 로고
    • Localization of lipids and lipoprotein in perivascular FGP cells of rat cerebellar cortex
    • Nakazawa T., Nishikawa M., Aikawa E., and Mato M. (1994) Localization of lipids and lipoprotein in perivascular FGP cells of rat cerebellar cortex. Acta Histochem. Cytochem. 27, 323-330.
    • (1994) Acta Histochem. Cytochem. , vol.27 , pp. 323-330
    • Nakazawa, T.1    Nishikawa, M.2    Aikawa, E.3    Mato, M.4
  • 30
    • 0017128530 scopus 로고
    • The distribution of inorganic lead in guinea pig brain and neural barrier tissues in control and lead-poisoned animals
    • O'Tuama L. A., Kim C. S., Gatzy J. T., Krigman M. R., and Mushak P. (1976) The distribution of inorganic lead in guinea pig brain and neural barrier tissues in control and lead-poisoned animals. Toxicol. Applied Pharmacol. 36, 1-9.
    • (1976) Toxicol. Applied Pharmacol. , vol.36 , pp. 1-9
    • O'Tuama, L.A.1    Kim, C.S.2    Gatzy, J.T.3    Krigman, M.R.4    Mushak, P.5
  • 31
    • 0013850803 scopus 로고
    • Morphology and morphogenesis of lead encephalopathy
    • Pentschew A. (1965) Morphology and morphogenesis of lead encephalopathy. Acta Neuropathol. 5, 133-160.
    • (1965) Acta Neuropathol. , vol.5 , pp. 133-160
    • Pentschew, A.1
  • 32
    • 0013916649 scopus 로고
    • Lead encephalomyelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseases
    • Pentschew A., and Garro F. (1966) Lead encephalomyelopathy of the suckling rat and its implications on the porphyrinopathic nervous diseases. Acta Neuropathol. 6, 266-278.
    • (1966) Acta Neuropathol. , vol.6 , pp. 266-278
    • Pentschew, A.1    Garro, F.2
  • 33
    • 0018837940 scopus 로고
    • Energy metabolism in rat brain synaptosomes from nembutal-anesthetized and nonanesthetized animals
    • Rafałowska U., Erecińska M., and Wilson D. W. (1980) Energy metabolism in rat brain synaptosomes from nembutal-anesthetized and nonanesthetized animals. J. Neurochem. 34, 1380-1386.
    • (1980) J. Neurochem. , vol.34 , pp. 1380-1386
    • Rafałowska, U.1    Erecińska, M.2    Wilson, D.W.3
  • 34
    • 0014109002 scopus 로고
    • Fine structural localization of a blood-brain barrier to exogenous peroxidase
    • Reese T. S., and Karnovsky M. J. (1967) Fine structural localization of a blood-brain barrier to exogenous peroxidase. J. Cell. Biol. 34, 207-215.
    • (1967) J. Cell. Biol. , vol.34 , pp. 207-215
    • Reese, T.S.1    Karnovsky, M.J.2
  • 35
    • 0014779155 scopus 로고
    • Two dimensional thin layer Chromatographic separation of polar lipid and determination of phospholipids by phosphorus analysis of spots
    • Rouser G., Fleischer S., and Yamamoto A. (1970) Two dimensional thin layer Chromatographic separation of polar lipid and determination of phospholipids by phosphorus analysis of spots. Lipids 5, 494-496.
    • (1970) Lipids , vol.5 , pp. 494-496
    • Rouser, G.1    Fleischer, S.2    Yamamoto, A.3
  • 37
    • 0023447279 scopus 로고
    • Blood-brain barrier protein recognized by monoclonal antibody
    • Sternberger N. H. and Sternberger L. A. (1987) Blood-brain barrier protein recognized by monoclonal antibody. Proc. Natl. Acad. Sci. USA 74, 8169-8173.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.74 , pp. 8169-8173
    • Sternberger, N.H.1    Sternberger, L.A.2
  • 38
    • 0022388536 scopus 로고
    • Changes in the integrity of the blood-brain barrier in suckling rats with low dose lead encephalopathy
    • Sundströ R., Müntzing K., Kalimo H., and Sourander P. (1985) Changes in the integrity of the blood-brain barrier in suckling rats with low dose lead encephalopathy. Acta Neuropathol. (Berl.) 68, 1-9.
    • (1985) Acta Neuropathol. (Berl.) , vol.68 , pp. 1-9
    • Sundströ, R.1    Müntzing, K.2    Kalimo, H.3    Sourander, P.4
  • 40
    • 0017801874 scopus 로고
    • Experimental lead encephalopathy in the suckling rat: Concentration of lead in cellular fractions enriched in brain capillaries
    • Toews A. D., Kolber A., Hayward J., Krigman M. R., and Morell P. (1978) Experimental lead encephalopathy in the suckling rat: concentration of lead in cellular fractions enriched in brain capillaries. Brain Res. 147, 131-138.
    • (1978) Brain Res. , vol.147 , pp. 131-138
    • Toews, A.D.1    Kolber, A.2    Hayward, J.3    Krigman, M.R.4    Morell, P.5
  • 41
    • 0017156478 scopus 로고
    • Observations on the blood-brain barrier in hypertensive rats with particular reference to phagocytic pericytes
    • Van Deurs B. (1976) Observations on the blood-brain barrier in hypertensive rats with particular reference to phagocytic pericytes. J. Ultrastruct. Res. 56, 65-77.
    • (1976) J. Ultrastruct. Res. , vol.56 , pp. 65-77
    • Van Deurs, B.1
  • 42
    • 0028797206 scopus 로고
    • Brain phagocytes and the microglia of the cerebral cortex of rats following an incident of total ischaemia
    • Walski M. and Borowicz J. (1995) Brain phagocytes and the microglia of the cerebral cortex of rats following an incident of total ischaemia. J. Brain Res. 36, 55-66.
    • (1995) J. Brain Res. , vol.36 , pp. 55-66
    • Walski, M.1    Borowicz, J.2
  • 43
    • 12644266057 scopus 로고    scopus 로고
    • Ultrastructural evaluation of brain phagocytes in the period of survival after clinical death
    • Walski M. and Chomiez L. (1996) Ultrastructural evaluation of brain phagocytes in the period of survival after clinical death. Eur. J. Haematol. 57, 21-27.
    • (1996) Eur. J. Haematol. , vol.57 , pp. 21-27
    • Walski, M.1    Chomiez, L.2
  • 44
    • 49049130278 scopus 로고
    • Effects of chronic low level lead exposure on brain development and function
    • Winder C., Carmichael N. G., and Lewis P. D. (1982) Effects of chronic low level lead exposure on brain development and function. Trends Neurosci. 6, 207-209.
    • (1982) Trends Neurosci. , vol.6 , pp. 207-209
    • Winder, C.1    Carmichael, N.G.2    Lewis, P.D.3


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