Anesthetic concentrations of propofol protect against oxidative stress in primary astrocyte cultures: Comparison with hypothermia

Anesthesiology

Volumn 94, Issue 2, 2001, Pages 313-321

  Peters, Caralei E ^a   Korcok, Jasminka ^a   Gelb, Adrian W ^a   Wilson, John X ^a,b  

^a Department of Physiology ^*

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LACTATE DEHYDROGENASE; PROPOFOL;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN PROTECTION; CELL CULTURE; CELL DEATH; CELL PROTECTION; DISULFIDE BOND; DRUG EFFECT; GLUCOSE TRANSPORT; HYPOTHERMIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN LIPID INTERACTION; RAT; RECEPTOR AFFINITY;

EID: 0035142925     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200102000-00022     Document Type: Article

References (46)

1. Effects of propofol on alterations of multineuronal activity of limbic and mesencephalic structures and neurological deficit elicited by acute global cerebral ischemia
2. Effect of 2,6-diisoprophylphenol on the delayed hippocampal cell loss following transient forebrain ischemia in the gerbil
3. Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat
4. Propofol neuroprotection in a rat model of ischaemia reperfusion injury
5. Propofol prevents delayed neuronal death following transient forebrain ischemia in gerbils
6. Effects of graded suppression of the EEG with propofol on the neurological outcome following incomplete cerebral ischaemia in rats
7. Effects of propofol and thiopentone on free radical mediated oxidative stress of the erythrocyte
8. Propofol attenuates hydrogen peroxide-induced mechanical and metabolic derangements in the isolated rat heart
9. Effect of propofol on in vitro lipid peroxidation induced by different free radical generating systems: A comparison with vitamin E
10. Propofol enhances red cell antioxidant capacity in swine and humans
11. Antioxidant effects of propofol in human hepatic microsomes: Concentration effects and clinical relevance
12. Mild hypothermia as a protective therapy during intracranial aneurysm surgery: A randomized prospective pilot trial
13. Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats
14. Hypothermic modulation of cerebral ischemic injury during cardiopulmonary bypass in pigs
15. The effect of extending mild hypothermia on focal cerebral ischemia and reperfusion in the rat
16. Neuroprotective effects of hypothermia and U-78517F in cerebral ischemia are due to reducing oxygen-based free radicals: An electron paramagnetic resonance study with gerbils
17. Real-time monitoring of the effects of normothermia and hypothermia on extracellular glutamate re-uptake in the rat following global brain ischemia
18. Cerebral metabolic rate and hypothermia: Their relationship with ischemic neurologic injury
19. 1H spectroscopic imaging
20. Effect of moderate hypothermia on lipid peroxidation in canine brain tissue after cardiac arrest and resuscitation
21. The effect of epidural cooling on lipid peroxidation after experimental spinal cord injury
22. 31P nuclear magnetic resonance study in unanesthetized neonatal rats
23. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
24. Synaptic activation of glutamate transporters in hippocampal astrocytes
25. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
26. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice
27. Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker
28. Oxidative stress-induced metabolic alterations in rat brain astrocytes studied by multinuclear NMR spectroscopy
29. Less core hypothermia when anesthesia is induced with inhaled sevoflurane than with intravenous propofol
30. Cerebral astrocytes transport ascorbic acid and dehydroascorbic acid through distinct mechanisms regulated by cyclic AMP
31. Expression of gap junction genes in astrocytes and C6 glioma cells
32. Fluorescence measurement of cytosolic pH in cultured rodent astrocytes
33. 3H]aspartate release from primary astrocyte cultures
34. Propofol prevents peroxide-induced inhibition of glutamate transport in cultured astrocytes
35. Accumulation of noradrenaline and its oxidation products by cultured rodent astrocytes
36. Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: Brain microdialysis study
37. Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia
38. Hypothermia ameliorates ischemic brain damage and suppresses the release of extracellular amino acids in both normo- and hyperglycemic subjects
39. Thiopental attenuates energetic impairment but fails to normalize cerebrospinal fluid glutamate in brain-injured patients
40. Glutamate stimulates ascorbate transport by astrocytes
41. Cardiopulmonary bypass-induced changes in plasma concentrations of propofol and in auditory evoked potentials
42. Concentration and regional distribution of propofol in brain and spinal cord during propofol anesthesia in the rat
43. Influence of rewarming conditions after hypothermia in gerbils with transient forebrain ischemia
44. Minimal effect of brain temperature changes on glutamate release in rat following severe global brain ischemia: A dialysis electrode study
45. Hypothermia protects astrocytes during ischemia in cell culture
46. Neuroprotective effect of mild hypothermia cannot be explained in terms of a reduction of glutamate release during ischemia