DNA intercalation, topoisomerase II inhibition and cytotoxic activity of the plant alkaloid neocryptolepine

Anti-Cancer Drug Design

Volumn 15, Issue 3, 2000, Pages 191-201

  Bailly, C ^a   Laine, W ^a   Baldeyrou, B ^a   De Pauw Gillet, M C ^a   Colson, P ^a   Houssier, C ^a   Cimanga, K ^a   Van Miert, S ^a   Vlietinck, A J ^a   Pieters, L ^a  

^a INSERM   (France)

Author keywords

Cytotoxicity; DNA binding; DNA intercalation; Neocryptolepine; Plant alkaloid; Topoisomerase

Indexed keywords

ALKALOID; CRYPTOLEPINE; DNA TOPOISOMERASE (ATP HYDROLYSING); NEOCRYPTOLEPINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL SURVIVAL; CIRCULAR DICHROISM; CYTOTOXICITY; DNA CLEAVAGE; DRUG ISOLATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTERCALATION COMPLEX; LIGAND BINDING; PLANT ROOT; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

ALKALOIDS; ANIMAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CATTLE; CIRCULAR DICHROISM; DNA; DNA DAMAGE; DNA FOOTPRINTING; DNA TOPOISOMERASES, TYPE II; HUMAN; INTERCALATING AGENTS; KB CELLS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED STRAINS; PLANT ROOTS; PLANTS, MEDICINAL; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T;

EID: 0033813885     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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